Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Guo-chang Song,Xing-yu Yang,Zhong-wei Li,Qiang Song
Arsenic (As) pollutants are highly toxic and using Ca-based minerals to adsorb As 2 O 3 is effective for emission control. In this study, a fixed-bed experimental system was used to study the adsorption of As 2 O 3 by the mixture of CaO, SiO 2 , and Al 2 O 3 at 1200 °C. The amount of As adsorbed by multiple minerals was higher than that by single minerals, indicating enhanced adsorption of As 2 O 3 under the coupling effects of Ca, Si, and Al. The adsorption amount of As first increased and then decreased with an increase in the CaO:(SiO 2 +Al 2 O 3 ) and SiO 2 :Al 2 O 3 ratios. Adsorbed As was mainly enriched in Ca-Si-Al mineral, including Ca 2 Al 2 SiO 7 . Density Functional Theory calculation was conducted to study the As 2 O 3 adsorption on the Ca 2 Al 2 SiO 7 (0 0 1) surface. The analysis of Mulliken charge and density of states showed that As 2 O 3 molecules formed Al-O, O-As, and Ca-O bonds with the Al, O, and Ca sites. Si and Al in Ca 2 Al 2 SiO 7 enhanced the adsorption ability of Ca sites by promoting electron transfer . Si/Al ratio close to 1:1 is conducive to the formation of Si-O-Al structures, thus further enhancing the adsorption. The results can help optimize coal blending strategies and modify adsorbents to further reduce As emissions during coal combustion .
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Xinnian Gou,Peng Shen,Jiang Wu,Xingyue Qi,Fei Qi,Ping He,Hong Yao,Guangqian Luo,Qizhen Liu,Yongfeng Qi
CaSiO 3 exhibits good arsenic capture performance, but it falls short of meeting the actual needs of power plants due to its susceptibility to acidic gases that inhibit its arsenic capture ability. In this study, an Al 2 O 3 /CaSiO 3 adsorbent was prepared by combining the anhydrous grinding and calcining methods. Arsenic vapor capture was conducted in flue gas containing or free of SO 2 and HCl within the temperature range of 800–1000 ℃. The research indicated that the preparation method used in this study resulted in uniform Al 2 O 3 doping that was less prone to agglomeration, thereby creating a good pore structure. The Al 2 O 3 /CaSiO 3 adsorbent exhibited the strongest arsenic capture capacity when the atomic molar ratio of Al/Si was 1:5, with an arsenic capture amount of 871.2 mg/kg, which was significantly higher than the capture capacity of the control group calcium silicate . The doping of Al atoms altered the structure and charge distribution of CaSiO 3 silica-oxygen chains, resulting in the formation of Al active sites with higher adsorption energy, which is more favorable for the adsorption of arsenic. Although the Al 2 O 3 /CaSiO 3 adsorbent reacts with acidic gases to form CaSO 4 and CaCl 2 , which can inhibit arsenic capture, it still maintains a high arsenic capture rate. Al 2 O 3 /CaSiO 3 has excellent arsenic removal, sintering resistance, and acid resistance, making it a promising composite adsorption material for arsenic removal.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Today Chemistry
·
2025
·
IF 6.7
Shouyu Lu,Lei Sun,Shun Liu,Ping He,Jiang Wu,Mei Ma,Yang Ling,Hong Yao,Guangqian Luo,Dapeng Wang
A Fe 2 O 3 /CaSiO 3 composite adsorbent was synthesized using calcium nitrate as a precursor for the adsorption and removal of As 2 O 3 from high-temperature flue gas at temperatures ranging from 1073 K to 1273 K. A combination of experimental investigations and theoretical calculations was employed to analyze the impact of Fe-doped calcium silicate on its arsenic adsorption performance, as well as to elucidate the adsorption mechanism of the Fe 2 O 3 /CaSiO 3 composite material for As 2 O 3 . The experimental results demonstrated that the incorporation of Fe 2 O 3 resulted in an enhanced pore structure within the material. When the molar ratio of Fe:Si was set at 1:5, the Fe 2 O 3 /CaSiO 3 adsorbent exhibited optimal As 2 O 3 adsorption capacity at 1273 K, achieving a remarkable value of 996.0 mg/kg—significantly higher than that observed with pure calcium silicate. During the adsorption process, the doped iron oxide released additional free electrons, thereby facilitating the conversion of lattice oxygen into chemisorbed oxygen. Furthermore, density functional theory (DFT) calculations were utilized to further investigate the microscopic mechanisms underlying the behavior of the Fe 2 O 3 /CaSiO 3 composite adsorbent. The findings indicated that Fe sites within Fe 2 O 3 /CaSiO 3 served as primary active sites and electron transport channels for this material, promoting both separation and conversion processes involving lattice oxygen. During arsenic adsorption, significant orbital hybridization occurred between Fe atoms and O atoms in As 2 O 3 , which contributed to enhancing stability within the chemisorption system. Overall, Fe 2 O 3 /CaSiO 3 displayed exceptional performance in terms of arsenic adsorption capabilities along with notable anti-sintering properties, positioning it as a promising composite material for effective arsenic removal under high-temperature conditions.
研究领域:
环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
·
2014
·Vol. 387
·期 11
·1079-1089
·
IF 2.36
Zhao Xin,Zhang Kai-ping,Huang Ting,Yan Cai-Chuan,Liu Li-Rong,Zhu Qi-Lei,Guo Feng-Feng,Liu Chen,Li Bao-Xin
Arsenic trioxide (As 2 O 3 ) is used to treat acute promyelocytic leukemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As 2 O 3 can damage the human ether-a-go-go-related gene (hERG) current via disturbing its trafficking to cellular membrane. This study aimed to investigate whether the As 2 O 3 -insulted hERG channel can be rescued by resveratrol, a recognized cardioprotective agent. The whole-cell patch clamp technique was used to record the hERG current and action potential duration. Co-immunoprecipitation and Western blot assay were applied to determine the function of hERG-Hsp70/Hsp90 chaperone complexes and the expression alteration of protein-folding-related proteins, respectively. Compared with treatment of As 2 O 3 alone, co-treatment with resveratrol successfully restored the current and surface expression of hERG and obviously shortened action potential duration in guinea pig ventricular myocytes. Further experiments demonstrate that resveratrol relieved As 2 O 3 -caused endoplasmic reticulum (ER) stress by restoring the function of hERG-Hsp70/Hsp90 chaperone complexes and downregulating the protein expression of ER chaperone proteins (calnexin and calreticulin) and activating transcription factor 6. In conclusion, resveratrol was able to rescue the trafficking deficiency and relieve the ER stress (ERS). Our findings suggest that resveratrol has a potential effect to alleviate the adverse effect of As 2 O 3 on cardiotoxicity.
研究领域:
药理学
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毒理学
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心脏病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Cleaner Production
·
2022
·
IF 11.072
Shilin Zhao,Xingyu Xie,Yiren Liao,Yuchen Wang,Zhiqiang Sun
Arsenic emitted from coal-fired power plants has attracted widespread attention. Metal oxides are promising adsorbents for arsenic removal , but the influence laws and mechanisms of temperature and flue gas components on their arsenic removal performance are unclear. In this work, systematic research on the effects of adsorption temperature and flue gas components on As 2 O 3 removal by Fe 2 O 3 , CaO, and γ-Al 2 O 3 was conducted. The results show that As 2 O 3 removal ability satisfies Fe 2 O 3 > CaO > γ-Al 2 O 3 at 300–900 °C, which is mainly related to their basic site strength. At 500 °C, Fe 2 O 3 has the largest As 2 O 3 removal capacity (adsorption capacity: 158.4 μg/g; removal efficiency: 84.68%). Increasing adsorption temperature is beneficial to the transformation of arsenic to high-valent arsenic (As(V)) on the surface of Fe 2 O 3 , CaO, and γ-Al 2 O 3 . Low-concentration SO 2 will compete with As 2 O 3 for adsorption on the three metal oxides surface, which thereby inhibits their As 2 O 3 removal ability. The presence of NO has an obvious inhibitory effect on the As 2 O 3 removal of Fe 2 O 3 , CaO, and γ-Al 2 O 3 , which is little affected by the change of NO concentration. Fe 2 O 3 is a metal oxide adsorbent with strong arsenic removal potential. Compared with basic simulated flue gas (BSFG) components, the presence of SO 2 , NO, and SO 2 +NO in the simulated flue gas all inhibits the adsorption of As 2 O 3 by Fe 2 O 3 . Finally, future work on arsenic removal from coal-fired flue gas adsorbents is presented. This work has important engineering applications and theoretical research guiding significance for the development of high-performance arsenic removal adsorbents.
研究领域:
环境科学
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能源工程
✓ 已验证
产品关联
DOI
高影响因子
FUEL
·
2021
·
IF 6.609
Jiandong Hong,Yanfeng Zhao,Jiang Wu,Xialin Xie,Pengcheng Zhao,Shuai Li,Hong Yao,Guangqian Luo,Zhenhao Liu,Xin Yang
Calcium oxide (CaO), as a high temperature sorbent, has been widely applied in the field of heavy metal removal due to its low price and stable chemical properties, but CaO tends to sinter at high temperature, which affects the adsorption performance. In this work, Al 2 O 3 /CaO sorbent with resistance to sintering was synthesized via citric acid and calcine method, which was innovatively employed to the adsorption of As 2 O 3 combining experiment and theoretical analysis. The experimental results demonstrate that the adsorption capacity of untreated CaO reduces immensely with the temperature rising from 1073 to 1273 K, and arsenic adsorption capacity reduces from 303 to 50 mg/kg. Whereas, arsenic adsorption capacity of Al 2 O 3 /CaO almost maintains at high level and reaches to 534 mg/kg at 1173 K, which proves that the addition of Al 2 O 3 can improve the anti-sintering ability of CaO. Meanwhile, through density functional theory (DFT), the adsorption sites of Al 2 O 3 /CaO was further studied. Al site of Al 2 O 3 /CaO was found to be the main adsorption active site and electron transfer channel, which effectively facilitates the separation of lattice oxygen. Finally, the adsorption mechanism of As 2 O 3 on Al 2 O 3 /CaO was proposed.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
TOXICOLOGICAL SCIENCES
·
2017
·Vol. 158
·期 2
·379-390
·
IF 4.081
Yan Meng,Feng Lifang,Shi Yanhui,Wang Junnan,Liu Yan,Li Fengmei,Li Baoxin
Arsenic trioxide (As2O3) has been verified as a breakthrough in the management of acute promyelocytic leukemia in recent decades. However, cardiotoxicity, especially long QT syndrome (LQTS) has become the most important issue during As2O3 treatment. The characterized mechanisms behind this adverse effect are inhibition of cardiac hERG channel trafficking and increase of cardiac calcium currents. In our study, we found a new pathway underlying As2O3–induced cardiotoxicity that As2O3 accelerates lysosomal degradation of hERG on plasma membrane after using brefeldin A (BFA) to block protein trafficking. Then we explored pharmacological rescue strategies on As2O3-induced LQTS, and found that 4 therapeutic agents exert rescue efficacy via 3 different pathways: fexofenadine and astemizole facilitate hERG trafficking via promotion of channel-chaperone formation after As2O3 incubation; ranolazine slows hERG degradation in the presence of As2O3; and resveratrol shows significant attenuation on calcium current increase triggered by As2O3. Moreover, we used human-induced pluripotent stem cell derived cardiomyocytes (hiPS-CMs) to evaluate the rescue effects of the above agents on As2O3-induced prolongation of action potential duration (APD) and demonstrated that fexofenadine and resveratrol significantly ameliorate the prolonged APD. These observations suggested that pharmacological chaperone like fexofenadine and resveratrol might have the potential to protect against the cardiotoxicity of As2O3.
研究领域:
药理学
·
心脏病学
·
干细胞生物学
·
毒理学
✓ 已验证
DOI
PubMed
高影响因子
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