REACTIVE & FUNCTIONAL POLYMERS
·
2022
·
IF 4.966
Xiao Li Li,Peng Liu,Bin Chu,Jin Mei He,Zhen Wang,Song Wang,Chang Sheng Chen,Xiao Hong Ge,Hui Li,Wei Qiang Liu
Myocardial infarction (MI) is a common heart emergency that potentially causes death. Injectable hydrogels with excellent malleability and filling properties are suitable for myocardial injection and can avoid the need for open surgery. In this study, dopamine grafted hyaluronic acid (HADOPA) was synthesized and combined with sodium alginate (Alg) and Ca 2+ -loaded liposomes (Ca-FVI) to prepare a series of injectable thermosensitive sodium hyaluronate/sodium alginate hydrogels (HADOPA/Ca-FVI/Alg). At 37 °C, the HADOPA/Ca-FVI/Alg solution rapidly changed from liquid to hydrogel because of the crosslinking between sodium alginate and the Ca 2+ released from Ca-FVI at a phase transition time of 100–200 s. The HADOPA/Ca-FVI/Alg scaffolds exhibited a porous 3D network structure, controlled porosity, and connected pore properties. Increasing the proportion of HADOPA increases the elasticity and absorbance of hydrogels. Experimental assessment showed that the hydrogels have good biocompatibility and that Alg1-HADOPA is more conducive to the adhesion, proliferation, and spreading of mouse cardiac myocytes while maintaining the best cell state. These findings suggest that HADOPA/Ca-FVI/Alg hydrogels improve cell proliferation and tissue repair, and that they are a promising therapeutic option for cardiac repair after MI.
研究领域:
生物材料学
·
心血管医学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Xia Zhao,Hong Wang,Hong Peng,Linling Wang,Xiaohua Lu,Yanjun Huang,Jing Chen,Taikang Shao
Two buoyant ALG/HA/HGMs composite adsorbents, AHG(acid) and AHG(base), were prepared by encapsulating hollow glass microspheres and humate within alginate gel beads in this study. Both AHG(acid) and AHG(base) were characterized and their adsorption properties for removal of copper(II) ions from aqueous solution and kaolin soil were investigated. In aqueous solution, the maximum adsorption capacities of copper on AHG(acid) and AHG(base) were 34.8 and 40.4 mg g −1 , respectively, and the adsorption kinetics for AHG(acid) and AHG(base) followed the mechanism of the pseudo-second order kinetic model, and their equilibrium data were well fitted with the Langmuir isothermal model. The removal of copper from contaminated kaolin by AHG(acid) and AHG(base) was conducted by soil washing with deionized water containing buoyant adsorbents. As AHG(acid) could release hydrogen ions and reduce the pH value of the system consisting of adsorbent, water and kaolin, while AHG(base) could release hydroxide ions and increase the pH value of the system, the removal efficiency of copper from kaolin soil by AHG(acid) was much higher than that by AHG(base). Under soil washing conditions of the dosage of AHG(acid) of 3%, water/soil ratio of 3/1, and washing time of 48 h, the removal efficiency of copper from kaolin by AHG(acid) was 72.8%, and after 5 times reuse of AHG(acid) it was kept at 70%, while the pH value of kaolin soil was maintained in the pH range of 4.60–4.80. The results indicate that AHG(acid) has a potential application prospect in removing heavy metals from soil compared with AHG(base).
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry B
·
2013
·Vol. 1
·期 9
·1326-1332
·
IF 0
Wei Cui,Yue Cui,Jie Zhao,Junbai Li
Layer-by-layer assembled TRAIL/ALG shells have been successfully coated on the surface of highly loaded doxorubicin (DOX) calcium carbonate (CaCO3) nanoparticles as drug carriers. The assembled core/shell structure was characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM). They show that the assembled TRAIL/ALG coated DOX@CaCO3 nanocomposites can be internalized by cancer cells. The outer layer of the system is TRAIL which can be specifically recognized by tumors and leads to the apoptosis of tumors. The release of DOX can directly kill the cancer cells. This demonstrates that the core/shell nanocomposites of TRAIL/ALG-CaCO3 loaded with DOX have good potential applications in the treatment of cancer.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
Biomaterials Advances
·
2022
·
IF 0
Xiaofang Wu,Kai Chen,Qi Chai,Siyu Liu,Cunao Feng,Linmin Xu,Dekun Zhang
There is an urgent need for vascular scaffolds as a treatment option for cardiovascular diseases in the clinic. Here, we developed a simple and effective method to fabricate vascular scaffolds by direct 3D printing in air with gelatine (Gt) - alginate (Alg) - montmorillonite (MMT) nanocomposite bioinks. This work includes the optimization of key 3D printing parameters and the characterization of microscopic morphology, physicochemical properties, mechanical properties and preliminary biological properties. Successful 3D printing of linear and branched vascular scaffolds showed that the addition of nano-MMT improved the printability and shape accuracy. Scanning electron microscopy revealed that the inner and outer surfaces of the vascular scaffolds exhibited interconnected microporous structures favourable for nutrient delivery and cell infiltration. Axial and radial tensile tests indicated that the tensile strength and elastic modulus were similar to those of the native artery. The burst pressure of Gt-4%Alg-MMT was also in good accordance with the physiological pressure of natural blood vessels. In addition, a haemolysis test demonstrated that the haemolysis rate of Gt-4%Alg-MMT matched the gold standard of blood vessel substitution. A Live & Dead stain and a CCK-8 test confirmed the safe applicability of Gt-Alg-MMT as a biomaterial. Overall, the 3D-printed vascular scaffolds are promising candidates for in situ vascular tissue regeneration.
研究领域:
生物医学工程
·
材料科学
·
组织工程
✓ 已验证
DOI
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Xuyi Wei,Xiaohui Mao,Wenqing Qin,Hongbo Zeng,Junwei Han
The increasing consumption of rare earth elements (REEs) and disposal of REE-containing wastes pose a threat to resources and environment. Hence, it is important to achieve efficient REEs recovery while use eco-friendly methods. Herein, natural kaolinite is loaded on alginate hydrogel to prepare ALG@KLN composites via a facile one-step cross-link reaction without any hazardous chemicals. The characterizations of ALG@KLN, adsorption isotherms, adsorption kinetics, and desorption were investigated by SEM-EDS, XPS, FT-IR, and Zeta-potential. The maximum adsorption capacity of Gd (Ⅲ), Y (Ⅲ), Ho (Ⅲ), and Nd (Ⅲ) reached 74.40, 84.48, 85.18, and 75.17 mg/g, respectively. The adsorption kinetics and isotherm were well fitted to pseudo-second-order model and Langmuir model, respectively. The ∼2 mm diameter ALG@KLN can be easily collected and reused. The presence of Na + , Mg 2+ , and Al 3+ has a minor effect on the adsorption of REEs. The adsorption mechanism is mainly via the chemical chelation of oxygen-containing functional groups and electrostatic interaction on negatively charged surface of ALG@KLN. In addition, the cost of ALG@KLN is as low as ∼0.041 USD/gram. This work greatly contributes to the development of economical and eco-friendly REE adsorbents, which plays an important role in sustainable development.
研究领域:
环境科学
·
材料科学
·
化学工程
·
可持续性
✓ 已验证
产品关联
DOI
高影响因子
Soft Matter
·
2019
·Vol. 16
·期 1
·132-141
·
IF 3.399
Yangjie Xu,Jiulong Zhao,Zhilun Zhang,Jing Zhang,Mingxian Huang,Shige Wang,Pei Xie
In this study, sodium alginate (ALG)/poly dopamine (PDA)–polyvinylpyrrolidone (PVP) nanocomposites was synthesized via a one-step electrostatic spraying method. The spinning solution of ALG and dopamine was electrostatically sprayed into an alkaline solution of PVP, calcium chloride and tris buffer (pH = 8.5), in which the gelation of ALG and the polymerization of dopamine could be simultaneously triggered. PDA hence produced possesses a high photothermal conversion efficiency, while the PVP that was facilely conjugated onto the surface of nanocomposites improves the colloidal stability and compatibility of the material. Moreover, the ALG renders the nanocomposite excellent drug (doxorubicine, DOX) loading capacity. Promisingly, the temperature increment during the PTT process could promote the DOX release, thus enhancing its therapeutic effect. The in vitro/in vivo biosafety and tumor treatment experiments further corroborate that the ALG/PDA–PVP nanocomposites have remarkable biocompatibility and synergism for tumor hyperthermia and chemotherapy. Consequently, such a one-step electrospray strategy provides a new way for designing nanomaterials and is expected to significantly promote the development of organic photothermal therapeutic agents with excellent bio-compatibility.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2015
·Vol. 3
·期 17
·3420-3424
·
IF 4.726
Yuangang Liu,Zongxiang Chen,Shibin Wang,Ruimin Long,Jingqian Fan,Aizheng Chen,Wenguo Wu
In order to improve alginate microbead stability and further broaden the application of alginate in biomaterials, a new biomaterial, ALG-g-Lys, was prepared and its possibility as a novel drug carrier investigated. The carrier exhibited a sustained release property and preserved activity with no initial burst release, and interestingly, GP-crosslinked ALG-g-Lys microspheres showed obvious fluorescence properties, which showed promising potential for the future drug delivery systems.
研究领域:
生物材料
·
药物递送系统
·
药剂学
✓ 已验证
DOI
PubMed
高影响因子
Biomaterials Science
·
2020
·Vol. 8
·期 11
·3173-3185
·
IF 6.183
Boguang Yang,Fanglian Yao,Lei Ye,Tong Hao,Yabin Zhang,Lei Zhang,Dianyu Dong,Wancai Fang,Yan Wang,Xiaoyang Zhang,Changyong Wang,Junjie Li
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering. Herein, we describe a facile approach for preparing a poly(3,4-ethylenedioxythiophene)/alginate (PEDOT/Alg) porous scaffold with a wide range of desirable properties. In the PEDOT/Alg scaffold, chemically crosslinked alginate networks are formed using adipic acid hydrazide as the crosslinker, and PEDOT is synthesized in situ in the alginate matrix simultaneously. PEDOT exists in the alginate matrix as particles and its morphology can be modulated by adjusting the ratio of PEDOT/alginate. The results also show that the swelling properties, degradation behaviors, mechanical strength and conductivity of the PEDOT/Alg scaffold can be controlled via adjusting the PEDOT/alginate ratio. The introduction of PEDOT can overcome the brittle nature of the pure alginate scaffold. Moreover, the PEDOT/Alg scaffold exhibits excellent conductivity (as high as 6 × 10−2 S cm−1). The introduction of PEDOT improves the protein absorption capacity of the alginate scaffold. To explore its potential application in cardiac tissue engineering, brown adipose-derived stem cells (BADSCs) are seeded in the prepared PEDOT/Alg porous scaffold. The results suggest that the PEDOT/Alg porous scaffold can support the attachment and proliferation of BADSCs. Moreover, it is beneficial for the cardiomyogenic differentiation of BADSCs, especially under electrical stimulation. Overall, we conclude that the PEDOT/Alg porous scaffold may represent an ideal platform to modulate the biological behaviors of BADSCs.
研究领域:
生物材料
·
干细胞研究
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Omega
·
2024
·
IF 3.7
Yize Lin,Yan Tan,Rong Deng,Li Gong,Xiaoshan Feng,Zhongqi Cai,Yanxian He,Longbao Feng,Biao Cheng,Yi Chen
Chronic wounds are characterized with excessive biofluid and persistent infection. Therefore, there is an urgent desire to develop a multifunctional wound dressing that can meet the extreme requirements including effective antibacterial and powerful wound microenvironment regulation and protection function to promote wounds heal quickly. In this study, a multifunctional composite dressing (HA-AMP/SF/Alg/Rb-BG-AIEgens) was synthesized by combining a mesoporous bioactive glass framework loaded with AIEgens (Rb-BG-AIEgens) with cross-linked antimicrobial peptide grafted hyaluronic acid (HA-AMP), sodium alginate (Alg), and silk fibroin (SF). It is important to note that the Rb-BG-AIEgens can achieve real-time and sensitive bacterial detection. HA-AMP can achieve broad spectrum antibacterial and avoid the residue of drug-resistant bacteria. The HA-AMP/SF/Alg/Rb-BG-AIEgens dressing can up-regulate related proliferative proteins, thereby promoting regeneration of tissue and the rapid healing of chronic wounds. With good biocompatibility and antibacterial ability, HA-AMP/SF/Alg/Rb-BG-AIEgens dressing has great potential to become a next generation wound dressing for clinical biological fluid management and chronic bacterial infection treatment.
研究领域:
生物医学工程
·
材料科学
·
伤口愈合
·
感染控制
✓ 已验证
产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Songyan Wang,Yuqing Lu,Xiao-kun Ouyang,Xue Xue Liang,Di Yu,Li-Ye Yang,Fangfang Huang
Groundwater contaminated by arsenic endangers our health. Therefore, in this work, a novel composite adsorbent consisting of magnetic chitosan (MCS), zinc oxide (ZnO), and sodium alginate (Alg) was prepared to remove arsenic from groundwater. First, chitosan was coated on the surface of Fe 3 O 4 nanoparticles by coprecipitation. Then, MCS/ZnO@Alg gel beads were fabricated by combining MCS with ZnO and Alg , and crosslinking the composite material in the presence of Ca 2+ ions. The MCS/ZnO@Alg beads were characterized by SEM, FTIR spectroscopy , XRD, VSM, and XPS . The adsorption experiments revealed that the MCS/ZnO@Alg magnetic gel beads have high stability and As(V) adsorption capability, and adsorbed As(V) through chemical adsorption. The maximum As(V) adsorption capacity as determined from the Langmuir model was 63.69 mg/g. In addition, MCS/ZnO@Alg exhibited good recyclability and high sustainability. This work proves that the MCS/ZnO@Alg gel beads are an ideal candidate for addressing the grievous environmental threats caused by water pollution.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Physical Chemistry C
·
2018
·
IF 4.484
Wei Lu,Chunxin Ma,Dong Zhang,Xiaoxia Le,Jiawei Zhang,Youju Huang,Chih-Feng Huang,Tao Chen
Shape memory hydrogels (SMHs) that take advantage of supramolecular chemistry cross-links to fix temporary shapes at room temperature are newly developed important shape memory polymers. It is thus highly desirable to explore in detail the in situ formation and real-time spatial distribution of temporary supramolecular cross-links in SMH systems, which can provide more in-depth information about the shape memory mechanism and promote the fabrication of new SMHs. However, related study still remains very challenging. We herein report the development of a special SMH system that involves fluorescent alginate–Eu3+ complexes as switching cross-links. Its coordination-triggered supramolecular shape memory/recovery processes and dynamics could be directly visualized by a high-contrast fluorescence imaging method. Remarkably, this efficient and sensitive fluorescence study enables real-time in situ monitoring of the process, in which Eu3+ ions gradually diffuse into the hydrogel sample and chelate with alginate to form the Eu3+–Alg temporary cross-links. Furthermore, a theoretical model correlating the fluorescence intensities of the SMH system with their shape memory effect (SME) was successfully established, which allows the facile and accurate prediction of both the shape memory and recovery ratios on the basis of quantitative emission spectral results. These details disclosed in this study will thus deepen the understanding of supramolecular shape memory process and mechanisms and accelerate the development of new practical shape memory hydrogels in the future.
研究领域:
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Building Engineering
·
2025
·
IF 7.4
Wencheng Wang,Nanxi Xie,Zhenkun Lin,Yong Zhang,Yan Chen,Zhongmin Liu
The application of corrosion inhibitors provides an efficient approach for mitigating steel rebar corrosion. However, the premature failure of corrosion inhibitors in concrete remains a pending issue. The adoption of microencapsulated inhibitors shows significant promise in addressing this concern. This study proposes a novel chloride ion-triggered microcapsule designed for the anti-corrosion protection of reinforcement. The microcapsules were synthesized using calcium carbonate (CaCO 3 ) particles as a template and sodium monofluorophosphate (MFP) as the encapsulated inhibitory core. The exterior of the CaCO 3 particles was coated with a silver alginate (Alg-Ag) layer, which confers the chloride ion-triggered release mechanism. The activation of microcapsules occurs through a chemical reaction between silver ions in the Alg-Ag layer and chloride ions from the environment, resulting in the formation of silver chloride and the subsequent disintegration of the microcapsule. The MFP inhibitor is released as a consequence. The fabricated microcapsules were characterized in terms of morphology and chemical composition. The inhibitory performance of the microcapsules was analyzed by electrochemical methods. The use of the CaCO 3 template was found to be effective in producing a porous matrix suitable for the loading of MFP. The microcapsules exhibit a well-defined spherical morphology with a distinct core-shell structure. Both FTIR and TG analysis confirmed the successful entrapment of MFP within the core of microcapsules. Electrochemical corrosion tests demonstrated that the microcapsules effectively retarded the corrosion process of the reinforcement, with the corrosion inhibition efficiency increasing from 59.1 % at 24 h to 63.8 % at 72 h, indicative of a controlled and progressive release of the inhibitor from the microcapsules.
研究领域:
材料科学
·
腐蚀与防护
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）