RUSSIAN JOURNAL OF GENERAL CHEMISTRY
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2024
·Vol. 94
·期 3
·616-629
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IF 0.9
Chen L.,Lian Q.,Li M.,Yu H.,Lv Y.,Guo M.,Zheng X.
Abstract Rod-shaped MnO 2 was synthesized by hydrothermal method. Ag@MnO 2 NRs were prepared with the Ag nanoparticles grown on the surface of rod-shaped MnO 2 by different reducing agents. The Ag@MnO 2 NRs were characterized by X-ray diffractometry, scanning and transmission electron microscopy, as well as X-ray photoelectron spectroscopy. The catalytic performance, catalytic mechanism and kinetic equation of the Ag@MnO 2 NRs were investigated. The as-prepared Ag@MnO 2 NRs were endowed with oxidase-like activity to catalyze the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) to a blue product without H 2 O 2 . Due to the inhibition of hydroquinone (HQ) on TMB oxidation, a simple, rapid, sensitive, and selective colorimetric sensor was set for the detection of HQ concentration in actual water. This method was established with an excellent linear range from 5–30 μM and a low detection limit of 1.7 μM. The colorimetric means could be availably used for the detection of HQ in river water samples and the RSD < 4.97%. The above results illustrated that the Ag@MnO 2 NRs had a great application prospect in environmental detection.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
International Journal of Nanomedicine
·
2025
·
IF 6.5
Jing Zhang,Min Zha,Shanghua Xiao,Nina Filipczak,Satya Siva Kishan Yalamarty,Xiangping Wu,Chenkai Gong,Xiang Li
Objective Nanoparticles constructed with silver/manganese dioxide (Ag@MnO2) as the core, in conjunction with survivin siRNA (sis) and cyclo(RGD-DPhe-K) (Ag@MnO2-sis-c-L), were prepared for integrated tumor diagnosis and therapy.Methods Ag@MnO2-sis-c-L particles were prepared and characterized. The silver and manganese content were determined by inductively coupled plasma optical emission spectroscopy (ICP-OES). The stability of sis in the system was evaluated by incubation with 50% FBS before the agarose gel electrophoresis experiment. The in vitro photothermal conversion ability, cytotoxicity to 4T1 cells, and cellular uptake of preparations were evaluated. The dialysis technique was employed to determine the in vitro release profile of Ag and Mn from Ag@MnO2-sis-c-L under various pH conditions. The pharmacokinetic behavior and tissue distribution of silver in vivo were detected by ICP-OES. Animal model experiments were conducted to further evaluate the anti-tumor efficacy of Ag@MnO2-sis-c-L against breast cancer in combination with infrared irradiation.Results Our newly synthesized Ag@MnO2-sis-c-L nanoparticles displayed superior physicochemical properties. The combined application of these nanoparticles with photothermal therapy (PTT) exerted the strongest synergistic inhibitory effects on tumor growth. Survivin protein expression in tumor tissues were markedly suppressed following delivery of nanoparticles loaded with sis. Additionally, magnetic resonance imaging revealed the high imaging capability of hybrid nanoparticles.Conclusion This study supports the potential utility of Ag@MnO2-sis-c-L coupled with PTT in therapeutic and diagnostic imaging applications.
研究领域:
纳米医学
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肿瘤学
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生物材料
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分子影像学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Jundong Zhu,Fan Yang,Chongwen Jiang,Zhonghua Li,Yanfang Zhou,Xin Li
Frequent oil spills and the discharge of oily wastewater pose serious threats to the environment, ecosystems, and humans. Herein, a multifunctional superhydrophobic sponge was successfully prepared through the in situ growth of Ag-MnO2 nanoparticles assisted by polydopamine rapid deposition and subsequent hydrophobic silicon modification. Owing to the synergistic effects of the hierarchical micro/nanostructure and methyl-terminated surface modification, the obtained superhydrophobic sponge has a water contact angle (WCA) of 156.5°, demonstrating excellent chemical stability and structural durability under harsh environmental media and mechanical damage. For oil–water separation, the adsorption capacity of modified sponge for various oils ranges from 58.2 to 132.6 times its own weight and great separation efficiency up to 98.38%. Through the photothermal conversion effect of Ag-MnO2 nanocomposite, the surface temperature of the material can reach 64.1 °C under simulated radiation, achieving rapid adsorption and recovery of high-viscosity oil. Additionally, the immobilization of silver nanoparticles within the sponge skeleton effectively inhibits the growth of Escherichia coli and Staphylococcus aureus, exhibiting antibacterial properties that facilitate the elimination of bacteria in organically contaminated water sources. Therefore, the multifunctional superhydrophobic sponge in this study provides high potential and efficient application for efficient oil–water separation, rapid crude oil recovery, and antibacterial pollution of water.
研究领域:
环境科学
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材料科学
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生物医学
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产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 41
·15340-15347
·
IF 8.307
Lin Tian,Zijun Huang,Weidan Na,Yuanyuan Liu,Shuai Wang,Yu He,Wenjing Cheng,Tianzi Huang,Zhao Li,Tongxiang Li
The biocatalytic design of nanomaterials with enzyme-like activity is considered a reliable and promising toolkit for the generation of diagnostic agents in complex biological microenvironments. However, the preparation of nanomaterials while maintaining a high catalytic activity in tumor cells (pH 6.0–6.5) poses a prominent challenge. Herein, we constructed a biomimetic enzyme-trigged dual-mode system with colorimetry at 652 nm and photothermal biosensors to detect glutathione based on hollow MnO2-nanosheet-decorated Ag nanowires (Ag@MnO2) as an oxidase-like nanozyme. As expected, Ag@MnO2 catalyzed the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the absence of H2O2, leading to a blue-colored oxidized TMB (oxTMB) that displayed oxidase-like activity in pH 6.0. Interestingly, the portable dual-mode colorimetry and photothermal method for GSH was developed based on the redox reaction between GSH and oxTMB. This detection method exhibited a wide linear range of 0.1–55 μM for GSH with a low detection limit of 0.08 μM. This work highlights a new insight into nanotechnology by taking advantage of biomimetic design in biological analysis.
研究领域:
生物化学
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纳米医学
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诊断学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
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IF 7.7
Yingchun Sun,Ru Liu,Yuhui Sun,Ling Long
Formaldehyde (HCHO) poses a significant threat as a common indoor air pollutant, leading to various health issues. However, effectively addressing HCHO removal at room temperature remains a considerable challenge. This paper presents the preparation of a robust, eco-friendly, and biodegradable composite cellulose nanofiber film, incorporating CeO 2 -Ag@MnO 2 catalysts and TEMPO-oxidized cellulose nanofiber (TOCNF), for high-efficiency HCHO removal at room temperature. A CeO 2 -Ag@MnO 2 ternary catalyst with a core–shell structure was constructed to enhance the catalytic oxidation activity and stability. This structure increased the number of active sites on the catalyst surface and enhanced the interfacial synergistic effect of Ce-Ag-Mn. The TOCNF physically adsorbed HCHO in the composite film , while the catalyst oxidized it to CO 2 and water. The composite films, particularly those with 20 wt% CeO 2 -Ag@MnO 2 catalyst, exhibited high HCHO removal rates of 91.2 % at 20 °C and 99.6 % at 60 °C. Furthermore, the TOCNF/20 CAM composite films demonstrated excellent mechanical properties and degradability. This composite film offers an efficient and eco-friendly solution for the catalytic oxidation of HCHO at room temperature.
研究领域:
环境科学
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材料科学
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纳米技术
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催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）