JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Xianqiang Song,Xin Chen,Zhaoxiong Liang,Dan Xu,Yong Liang
In this work, we present core/shell Au@MnO 2 nanoparticles-based visual sensing strategy for mercury ion (Hg 2+ ) detection. The MnO 2 shell of Au@MnO 2 nanoparticles catalyzes the oxidation reaction between tetramethylbenzidine (TMB) and oxygen in the air, generating blue derivative (oxTMB) with an absorption peak at 650 nm. Glutathione (GSH) inhibits the formation of oxTMB, reversing the reaction and turning it back into colorless TMB molecules. While in the existence of Hg 2+ , GSH binds to Hg 2+ due to the strong affinity between the Hg 2+ and the -SH, and in this situation, Au@MnO 2 catalyzes the oxidation of TMB to make the solution become blue. Using the colorimetric sensor, the detection limit of Hg 2+ reached as low as 0.473 nM by UV–vis spectroscopy and 1 nM under the naked eye observation, which is lower than toxicity level of Hg 2+ (10 nM) formulated by the U.S. Environmental Protection Agency.
研究领域:
分析化学
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环境科学
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
Mingcong Rong,Yi Huang,Xiaoting Zhuang,Yingming Ma,Haijiao Xie,Yanfang Wu,Li Niu
Tetracyclines (TCs) are the most common antibiotic drugs in the world. However, due to the overuse and difficulty of degradation, TCs pollution is becoming a global threat to aquatic and terrestrial biodiversity. Current methods for detecting TCs mainly rely on fluorescent probes or nanomaterials with enzyme-mimicking catalytic activities , which only provide a single signaling mode and are vulnerable to experimental factors. Herein, this study reports the development of an AND logic-gate-based sensing platform for TCs with fluorescent and colorimetric dual-signal readouts using Au@MnO 2 nanoparticles that could be mutually verified for the selective sensing of TCs. It was found that Au@MnO 2 nanoparticles could oxidize TC into its oxidation state (oxTC), resulting in significant green fluorescence emission . Meanwhile, the MnO 2 shell was etched away, and the released Au core nanoparticles gradually aggregated, with a color change from brown to light blue. As such, we established the fluorescence “turn-on” and colorimetric quantitative relationships towards TC with detection limits of 21.9 and 83.3 nM, respectively. Furthermore, Au@MnO 2 -based analytical paper devices were prepared and demonstrated successfully for the fluorescent and colorimetric dual-signal readout detection of TC in real samples. This paper sheds light on the on-site detection of tetracycline using paper-based analytical devices and smartphones.
研究领域:
分析化学
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环境科学
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生物医学工程
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DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Du Huang,Zhenya Lu,Xingyue Liu,Junning Gao,Zhiwu Chen,Xin Wang,Xiaoyi Fu
NiCo 2 O 4 nanoflowers with high specific surface area were prepared on nickel foam (NF) by hydrothermal method and used as frameworks for developing cathode and anode of flexible asymmetric supercapacitor. With the unique nanoflower-like NiCo 2 O 4 arrays as skeleton, the NiCo 2 O 4 /Au/MnO 2 cathode was prepared by gold-spraying and electrochemical deposition and the NiCo 2 S 4 /PPy anode was prepared by second-hydrothermal and electro-polymerization. The hierarchical structured electrodes offer sufficient redox sites and adequate channels for accelerating ion and electron transport between electrodes and electrolyte. Moreover, the NiCo 2 S 4 /PPy was first reported as the anode, and its cycling stability (capacitance retention of 86.04 % after 5000 cycles) and specific capacitance (1612.5F/g at 1 A/g). The assembled flexible all-solid-state asymmetric supercapacitor (NiCo 2 O 4 /Au/MnO 2 // NiCo 2 S 4 /PPy) displays a high energy density of 206.37 Wh kg −1 at a power density of 398.57 W kg −1 and an outstanding cyclability (capacitance retention of 83.41 % after 5000 cycles).
研究领域:
材料科学
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能源存储技术
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DOI
高影响因子
Materials Today Bio
·
2024
·
IF 8.7
Diyu Wang,Subin Lin,Tuanwei Li,Xiaohu Yang,Xiang Zhong,Qian Chen,Guoqin Jiang,Chunyan Li
ABSTRACT Radiotherapy plays a critical role in the clinical treatment of breast cancer. However, the efficacy of traditional X-ray radiotherapy is greatly limited by its low tumor specificity and treatment tolerance mediated by the tumor microenvironment. Herein, we proposed a novel nano-radiotherapy sensitization strategy to design and construct a cancer cell membrane-coated siRNA-decorated Au/MnO 2 nanosensitizer (R&F@Au/MnO 2 -CM) to synergistically enhance radio-immunotherapy for breast cancer. In the integrated nanosensitizer, the cancer cell membrane (CM) derived from 4T1 breast cancer cells is utilized for targeted functionality, while Au/MnO 2 is designed to improve X-ray absorption and alleviate tumor hypoxia. Additionally, PD-L1 siRNA (R) is used to downregulate PD-L1 expression in tumor cells. In an in situ mouse model of 4T1 breast cancer, R&F@Au/MnO 2 -CM demonstrated accurate tumor identification via CM-mediated homologous targeting after intravenous injection, which was monitored in real-time through NIR-II fluorescence imaging of NIR-935 (F). Subsequently, the radiotherapy sensitivity was achieved due to the strong radiation absorption properties and oxygen generation through catalysis of Au/MnO 2 upon X-ray irradiation. Furthermore, the immunosuppressive microenvironment of the tumor is improved by downregulating PD-L1, enhancing synergistic anti-tumor effect. Our findings demonstrate a promising approach for tumor treatment by combining targeted enhanced radiotherapy with immune activation.
研究领域:
纳米技术
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癌症研究
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诊疗学
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放射生物学
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免疫治疗
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
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2022
·
IF 12.545
Yingzhi Zhang,Jiayuan Fan,Jing Zhao,Zhangrun Xu
Exosomes, carrying specific molecular information of their parent cells, have been regarded as a kind of promising noninvasive biomarker for liquid biopsy. Plentiful fluorescence methods have been proposed for exosome assay. However, most of them are dependent on nucleic acid signal amplification strategies, which require complicated sequence design and experimental operation. Herein, a metal-enhanced fluorescence (MEF) biochip based on shell-isolated [email protected] 2 nanoparticle array was designed for simple and sensitive assay of exosomes. The designed method consists of only two parts: signal conversion and MEF amplification. The conversion of exosome signals to DNA signals was realized by means of chain displacement reaction. The subtle conversion effectively averts the effect of steric hindrance on MEF while amplifying the signal easily for the first time. The MEF biochip based on shell-isolated [email protected] 2 nanoparticle array achieves a second signal amplification in a simple way. Profiting from the two signal amplifications, this strategy displays high sensitivity toward exosomes with a detection limit of 4.5 × 10 3 particles μL −1 . Compared with the result without MEF, the sensitivity is enhanced about thirty times. As far as we know, this is the first attempt for exosome assay by using MEF strategy. In addition to the favorable fluorescence enhancement, both shell-isolated [email protected] 2 nanoparticles and [email protected] 2 nanoparticle array show excellent stability in buffer solutions, which is conducive to practical application. Moreover, the proposed method is able to distinguish breast cancer patients from healthy people, showing its potential for exosome-based liquid biopsy.
研究领域:
生物医学工程
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纳米技术
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癌症研究
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分子诊断
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2020
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IF 6.182
Mengwei Gao,Yuanbo Song,Yidan Liu,Wentao Jiang,Jianchao Peng,Liyi Shi,Rongrong Jia,Yaseen Muhammad,Lei Huang
In this work, we proposed a new approach for the fabrication of Au@MnO 2 core/shell assembled nanosheets using localized surface plasmon resonance ( LSPR) effect of gold nanoparticles (Au NPs). When KMnO 4 and Au NPs mixed solution were irradiated by 520 nm light, LSPR effect driven the reduction of KMnO 4 to MnO 2 on Au NPs, and gradually assembled into thin sheeted morphology. The influences of irradiation conditions and surface functional groups were systematically studied. Both 520 nm light and citrate group were proved significant for the formation of stable Au@MnO 2 core-shell assembled nanosheets. This approach is controllable, green and facile, and can be extended to synthesize other complex nanomaterials for a variety of applications.
研究领域:
材料科学
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纳米技术
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DOI
高影响因子
Materials Horizons
·
2025
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IF 10.7
Zhenghuan Yin,Yajun He,Peiyu Huang,Wenjie Ma,Jian Liang,Tianyi Wang,Yuhao Peng,Wei Xiao,Dong Gu
Formaldehyde (HCHO) is a major indoor air pollutant that poses serious risks to human health, making its efficient removal a critical environmental concern. Catalytic oxidation at room and sub-ambient temperatures has attracted significant attention due to its potential to completely decompose HCHO into harmless CO2 and H2O. However, practical implementation remains challenging because of low reaction activation energy and limited catalyst performance at reduced temperatures. In this study, Au-loaded manganese oxide nanowire catalysts (x% Au/MnO2-NWs) were synthesized using a colloidal deposition strategy to achieve efficient HCHO removal under ambient and sub-ambient conditions. The optimized 1% Au/MnO2-NWs catalyst achieved complete conversion of 280 ppm HCHO at 30 °C and, remarkably, fully oxidized 20 ppm HCHO even at 0 °C, demonstrating outstanding low-temperature activity and practical potential. Comprehensive characterization studies including H2-TPR, EPR, Raman spectroscopy, and in situ DRIFTS revealed that Au nanoparticles induced abundant oxygen vacancies, which acted as active sites for HCHO adsorption and promoted O2 activation. The synergistic interaction between Au and MnO2 significantly enhanced low-temperature catalytic performance, providing mechanistic insights and a solid foundation for the rational design of highly efficient catalysts for indoor formaldehyde removal.
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DOI
PubMed
高影响因子
FOOD RESEARCH INTERNATIONAL
·
2026
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IF 8.8
Qingluan Li,Wenhui Geng,Yibin Ying,Lijuan Xie
Neonicotinoids (NEOs) pose significant threats to environmental safety and the food chain. To overcome the limitations of conventional nanozymes in achieving simultaneous pesticide discrimination and ultrasensitive quantification, a tunable platinum/gold@manganese dioxide (Pt/Au@MnO 2 ) nanozyme was developed. The material was engineered by synthesizing urchin-like Pt/Au nanoparticles via a two-step hydrothermal method, followed by electrostatic self-assembly onto MnO 2 nanosheets. By modulating the Pt/Au to β-MnO 2 ratio, the nanozyme's activity could be precisely switched between laccase-like (LAC) and peroxidase-like (POD) modes. The LAC mode enabled discriminative analysis of four NEOs through distinct colorimetric fingerprints analyzed by principal component analysis (PCA). For quantification, the POD mode was amplified by glutathione (GSH), which enhanced the signal through a nucleophilic reaction, resulting in a visible color gradient from dark green to light yellow. This strategy achieved highly sensitive detection of imidacloprid with a wide linear range (10 −8 –10 −4 M), a low detection limit of 4.42 × 10 −9 M, and high accuracy in real samples (recoveries: 96.2–104.0%). This dual-mode platform offers a robust and practical strategy for on-site NEO monitoring in food safety and agricultural control.
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DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2021
·Vol. 45
·期 40
·19065-19072
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IF 3.591
Yandi Liu,Yijun Hao,Yingjiao Wu,Sha Lu,Juan Li,Zhijun Zhou
Owing to its excellent biocompatibility, abundant functional groups and injectability, the gellan hydrogel is widely used in the biomedical field. In this work, a Au/MnO2@GG nanocomposite hydrogel was prepared by a one-pot method using the gellan hydrogel as a template. The obtained Au/MnO2@GG exhibits a broad plasmon-enhanced absorption in the near-infrared region. As a result, the nanocomposite hydrogel has an enhanced photothermal conversion efficiency of 71.3% at 808 nm, superior to those of MnO2@GG (27.1%) and Au@GG (25.7%) alone. The local surface plasmon resonance induced by Au could transfer energy to MnO2, and thus improve the photothermal conversion efficiency through non-radiative energy dissipation. Moreover, the nanocomposite hydrogel displays excellent biocompatibility, long-term stability, good shear-thinning and self-recovery properties. In vivo antitumor studies proved that the nanocomposite hydrogel could completely ablate the solid tumors under NIR illumination. This work may encourage the development of more advanced nanocomposite materials with high photothermal conversion efficiency, stability, and multiple functionalities.
研究领域:
生物医学工程
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材料科学
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肿瘤学
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产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
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IF 9.9
Jin Li,Xiao-Peng Liu,Wen-Qi Ye,Zhang-Run Xu
Alkaline phosphatase (ALP), as a crucial enzyme involved in many physiological activities, is always used as one of the significant biomarkers in clinical diagnosis. Herein, a novel, simple, and effective photothermal quantitative method based on the etching of MnO 2 -coated gold nanoparticles ( [email protected] 2 NPs) was established for ALP activity assay with a household thermometer-based visual readout. The photothermal effect of [email protected] 2 NPs is much higher than that of MnO 2 NPs or Au NPs. The MnO 2 shell of [email protected] 2 NPs can be etched by ascorbic acid , a product of ALP-catalyzed hydrolysis of 2-phospho- l -ascorbic acid. With the etching of [email protected] 2 NPs, the photothermal conversion efficiency decreased gradually, causing the decrease of the temperature increment of the solutions by degrees. A household thermometer, instead of large-scale and professional instruments, was used as a signal reader to realize the visual quantitative detection. The photothermal platform was used successfully for the determination of ALP with a wide linear range from 2.0 to 50 U/L and a detection limit as low as 0.75 U/L. Moreover, the inhibition efficiency of sodium vanadate for ALP activity was investigated, proving the photothermal quantitative method will be a potential platform for screening enzyme inhibitors . Such a sensitive, facile, and low-cost sensing assay provides a new prospect to develop platforms for point-of-care testing.
研究领域:
生物化学
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纳米技术
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分析化学
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临床诊断
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
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IF 13.273
Min Zhang,Baolong Li,Yu Du,Gaojian Zhou,Yanyan Tang,Yanfen Shi,BiYu Zhang,Zhou Xu,Qingli Huang
The preparation and construction of novel nanostructures as targeting theranostic is of great significance for diagnosis and treatment of tumor. Herein, a novel PANI/ [email protected] @MnO 2 (PPAuMns) yolk-shell enzymatic theranostic agent was fabricated firstly via in situ deposition of Au nanoparticles (Au NPs) and reduction of KMnO 4 on the surface of PANI/PPy nanocomposites. In addition to high biocompatible and biodegraded performance, PPAuMns possessed amazing tumor microenvironment (TME)-responsive O 2 generation capacity, magnetic resonance imaging (MRI) property, enzymatic activity and excellent photothermal conversion effect. Chemotherapeutics doxorubicin and folic acid (FA) were further loaded and decorated on it for targeted tumor therapy. Experiments in vitro and in vivo indicated that DOX-loaded [email protected] demonstrated excellent synergistic anti-tumor effect combining chemotherapy (CT), chemo-dynamic therapy (CDT) and photothermal therapy (PTT). This work offers a paradigm to design and construct tumor diagnosis and therapy platforms employing TME-responsive synergistic strategy of photothermal ablation, chemo-dynamic and chemotherapy.
研究领域:
纳米技术
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生物医学工程
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癌症治疗
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材料科学
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医学成像
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DOI
高影响因子
Nanoscale
·
2025
·
IF 5.1
Mi Li,Haorong Cheng,Yang Song,Xinxin Shi,Tongxiang Li,Yan Chen,Zhao Li,Lin Tian
The rapid detection of sulfide compounds including glutathione (GSH) and Na2S2O8 is of great interest because they play an essential role in the process of food processing. Here, we design a colorimetric/smartphone dual-mode sensing platform to detect GSH and Na2S2O8 simultaneously, depending on gold nanoparticle-decorated MnO2 nanosheets (Au/MnO2 NSs). Because of the distinct structure, Au/MnO2 possesses superior catalytic activity similar to native oxidase capable of catalysing the directly oxidation of 3,3’,5,5’-tetramethylbenzidine (TMB) under near-neutral pH conditions. Meanwhile, this catalytic reaction results in an obvious color change or the solution, which senses GSH and Na2S2O8 through redox and diazotization reactions. The designed sensor enables value-assisted and visual determination of GSH and Na2S2O8 with limits of detection of 2.3 nM. Based on the dual-modal sensing system, a smartphone-mediated “all-in-one” sensing platform is designed to realize the real-time and intelligent monitoring of GSH and Na2S2O8. This work provides a new avenue to construct multifunctional sensors to achieve the visualization and portable determination of sulfide compounds.
研究领域:
纳米生物技术
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分析化学
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环境监测
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食品安全
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分子诊断
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转化医学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）