SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Chengyu Duan,Jianyu Wang,Qikai Liu,Yi Zhou,Yanbo Zhou
Salbutamol (SAL) and Atenolol (ATL), two common medical ingredients acting on adrenal receptor, are often used for treating chronic illnesses. However, the incomplete metabolism in organism and widespread utilization lead to unneglected problems of water pollution, which the traditional treatment plant cannot satisfactorily deal with. For efficient removal of SAL and ATL, a kind of silanized β-cyclodextrin compound adsorbents (GD-EDTS) was designed based on the ionization features of two pollutants. Through an introduction of rich carboxyl groups by N-[(3-Trimethoxysilyl)propyl]ethylenediamine triaceticacid trisodium salt (EDTS), GD-EDTS surface obtains an appropriate electronegativity to meet different forms of IOCs and maintain a good adsorption performance in a wide pH range. The maximum adsorption capacities of SAL and ATL are 140.24 mg/g and 236.92 mg/g, respectively. And a remarkable rise is known from the adsorption capacity of SAL and ATL increasing to 162% and 706%, respectively, after EDTS modification. Adsorption data fit the Sips adsorption isotherms and the pseudo second-order kinetic model, and a weak competitive behavior between SAL and ATL indicates two pollutants can be removed simultaneously by GD-EDTS in their binary system. In this work, GD-EDTS is suggested to be an efficient adsorbent in the removal of SAL and ATL.
研究领域:
环境科学
·
药物化学
·
吸附材料研究
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DOI
高影响因子
Frontiers in Pharmacology
·
2016
·
IF 4.418
Shan Yun,Zhang Mengmeng,Wang Tengfei,Huang Qin,Yin Dan,Xiang Zemin,Wang Xuanjun,Sheng Jun
Oxidative tea polyphenols (OTPs) is the oxidative polymerization product of epigallocatechin-3-O-gallate (EGCG) forms during the process of Pu-er tea fermentation, and possesses absorption property, which may absorbs on drugs thus impact the drug bioavailability when taking medicines with Pu-er tea. Here we demonstrated that OTP inhibited the absorption of atenolol in the intestine, which was determined by testing atenolol levels of plasma via high performance liquid chromatography (HPLC). After administration of atenolol (50 mg/kg), atenolol was absorbed (Tmax: 1.867 h) with the half-life (t1/2) of 6.663 h in control group; Compared with atenolol group, AUC0-t (h*ng/ml), AUC0-∞(h∗ng/ml), and Cmax of OTP+atenolol group (OTP 500 mg/kg + atenolol 50 mg/kg) reduced 38.7, 27, and 51%, respectively, the atenolol concentration of plasma was reduced by OTP approximately 43, 49, and 55.5% at 30 min, 1 and 2 h, respectively, (P < 0.01). Furthermore, the level of atenolol in feces was higher in the OTP+atenolol group, indicating that the absorption of atenolol in rats was inhibited by OTP. Isothermal titration calorimetry assay identified that EGCG can bind to atenolol and the in vitro results showed that OTP absorbed on atenolol and formed precipitate in acid condition, demonstrating a significant positive relationship between atenolol levels and OTP dosage. Taken together, these results suggested that consuming Pu-er tea with atenolol might inhibit atenolol absorption and possible other drugs.
研究领域:
药理学
·
茶叶科学
·
药物相互作用
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DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2020
·
IF 5.115
Kai Zhang,Yanling Zhuang,Jiwen Li,Xiaochang Liu,Shaoheng He
Introduction Hypertension is a major health problem worldwide and is typically treated using oral drugs. However, the frequency of oral administration may result in poor patient compliance, and reduced bioavailability owing to the first-pass effect can also prove problematic.Methods In this study, we developed a new transdermal-drug-delivery system (TDDS) for the treatment of hypertension using atenolol (ATE) based on poly(acrylic acid) (PAA)-decorated three-dimensional (3D) flower-like MoS2nanoparticles (PAA-MoS2 NPs) that respond to NIR laser irradiation. The PAA-modified MoS2 NPs were synthesized and characterized using attenuated total reflection Fourier-transform infrared spectroscopy, X-ray diffraction measurements, scanning electron microscopy, transmission electron microscopy, dynamic light scattering, and the sedimentation equilibrium method. The drug-loading efficiency and photothermal conversion effect were also explored.Results The results showed that the colloidally stable PAA-MoS2 NPs exhibited a high drug-loading capacity of 54.99% and high photothermal conversion ability. Further, the capacity of the PAA-MoS2 NPs for controlled release was explored using in vitro drug-release and skin-penetration studies. The drug-release percentage was 44.72 ± 1.04%, and skin penetration was enhanced by a factor of 1.85 in the laser-stimulated group. Sustained and controlled release by the developed TDDS were observed with laser stimulation. Moreover, in vivo erythema index analysis verified that the PAA-MoS2 NPs did not cause skin irritation.Discussion Our findings demonstrate that PAA-MoS2 NPs can be used as a new carrier for transdermal drug delivery for the first time.
研究领域:
药剂学
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
Chemical Engineering and Processing-Process Intensification
·
2018
·
IF 2.826
Weifeng Xu,Qing Cheng,Shichuan Wang,Panliang Zhang,Kewen Tang
This paper reports the asymmetric separation of atenolol (AT) enantiomers using n -hexyl ( L )-tartrate (LT) and boric acid (BA) as chiral selector in a cascade of centrifugal contactor separators (CCSs). A multistage extraction model governing phase equilibrium equations and mass balance equations was established. The model was applied to predict and optimize the asymmetric separation of AT enantiomers. The effects of important factors on the multistage separation process, including the extract to wash phase ratio (O/W), the feed to wash phase ratio (F/W), the concentrations of LT and BA, and the location of feed stage, were simulated and optimized by the multistage extraction model. Under the optimal conditions for asymmetric separation, AT S was purified with enantiomeric excess (ee) of 0.9416 when F/W was 0.50.
研究领域:
化学工程
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药学
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产品关联
DOI
高影响因子
CHEMOSPHERE
·
2022
·
IF 8.943
Jian Zhao,Shangbiao Fang,Weixiao Qi,Huijuan Liu,Jiuhui Qu
Biodegradation is regarding as the most important organic micro-pollutants (OMPs) removal mechanism during riverbank filtration (RBF), but the OMPs co-metabolism mechanism and the role of NH 4 + -N during this process are not well understood. Here, we selected atenolol as a typical OMP to explore the effect of NH 4 + -N concentration on atenolol removal and the role of ammonia oxidizing bacteria (AOB) in atenolol biodegradation. The results showed that RBF is an effective barrier for atenolol mainly by biodegradation and adsorption. The ratio of biodegradation and adsorption to atenolol removal was dependent on atenolol concentration. Specifically, atenolol with low concentration (500 ng/L) is almost completely removed by adsorption, while atenolol with higher concentration (100 μg/L) is removed by biodegradation (51.7%) and adsorption (30.8%). Long-term difference in influent NH 4 + -N concentrations did not show significant impact on atenolol (500 ng/L) removal, which was mainly dominated by adsorption. Besides, AOB enhanced the removal of atenolol (100 μg/L) as biodegradation played a more crucial role in removing atenolol under this concentration. Both AOB and heterotrophic bacteria can degrade atenolol during RBF, but the degree of AOB's contribution may be related to the concentration of atenolol exposure. The main reactions occurred during atenolol biodegradation possibly includes primary amide hydrolysis, hydroxylation and secondary amine depropylation. About 90% of the bio-transformed atenolol was produced as atenolol acid. AOB could transform atenolol to atenolol acid by inducing primary amide hydrolysis but failed to degrade atenolol acid further under the conditions of this paper. This study provides novel insights regarding the roles played by AOB in OMPs biotransformation during RBF.
研究领域:
环境科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
Separations
·
2026
·Vol. 13
·期 5
·130
·
IF 3.5
Yanlin Wu,Lanhua Luo,Yuan Li,Shanghua Shi,Xiaoning Wang,Wenbo Dong,Gilles Mailhot
Over the past 20 years, the iron-activated persulfate systems have been widely used for removing pharmaceuticals and personal care products (PPCPs) from water. However, slow Fe(III)/Fe(II) redox cycling and precipitation of iron, unless in very acidic conditions, were the main limitations. Thus, two ligand-assisted Fe(III)/persulfate systems, Fe(III)-acetohydroxamic acid (AHA)/peroxydisulfate (PDS) and Fe(III)-nitrilotriacetic acid (NTA)/peroxymonosulfate (PMS), were comparatively investigated for the degradation of atenolol (ATL) in this study. The experimental results showed that the Fe(III)-NTA/PMS system worked much better than the AHA system. However, the cost of PMS is higher than that of PDS, which should be considered. The primary advantage of the NTA system was its ability to overcome the pH limitations. It worked well over a wide pH range (3.0–10.0), whereas the AHA system could only be used in a narrower pH window (pH 2.4 to 6.5). The investigation of radicals that contributed to ATL degradation revealed that sulfate radicals (SO4•−) were dominant in the NTA system, while hydroxyl radicals (•OH) and SO4•−were the primary and secondary radicals in the AHA system. These results provided useful insight into the comparative behavior of two ligand-assisted Fe(III)/persulfate systems for ATL degradation, with the Fe(III)-NTA/PMS system showing clear potential under neutral or near-neutral conditions, while Fe(III)-AHA/PDS may still represent a lower-cost option under acidic conditions.
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产品关联
DOI
高影响因子
CHROMATOGRAPHIA
·
2022
·Vol. 85
·期 4
·373-382
·
IF 2.213
Gao Lidi,Xing Zhanfen,Zhang Shuai,Lin Xiaotong,Qin Shili,Chu Hongtao,Tang Yimin,Zhao Xuan
Simultaneous enantioseparation and rapid determination method of atenolol (AN) and amlodipine besylate (AMB) was firstly established using diphenylmethane diisocyanate-β-CD-modified COF (MDI-β-CD-modified COF) as chiral solid phases (CSP) by capillary electrochromatography (CEC). The optimal separation conditions were explored and the concentration of the acetate buffer solution was 20 mmol/L, pH = 5.0, operating voltage 20 kV, column temperature 20 °C, and then the four enantiomers of AN and AMB were baseline separated less than 5 min. The method validation was assessed by applying standard addition technique. The results showed that the concentration of each enantiomer exhibited a good linear relationship with the chromatographic peak area ( r 2 > 0.9918); the limit of detection (LOD) was 0.55–0.98 mg/L; the limit of quantification (LQD) was 1.83–3.27 mg/L; the average recoveries were in the range of 95.4–103.0%; the relative standard deviation (RSD) was less than 3.8%. The method established is rapid, simple, sensitive, accurate and reliable, and it can be used for routine analysis and quality control of the two chiral drugs separately or in combinations.
研究领域:
分析化学
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药物分析
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分离科学
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产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Xiaoping Yu,Wenlei Qin,Xiangjuan Yuan,Lei Sun,Fei Pan,Dongsheng Xia
The present research systematically investigates the atenolol (ATL) degradation in integrated UV/Ozone (O 3 )/peroxymonosulfate (PMS) process focusing on the synergistic mechanism, reaction kinetics, pollutant degradation pathway and antibacterial activity. The results manifested that the integrated UV/O 3 /PMS process showed the noteworthy superiority to ATL degradation compared with UV/PMS, UV/O 3 and O 3 /PMS systems. Simultaneously, the impacts of operating parameters like PMS dosage, initial ATL concentration, solution pH and water matrix were comprehensively explored. The ATL elimination efficiency increased linearly with PMS dose and significantly enhanced in alkaline conditions. The • OH and SO 4 •− were the primary reactive radicals for ATL oxidation in UV/O 3 /PMS system based on the radical scavenging experiments and electron paramagnetic resonance characterization. Besides, a simplified kinetic model on the basis of the dominant reactions and the steady-state assumption was established to foretell the relative contributions of reactive oxidants for ATL elimination in UV/O 3 /PMS process. Main transformation products were determined via UPLC-QTOF-MS to infer the possible degradation pathways of ATL. Furthermore, the UV/O 3 /PMS process could distinctly mitigate the antibacterial activity of ATL and its intermediates to E. coli and B. subtilis . Our findings may have critical implications for the development of novel oxidation processes for recalcitrant contaminants mitigation in water purification .
研究领域:
环境科学
·
化学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Environmental Chemical Engineering
·
2023
·
IF 7.7
Qian Wang,Can He,Yue Shan,Zhongguo Zhang,Jiuyi Li
The aim of this study is to investigate the degradation efficiency and mechanism of atenolol (ATL) by catalytic ozonation with Al 2 O 3 supported manganese-cerium mixed oxides (Mn-Ce@Al 2 O 3 ), prepared by the impregnation-calcination method. The Mn-Ce@Al 2 O 3 with 0.2 wt% manganese and 0.2 wt% cerium exhibited superior catalytic performance, resulting in complete ATL degradation and 63% mineralization. Mn-Ce solid solution on the surface significantly increased the specific surface area (279.5 m 2 /g). High amount of Ce 3+ , Mn 3+ and high density of surface-active oxygen were contained on the surface of the catalyst, which facilitates the formation of oxygen vacancies and promotes the electron transfer in the catalyst. Combined with the low charge transfer resistance, surface protonated hydroxyl group, which was the active site of 0.2Mn-Ce@Al 2 O 3 , was more likely to adsorb ozone and decompose it into reactive oxygen species . O 2 · − and •OH were found to be the dominant active radicals for ATL degradation and mineralization that followed first-order kinetics. 17 intermediates were identified and 3 main degradation pathways were summarized, in order to provide reference for the complete mineralization of ATL.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
CHINESE JOURNAL OF CHEMICAL PHYSICS
·
2021
·Vol. 34
·期 4
·406-412
·
IF 1.114
Wang Chen,Xiong Ming-chen,Zhao Xuan,Liu Kun-hui
The pharmaceutically active compound atenolol, a kind of β -blockers, may result in adverse effects both for human health and ecosystems if it is excreted to the surface water resources. To effectively remove atenolol in the environment, both direct and indirect photodegradation, driven by sunlight play an important role. Among indirect photodegradation, singlet oxygen ( 1 O 2 ), as a pivotal reactive species, is likely to determine the fates of atenolol. Nevertheless, the kinetic information on the reaction of atenolol with singlet oxygen has not been well investigated and the reaction rate constant is still ambiguous. Herein, the reaction rate constant of atenolol with singlet oxygen is investigated directly through observing the decay of the 1 O 2 phosphorescence at 1270 nm. It is determined that the reaction rate constant between atenolol and 1 O 2 is 7.0×10 5 (mol/L) −1 · s −1 in D 2 O, 8.0×10 6 (mol/L) −1 · s −1 in acetonitrile, and 8.4×10 5 (mol/L) −1 · s −1 in EtOH, respectively. Furthermore, the solvent effects on the title reaction were also investigated. It is revealed that the solvents with strong polarity and weak hydrogen donating ability are suitable to achieve high rate constant values. These kinetics information on the reaction of atenolol with singlet oxygen may provide fundamental knowledge to the indirect photodegradation of β -blockers.
研究领域:
环境科学
·
药理学
·
化学动力学
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DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2022
·
IF 3.475
Yafang Zhang,Shuning Yang,Linsheng Wei,Xiaoyang Zhao,Xiangdong Lu
Photocatalysis is a promising technology for wastewater treatment. It is of great significance to find catalysts with high photoactivity. In this paper, a catalyst with high photocatalytic degradation efficiency to organic wastewater, carbon nitride modified by graphene quantum dots (SCN-GQDX), is prepared by supramolecular self-assembly thermal polycondensation method and doping graphene quantum dots (GQDs). The results show that SCN-GQD0.5 has the best catalytic performance, and its photocatalytic degradation efficiency to organic pollutants can reach 86% and still remains above 83% after five cycles, which shows the modified carbon nitride has high catalytic efficiency and stability. In a word, SCN-GQDX is a highly efficient, non-toxic and stable photocatalyst for organic pollutants in wastewater.
研究领域:
环境科学
·
材料科学
·
废水处理
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产品关联
DOI
PubMed
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2019
·
IF 4.527
Yiping Feng,Mengyao Shen,Zhu Wang,Guoguang Liu
In this study, we investigated the transformation of atenolol (ATL) by the naturally occurring laccase from Trametes versicolor in aqueous solution. Removal efficiency of ATL via laccase-catalyzed reaction in the presence of various laccase mediators was examined, and found that only the mediator 2, 2, 6, 6-tetramethyl-1-piperidinyloxy (TEMPO) was able to greatly promote ATL transformation. The influences of TEMPO concentration, laccase dosage, as well as solution pH and temperature on ATL transformation efficiency were tested. As TEMPO concentrations was increased from 0 to 2000 μM, ATL transformation efficiency first increased and then decreased, and the optimal TEMPO concentration was determined as 500 μM. ATL transformation efficiency was gradually increased with increasing laccase dosage. ATL transformation was highly pH-dependent with an optimum pH of 7.0, and it was almost constant over a temperature range of 25–50 °C. Humic acid inhibited ATL transformation through competition reaction with laccase. The presence of anions HCO 3 − and CO 3 2− reduced ATL transformation due to both anions enhanced solution pHs, while Cl − , SO 4 2− , and NO 3 − at 10 mM showed no obvious influence. The main transformation products were identified, and the potential transformation pathways were proposed. After enzymatic treatment, the toxicity of ATL and TEMPO mixtures was greatly reduced. The results of this study might present an alternative clean strategy for the remediation of ATL contaminated water matrix.
研究领域:
环境科学
·
生物化学
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产品关联
DOI
PubMed
高影响因子
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