Antibiotics-Basel
·
2022
·Vol. 11
·期 12
·1737
·
IF 5.222
Fang Zhou,Elie Kostantin,De-Quan Yang,Edward Sacher
Although Ag nanoparticles (NPs) have been widely applied in daily life and in biomedical and industrial fields, there is a demand for Ag-based bimetallic nanoalloys (NAs), such as AgCu and AgFe, due to their enhanced antibacterial efficacy and reduced Ag consumption. In this work, we present a comparison study on the antibacterial efficacy and cytotoxicity rates of Ag NPs and AgCu and AgFe NAs to L929 mouse fibroblast cells using the CCK-8 technique based on the relative cell viability. The concept of the minimum death concentration (MDC) is introduced to estimate the cytotoxicity to the cells. It is found that the minimum inhibitory concentrations (MICs) of the NPs againstE. coliandS. aureusdecrease with the addition of both Cu and Fe. There is a strong correlation between the MDC and MIC, implying that the mechanisms of both antibacterial efficacy and cytotoxicity are similar. The enhanced antibacterial efficacy to bacteria and cytotoxicity toward the cell are attributed to Ag+release. The following order is found for both the MIC and MDC: AgFe < AgCu < Ag NPs. However, there is no cytotoxicity to the L929 cells for AgFe and AgCu NAs at their MIC Ag concentrations againstS. aureus.Keywords:AgCu;AgFe;antibacterial efficacy;cytotoxicity;L929 cells;nanoalloy
研究领域:
材料科学
·
生物学
·
医学
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DOI
PubMed
高影响因子
Surfaces and Interfaces
·
2024
·
IF 5.7
Pengfei Zhu,Shuang Qin,Mengrong Geng,Heyang Cao,Zhiliang Jin,Chuanyi Wang
Photocatalytic NO removal technology is considered as one of the most effective green methods for reducing atmospheric NO but there remains the problems of lower efficiency and poor stability of photocatalysts . Rapid recombination of photogenerated electron (e − ) and holes (h + ) is known as a key issue that causes low activity and poor stability of catalysts. Herein, we report a novel AgCu@UiO-66-NH 2 photocatalyst (AgCu@UN) that is made up of AgCu alloy on the surface of Zr-MOF (UiO-66-NH 2 ) by employing in-situ photodeposition method. The experimental results of photocatalytic NO removal indicated that the optimized 0.5Ag0.5Cu@UN sample with 0.5 mg of Ag and Cu exhibited the best NO removal efficiency of 63 % for ppb-level atmospheric NO, more higher than that of pure UiO-66-NH 2 (38 %). The characterizations suggested that the excellent photocatalytic performance of 0.5Ag0.5Cu@UN can be ascribed to the efficient charge separation and transfer and the visible-light-harvesting ability due to benefiting electron migration process between AgCu alloys and UN. Moreover, the enriched electrons around AgCu could be transferred to O 2 to generate more superoxide radicals (•O 2 − ), which could oxidize NO to the final product, nitrate (NO 3 − ). The present findings can provide some novel insights for the design of efficient MOF based photocatalysts to eliminate low concentrations of NO X .
研究领域:
材料科学
·
环境科学
·
化学工程
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DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 13
·3027
·
IF 4.2
Yuping Le,Fang Zhou,Longlai Yang,Yan Zhu,Dequan Yang
AgCu bimetallic· nanoparticles (NPs) represent a novel class of inorganic, broad-spectrum antimicrobial agents that offer enhanced antimicrobial effectiveness and reduced cytotoxicity compared to conventional Ag NP antibacterial materials. This study examines the antimicrobial performance and structural characteristics of AgCu nanoparticles (NPs) synthesized via two distinct chemical reduction processes using PVP-PVA as stabilizers. Despite identical chemical elements and sphere-like shapes in both synthesis methods, the resulting AgCu nanoparticles exhibited significant differences in size and antimicrobial properties. Notably, AgCu NPs with smaller average particle sizes demonstrated weaker antimicrobial activity, as assessed by the minimum inhibitory concentration (MIC) measurement, contrary to conventional expectations. However, larger average particle-sized AgCu NPs showed superior antimicrobial effectiveness. High-resolution transmission electron microscopy analysis revealed that nearly all larger particle-sized nanoparticles were AgCu nanoalloys. In contrast, the smaller particle-sized samples consisted of both AgCu alloys and monometallic Ag and Cu NPs. The fraction of Ag ions (relative to the total silver amount) in the larger AgCu NPs was found to be around 9%, compared to only 5% in that of the smaller AgCu NPs. This indicates that the AgCu alloy content significantly contributes to enhanced antibacterial efficacy, as a higher AgCu content results in the increased release of Ag ions. These findings suggest that the enhanced antimicrobial efficacy of AgCu NPs is primarily attributed to their chemical composition and phase structures, rather than the size of the nanoparticles.
研究领域:
微生物学
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材料科学
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纳米技术
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2019
·
IF 3.131
Yumei Peng,Lixia Qin,Jiefei Liu,Shi-Zhao Kang,Guodong Li,Xiangqing Li
Here, by a simple one-step in situ chemical reduction method, the Ag x Cu y alloy was tailored on the surface of mesoporous TiO 2 (M-TiO 2 ), therefore, a series of bi-functional mesoporous TiO 2 nanohybrids (M-TiO 2 /Ag x Cu y ) for both surface enhanced Raman scattering (SERS) detection and photocatalytic degradation of ampicillin (AMP) were achieved. The composition and structure of the nanohybrids were well characterized using XRD, TEM, XPS and HRTEM-EDS measurements. Results indicated that Ag x Cu y alloy was mainly attached around the pores of M-TiO 2 which may generate more active sites than nonporous P25−Ag−Cu. Thus, the M-TiO 2 /Ag x Cu y nanohybrids could be used as efficient SERS substrates to sensitively monitor the AMP in water with lower detection limit (˜ 1 ppt) than P25−Ag−Cu. Besides, the M-TiO 2 /Ag 3 Cu 1 nanohybrid also showed higher photocatalytic activities for the degradation of AMP under UV irradiation over the M-TiO 2 /Ag, the M-TiO 2 /Cu and the P25−Ag−Cu. This work provided a simple and effective approach to synthesize bi-functional nanohybrids for detection and degradation of organic contaminants in wastewater.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Xinghao Li,Sara Ajmal,Penghui Fang,Xiaoxing Zhou,Maoni Lu,Sichen Li,Ping Chen,Peng Li,Manzhou Zhu
Ultrafine metal nanoclusters have been extensively studied due to their fascinating chemical characteristics. In this work, ultrafine AgCu nanoclusters are synthesized and loaded on the defective ZIF-8 (denoted as AgCu/D-ZIF-8). The findings show that the as-obtained AgCu/D-ZIF-8 catalysts with low AgCu loading (0.387 wt%) exhibit outstanding catalytic performance and recyclability for the reaction of azide–alkyne cycloaddition (click reaction) at 35 °C. Compared with monometallic Ag25/D-ZIF-8 and Cu25/D-ZIF-8 catalysts, bimetallic AgCu/D-ZIF-8 catalysts present exceptional activity for the click reaction. Additionally, AgCu/D-ZIF-8 catalysts display a higher yield of target product for this reaction compared to AgCu/ZIF-8. The experimental results suggest that some defective sites in D-ZIF-8 are occupied by AgCu nanoclusters, which may be key to improving the activity and recyclability of AgCu/D-ZIF-8 catalysts. Consequently, this work provides valuable insights for designing ultrafine bimetallic catalysts with high performance.
研究领域:
化学
·
材料科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2022
·
IF 7.139
Huimin Li,Tiantong Zhang,Mao Peng,Qianqian Zhang,Jing Liu,Jinli Zhang,Yan Fu,Wei Li
Electrochemical reactions are important method for reducing the carbon footprint of large-scale chemical processes. Highly selective conversion of 5-hydroxymethylfurfural (HMF) to 2,5-dihydroxymethylfuran (DHMF) is achieved under mild conditions through electrocatalytic hydrogenation (ECH) over AgCu nanoalloys supported by the pyrolyzed biomass alginic acid sodium (PA), with the advantage of utilizing the active hydrogen intermediates in the process. The Ag 1 Cu 1 /PA exhibits outstanding performance in ECH of HMF with a selectivity of 94% toward DHMF at a conversion of 93.2% and the Faraday efficiency (FE) of 61.8%, which are significantly superior to those over Ag/PA (selectivity of 53.89%, conversion of 90.6%, and FE 25.79%). The incorporation of Cu into Ag nanoparticles boosts the charge transferability and lowers the onset potential of ECH. Density functional theory calculations reveal that AgCu alloy provides more electron transfer to HMF and lowers the energy barrier for HMF hydrogenation.
研究领域:
化学工程
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材料科学
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环境科学
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产品关联
DOI
高影响因子
ELECTROCHIMICA ACTA
·
2024
·
IF 5.5
Zhefei Zhao,Xuyao Yao,Linlin Zhang,Minhao Chen,Xingyu Luo,Ruopeng Yu,Yinghua Xu,Youqun Chu,Xinbiao Mao,Huajun Zheng
Electrochemical selective dechlorination for the synthesis of high value-added chemical products is an economical and promising technology. Although silver (Ag) electrode is the most representative catalyst in most electrocatalytic dehalogenation reactions, the selectivity for specific reaction needs to be improved. In this framework, AgCu bimetallic electrocatalysts were designed for the selective dechlorination of 4-amino-3,5,6-trichloropyridine carboxylic acid (4-N-3,5,6-TCP) to 4-amino-3,6-dichloropyridolinic acid (4-N-3,6-DCP). The optimum Ag 16 Cu 4 electrode exhibits excellent performance with 99.0% selectivity and 98.8% yield of 4-N-3,6-DCP, surpassing the pure Ag electrode. The combined results of experimental measurements and theoretical calculations indicated that the introduction of Cu modulates the electronic structure of Ag, which not only promoted the transfer of charges, but also reduces the energy barrier of the rate-determining step (the C H formation). In addition, the practicality and scalability of this system was evaluated using a flow-cell reactor. This study demonstrates that AgCu bimetallic catalyst plays a crucial role in determining the selectivity and activity in the electrochemical dechlorination of 4-N-3,5,6-TCP and displays the prospective applications.
研究领域:
环境科学
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材料科学
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电化学工程
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DOI
高影响因子
WATER RESEARCH
·
2024
·
IF 11.4
Wenjuan Zhang,Zhe Wang,Zilong Zhao,Peizhi Wang,Shaopo Wang,Jun Ma,Wei Cheng
Nanofiltration (NF) is crucial for advancing water purification and wastewater reuse technologies. Incorporating biocidal nanoparticles (NPs) such as AgNPs and CuNPs is promising for developing antibacterial and antibiofouling NF membranes, while their application is limited by NPs aggregation, high cost, and severe ion release. In this study, we developed novel NF membranes by integrating bimetallic AgCu nanoalloys via an in-situ reduction and coordination method facilitated by a polydopamine/polyethyleneimine (PDA/PEI) intermediate layer. The sequential deposition of Cu 2+ onto nascent AgNPs formed uniform AgCuNPs with a unique core-shell structure. The Cu shell layer can shield the release of Ag + from the Ag core and chelate with the PDA/PEI intermediate layer, thus controlling the release of biocidal ions and prolonging the biocidal properties of the membranes. As a result, the AgCuNP-modified membranes exhibited significantly improved membrane water permeability, salt rejection, and performance stability, along with reduced release of biocidal ions in the long-term operation. Notably, the bimetallic AgCuNP-modified membrane displayed superior antibacterial activity and biofouling reversibility compared to the commercial NF and monometallic Ag/Cu-modified membranes, achieving the highest sterilization rate (> 99 %), largest flux recovery rate (93 %), and lowest flux decline rate (16 %) in both static antibacterial and dynamic biofouling processes. The metal-semiconductor heterostructure of the AgCuNPs facilitated the electron transfer from the Ag core to the Cu shell, intensifying the substantial generation of reactive oxygen species (H 2 O 2 : 71.6 mmol l -1 m -2 , • OH: 43.4 mmol l -1 m -2 , and O 2 •– : 1.3 × 10 –4 ) at the membrane-bacteria interface. The synergistic effects of the unique properties of AgCuNPs including microstructure, atomic composition, charge transfer, and ROS generation significantly enhanced the antibacterial capacity of the AgCuNP-modified membrane. This study presents a facile method for modifying NF membranes with bimetallic AgCuNPs to achieve enhanced antibacterial activity and biofouling reversibility, providing fundamental insights and promising potential for water treatment applications.
研究领域:
环境科学
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材料科学
·
水处理技术
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Fang Zhou,Yan Zhu,Longlai Yang,De-Quan Yang,Edward Sacher
Aqueous dispersions of AgCu nanoparticles (NPs), with enhanced antibacterial efficacy, have been prepared through the catalyzed reduction of Cu ions by PVP/PVA-stabilized Ag nanoparticles at 85 °C. The effects of Cu concentration and heating time on NP morphology and antibacterial efficacy were investigated, using TEM, UV-Vis and FTIR spectroscopies , and antibacterial evaluations. The enhanced antibacterial performance of these NPs was correlated with Ag ion release. We propose a simple model of AgCu NP formation, and an enhanced antibacterial efficacy mechanism involving Ag ion release, in which AgCu NPs formation plays a role to control of Ag ion release.
研究领域:
材料科学
·
微生物学
·
纳米医学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF LEGAL MEDICINE
·
2019
·Vol. 134
·期 1
·177-183
·
IF 2.094
Xie Mingkun,Song Feng,Li Jienan,Xie Bowen,Wang Shuangshuang,Wang Weizhi,Ma Hong,Luo Haibo
Genotyping by targeting short tandem repeats (STRs) has been widely used in forensic applications. However, most commercial kits detect autosomal STRs or Y-STRs alone, which waste both time and opportunity. The AGCU Expressmarker 16 + 22Y Kit includes 16 autosomal and 22 Y-chromosomal STR loci and is designed for the forensic science field and obtaining quicker results. Here, we conducted the validation study according to Scientific Working Group on DNA Analysis Methods (SWGDAM) guidelines. Validation of PCR-based studies, species specificity, sensitivity, DNA mixture studies, inhibitors, precision, and sizing accuracy were performed. Furthermore, this system was also tested in 346 random male samples from Han, Hui, Tibetan, and Zhuang populations in China, showing its high power for forensic discrimination in the Chinese population. In addition, this system was able to deal with AMELY deletion cases, which can correctly identify sex in forensic criminal investigations. Our results suggested that the AGCU Expressmarker 16 + 22Y Kit is a useful tool for rapid criminal investigation.
研究领域:
法医学
·
分子生物学
·
遗传学
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DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2025
·Vol. 13
·期 3
·117212
·
IF 7.2
Yunjie Li,Yawen Guan,Shuo Li,Yuting Zhao,Yakun Luo,Liang Si,Li Wang,Fang Chai
As a key neurotransmitter in the central nervous system, dopamine (DA) plays a significant role in the function of human metabolism. Precise detection of DA levels is essential for disease prevention and health maintenance. Herein, AgCu bimetallic microspheres (AgCu-MS) were synthesized by a simple solvothermal method with fumaric acid as the reducing agent and loaded on reduced graphene oxide (rGO) to produce composites for constructing an establishing convenient, cost-effective, and accessible electrochemical (EC) sensor for the sensitive determination of DA. The nano-micro coarse-grained surface supplied a large specific surface area and rich active sites, giving a forceful support for the adsorption and oxidation of DA. Meanwhile, by taking advantage of the high conductivity of rGO, intense production of electrical signals for DA detection was achieved. The AgCu-MS/rGO sensor fulfilled the sensitive and selective detection for DA with a limit of detection of 34.6 nM within a large scale of 3–100 μM. Notably, the AgCu-MS exhibited oxidase-like activity, contributed to significant antibacterial capabilities. The excellent sensing and antibacterial activity were assigned to the synergies of the bimetallic AgCu-MS, promising as a candidate in the realms of electrochemical analysis and antibacterial applications.
研究领域:
电化学分析
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纳米材料
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生物传感器
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抗菌材料
·
神经化学
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产品关联
DOI
高影响因子
CELLULOSE
·
2024
·
IF 4.9
Zheng Jiaojiao,Cao Tianyu,Wang Jianxiao,Xu Wenhao,Qu Yihan,Wang Jiafen,Wu Yunlong,Song Yanyan,He Lizhong,Chen Xudong,Yang Jie,Qu Yinhu
Engineering the active layer of pressure sensors with micro-nano structures is increasingly important in improving their sensing properties, such as sensitivity and detection range. However, existing structures based on template methods continue to face manufacturing challenges and uncontrolled structures, making it difficult to optimize sensing performance. To address the aforementioned shortcomings, this study proposes highly tunable metallic silver copper micro-nano structures adapted on cotton fabric (AgCu/cotton) to adjust the interfacial contact sites and optimize the sensing properties. The shape, size, and distribution of the metallic AgCu nano structures are precisely regulated, and various distinctive morphologies including two-dimensional (2D) nanosheet stacking, three-dimensional (3D) irregular protrusions, and nanoparticle aggregation were obtained. Specifically, the 3D irregular protrusions of varying heights and shapes (nanosheets, nanoparticles, and so on), encouraging multiple deformations and enhanced interfacial contact sites. On the other hand, the hierarchical porous structure of cotton fabric enhances structural compressibility. Collectively, the synergistic results of the 3D irregular protrusions and the hierarchical porous structure allow for a high sensitivity (115.65 kPa −1 ), a quick response time (500 ms), and outstanding stability (2000 cycles). The above sensing properties enable the pressure sensor to be successfully applied in joint movement detection and swallowing recognition. The discovery could pave the way for a more cost-effective and widespread approach to a controlled and improved piezoresistive pressure sensor. Graphical abstract We herein develop a highly morphology-controlled AgCu/cotton flexible pressure sensor with an economical strategy toward superior sensing performance. Such regulated morphology is responsible for optimized contact sites and structural deformation, resulting in a high sensitivity of 115.65 kPa −1 over 2–7.5 kPa, and showing great potential in various human motion detections.
研究领域:
材料科学
·
传感器技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）