JOURNAL OF APPLIED POLYMER SCIENCE
·
2015
·Vol. 132
·期 20
·
IF 1.768
Yaobin Liu,Zhiqiang Fan
Two tribromide compounds, 1,3-(propanoic acid, 2-bromo-)-2-(2-bromo-1-oxopropylamino)propyl ester (A 1 ) and trimethylolpropane tris(2-bromopropionate) (A 2 ), were synthesized. By Cu/ N,N,N′,N′,N″ -pentamethyldiethylenetriamine (PMDETA)-mediated radical addition-coupling polymerization (RACP) of 2-methyl-2-nitrosopropane (MNP) with the tribromide compounds, two types of hyperbranched polymers were synthesized under mild conditions, respectively. Polymerization degrees of the polymers increased with time gradually, which is in line with a step-growth polymerization mechanism. By tracing the polymerization process by gel permeation chromatography and NMR analysis, proper reaction conditions to get hyperbranched polymers was obtained. Based on the results of NMR analysis on the polymer chain structure, mechanism of forming hyperbranched polymer has been proposed, which includes formation of carbon radicals from the tribromo monomer through single electron transfer, their reaction with MNP to form nitroxide radicals, and cross-coupling reaction of the nitroxide radicals with other carbon radicals. The gelation point of the A 2 -MNP system is larger than that of the A 1 -MNP system, indicating that probability of intramolecular cyclization in A 2 -MNP RACP system is higher than the A 1 -MNP system. The reactivity of —NHCOCH(CH 3 )Br group of A 1 is lower than its two —OCOCH(CH 3 )Br groups, and this resulted in longer distance between two adjacent branch points in the hyperbranched polymer of A 1 -MNP than the A 2 -MNP system. It is possible to adjust the chain structure of RACP-based hyperbranched polymer by changing the reactivity of the functional groups in A 3 monomer. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41972.
研究领域:
高分子化学
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聚合物合成
·
功能高分子
·
材料化学
·
有机合成方法学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Ying Han,Xuening Yang,Shiyao Fu,Chuqiang Que,Zuxin Zhang,Xiaoting Wang,Jing Wang,Xin Yang
Proanthocyanidin B2 (Pac B2) exhibits potent antioxidant properties but suffers from poor stability in vivo , limiting its applications in food and medicine. This study developed composite nanoparticles (NPs) utilizing abietic acid (AA) and oleanolic acid (OA) as carriers, significantly enhancing Pac B2's stability. The OA/AA-Pac B2 NPs, prepared via solvent co-precipitation, were spherical with an average diameter of 164.18 nm and an encapsulation efficiency of 43.26 %, demonstrating improved thermal stability. Analytical techniques such as infrared spectroscopy, ultraviolet spectroscopy, and molecular dynamics revealed interactions such as hydrogen bonding and hydrophobicity between AA and Pac B2. The NPs facilitated sustained release of Pac B2 in simulated gastric and intestinal fluids over 2 h at 37 °C. In vitro tests demonstrated enhanced bioavailability and absorption efficiency of OA/AA-Pac B2 NPs compared with free Pac B2, validating the effectiveness of the co -assembly strategy in improving polyphenols' stability and bioavailability.
研究领域:
食品科学
·
药物化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Jianxing Feng,Zhenqing Guo,Runli Li,Chaoqun Zhang,Ting Du,Xiang Li,Xuewei Yang,Junchen Zhuo,Yanmin Liang,Yaru Han,Jianlong Wang,Shuo Shi,Wentao Zhang
Recent advances in functionalized micro-nanostructures have enlightened promising non-thermal-dependent antibacterial strategies with broad applications in preventing agrofood spoilage, clinical infections, and environmental pollution caused by pathogens. These advances highlight the need for precise design of efficient and multi-mode bactericides. Herein, photosensitive vitamin B 2 (VB 2 ) was exploited to functionalize semiconductors with limited visible-light response and intrinsic antibacterial activity, while ZnO served as a paradigm for the fabrication of VB 2 -functionalized zinc oxide (VB 2 -ZnO) with persistent antibacterial effects. The enhanced visible photocatalytic activity and the released Zn 2+ in VB 2 -ZnO contribute to potent antibacterial and anti-biofilm effects by disrupting bacterial structures and inducing oxidative stress. Furthermore, the successful fabrication of composite films incorporating VB 2 -ZnO and natural locust bean gum (LBG) exhibited improved physicochemical properties and persistent antibacterial effects, resulting in the shelf-life extension of perishable berries. This work pioneers a novel approach to functionalizing semiconductor photocatalysts with VB 2 photosensitizer, offering novel solutions for ensuring agrofood safety through multi-mechanism antibacterial materials.
研究领域:
食品科学
·
材料科学
·
微生物学
✓ 已验证
DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2015
·
IF 4.642
Fang Xu,Xiang-Ning Song,Guo-Ping Sheng,Hong-Wei Luo,Wen-Wei Li,Ri-Sheng Yao,Han-Qing Yu
The generation of hydroxyl radical (•OH) under solar irradiation from natural photosensitizers is widely recognized to play a key role in the photochemical degradation of biorefractory organic pollutants. Solar-light-mediated •OH production has been supposed as a green and sustainable strategy in water and wastewater treatment. In this study, an efficient visible-light-mediated •OH generation method using the photosensitization of vitamin B2 (VB2) catalyzed by dissolved iron was proposed. •OH generation was validated by electron paramagnetic resonance spectroscopy combined with spin trapping, and was further confirmed using the hydroxylation of nitrobenzene. VB2 plays a dual role of in the process of •OH generation. In the initial step, VB2 works as an excellent photosensitizer. Upon absorption of a photon, VB2 gives rise to its excited singlet state (1VB*) and, through intersystem crossing, to its excited triplet state (3VB*). In the subsequent step, VB2 works as an effective electron mediator to mediate O2•– generation. However, O2•– is sensitive to proton and is converted to H2O2 quickly in water. Ultimately, the •OH generation occurs through dissolved-iron catalyzed decomposition of H2O2. All ingredients involved in this process are nontoxic, environmentally benign, and easily available. Thus, this process might have potential environmental implications.
研究领域:
环境科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
CANCER GENE THERAPY
·
2022
·Vol. 29
·期 8
·1217-1227
·
IF 5.854
Wang Zhiwei,Li Mingxing,Liu Yuanfeng,Qiao Zhentao,Yang Ling,Liu Bo,Bai Tao
Autophagy is the predominant self-eating catabolic pathway activated in response to nutrient starvation and hypoxia within the microenvironment of varied malignancies, including hepatocellular carcinoma (HCC). SQSTM1/p62 links its cargos to autophagosomes for degradation, and reportedly acts as a contributor for hepatocarcinogenesis. Five GEO gene microarrays identified corticotropin releasing hormone (CRH) binding protein (CRHBP) as a significantly downregulated gene in HCC (log2 Fold change < −3 and p < 0.001), and an earlier human interactome study indicated that CRHBP may interact with p62. This study aimed to explore (1) the role of CRHBP in HCC development, and (2) whether p62-mediated autophagy was responsible for low CRHBP expression within HCC tissue. Following functional experiments first revealed an anti-proliferative, anti-metastatic, and anti-angiogenic role of CRHBP in HCC cells (Huh-7, Li-7 and HCCLM3) and xenografts. CRHBP negatively regulated cyclin B2 expression, and dissociated cyclin B2-CDK1 complex in HCC cells, thereby leading to cell cycle arrest at G2 phase. To simulate HCC microenvironment in vitro, Huh-7 cells were incubated in Earle’s Balanced Salt Solution (nutrient starvation) or exposed to 1% O 2 (hypoxic exposure). In addition to activating autophagy, nutrient starvation and hypoxic exposure also induced CRHBP degradation. Interestingly, CRHBP was demonstrated as a novel cargo targeted by p62 for degradation in autophagosomes. Blocking autophagy with 3-MA, chloroquine or siSQSTM1 prevented CRHBP degradation in HCC cells. Collectively, our study uncovers a role for CRHBP in retarding HCC development, reducing cyclin B2 expression and impairing cyclin B2-CDK1 interaction. CRHBP downregulation in HCC may attribute to p62-mediated autophagy.
研究领域:
肿瘤学
·
细胞生物学
·
分子生物学
·
癌症研究
✓ 已验证
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Huimin Wang,Xueli Zhang,Shuangjue Wang,Sa Xiao,Hanyue Ma,Xia Wang
Vitamin B 2 (VB 2 ) and vitamin B 6 (VB 6 ) as important vitamins for human health are mainly produced by industrial microorganism fermentation. Due to the complexity of fermentation system, there is a lack of an efficient, rapid, and convenient detection method in the fermentation production of these two vitamins. In this study, a multianalyte electrochemical electrode based on glassy carbon electrode (GCE) modified by nanoporous gold (NPG) film was developed. This is the first time that NPG realized the electrochemical detection of VB 2 and VB 6 in complex fermentation analysis. Under optimized conditions, the NPG-modified electrode exhibited good performance in VB 2 and VB 6 detection using differential pulse voltammetry (DPV). Two linear responses in wide concentration ranges for VB 2 from 5 to 250 μM and for VB 6 from 40 to 1000 μM were obtained with the limit of detection (LOD) of 0.1 μM and 0.4 μM as well as the high sensitivities of 178.02 μA mM −1 cm −2 and 43.14 μA mM −1 cm −2 , respectively. Furthermore, the detection of VB 2 and VB 6 in fermentation media was successfully achieved using the NPG-modified electrode with high sensitivity and strong anti-interference ability. Additionally, the NPG-modified electrode has a long life because of the metal characteristics of NPG. These above characteristics conformed that the multianalyte electrochemical electrode can realize the simultaneous detection of multiple substances such as substrates and products in a complex biosystem.
研究领域:
生物工程
·
分析化学
✓ 已验证
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Ying Han,Xuening Yang,Shiyao Fu,Xiaoting Wang,Hua Zhang,Xiaojie Wei,Bin Li,Xin Yang
Procyanidin B2 ( Pac B2 ) has attracted much attention due to its strong antioxidant activity , but poor in vivo stability limits its wide application in food and medicine. In this paper, composite nanoparticles ( NPs ) were constructed using abietic acid ( AA ) as a carrier, which significantly enhanced Pac B2 stability. A spherical morphology and average diameter of 396.05 nm were observed in AA-Pac B2 NPs synthesized by solvent co-precipitation. Pac B2 encapsulation was 11.28 %, and thermal stability is improved. Infrared, Ultraviolet spectrum, and MD (molecular dynamics) spectroscopy revealed hydrogen bonding and hydrophobic interaction between AA and Pac B2 . For up to 2 h at 37 °C, Pac B2 can be sustainably released in simulated gastric and intestinal fluids. In vitro , AA-Pac B2 NPs at the same concentration exhibited higher bioavailability and uptake efficiency than free Pac B2 . The data demonstrate the potential of AA NPs for improving polyphenol thermal stability and bioavailability.
研究领域:
食品科学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2020
·Vol. 56
·期 1
·902-912
·
IF 3.553
Li Bingya,Hu Xiaoran,Zhang Qian,Peng Xiaoli,Xiang Yong
In this study, we designed and fabricated a poling-free piezoelectric nanogenerator using bio-based polymer and filler, a poly( l -lactic acid) (PLLA)/vitamin B 2 (VB 2 ) composite film. The addition of VB 2 to PLLA led to improved crystallinity and enhanced the molecular orientation of PLLA, resulting in a significantly enhanced output performance of the PLLA/VB 2 nanogenerator. The proposed nanogenerator provides a maximum power density of 75.68 mW cm −3 , which is approximately 28.7 times higher than that of pure PLLA nanogenerator. Moreover, the PLLA/VB 2 nanogenerator exhibits good electrical responses under both mechanical and acoustic stimulations. The collected mechanical energy from the motion of human joints can power up several LEDs. The PLLA/VB 2 nanogenerator can sensitively detect sound frequency from 1 to 27 kHz. Thus, it has great application potential in ambient mechanical and acoustic energy harvesting, wearable devices, and human–machine controlling systems.
研究领域:
材料科学
·
能源技术
·
生物医学工程
✓ 已验证
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2024
·
IF 5.8
Xian Dang,Zhulin Huang,Jieyan Yuan,Ke Li,Mengen Hu,Zhuoming Xie,Haoran Song,Bensong Chen,Xinyang Li,Ming Li,Xiaoye Hu,Yue Li
High-purity, nano-sized (Ti 0.2 Zr 0.2 Nb 0.2 Mo 0.2 Hf 0.2 )B 2 (TZNMH) diboride powders were successfully synthesized via a combined flocculation precipitation and boro/carbothermal reduction method. Then, the solid solution formation, thermal radiation performance and mechanical properties of TZNMH were investigated. It is found that high entropy effect endows TZNMH ceramic with outstanding near-blackbody radiation performance in the UV-Vis-NIR region, with a thermal emissivity ≥ 95%. This is because high entropy induces robust intraband transition. A dense and single-phase TZNMH ceramic was obtained by spark plasma sintering with high hardness (HV 0.1 =31.6 GPa) which remained above 30 GPa even after 60 h exposure at 1800 °C in Ar environment. This high hardness of TZNMH ceramic is believed to arise from the strong hybridization between metals and boron, as revealed by density functional theory calculations. This study demonstrates that high-entropy boride ceramics can be used as ideal high-temperature structural component with high thermal emissivity.
研究领域:
材料科学
·
陶瓷工程
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS CHARACTERIZATION
·
2024
·
IF 4.8
Wenya Li,Yongsheng Liu,Jingxin Li,Yejie Cao
(Ti 0.2 Zr 0.2 Hf 0.2 Nb 0.2 Ta 0.2 )B 2 -SiC ceramics with an open porosity of only 0.49 % were successfully fabricated in this work by the reactive melt infiltration (RMI) method. Air plasma flame ablation behavior of (Ti 0.2 Zr 0.2 Hf 0.2 Nb 0.2 Ta 0.2 )B 2 -SiC ceramics under 2300 °C temperature exhibited excellent resistance with mass and linear ablation rates of 3.66 mg/s and 0.88 μm/s, respectively. During ablation, the transition from continuous melting sublimation of Si and oxidation of SiC to oxidation of (Ti 0.2 Zr 0.2 Hf 0.2 Nb 0.2 Ta 0.2 )B 2 occurred. The uphill diffusion of Ti atoms transited (Ti,Zr,Hf,Nb,Ta)O x to Ti(Nb x Ta 1-x ) 2 O 7 while Zr 0.5 Hf 0.5 O 2 continuously precipitated. A multicomponent oxide layer of (Ti,Zr,Hf,Nb,Ta)O x along with (Zr,Hf) 6 Ta 2 O 17 , (Hf,Zr)(TiO 4 ) 2 , and (Zr,Hf) x (Ti,Ta) 1-x O embedded in SiO 2 melt was eventually formed on the ceramic surface. This oxide layer was spread above the high melting point Zr 0.5 Hf 0.5 O 2 , Ti(Nb x Ta 1-x ) 2 O, and low oxygen content (Ti,Zr,Hf,Nb,Ta)O x to form a stable, dense, and high viscosity protective layer.
研究领域:
材料科学
·
航空航天材料
✓ 已验证
产品关联
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2025
·
IF 6.3
Xinkai Zou,Xiaofei Sun,Anxin Xu,Yang Liu,Wei Zhao,Yingxia Zong,Jingjiang Sun,Qingfu Wang
The research on hyperbranched polyethers (HBPEths) currently focused on two main areas: (1) the development of a practical synthesis method and (2) the functionalization of HBPEths. “A 1 + B 2 ” ring-opening polymerization (“A 1 + B 2 ”-ROP) offers an efficient approach to access functional HBPEths with controllable structures. In the present study, a series of HBPEths were successfully prepared by employing “A 1 + B 2 ”-ROP, where the A 1 and B 2 represent a monofunctional primary alcohol and a biepoxy monomer, respectively. The obtained HBPEths possessed molar masses ranging from 2600 to 30000 g/mol. By employing functional A 1 primary alcohol initiators, it is possible to directly introduce a single type or a mixture of functionalities including fluoride, alkyne, alkene, azide, and furfuryl groups into the HBPEths terminal structures, while by adjusting various B 2 monomers with different linkage between both epoxy groups the main chain structures could be well controlled. Moreover, apart from conventional end group modification via esterification, the functionalities can be introduced during the one-pot “A 1 + B 2 ”-ROP process via ether bonds, which are stable against hydrolysis and redox-reaction.
研究领域:
高分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Nano
·
2025
·
IF 16
Xiquan Ding,Qian Du,Fei Gao,Long Chen,Tingyu Wang,Fangyuan Chen,Zhanghua Zeng,Yan Wang,Haixin Cui,Bo Cui
Root-knot nematodes are globally prevalent plant-parasitic pests, distinguished by their widespread distribution, extensive host range, and challenging control measures. Avermectin B2, one of the few effective nematicides available, faces limitations in efficacy and poses environmental concerns due to its eco-unfriendly composition and poor utilization in traditional emulsifiable concentrate (EC) formulations. In this study, we developed core–shell structured Ave B2-BS@Zein@SC nanospheres, incorporating zein as the carrier, sodium caseinate as the stabilizer, and butyl stearate as the temperature “switch”. These nanospheres demonstrated multiresponsive characteristics to temperature, pH, and enzymatic conditions, facilitating rapid pesticide release under elevated temperatures, mildly acidic or alkaline conditions, and in the presence of protease. These controlled-release properties effectively responded to both environmental factors during nematode outbreaks and the intestinal conditions of the nematodes, enhancing pesticide targeting and utilization efficiency. The engineered nanospheres improved the mobility and stability of avermectin B2 in soil, enabling more comprehensive control of nematodes across broader and deeper soil layers. Additionally, the penetration capability of Ave B2-BS@Zein@SC into plant roots effectively eliminated nematodes that had already invaded the root system, thereby strengthening crop protection. Crucially, Ave B2-BS@Zein@SC demonstrated enhanced safety for nontarget organisms. This environmentally conscious, and multiresponsive pesticide nanodelivery system presents a promising strategy for sustainable subterranean pest management.
研究领域:
植物保护
·
农药科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）