CERAMICS INTERNATIONAL
·
2017
·
IF 2.986
Xiaolin Liu,Yongxin Tao,Huihui Mao,Yong Kong,Jian Shen,Linhong Deng,Linsong Yang
Near-infrared (NIR) light has great potential in biomedical applications due to its advantages of deep penetration depth and low photodamage to biological tissues. In this paper, we constructed a novel core-shell structured drug nanocarrier, Fe 3 O 4 @Au@SiO 2 , for the controlled delivery of etoposide (VP16), a chemotherapeutic drug for cancer patients. The novel core-shell structured drug delivery platform is composed of a mesoporous silica shell and a magnetic Fe 3 O 4 core using Au nanoparticles (AuNPs) as the interlayer, which is characterized by atomic force microscopy (AFM), X-ray diffraction (XRD), Fourier-transform infrared (FTIR) spectroscopy, N 2 adsorption/desorption isotherms and the magnetic measurements with vibrating-sample magnetometer (VSM). The synergistic effects of AuNPs, mesoporous silica and Fe 3 O 4 make the core-shell structured nanocomposites an excellent candidate for targeted and NIR light irradiation-controlled drug delivery. For the proposed nanocarrier of VP16, the mesopores in silica can enhance the encapsulation capacity of the nanocarrier and the AuNPs can effectively convert the NIR light into heat to speed up the drug deliver; meanwhile, the incorporation of Fe 3 O 4 with high magnetization to the drug delivery platform realize drug targeting under an applied external magnetic field.
研究领域:
生物医学工程
·
药学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
WATER RESEARCH
·
2020
·
IF 9.13
Dingyuan Liang,Xiangrui Wang,Ying Wang,Zhaomin Dong,Xiaoli Zhao,Wenhong Fan
Dissolved organic matter (DOM) in aquatic ecosystems reshapes the surface of nanoparticles (NPs) greatly. Understanding how these changes influence the bioavailability of NPs is critical for accurately predicting the ecological risks of NPs. A quantitative model based on the two-step internalization process enabled the differentiation between the adhesion ability of NPs to membranes and the internalization capacity. Using protozoa Tetrahymena thermophila as the test organism, fluorescein isothiocyanate-modified silica NPs (FITC-SiO 2 ) and silica-coated gold NPs (Au@SiO 2 ) were prepared to validate the model and study the influence of DOM on uptake. DOM reduced the ability of Au@SiO 2 to adhere onto cell membranes and the inhibitory effect of bovine serum albumin (BSA) and β-lactoglobulin was higher due to their higher molecular weights and the weaker interaction. Moreover, DOM increased the internalization capacity. 80% Au@SiO 2 was internalized in the presence of humic acid (HA), over 90% Au@SiO 2 was internalized in the presence of the two proteins, whereas only 60% were internalized by the control group. Next, the specific recognition of the cell internalization in the presence of DOM was confirmed. We concluded that the traditional “accumulation” may misestimate the true biological effect caused by NPs coated with DOM. NPs coated with highly bioavailable DOM pose a greater risk to aquatic ecosystems because they are more likely to be internalized by living organisms.
研究领域:
环境科学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Inorganic and Organometallic Polymers and Materials
·
2021
·Vol. 32
·期 2
·478-485
·
IF 3.543
Abdallah Rusul Mohammed,Al-Haddad Raad M. S.
Core–shell nanoparticles (CSNPs) have attracted attention in biomedical applications as they have highly useful materials with modified characteristics, such as high stability, dispersibility, higher permeability to certain target cells and reduction in consumption of precious materials. Synthesis of core–multishell nanoparticles with suitable sizes, structural characteristics and absorption using simple methods continues to be a challenge. In this study, \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs were synthesized in three stages to control their size and the potential for tuning their properties. Field emission scanning electron microscope images confirmed that \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs have a small particle size of about 22.5 nm, average crystalline size in X-ray diffractometer analysis was 22.8 nm, stability was about − 49.1 mV, and synthesis with magnetic and optical properties improved their biocompatibility. Treatment of CAL-51 and HBL-100 cell lines by \({\text{F}\text{e}}_{3}{\text{O}}_{4}@\text{A}\text{u} @{\text{S}\text{i}\text{O}}_{2}\) CSNPs under NIR laser and alternating magnetic field generated enough heat to increase cell death.
研究领域:
纳米医学
·
生物材料
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2016
·
IF 4.758
Yuan Zhou,Zhanfang Ma
Pursuing for a simple, sensitive and inexpensive method of detecting copper ions is very essential for both environment and human health. Herein, a new strategy for fluorescence detection of Cu 2+ was designed which is based on the reduction of Cu 2+ to Cu + by sodium ascorbate to get cycloaddition reaction between 4-azidobenzoic acid-tagged Au@SiO 2 and propiolic acid-tagged carbon dots (CDs). The proposed approach not only possesses a good selectivity, but also has a linear relationship between the fluorescence intensity and the concentrations of Cu 2+ in the range of 0.1–100 nM with the detection limit of 0.08 nM (5.12 × 10 −9 mg mL −1 ), which is far below the limit value of 1.3 mg mL −1 defined by U.S. Environmental Protection Agency in drinkable water. In the actual sample, the standard deviation ranges from 97.6% to 101.8%, indicating the high precision of present approach.
研究领域:
分析化学
·
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Zhihai Cao,Hangnan Chen,Yi Shang,Yushan Zhang,Dongming Qi,Ulrich Ziener
Rice roll-like (RR-like) Au/SiO 2 nanocatalysts (NCs) were synthesized through simultaneous sol–gel process of tetramethoxysilane and 3-aminopropyltriethoxysilane (APTES) and in situ reduction of gold salt in inverse miniemulsions. APTES played an important role in formation of RR-like SiO 2 nano-supports, reduction of gold salts to narrowly size-distributed sub–10 nm Au nanoparticles (NPs), and improved attachment of Au NPs to the SiO 2 nano-supports. The prepared RR-like Au/SiO 2 NCs displayed a pH-dependent, reversible colloidal stability in water, which facilitated to recycle them through tuning the pH value of the dispersion. Most importantly, the catalytic activity of the RR-like Au/SiO 2 NCs towards reduction of p -nitrophenol was about 7–9 times higher than that of the raspberry-like Au/SiO 2 NCs reported in our previous paper (Colloids Surf. A, 489, 2016, 223–233). The formation mechanism of the RR-like Au/SiO 2 NCs was also discussed.
研究领域:
材料科学
·
催化
·
纳米技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Biomedical Nanotechnology
·
2022
·Vol. 18
·期 1
·158-165
·
IF 3.641
Wang Ruizhi,Zhou Guofeng,Yang Yuchan,Wang Shiqing,Gao Shanshan,Gao Dongmei,Wang Xiaolin
The advantages of deep tissue penetration and the high spatial accuracy of photothermal therapy have been widely studied. Gold, as a photothermal material, has received particular attention. Different sizes and shapes of gold have been studied and characterized for their varying photothermal
properties. The core–shell structure of gold nanoparticles and silica enhances the photothermal conversion through the coupling effect between gold clusters on the material’s surface. With excellent photothermal conversion performance, the core–shell nanoparticles can quickly
reach 40 °C in 200 s under the irradiation of 808 nm, 1.5 W·cm−2. The highest conversion temperature of these nanoparticles is 56 °C, and the photothermal conversion rate is 45%. In vitro cell experiments displayed that NPs with targeted function can
efficiently aggregate in prostate cancer cells and effectively kill cells. In vitro experiments showed that the tumor cells of mice after photothermal treatment completely disappeared after 15 days, which fully demonstrated the potential of the nanoparticles for targeted photothermal
therapy.
研究领域:
癌症治疗
·
纳米技术
·
材料科学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2017
·
IF 2.714
Yi Shang,Zhihai Cao,Hangnan Chen,Yangyi Sun,Jia Yao,Lin Yang,Dongming Qi,Ulrich Ziener
In our previous paper, we reported the synthesis of easily recyclable and highly active rice roll-like (RR-like) Au/SiO 2 nanocatalysts (NCs) in inverse miniemulsions [Colloids Surf. A 517, 2017, 52–62]. In the present contribution, the influences of three key synthesis parameters, including the 3-aminopropyltriethoxysilane (APTES) content, reaction temperature, and urea amount, on the particle properties of the Au/SiO 2 NCs were systematically investigated. The role of these synthesis parameters in the formation of SiO 2 nanosupports and Au nanoparticles (NPs) was discovered. The RR-like SiO 2 nanosupports could only be formed in the systems within the range of 20–80 mol% of APTES content, at reaction temperatures above 60 °C, and with more than 0.72 mg of urea. The AuCl 4 − ions could be immobilized onto the aminopropyl-functionalized SiO 2 nanosupports through a coordination interaction. The immobilized ions were reduced by the aminopropyl groups at elevated temperatures. The APTES content and reaction temperature play an important role in controlling the particle size and its distribution of Au NPs. The catalytic activity of Au/SiO 2 NCs depends significantly on the APTES content. The RR-like Au/SiO 2 NCs with smaller immobilized Au NPs and higher specific surface area display higher catalytic activity towards hydrogenation of p -nitrophenol.
研究领域:
纳米技术
·
催化
·
化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ChemNanoMat
·
2023
·Vol. 9
·期 4
·e202200532
·
IF 3.8
Xinbing Jiang,Lu Qiao,Huan Yang,Ben Q Li,Shujiang Ding
Graphical SiO 2 @Au@SiO 2 @QDs nanocomposite with dual-functionality of simultaneous heating and temperature sensing were prepared. The heating is activated by a NIR laser through SPR effect while thermal sensing is accomplished by QDs PL thermometry. These nanocomposites are used as a drug carrier for in vitro chemotherapy-photothermal co-treatment for malignant cells. This paper reports the synthesis of multi-layer SiO 2 @Au@SiO 2 @QDs nanoparticles with a dual-functionality of simultaneous heating and temperature sensing and their applications to in vitro chemo-thermal therapy. The heating is activated by a NIR-light through resonance excitation of surface plasma while in-situ thermal sensing is accomplished by the QDs photoluminescent (PL) effect. These dual function nanoparticles are used as a drug carrier for in vitro chemotherapy-photothermal co-treatment for malignant cells. A comparative study of drug release profiles was performed with and without 808 nm laser irradiation. The drug release rate was accelerated by a rise of temperature, which is induced by plasmonic heat generation associated with Au nanoshells; while the temperature change is monitored by the QD nanoparticles at the same time. The results showed that SiO 2 @Au@SiO 2 @QDs-DOX platform enabled the combination of local specific chemotherapy with external near-infrared (NIR) photothermal therapy and significantly improved the efficacy of cancer treatment. This combined treatment demonstrated synergistic chemotherapeutic-thermal effects compared to chemotherapy or photothermal therapy alone, resulting in higher efficacy.
研究领域:
纳米技术
·
癌症治疗
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2014
·Vol. 4
·期 91
·49866-49872
·
IF 3.708
Zhihui Fang,Duanguang Yang,Yong Gao,Huaming Li
In this study, we reported a novel, facile, Pickering emulsion-templating method to prepare massage ball-like, hollow-structured Au/SiO2 microspheres. Firstly, oil-in-water Pickering emulsions stabilized by Au@poly(ethylene oxide)-b-poly(4-vinylpyridine) (Au@PEO-b-P4VP) hybrid emulsifier micelles, which were formed by a P4VP/Au complex induced self-assembly process, were generated. Then hollow Au/SiO2 hybrid microspheres with nano-/submicro-sized protrusions on their shells, termed as massage ball-like microspheres, were successfully synthesized using the generated Pickering emulsion as template, in which the P4VP catalyzed hydrolysis and condensation of tetraethoxysilane (TEOS) in the TEOS/n-decanol mixed oil phase occurred at the oil/water interface. As a result, a continuous SiO2 shell was formed. The uneven adsorption of polydisperse hybrid micelles at the oil/water interface as well as the volume shrinkage of the oil phase during the early hydrolysis and condensation of TEOS facilitated the formation of protrusions on the shell surface. After further removal of the polymer components embedded in the shell by calcination, hollow Au/SiO2 hybrid microspheres with micropore/mesopore bimodal porous shells were produced. The as-prepared Au/SiO2 hybrid microspheres were applied as catalysts for the reduction of p-nitrophenol with NaBH4, showing a high catalytic activity with a good recyclability owing to the large specific areas, the easily accessible Au active centres, and the enhanced mass transportation.
研究领域:
材料科学
·
化学工程
·
纳米技术
·
催化
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
·
2020
·
IF 4.192
Lihong Su,Lulu Wang,Jingke Xu,Zonghan Wang,Xiaolin Yao,Jing Sun,Jianlong Wang,Daohong Zhang
Gold nanoparticles (AuNPs) are the most commonly used signal materials in lateral flow immunoassay (LFIA). However, the assay sensitivity of traditional AuNP-based LFIA is usually limited by the incomplete competition between free target analytes and immobilized antigens for the binding of AuNP-labeled antibodies. To unfreeze this limitation, here, asymmetric Au–SiO2 Janus NPs (about 66 nm) were designed and synthesized. Au–SiO2 Janus NPs can assemble into snowman-like anisotropic structures and combine two different physicochemical properties at their opposite sides, where the AuNP side mainly possesses the antibody conjugating and signal providing functions and the SiO2 side primarily offers the stable function. In virtue of the unique asymmetric nanostructure, only the AuNP side can interact with target analytes by specific antigen–antibody interactions, which could significantly improve the efficiency of competition. Selecting furazolidone as a model analyte, the immunoassay biosensor showed a limit of detection as low as 0.08 ng/mL, 10-fold decreased than that of the AuNPs-LFIA. Moreover, the Au–SiO2 Janus NP lateral flow immunoassay was well applied in chicken, pork, honey, and beef food samples with visual detection limits of 0.8 ng/g, 0.16 ng/g, 0.4 ng/mL, and 0.16 ng/g, respectively. The Au–SiO2 Janus NPs possess the advantages of both materials, which will broaden their applications as a potential alternative in the rapid and sensitive detection of antibiotic residues.
研究领域:
分析化学
·
纳米技术
·
食品安全
·
生物技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Nian Cao,Faqiong Zhao,Baizhao Zeng
In this work, a novel self-enhanced solid state electrochemiluminescence (ECL) platform, based on polyethyleneimine (PEI) capped CdS quantum dots (PEI-CdS QDs) as coreactant and [email protected] 2 @Ru(bpy) 3 2+ doped silica ( [email protected] 2 @RuDS) nanocomposite as ECL emitter, was constructed. The PEI-CdS QDs integrated double coreactant of PEI and CdS QDs, thus significantly promoted the ECL of [email protected] 2 @RuDS. Polyaniline hydrogel was introduced to boost the electron transfer and to improve the immobilization of PEI-CdS/ [email protected] 2 @RuDS. In addition, creatinine imprinted poly(o-aminophenol) film was electrodeposited on the PEI-CdS/ [email protected] 2 @RuDS surface as recognition element. Thus, the obtained sensor possessed high sensitivity, stability, reproducibility and selectivity for creatinine sensing. The change of ECL intensity and logarithm of creatinine concentration showed a good linear relationship in the range of 0.05 nM to 5 μM, and the detection limit was low to 0.02 nM. The sensor was applied to detect creatinine in human serum and urine samples, and the results were in good agreement with those of commercial enzyme-linked immunosorbent assay kit.
研究领域:
分析化学
·
纳米技术
·
生物传感器
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Colloid and Interface Science Communications
·
2022
·
IF 5.633
Zhiguo Zhang,Zilong Guo,Wensheng Yang
Coating silica on Au particles has been known to be effective to improve their stability and performance. In this work, we demonstrated a cetyltrimethylammonium bromide (CTAB) assisted approach for preparation of Au@SiO 2 particles in ethanol/water mixtures. At ethanol content of 0.25, Au particles were well dispersed, while at ethanol content of 0.50, the aggregated Au particles were gradually dispersed with increasing CTAB concentration, attributed to the gradual formation of CTAB bilayer on the particle surface. When tetraethyl orthosilicate and ammonia were added directly to the Au particle dispersions, the Au@SiO 2 particles formed at the low ethanol content (0.25) were red in color and spherical in shape with a core composed of single Au particles, and these formed at the medium ethanol content (0.50) were purple in color and fractal-like in shape with a core composed of multiple Au particles.
研究领域:
材料科学
·
纳米技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）