Journal of Materials Chemistry B
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2024
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IF 6.1
Ruofei Ma,Qi Zhang,Yue Wang,Zhangrun Xu
Much effort has been devoted to designing diverse photosensitizers for efficient photodynamic therapy (PDT) and photothermal therapy (PTT) performance. However, the effect of PS morphology on the PDT and PTT performance needs to be further explored. In this work, a photosensitizer, Au–Ag2S nanoparticles functionalized with indocyanine green, caspase-3 recognition peptides, and mitochondria-targeting peptides (AICM NPs) with different morphologies, including core–shell, eccentric core–shell-I, eccentric core–shell-II, and Janus morphologies, were synthesized to enhance PDT and PTT performance. Among them, AICM Janus NPs with enhanced charge-transfer efficiency and photothermal conversion demonstrate superior PDT and PTT performance compared to those of other morphologies. In addition, AICM NPs exhibit satisfactory surface-enhanced Raman scattering performance for in situ SERS monitoring of caspase-3 during PDT and PTT processes. After PDT and PTT treatment with AICM Janus NPs, the damaged mitochondria released caspase-3. AICM Janus NPs achieved a superior apoptosis rate in tumor cells in vitro. Furthermore, AICM Janus NPs treat the tumors in vivo within only 10 days, which is half the time reported in other work. The AICM NPs demonstrated superior therapeutic safety both in vitro and in vivo. This study investigates the effects of morphology-property-performance of photosensitizers on the PDT and PTT performances, which opens a new pathway toward designing photosensitizers for efficient PDT and PTT.
研究领域:
生物医学工程
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纳米医学
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肿瘤治疗学
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PubMed
高影响因子
TALANTA
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2016
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IF 4.035
Yuhong Liu,Linlin Zhao,Jin Zhang,Jinzha Zhang,Wenbo Zhao,Chun Mao
The work investigates a new fluorescence resonance energy transfer (FRET) system using NaEuF 4 nanoparticles (NPs) and [email protected] 2 S NPs as the energy donor–acceptor pair for the first time. The NaEuF 4 / [email protected] 2 S NPs-based FRET DNA sensor was constructed with NaEuF 4 NPs as the fluorescence (FL) donor and [email protected] 2 S core−shell NPs as FL acceptor. In order to find the matching energy acceptor, the amount of AgNO 3 and Na 2 S were controlled in the synthesis process to overlap the absorption spectrum of energy acceptor with the emission spectrum of energy donors. The sensitivity of FRET-based DNA sensor can be enhanced and the self-absorption of ligand as well as the background of signals can be decreased because of Eu 3+ which owns large Stokes shifts and narrow emission bands due to f–f electronic transitions of 4f shell. We obtained the efficient FRET system by studying suitable distance between the donor and acceptor. Then the FRET-based DNA sensor was used for the design of specific and sensitive detection of target DNA and the quenching efficiency (ΔFL/F 0 , ΔFL=F−F 0 ) of FL was logarithmically related to the concentration of the target DNA, ranging from 100 aM to 100 pM. We can realize an ultrasensitive detection of target DNA with a detection limit of 32 aM. This proposed method was feasible to analyse target DNA in real samples with satisfactory results.
研究领域:
生物化学
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分子生物学
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纳米技术
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PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2021
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IF 8.128
Yongli Cao,Song Li,Xiaodi Yu,Wenhua Li,Zhishan Bo
Hybrid nanocrystals (NCs) with multiple components and junctions have attracted considerable attention due to their promising synergistic properties. In particular, great attention has been paid to the manipulation of buried multijunction heterointerfaces because they are closely related to the surface energy and carrier transfer of NCs. However, heterointerfaced NCs are usually constructed by sequential step-by-step pathways, and buried interfaces can only be formed along a given direction, resulting in the one and only spatial orientation of multiple interfaces. In this work, we demonstrate two types of Au-Ag 2 S-Cu 2-x S NCs with disparate interfacial features. Specifically, the first type (Type I) is prepared through a routine two-step method and shows that Au domain close to the Ag 2 S-Cu 2-x S interface; another type (Type II) is achieved by a facile one-pot synthesis procedure and contains Au domain with an interphase only with the Ag 2 S domain, far from the Cu 2-x S domain. More importantly, type II NCs could not be formed through other traditional strategies and an underlying mechanism of formation is developed by monitoring the evolution process. Au@Ag core–shell NCs, metastable Au@Ag 2 S NCs and Janus Au-Ag 2 S NCs are formed successively before the Cu 2-x S domain appears. We speculate that the Au@Ag 2 S intermediate plays an essential role in building the final complex nanostructure . We expect that such a simple and facile one-pot method will be used to fabricate additional asymmetric multicomponent NCs with distinctive interfacial features and promising potential applications.
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高影响因子
NEW JOURNAL OF CHEMISTRY
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2022
·Vol. 46
·期 36
·17331-17337
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IF 3.925
Chen Chen,Jin-Xin Ma,Hui Wang,Hui-Qiao Liu,Shu-Wei Ren,Jun-Tao Cao,Yan-Ming Liu
It is promising to devise a signal-amplified ratiometric electrochemiluminescence (ECL) sensing platform owing to the eliminated external interference and increased analysis reliability in complex samples. Herein, a spatially resolved ratiometric ECL immunosensor for myoglobin (Myo) detection was developed via resonance energy transfer (RET) for signal amplification. In the ECL system, Ru(bpy)32+-conjugated silica nanoparticles (Ru(bpy)32+@RuSi NPs) and sulfur quantum dots (SQDs) used as the potential-resolved ECL emitters were modified on two spatially resolved electrodes, respectively. Au@Ag2S NPs with a wide light absorption range could serve as perfect acceptors of Ru(bpy)32+@RuSi NPs, between which an effective RET could occur. For Myo detection, the signal from the Ru(bpy)32+@RuSi NP-modified electrode for Myo with various concentrations acted as the working signal (ECLanode) and that from the SQD electrode for Myo with fixed concentration served as a reference signal (ECLcathode). Owing to the steric hindrance and effective RET between Ru(bpy)32+@RuSi NPs and Au@Ag2S NPs, the working signal presented a great decrease in the presence of Myo. The ratio of ECLanode to ECLcathode showed a linear relationship with the logarithm of the Myo concentration in the range from 1.0 × 10−13 to 1.0 × 10−7 g mL−1. The limit of detection of the fabricated biosensor was 5.0 × 10−14 g mL−1. Moreover, it continued to show favorable detection results in human serum samples with recoveries ranging from 83.0 to 110%. The RET and ratiometric strategy on the spatially resolved platform endow the method with the merits of high selectivity, sensitivity, and accuracy and it can be envisioned that the method would provide a general tool for biomarker analysis.
研究领域:
分析化学
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生物化学
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纳米技术
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生物传感器
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电化学
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DOI
高影响因子
APPLIED SURFACE SCIENCE
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2023
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IF 6.7
Ruofei Ma,Hanfei Gao,Yue Wang,Zhangrun Xu,Yuchen Wu
Efficient visible-light photocatalysts are essential for energy and environmental sustainability. Many efforts have been devoted to designing diverse heterostructures in the pursuit of high-performance photocatalysts. However, the effect of morphology of the heterostructures on the photocatalytic performance still needs to be further explored. Here, tunable Au-Ag 2 S heterostructures were synthesized to investigate the morphology-induced photocatalytic performance by surface-enhanced Raman scattering (SERS) spectroscopy. All the Au-Ag 2 S heterostructures possess remarkable visible-light photocatalytic and SERS activity compared with Au or Ag 2 S. Moreover, with increasing exposure of the Au component, the Janus heterostructures display better photocatalytic performance than the heterostructures with other morphologies. The possible mechanism is that the axially separated structure enhances the plasmon-induced electron-hole separation and facilitates interfacial charge transfer in the anisotropic heterostructures, owing to a stronger plasmon-enhanced near field. The photocatalytic degradation efficiency of methylene blue by the Au-Ag 2 S Janus heterostructures reached 93.9% within only 60 s. The photocatalytic degradation rate is 2.38, 1.53 and 1.48 times higher than that of the core–shell, eccentric core–shell-I and eccentric core–shell-II heterostructures. Our work demonstrates that the morphology of the Au-Ag 2 S heterostructures exhibits a significant effect on the visible-light photocatalytic performance, which opens a new pathway toward the design of heterostructures for high-performance photocatalysis.
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2019
·Vol. 30
·期 21
·19541-19551
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IF 2.195
Xiang Di,Hou Ying,Zhu Jiaqi,Yang Ming
In this study, we report a facile cation-exchange method to synthesize three different metal@dual sulfide hybrid nanostructures with enhanced photocatalytic properties. Starting from clusters of Au@Ag 2 S with a poorly crystalline shell, excess amounts of Cd 2+ , Zn 2+ and Pb 2+ are used to promote the thermodynamically unfavored cation-exchange under elevated temperature. The change of shell compositions accompanies the disassembly of Au@Ag 2 S clusters into monodisperse ternary core–shell nanostructures with modulated optical properties. Interestingly, it is found that Au@Ag 2 S–CdS outperforms Au@Ag 2 S–ZnS and Au@Ag 2 S–PbS in the visible-light-driven photodegradation of methylene blue, which can be largely attributed to the improved shell crystallinity, enhanced visible light absorption and appropriate band alignment for charge transfer.
研究领域:
材料科学
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纳米技术
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光催化
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高影响因子
JOURNAL OF APPLIED PHYSICS
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2019
·Vol. 125
·期 18
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IF 2.328
Zhang Kaixuan,Xu Na,Jia Mengyu,Li Ruoping,Huang Mingju
Noble-metal-based surface-enhanced Raman spectroscopy (SERS) substrates can be employed as catalysts capable of generating hot electrons to drive chemical reactions of target molecules adsorbed on their surface. However, the localized surface plasmons excited from pure noble metals generally exhibit relatively low hot-electron utilization efficiency with the reactants owing to charge carrier recombination. This problem can be solved by integrating heterogeneous structures with the noble metal. Herein, we describe the fabrication of bifunctional SERS substrates by constructing Au@Ag, Au@Ag 2 S, and Au@SiO 2 core-shell nanoparticles and evaluate the effects of the three heterostructures (Au cores encapsulated by shells composed of metal, semiconductor, or insulator) on the hot-electron transfer efficiency by in situ monitoring of the catalytic dimerization of p -nitrophenol to form p , p ′-dimercaptoazobenzene under 632.8 nm laser illumination. The developed SERS strategy opens up new opportunities for exploring hot-electron-induced reactions as well as providing a useful reference for photocatalyst selection.
研究领域:
材料科学
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光催化
·
纳米技术
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DOI
高影响因子
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