ACS Applied Materials & Interfaces
·
2023
·
IF 9.5
Xiaohui Niu,Simeng Yan,Rui Zhao,Hongxia Li,Xiaoyu Liu,Kunjie Wang
In the pursuit of chiral materials with significant chiral recognition effects and stability, various strategies have been explored, among which the integration of metal nanoparticles and chiral metal–organic frameworks (CMOFs) is highly promising. However, metal nanoparticles (MNPs)/CMOFs show high chiral properties but inferior stabilities due to the MNPs being easily detached from the outside layer under certain conditions. Sandwich MOFs@MNPs@CMOF chiral materials can overcome this dilemma because the sandwich structure can maximize the regulation of the chiral interface activity, while the controlled outer layer can stop the MNPs from falling off in the procedure of chiral recognition. Here, a novel sandwich chiral material (d-His-ZIF-8@Au@ZIF-8) was synthesized by a ligand-assisted strategy with a well-defined sandwich morphology and chiral recognition capabilities. The electrochemical chiral recognition showed that d-His-ZIF-8@Au@ZIF-8 was the most efficient for the enantiomer of phenylalanine (Phe). This experiment presents a novel perspective for the fabrication of a chiral electrochemical sensing platform based on a solid sandwich chiral nanocomposite.
研究领域:
材料科学
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电化学
·
纳米技术
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DOI
PubMed
高影响因子
Nanomaterials
·
2020
·Vol. 10
·期 10
·2044
·
IF 4.324
Weiwei Ye,Yu Zhang,Wei Hu,Liwen Wang,Yu Zhang,Ping Wang
A sensitive fluorescence resonance energy transfer (FRET) biosensor is proposed to detect 8-hydroxy-2′-deoxyguanosine (8-OHdG), which is a typical DNA oxidation damage product excreted in human urine. The FRET biosensor was based on carbon dots (CDs)-modified nanoporous alumina membrane with CDs as fluorescence donors. Gold nanoparticles were encapsulated in zeolitic imidazolate framework-8 to form Au@ZIF-8 nanoparticles as signal quenchers. CDs and Au@ZIF-8 nanoparticles were biofunctionalized by 8-OHdG antibody. The capture of 8-OHdG on the membrane substrates can bring Au@ZIF-8 nanoparticles closely to CDs. With 350 nm excitation, the fluorescence of CDs was quenched by Au@ZIF-8 nanoparticles and FRET effect occurred. The quenching efficiency was analyzed. The limit of detection (LOD) was 0.31 nM. Interference experiments of the FRET biosensor showed good specificity for 8-OHdG detection. The biosensor could detect urinary 8-OHdG sensitively and selectively with simple sample pretreatment processes. It shows applicability for detecting biomarkers of DNA damage in urine or other biological fluids.Keywords:nanoporous alumina membrane;fluorescence resonance energy transfer;Au@ZIF-8 nanoparticles;DNA oxidation damage;8-OHdG detection
研究领域:
生物传感技术
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医学诊断
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纳米生物学
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DOI
PubMed
高影响因子
Materials Today Chemistry
·
2024
·
IF 6.7
Zhuluni Fang,Yihan Liu,Jinteng Qi,Miao Yu,Yuhang Wang,Yunfeng Qiu,Zhuo Ma,Shaoqin Liu
Solar-driven interfacial water evaporation holds great promise for water purification and desalination, but challenges such as insufficient light absorption, suboptimal energy conversion, and microbial contamination hinder its practical applications. This study presents a novel Au@ZIF-8/Ti 3 C 2 T x alginate hydrogel, integrating nanocomposites into a three-dimensional hydrogel network to enhance both water transport and light-to-heat conversion. The incorporation of Au nanoparticles significantly improves light absorption, while the Schottky junction between ZIF-8 and Ti 3 C 2 T x promotes photocatalytic generation of reactive oxygen species (ROS), including superoxide radicals (O 2 − ) and singlet oxygen ( 1 O 2 ). This photocatalytic activity, combined with the photothermal effects of Ti 3 C 2 T x , leads to effective bacterial sterilization, achieving 99.54 % and 97.22 % antibacterial efficiency against E. coli and S. aureus , respectively. The hydrogel exhibits a high evaporation rate of 1.589 kg m −2 h −1 and demonstrates a 100 % steam sterilization rate against both bacterial strains under one sun illumination. These findings highlight the potential of the Au@ZIF-8/Ti 3 C 2 T x alginate hydrogel as a promising, efficient, and cost-effective sterilization strategy for various applications, including water purification, desalination, and disinfection in off-grid areas and specialized settings.
研究领域:
材料科学
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环境科学
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纳米技术
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水处理
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太阳能
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产品关联
DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Jie Liu,Zixuan Zhang,Jie Dong,Anyi Chen,Jingfu Qiu,Chaorui Li
As a reliable biomarker to evaluate the severity of sepsis, sensitive and accurate detection of procalcitonin (PCT) is essential. In this study, a dual-mode electrochemical immunosensor based on Au/ZIF-8 as substrate and Pt@Cu 2 O as signal label was constructed for the detection of PCT. By loading Au nanoparticles onto rhombic dodecahedral ZIF-8, the substrate (Au/ZIF-8) has large specific surface area and can immobilize antibody (Ab 1 ) by Au–N bonds. Meanwhile, hollow Pt@Cu 2 O nanocomposite with excellent peroxidase-like activity and electrocatalytic activity were synthesized as signal label. In the process of electrochemical testing, Pt@Cu 2 O catalyzed the reduction of hydrogen peroxide (H 2 O 2 ) and further promotes the oxidation of hydroquinone (HQ) to achieve the synergistic amplification of electrochemical signals. The proposed immunosensor detected PCT by amperometric i-t and differential pulse voltammetry (DPV) tests with a good linear response and low limit of detection (i-t: 0.70 fg/mL and DPV: 0.40 fg/mL) in the range of 10 fg/mL∼100 ng/mL. The immunosensor exhibited excellent sensitivity and accuracy, indicating the potential application of this method for PCT detection.
研究领域:
生物医学工程
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分析化学
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免疫学
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DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2025
·
IF 4.2
Shiya Rong,Pengfei Cheng,Weiming Song,Xuyan Zhang,Jieming Huang,Guofu Zhou,Zhang Zhang,Junming Liu
Core-shell nanostructures have attracted the interest of many researchers due to their unique structural features and suitable band structure match. However, the fabricated core-shell nanostructures generally have only one core, which makes it challenging to explore the collective effect of multiple cores. Herein, two kinds of multicore-shell Au@ZIF-8 and Au@ZnO were synthesized, focusing on the effect of Au concentration on the optical and photocatalytic properties of the latter. By controlling the concentration of Au precursor, different quantities of Au NPs can be encapsulated in one ZIF-8 nanocrystal. Consequently, the hybridization effect and its localized surface plasmon resonance effect of Au NPs could also be accordingly regulated, with Au-0.4@ZnO showing the best photocatalytic activity. This work offers a new inspiration on regulating the plasmonic properties of the multicore-shell nanostructure, which holds an appealing prospect in plasmonic photocatalysis, surface-enhanced Raman scattering detection, and intermediates identification in catalytic reactions.
研究领域:
纳米材料科学
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光催化
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材料化学
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产品关联
DOI
高影响因子
ACS Sensors
·
2026
·
IF 10.9
Runcheng Liu,Jie Yan,Shujun Zhang,Wen Yang,Juan Li,Xiaoyan Sun,Lutao Du,Mingshun Jiang
DNA methylation has emerged as a pivotal molecular biomarker for early cancer diagnosis. Nevertheless, existing detection strategies remain limited by complex workflows, poor efficiency in trace DNA capture, and the inability to resolve both absolute concentration and methylation ratio simultaneously. Herein, we engineer a tilted fiber Bragg grating (TFBG) biosensor functionalized with Au@zeolitic imidazolate framework-8 (Au@ZIF-8) core-shell nanoparticle arrays. This architecture overcomes the diffusion-limited capture of conventional biosensors through a powerful hydrodynamic−plasmonic synergy. First, hydrodynamic stagnation flow efficiently preconcentrates trace DNA molecules onto the sensing interface. Subsequently, plasmon-enhanced dielectrophoresis provides an active trapping force, precisely localizing these molecules onto sensing hotspots. To enable multiparametric methylation profiling, a dual-recognition strategy was developed by integrating sequence-specific DNA hybridization with 5-methylcytosine (5mC) antibody binding. This approach allows for rapid (<15 min), amplification-free quantification of both methylated DNA concentration and methylation ratio in complex biological samples, with an ultralow detection limit of 6.9 × 102 copies/μL. Clinical validation using patient-derived samples demonstrates excellent diagnostic accuracy, achieving a receiver operating characteristic (ROC) area under the curve (AUC) of 0.941 through multilocus methylation analysis. This study establishes a robust, amplification- and label-free biosensing platform that integrates microfluidic manipulation with plasmonic nanoengineering, offering a powerful strategy for high-throughput, clinically translatable DNA methylation analysis in early cancer detection.
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DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2026
·
IF 6.6
Runcheng Liu,Jie Yan,Wen Yang,Cuiyun Qu,Mingshun Jiang
Sensitive detection of metabolites in biofluids is fundamentally limited by surface-related challenges, including insufficient enrichment, nonspecific adsorption, and poor interfacial durability. Here, we report an interface-engineering strategy for surface plasmon resonance (SPR) biosensors based on tri-functional Au@ZIF-8 core–shell nanostructures. By integrating plasmonic enhancement, molecular sieving, and photocatalytic activity into a single interface, the architecture simultaneously addresses trade-offs between sensitivity, selectivity, and reusability. The ZIF-8 shell serves as a size-selective molecular sieve for target enrichment and protein exclusion, while the plasmonic Au core provides electromagnetic field enhancement and enables light-driven degradation of adsorbed species. Finite element simulations were employed to analyze the interfacial optical response and near-field distribution, quantitatively revealing the interplay between field confinement and molecular capture volume to identify an optimal shell thickness. This interface, integrated onto a tilted fiber Bragg grating (TFBG)-SPR platform, was validated using uric acid. The system exhibits a detection limit of 3.28 × 10 −10 M, 93.4% recovery in artificial serum, and over 92.2% signal retention after ten visible-light-driven regeneration cycles. This work establishes a generalizable, robust, and regenerable interface framework for high-fidelity sensing in complex biological environments.
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DOI
高影响因子
Foods
·
2023
·Vol. 12
·期 4
·813
·
IF 5.2
Yunfei Xie,Xianghui Dong,Nifei Cai,Fangwei Yang,Weirong Yao,Lijun Huang
Bisphenol A (BPA) is an endocrine disruptor which is widely present in fish under the influence of environmental pollution. It is essential to establish a rapid detection method for BPA. Zeolitic imidazolate framework (ZIF-8) is a typical metal-organic framework material (MOFs) with a strong adsorption capacity, which can effectively adsorb harmful substances in food. Combining MOFs and surface-enhanced Raman spectroscopy (SERS) can achieve rapid and accurate screening of toxic substances. In this study, a rapid detection method for BPA was established by preparing a new reinforced substrate Au@ZIF-8. The SERS detection method was optimized by combining SERS technology with ZIF-8. The Raman peak at 1172 cm−1was used as the characteristic quantitative peak, and the lowest detection concentration of BPA was as low as 0.1 mg/L. In the concentration range of 0.1~10 mg/L, the linear relationship between SERS peak intensity and the concentration of BPA was good, and R2was 0.9954. This novel SERS substrate was proven to have great potential in rapidly detecting BPA in food.Keywords:SERS;metal-organic frameworks;bisphenol A;rapid detection
研究领域:
分析化学
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食品安全
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DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Yue Wang,Xue Li,Geoffrey I.N. Waterhouse,Yunlei Zhou,Huanshun Yin,Shiyun Ai
In this work, a novel and sensitive photoelectrochemical (PEC) strategy was designed for protein kinase A (PKA) detection, comprising carbon microsphere (CMS) modified ITO electrode, TiO 2 as the phosphate group recognition material and graphite-carbon nitride (g-C 3 N 4 ) as photoactive material. For the first time, gold nanoparticle decorated zeolitic imidazolate frameworks (Au-ZIF-8) was employed to fabricate biosensor for PKA activity assay with the function of substrate peptide immobilization and signal amplification. Firstly, substrate peptides were assembled on the Au-ZIF-8/CMS/ITO surface through the covalent bonding between the gold nanoparticles (AuNPs) and sulfydryl groups of the peptides. Then, in the presence of ATP , phosphorylation of the substrate peptide was achieved under PKA catalysis. Finally, TiO 2 -g-C 3 N 4 composites were further modified on the electrode surface based on bonding between TiO 2 and phosphate groups created via phosphorylation of the peptide (yielding TiO 2 -g-C 3 N 4 /P-peptide/Au-ZIF-8/CMS/ITO), which is different with our previous work by directly immobilizing g-C 3 N 4 composite on electrode surface. The developed method showed a wide linear range from 0.05–50 U mL −1 . The detection limit was 0.02 U mL −1 (S/N = 3). The constructed biosensor exhibited high detection specificity for PKA. In addition, the wide applicability of this biosensor was demonstrated by evaluating the inhibition ability of ellagic acid towards PKA.
研究领域:
生物化学
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分析化学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
International Journal of Electrochemical Science
·
2023
·
IF 1.5
Juan Liu,Wenju Weng,Chunxiao Yin,Guiling Luo,Hui Xie,Yanyan Niu,Xiaoyan Li,Guangjiu Li,Yaru Xi,Yutong Gong,Shuyao Zhang,Wei Sun
In this paper zinc-based metal organic framework material (ZIF-8) modified carbon ionic liquid electrode (CILE) was prepared and electrodeposited with gold nanoparticles to get a composite modified electrode, which was used as the sensing interface for the immobilization of hemoglobin (Hb) with Nafion to prepare a modified electrode (Nafion/Hb/Au/ZIF-8/CILE). Electrochemical behaviors of Hb on the modified electrode were checked by cyclic voltammetry with a pair of well-defined redox peaks appeared. The effects of pH and scan rate on direct electrochemistry of Hb were studied with electrochemical parameters calculated. The prepared electrochemical enzyme sensor showed good catalytic activity to the electroreduction of bromate and nitrite with the linear ranges from 0.5 to 10.0 mmol/L and from 0.1 to 0.8 mmol/L, respectively. The detection limits were calculated as 0.83 mmol/L and 0.03 mmol/L, and the water samples were analyzed to prove the practical application.
研究领域:
生物化学
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分析化学
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产品关联
DOI
高影响因子
Journal of Saudi Chemical Society
·
2024
·
IF 5.8
Liang Guo,Shijin Zhou,Yanju Liu,Huaixia Yang,Mingsan Miao,Wei Gao
Herein, a sandwich electrochemical sensing strategy for aflatoxin b 1 (AFB 1 ) detection based on hybrid-nanoengineering was presented. First, Au nanoparticle was doped into zeolitic imidazolate framework-8 (ZIF-8) to form Au@ZIF-8 by in-situ growth method, followed by multi-walled carbon nanotubes (MWCNTs) addition to synthesize MWCNTs/Au@ZIF-8 via self-assembly. The structural “confinement effect” of ZIF-8 afforded a microenvironment for Au nanoparticles and SMCNTs in a certain spatial region, giving MWCNTs/Au@ZIF-8 excellent electrochemical property as the substrate material. In addition, Au-Pt bimetallic nanoparticle, which exhibited excellent stability and catalytic activity was loaded on the hollow cerium oxide (CeO 2 ) to form AuPt@CeO 2 nanoparticle through one-step aqueous phase reduction. Owning to its high surface-to-volume ratio, satisfied electron transfer efficiency and biocompatibility, massive toluidine blue (TB) and AFB 1 antibody (Ab) could be modified on the AuPt@CeO 2 to form AuPt@CeO 2 -Ab-TB, which acted as signal tag for the ultrasensitive assay of AFB 1 . The proposed electrochemical sensing system exhibited wide detection range (2 × 10 -5 − 20 ng/mL) and low detection limit (2.13 fg/mL), which has been successfully applied to AFB 1 determination in four real samples. The hybrid nanoengineering presented in this work is an active attempt to prepare high-performance substrate material and signal tag, which provides a new insight for the development of highly sensitive and specific electrochemical sensing systems.
研究领域:
食品安全检测
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纳米材料科学
·
分析化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）