TALANTA
·
2024
·
IF 5.6
Shuning Yang,Li Tian,Weiwei Fu,Huiling Li,Chao Li,Yujia Song,Ruidan Li,Yanjia Guo,Lun Zhao
The novel TiO 2 and Ni-MOF materials were synthesized and utilized for the detection of permethrin (PET). A highly sensitive solid-state electrochemiluminescence (ECL) sensor was developed based on Ni-MOF@Ru(bpy) 3 2+ and Au NPs@TiO 2 . In this sensing platform, Ru(bpy) 3 2+ -Tripropyl Amine (TPrA) was used as a luminescent signal, Ni-MOF acted as a carrier to carry more luminescent reagents Ru(bpy) 3 2+ . Au NPs acted as promoters facilitated electron transport and TiO 2 could further enhance the luminescence intensity of the system by synergistical interaction with Au NPs. The possible mechanisms of signal amplification were investigated. The ECL intensity decreased significantly with increasing PET concentration, enabling the determination of PET amount through the observation of the change in ECL signal intensity (ΔI). Under optimal experimental conditions, the linear range of PET concentration from 1.0 × 10 −11 mol L −1 to 1.0 × 10 −6 mol L −1 , with a detection limit of 3.3 × 10 −12 mol L −1 (3S/N). This method was successfully applied to determine PET in various vegetable samples.
研究领域:
分析化学
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2019
·
IF 7.65
Dandan Song,Xinyu Jiang,Yanshan Li,Xiong Lu,Sunrui Luan,Yuanzhe Wang,Yan Li,Faming Gao
Transition metal oxides (TMOs) derived from metal − organic frameworks (MOF) combined with two-dimensional (2D) transition metal carbides possibly pave an innovative pathway for designing promising biosensors. Herein, a novel electrochemical sensing platform has been fabricated for ultra-sensitive determination of organophosphorus pesticides (OPs), based on MOF-derived MnO 2 /Mn 3 O 4 and Ti 3 C 2 MXene/Au NPs composites. Remarkably, the three-dimensional (3D) MnO 2 /Mn 3 O 4 hierarchical microcuboids derived from Mn-MOF are composed of vertically aligned, highly ordered nanosheets, and further combined with MXene/Au NPs yields synergistic signal amplification effect, with outstanding electrochemical performance, large specific surface area, and good environmental biocompatibility. Under the optimum conditions, the reported sensing platform AChE-Chit/MXene/Au NPs/MnO 2 /Mn 3 O 4 /GCE can be utilized to detect methamidophos in a broad concentration range (10 −12 –10 −6 M), together with a good linearity (R = 0.995). Besides that, the biosensor possesses a low limit of detection (1.34 × 10 −13 M), which far exceeds the maximum residue limits (MRLs) for methamidophos (0.01 mg/kg) established by European Union. Additionally, the feasibility of the proposed biosensor for detecting methamidophos in real samples has been demonstrated with excellent recoveries (95.2%–101.3%). Interestingly, the unique structures and remarkable properties of these composites make them attractive materials for various electrochemical sensors for monitoring either pesticide residuals or other environmentally deleterious chemicals.
研究领域:
材料科学
·
环境科学
·
生物传感
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Analytical Methods
·
2025
·
IF 2.6
Xinxing Jiang,Jihong Fu,Shuxian Ren,WenXia Xue
Substrate materials with high sensitivity and good reproducibility are highly desirable for the practical applications of surface-enhanced Raman scattering (SERS) techniques. In this study, a novel Ni-based metal-organic frameworks loaded gold nanoparticles (Ni-BDC-NH2/Au NPs) SERS substrate was successfully synthesized via electrostatic self-assembly method. The enhancement of the SERS signal is achieved owing to the synergy between chemical enhancement (CM) effect of Ni-BDC-NH2 and the electromagnetic enhancement (EM) of Au NPs, and the enriching of the analyte near the SERS “hot spots” through the strong adsorption capacity of the Ni-BDC-NH2. The Ni-BDC-NH2/Au NPs exhibited a high enhancement factor (EF) of 1.10×107 and a low detection limit of 5×10-9 mol/L. Besides, the substrate material showed exceptional stability up to 45 days at room temperature. The Ni-BDC-NH2/Au NPs was used to detect methylene blue (MB) that displayed a wide linearity (5×10-7-5×10-5 mol/L) and high recoveries (86.82-104.46%). These indicate that the Ni-BDC-NH2/Au NPs hybrid substrate has great potential for the detection of environmental pollution in practical applications.
研究领域:
材料科学
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环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2015
·
IF 5.33
Xiaolei Zhang,Jingjing Deng,Yumeng Xue,Guoyue Shi,Tianshu Zhou
In this study, we demonstrate a colorimetric and fluorescent dual-mode method for alkaline phosphatase activity (APA) sensing in freshwater lake with stimuli-responsive gold nanoparticles@terbium-guanosine monophosphate (Au-NPs@GMP-Tb) core–shell nanoparticles. Initially, the core–shell nanoparticles were fabricated based on Au-NPs decorated with a fluorescent GMP-Tb shell. Upon being excited at 290 nm, the as-formed Au-NPs@GMP-Tb core–shell nanoparticles emit green fluorescence, and the decorated GMP-Tb shell causes the aggregation of Au-NPs. However, the addition of ALP destroys GMP-Tb shell, resulting in the release of Au-NPs from the shell into the solvent. As a consequence, the aggregated Au-NPs solubilizes with the changes in the UV–vis spectrum of the dispersion, and in the meantime, the fluorescence of GMP-Tb shell turns off, which constitutes a new mechanism for colorimetric and fluorescent dual-mode sensing of APA. With the method developed here, we could monitor the dynamic change of APA during an algal bloom of a freshwater lake, both by the naked eye and further confirmed by fluorometric determination. This study not only offers a new method for on-site visible detection of APA but also provides a strategy for dual-mode sensing mechanisms by the rational design of the excellent optical properties of Au-NPs and the adaptive inclusion properties of the luminescent infinite coordination polymers.
研究领域:
环境科学
·
分析化学
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Zhirou Xu,Zhengtong Wu,Xuyang Sun
An ultrasensitive fluorescence immunosensor based on silver nanoparticles@ nitrogen-doped carbon quantum dots (Ag NPs@N/CQDs) and exploiting the quenching effect of gold nanoparticles (Au NPs) was fabricated for squamous cell carcinoma antigen (SCCA) detection. Ag NPs@N/CQDs were immobilized on the surface of an indium tin oxide (ITO) electrode and then coupled with the primary antibody of SCCA. The primary antibody captured SCCA on the ITO electrode, forming an immune complex with the secondary antibody labeled with gold nanoparticles, thereby constructing a sandwich-structured fluorescent sensor. Using the prepared sensor, a new method for detecting trace amounts of SCCA in human serum was established. Owing to the effective quenching of fluorescence intensity of Ag NPs@N/CQDs by Au NPs, combined with the presence of a sandwich immune structure, the sensor exhibits high sensitivity and selectivity. The method demonstrates a linear range of 2 − 4000 fg mL −1 and a detection limit of 0.87 fg mL −1 . The the recovery rate for real serum samples was between 94.45 % to 103.43 %.
研究领域:
生物医学工程
·
肿瘤学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Xiangyu Shan,Juan Lu,Qian Wu,Chao Li,Huiling Li,Shuning Yang,Li Tian
In this paper, a novel and simple electrochemiluminescent sensor of CQDs based on ZIFs electrospun carbon fiber was constructed for the detection of malathion. Carbon quantum dots (CQDs) was obtained by pyrolysis of citric acid at high temperature. ZIFs electrospun carbon fiber (ENCF-67) prepared by electrospinning combined with high temperature calcination adsorbed Au NPs to obtain ENCF-67@Au. And the sensor of Nafion/ENCF-67@Au/CQDs/GCE was constructed by sequentially modified CQDs, ENCF-67@Au and Nafion on the electrode surfaces. ENCF-67@Au was used as the fixation material of CQDs and accelerator of system because ENCF-67 had the advantage of large specific surface area and porosity. Nafion/ENCF-67@Au/CQDs/GCE obtained sensitive and stable electrochemical luminescence signal in PBS containing S 2 O 8 2- . The addition of malathion enhanced the ECL signal of the sensor with a linear increase in the range of 1.0 × 10 -12 − 1.0 × 10 -7 M and the limit of detection 3.3 × 10 -13 M (S/N = 3). The sensor had good selectivity for malathion, which provided a simple and sensitive method for the detection of malathion in fruits and vegetables in real life and had potential applications.
研究领域:
分析化学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2015
·
IF 6.409
Jianxiu Li,Hongmin Ma,Dan Wu,Xiaojian Li,Yongbei Zhao,Yong Zhang,Bin Du,Qin Wei
A high sensitive label-free electrochemiluminescence (ECL) immunosensor was fabricated for the detection of prostate specific antigen (PSA) based on potassium niobate-Au nanoparticles@bismuth sulfide (KNbO 3 –Au NPs@Bi 2 S 3 ) modified glassy carbon electrode (GCE). The prepared Bi 2 S 3 nanosheets exhibited strong and stable cathodic ECL activity. The synthesized KNbO 3 –Au NPs was firstly used to fabricate ECL modified electrodes and Bi 2 S 3 nanosheets worked as luminophores for the first time in ECL sensors. Au NPs were used to combine with Bi 2 S 3 and anti-PSA via the Au–S covalent bond and Au–NH 2 covalent bond without the usage of crosslinking agents respectively, further enhancing the sensitivity and stability of immunosensor. Under the optimum experimental conditions, the ECL signal of KNbO 3 –Au NPs@Bi 2 S 3 linearly decreased with the increase of PSA concentration in the range of 0.005–5 ng/mL with a detection limit of 3 pg/mL. The preparated label-free ECL immunosensor exhibited high sensitivity and selectivity, good repeatability and long-term stability. The applicability of the proposed ECL immunosensor was also evaluated by detecting PSA in real samples.
研究领域:
生物医学工程
·
分析化学
·
纳米技术
✓ 已验证
DOI
高影响因子
JOURNAL OF FOOD AND DRUG ANALYSIS
·
2025
·Vol. 33
·期 4
·451
·
IF 3
Zhang Yun,Wu Qiong,Gao Hui,Zhang Hua,Miao Xiang-Min
Evidence had accumulated that serotonin (5-HT), a hormone and neurotransmitter, was not only involved in a variety of different physiological and central nervous system functions but also in the development and manifestation of psychiatric diseases. Here, DNA tetrahedron-Au NPs-GO for enhanced fluorescence sensor was designed for detecting serotonin. Au NPs-GO was used as a fluorescence quencher, while fluorophore-labeled DNA tetrahedron was used as a donor, resulting in fluorescence resonance energy transfer (FRET) from the fluorophore to Au NPs-GO (signal off). With the strong binding ability of aptamer to serotonin, S5 was released from Aptamer: S5 duplex, then reacted with the tail of DNA tetrahedron (DTNs), followed by the formation of three double stranded DNA products in the tail of DTNs, bringing in signal readout responses (signal on). Consequently, a reliable, sensitive and selective sensor was obtained for one-step quantificative detection of serotonin from 50 pM to 200 nM with a detection limit of 16.8 pM. Furthermore, satisfactory stability, reproducibility, specificity and good recovery efficiency in human serum samples revealed that the proposed sensor could be served as a prospective tool for serotonin detection.
研究领域:
生物传感器
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纳米技术
·
分析化学
·
神经化学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POROUS MATERIALS
·
2021
·Vol. 28
·期 6
·1655-1666
·
IF 2.496
Fang Wei,Chen Hui,He Xuan,Li Weixin,Zhang Wenhao,Shen Yue,Chen Xiaodong,Zhao Lei
In this work, we report a 3D biomass foam absorber by uniformly loading plasmonic Au nanoparticles (Au-NPs) on carbonized rice husk porous substrate for solar vapor generation. The organic bubbles were simultaneously used as templates to construct porous channels and as carriers to introduce Au-NPs. Owing to the characteristic plasma heating effects, Au-NPs can be as additional heat spots for vapor generation to enhance the solar-thermal conversion effect at visible waves. The 3D porous absorber enables convenient water transport and high light absorption of ~ 94.6%. The solar vapor evaporation efficiency is ~ 84% in pure water and ~ 75% in 15 wt% NaCl solution under 1 kW m −2 .
研究领域:
材料科学
·
能源研究
✓ 已验证
产品关联
DOI
高影响因子
OPTICS AND LASER TECHNOLOGY
·
2024
·
IF 4.6
Hua-Long Du,Nuerguli Kari,Ben Li,Qi Wang
The fiber Surface plasmon resonance (SPR) sensor based on titanium dioxide(TiO 2 ) and Au nanoparticles (Au-NPs) sensitization is offered as a practical means of increasing the sensitivity and figure of merit (FOM). Through finite element simulation and experimental testing, it is found that in TiO 2 with high dielectric constant and high dielectric conductivity, the carrier movement is fast and consumption is low, which enhances the photocurrent signal and leads to charge redistribution, thus enhances the electric field; while the Au-NPs will stimulate the stronger Localized Surface plasmon resonance (LSPR) phenomenon, and both of them will undergo electric field resonance coupling. The sensitivity of the sensor is higher because its surface electric field is 3.67 times stronger than the conventional Au film sensor. When exposed to external conditions, the sensitivity can reach 9715 nm/RIU within the refractive index (RI) at 1.33213–1.34055, which is 4.69 times higher than a conventional Au film sensor. The FOM can reach 57.8 RIU -1 , which is 2.05 times higher than the conventional Au film sensor. In addition, TiO 2 and Au-NPs on the surface of the sensor are less prone to collapse, and the stability test results show that the relative standard deviation (RSD) is 0.5929 %, which exhibits good reliability and stability. The structure of the sensor is very simple, relatively easy to fabricate, and has good applicability in the field of biochemical testing.
研究领域:
光学传感器
·
材料科学
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2016
·Vol. 28
·期 3
·3067-3074
·
IF 1.798
Li Jiali,Yan Luting,Wang Huili,Wang Haiwei,Chen Xiao,Wang Lei,Wu Meng
Gold nanoparticles (NPs) were deposited directly on an indium tin oxide (ITO) substrate using the successive ionic layer adsorption and reaction (SILAR) method by chemically reducing precursor metal salts with dopamine aqueous solution. The Au NPs decorated on the ITO substrate were approximately spherical, with an average particle size of about 40 nm, which varied in accordance with different SILAR cycles, reactant concentrations, and intermediate media. Strong surface plasma resonance characteristics were confirmed by the surface-enhanced Raman scattering and absorption spectra of the Au NPs. Through this simple method, glucose sensors based on this kind of Au NPs/ITO exhibited a sensitivity of 524 μA mM −1 cm −2 , which is higher than any other similar study.
研究领域:
材料科学
·
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
·
2024
·
IF 2.5
He Wang,Haidu Yuan,Jianhao Zhang,Wenjing Yan
Bacterial infections are becoming a significant threat to global human health due to the growing prevalence of biofilm-related infections and the rise in antibiotic resistance. D/ l -cysteine functionalized chiral gold nanoparticles (D/P-Au NPs or L/P-Au NPs) have demonstrated a potent antibacterial effect against E. coli , while the mechanism remains to be elucidated through additional research. Threonine deaminase (TD) is a crucial enzyme involved in branched-chain amino acid (BCAA) biosynthesis in E. coli and is involved in cysteine's antimicrobial effects. This study investigated the interaction between chiral Au NPs (D/P-Au NPs or L/P-Au NPs) and TD as well as its effect on enzyme activity. It demonstrates that chiral Au NPs interact with TD through hydrophobic forces, forming a ground state complex that induces changes in the secondary structure of TD and reduces enzyme activity in a concentration-dependent manner. We found that the exogenous supplementation of isoleucine and valine (2 mg/mL) significantly reduced the antibacterial activity of chiral Au NPs, especially for L/P-Au NPs. The proteomics results indicate that the expression of ilvA and ilvB was down-regulated after L/P-Au NPs treatment, which would interfere with the synthesis of BCAAs. These results demonstrate that chiral Au NPs cause cell death of E. coli partly due to inhibition of TD enzyme activity and the synthesis of branched-chain amino acids.
研究领域:
微生物学
·
纳米生物学
·
生物化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）