BIOCONJUGATE CHEMISTRY
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2020
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IF 4.031
Shuhan Hui,Qiqi Liu,Zhenzhen Huang,Jun Yang,Yanmei Liu,Shan Jiang
The serious threat of antibiotic-resistant bacterial infections has brought an urgent need for the development of new antibacterial nanomaterials. We encapsulate glutathione (GSH)-protected gold nanoclusters (AuNCs) in zeolitic imidazolate frameworks-8 (ZIF-8) and present their potential in antibacterial capabilities. Under white light irradiation, AuNCs-embedded ZIF-8 nanocomposites show assembly-enhanced emission and reactive oxygen species (ROS) generation. AuNCs@ZIF-8 exhibit almost complete inactivation of bacterial growth within 60 min of light irradiation. Scanning electron microscopic results show that AuNCs@ZIF-8 nanocomposites are captured by bacterial cells, and the leakage of alkaline phosphatase and nucleotides from bacteria demonstrate that the photoinduced ROS can easily destroy the bacterial surface and totally kill the bacteria. Herein, our antibacterial nanocomposites have photoenhanced bactericidal capability and show promising applications for sterilization.
研究领域:
材料科学
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纳米技术
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细菌学
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光催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
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2023
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IF 6.1
Meng Zhang,Jianhong Zhang,Xin Che,Jingjing Jiang,Qin Tu,Jinyi Wang
As one of the essential trace elements in life activities, copper ion (Cu 2+ ) plays a very important role in human health. However, copper-containing pesticides are usually used for sterilization and disinfestation in agriculture. Thus, the residues of copper-containing pesticides in agricultural samples increase the risk of excessive intake of Cu 2+ for human. The development of an effective method for detecting Cu 2+ is still an important task. Herein, a detecting system based on AuNCs@ZIF-8 modified paper and smartphone platform was developed for visual detection of Cu 2+ in agricultural samples. Herein, a detecting system based on AuNCs@ZIF-8 modified paper and smartphone platform was developed for visual detection of Cu 2+ in agricultural samples. In the detecting system, gold nanoclusters (AuNCs) were packaged by ZIF-8 to limit their molecular motion and enhance the fluorescence effectively. In the meanwhile, by ultrasound-assisted biomimetic mineralizing, AuNCs@ZIF-8 composites were uniformly synthesized in situ on the surface of the paper fibers to indicate Cu 2+ by fluorescence quenching . A portable visual monitoring system consisted of the prepared Cu 2+ paper sensor and a smartphone platform was then successfully built and applied to on site detecting Cu 2+ in agricultural samples. The limit of detection (LOD) was 4.57 μM and recovery rate varied from 96.50 % to 121.58 %. The developed detecting system for Cu 2+ has the advantages of easy preparation and operation, and is very suitable for the use in agricultural products and farmland.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Chemistry-X
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2024
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IF 6.5
Doudou Lei,Lingling Li,Pengyue Song,QingBin Xu,Lihua Huang,Xiao Ma,Lidong Zhou,Weijun Kong
Glyphosate (Gly) is a widely-used herbicide in food production, while, the residue of which due to the long-term and excessive overspray poses serious threats to public health. The development of reliable methods for its sensitive detection is of great urgency. In this study, a novel ratiometric fluorescent nanosensor by encapsulating N-doped carbon dots (N-CDs) and gold nanoclusters (AuNCs) in zeolitic imidazole framework-8 (ZIF-8) as the dual-emissive fluorescence probes at 410 and 650 nm, respectively, was constructed for Gly detection. Due to the adsorption property of ZIF-8, the N-CDs/AuNCs@ZIF-8 nanoprobes accumulated Cu 2+ to quench the red fluorescence of AuNCs, and the blue fluorescence of N-CDs was stable. While thiocholine, a product of acetylthiocholine, hydrolyzed by acetylcholinesterase could coordinate with Cu 2+ , resulting in significant fluorescence recovery of AuNCs. This phenomenon was utilized for the quantitation of Gly, due to its inhibitory effect on acetylcholinesterase activity. By calculating the fluorescence intensity ratio ( I 650 /I 410 ), Gly in real sample could be accurately determined in a concentration range of 2–100 ng/mL with a limit of detection of 1.92 ng/mL because of the anti-interference and the self-correction ability of the two fluorescence signals. The N-CDs/AuNCs@ZIF-8 nanoprobes-assisted ratiometric fluorescent nanosensor exhibited unique merits of rapid construction, simple operation, high specificity, and good accuracy for Gly in edible and medicinal malt samples with recoveries of 93.7–108.2 %. This study presents a multiple tool for the versatile sensing of trace pesticides in more food matrices, which can be extended to a full range of environmental and food safety applications.
研究领域:
分析化学
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食品安全
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
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2025
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IF 6.1
Pengyue Song,Doudou Lei,Lingling Li,Nan Long,Qingbin Xu,Ying Li,Lidong Zhou,Ruile Pan,Weijun Kong
Regarding the high incidence of residue and serious toxicity of acetochlor (ATC) pesticide, it is urgent to explore simple and low-cost methods for their sensitive detection in food. In this study, with zeolite-like imidazole frameworks (ZIFs) as the carriers for embedding glutathione-modified luminescent gold nanoclusters (GSH-AuNCs) exhibiting aggregation-induced emission (AIE) effect, a GSH-AuNCs@ZIF-8 probe driven strip-based lateral flow immunosensor (LFIS) was developed for visual qualitative and fluorescent quantitative dual-modal detection of ATC. The encapsulation of GSH-AuNCs into ZIF-8 with restriction effect not only significantly improved the stability and anti-interference ability of AuNCs, but also remarkably enhanced the fluorescence efficiency for signal amplification due to the enhanced AIE effect of GSH-AuNCs, endowing the LFIS platform with unique performance. Under optimal conditions, the LFIS platform could realize the point-of-care visualization and quantitation of ATC within 20 min with a detection limit of 8.3 pg/mL and a broad linear range of 0.01–10.0 ng/mL. High recoveries of 96.44%–106.8 % in the spiked ginger samples confirmed the outstanding accuracy and dependability of the new platform for ATC analysis of real samples. Compared with other immunoassays, the AuNCs@ZIF-8-based dual-modal LFIS exhibited the advantages of simple preparation, simple operation, short analytical time, and low cost, which could be expanded to monitor more pesticides and more trace contaminants in diverse food and agricultural products, and medicinal material matrices.
研究领域:
食品安全
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分析化学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
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