RARE METALS
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2025
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IF 11
Zhao Zhi-Hua,Ma Shi-Xin,Pan Ya-Fang,Rahmatullah Abu-Bakker-Md,Shen Xiao-Qing,Shao Zhi-Gang,Wu Lan
To facilitate real-time monitoring and recording of humidity in the environment and to satisfy the requirement for strain performance in certain applications (such as wearable devices), this paper proposes an in-situ method for synthesising Au nanoparticles on ZIF-67. In this study, an Au@ZIF-67 composite humidity-sensitive material was combined with flexible polyethylene terephthalate interdigitated electrodes to create an Au@ZIF-67 flexible humidity sensor. The prepared samples were characterised using X-ray diffraction, X-ray photoelectron spectroscopy, and transmission electron microscopy. The humidity-sensitive properties of the sensor were investigated, and its monitoring capabilities in applications involving respiration, gestures, skin, and baby diapers were tested. The experimental results indicate that compared with a pure ZIF-67 humidity sensor, the Au@ZIF-67 (0.1Au@Z) flexible humidity sensor exhibits a 158.07% decrease in baseline resistance and a 51.66% increase in sensitivity to 95% relative humidity, and the hysteresis, response time, and recovery time are significantly reduced. Furthermore, the sensor exhibits excellent characteristics such as high resolution, repeatability, and stability. The obtained results regarding the material properties, humidity sensitivity, and practical application of non-contact humidity monitoring demonstrate that the prepared sensors exhibit excellent and comprehensive performance, indicating their broad prospects in wearable medical devices, wireless Internet of Things, humidity detection in complex environments, and intelligent integrated systems. Graphical abstract
研究领域:
材料科学
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生物医学工程
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传感器技术
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DOI
高影响因子
MICROCHIMICA ACTA
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2025
·Vol. 192
·期 8
·1-9
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IF 5.3
Yang Yufan,Zhao Bo,Hu Xiaopeng,Gu Huiwen,Yan Xiu-Fang,Yin Xiaoli
A dual-mode fluorescent/colorimetric sensor is presented utilizing Au/ZIF-67 nanocomposites for an ultrasensitive ochratoxin A (OTA) detection. The system employs polydopamine-coated Fe 3 O 4 nanoparticles (Fe 3 O 4 @MIP) as magnetic recognition elements and aptamer/3,3′,5,5′-tetramethylbenzidine (TMB)-functionalized Au/ZIF-67 nanocomposites (Apt/TMB/Au/ZIF-67) as dual-signal probes for both fluorescence and colorimetric detection. Through molecular imprinting-aptamer synergistic recognition, OTA binding induces the formation of sandwich-structured particles (Fe 3 O 4 @MIP-OTA-Apt/TMB/Au/ZIF-67). Magnetic separation of these particles facilitates fluorescence measurements, while residual Apt/TMB/Au/ZIF-67 in solution permits simultaneous colorimetric detection. Crucially, fluorescence intensity increases while colorimetric absorption decreases proportionally with OTA concentration (0.5–25 ng mL⁻ 1 ), enabling self-validating dual-mode detection without requiring reagent replacement. The platform achieves detection limits of 0.15 ng mL⁻ 1 (fluorescence) and 0.13 ng mL⁻ 1 (colorimetry). The sensor was successfully validated for OTA quantification in real food samples, demonstrating significant potential for food safety applications. Graphical
研究领域:
分析化学
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纳米技术
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食品科学
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生物传感器
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毒素检测
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2025
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IF 5.6
Mengmeng Xu,Yuan Liu,Zhe Tang,Xiaolin Yu,Li Gao,Bo Yang,Yan Wang,Xuehui Dong,Qianqian Yu,LinGe Wang
Rational surface engineering of nanocatalysts offers new solutions against antibiotic-resistant infections. We designed and fabricated hierarchical MnO₂@Au@ZIF-67 nanoparticles (NPs) with triple interfacial functionalities for synergistic antibacterial therapy. The acid-responsive ZIF-67 surface degrades in infected wounds, releasing Co²⁺ to catalyze •OH generation via Fenton-like reactions at the material-bacteria interface. Simultaneously, ultrasmall Au surfaces deplete glucose through oxidase-mimetic catalysis, producing gluconic acid that accelerates ZIF-67 dissolution. The MnO₂ core surface decomposes H₂O₂ to supply O₂, enhancing Au catalysis and alleviating hypoxia. Comprehensive surface characterization (TEM, SEM, XPS, XRD) confirmed structural integrity and reactive sites. In vitro , the NPs achieved > 99 % bacterial killing (S. aureus/E. coli ) through ROS-mediated membrane disruption (validated by SEM/CLSM). In vivo , they enabled 98.45 % bacterial clearance and accelerated wound healing via collagen reorganization (H&E/Masson staining). This surface-engineered platform demonstrates how interfacial catalytic cascades can be harnessed for effective non-antibiotic antimicrobial applications.
研究领域:
纳米医学
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催化治疗
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抗菌材料
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伤口愈合
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纳米催化剂
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活性氧
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DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
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2022
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IF 4.598
Qian Luo,Xiaomin Qian,Xiaona Mi,Yifeng Tu
A new type of immunosensor was prepared by using a gold nanoparticles/aminozeolitic imidazolate framework-67 nanocomposite (AuNPs/ZIF-67) as the sensing matrix and luminol as the signaling probe to detect the heart failure biomarker N -terminal probrain natriuretic peptide (NT-proBNP). The hybrid nanocomposite was deposited on the surface of indium tin oxide (ITO)-coated glass via the linkage of 3-aminopropyltrimethoxysilane (APTMS); thereafter, the NT-proBNP antibody was immobilized to endow biological specificity, and bovine serum albumin was used to block residual active sites. The resultant sensor has an excellent response when NT-proBNP was attached to the antibody via immunoreaction; here, the output signal was reduced because of the depressed mass transportation of the electrochemiluminescence (ECL) probe and electron transference. The resultant ECL immunosensor displayed a broad linear range from 10 pg/mL to 50 ng/mL, and the low detection limit was 0.74 pg/mL. The ECL immunosensor also has good specificity, stability and reproducibility and can be used to detect NT-proBNP in real blood samples.
研究领域:
生物化学
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纳米技术
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分析化学
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医学诊断
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Biaobiao Ge,Jie Huang,Qianmin Dong,Fen Yang,Mengmeng Wang,Pei Liang
This work reveals a novel SERS enhancement mechanism of “satellite” structure. • Stable and uniform L-Au@ZIF-67@S-Au NPs were synthesized by self-assembly method. • L-Au@ZIF-67@S-Au NPs substrates was prepared with an enhancement factor of 3.4 × 10 6 . • Determination of fenpropathrin in citrus peel, and its LOD reached 0.995 μg/L. A new hybrid substrate of core-satellite plasma MOF, namely L-au @ ZIF-67 @ S au NPs, was developed in this study. The substrate aims to improve SERS performance by combining the molecular trapping layer of ZIF-67 with double electromagnetic hot spots distributed on the inner surface and the outer surface. The interface self-assembly strategy was adopted to combine MOF with plasma nanostructures, thus combining excellent molecular adsorption ability with strong local field enhancement effect. The results showed that the substrate had a low detection limit of 1.43 × 10 −10 M for rhodamine 6G, achieved rapid adsorption equilibrium within 10 min, and showed high signal reproducibility (relative standard deviation, RSD = 1.66%, n = 20). The substrate was applied to the detection of fenpropathrin residues in citrus peels, showing good sensitivity, and the detection limit was 0.995 μg·L −1 , with an enhancement factor of 3.4 × 10 6 and excellent reproducibility. This work builds a multifunctional and environment-friendly SERS platform, which effectively combines advanced nano-material design with practical applications of food safety monitoring Download: Download high-res image (146KB) Download: Download full-size image
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