Doklady Biochemistry and Biophysics
·
2021
·Vol. 497
·期 1
·123-129
·
IF 0.788
Zhao Liang,Luo Yuming,Wang Yijun,Zhao Fujian,Chen Xiaofeng,Cai Daozhang
Abstract This study aimed to evaluate if the 3D printed bioactive glass porous scaffolds (BGS) can improve the reconstruction of the large bone defect. A rabbit model of large bone defects was established by making a 1.0 or 1.5 cm segmental defect in the middle of the femur bone. Then a 1.0 or 1.5 cm BGS was implanted into the bone defect. X-ray imaging showed that in both 1.0 and 1.5 cm groups, the newly formed bone tissue could be observed at 4 weeks after implantation, but a strengthened ossification trend could be observed at different time points. In the 1.0 cm group, a larger number of newly formed bone tissues were observed at 4 weeks, and in the 1.5 group, more newly formed bone tissues were found at 8 weeks. Nevertheless, ossified tissue generation on the BGS mainly completed at 12 weeks after implantation in both groups. The H&E staining revealed that the 3D BGS was easily degraded to form osteoid-like material in vivo , where the neo-ossification gradually occurred from the edge to the center. Immunohistochemical analysis showed that in the 1.0 group, protein expressions of three osteogenesis-related genes- BMP, collagen I and RUNX-2-all peaked at 8 weeks, and then gradually decreased at 12 and 18 weeks. In the 1.5 group, BMP and collagen I peaked at 18 weeks.
研究领域:
骨科
·
组织工程
·
材料科学
✓ 已验证
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2019
·
IF 4.959
Weijing Cao,Shouyang Zong,Yin Zhang,Fan Qiu,Jun Tang,Zhenning Wu,Jiapan Luan
Amino-grafted and vaterite-contained tricalcium silicate cement (A-V-C 3 S) was composited with 58S bioglass/chitosan/carboxy methyl cellulose (BG/CS/CMC, referred as BGs) to surmount the non-absorbability and infection problems of traditional bone wax. Its material, bioactive, biocompatible and antibacterial properties were systematically characterized. The results revealed that A-V-C 3 S/BGs possessed self-setting, injectable, mechanical and degradable abilities. A-V-C 3 S/BGs (1:1 g/g) was optimum owing to its higher compressive strength (9.91 MPa) and lower pH value (7.6 to 8.1) in the test groups. In vitro immersion experiment demonstrated that A-V-C 3 S/BGs had good hydroxyapatite formation ability, and its excellent cell adhesion, low cytotoxicity and superior cell proliferation were verified by mouse embryonic osteoblast precursor cells in cell tests. Compared with A-V-C 3 S, antibacterial experiment illustrated the significantly enhanced antibacterial property of A-V-C 3 S/BGs to Staphylococcus aureus and Escherichia coli .
研究领域:
生物材料学
·
医学工程
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Blue-Green Systems
·
2019
·Vol. 1
·期 1
·18-32
·
IF 0
Zheng Ke,Zhou Shaoqi
In this study, cyanoethyl cellulose (CEC) was used as a membrane material, and polyvinylpyrrolidone (PVP) was used as pore-forming agent to prepare the substrates for the thin-film composite (TFC) forward osmosis (FO) membrane for the first time. The experimental results demonstrate that the properties of the substrates were significantly improved after PVP was added. The scanning electron microscope (SEM) images show that a two-sublayer structure, a fringe-like top sublayer and macrovoids with sponge-like wall bottom sublayer, were formed after the addition of PVP. These improvements contributed to improved membrane performance during FO tests. Meanwhile, after adding PVP, the TFC membranes exhibited good water flux, and excellent specific reverse salt flux. For instance, the TFC-M2 exhibited 9.10/20.67 LMH water flux, 1.35/2.24 gMH reverse salt flux, and 0.15/0.11 g/L specific reverse salt flux in FO/pressure-retarded osmosis mode while using 1 M NaCl as the draw solution and deionized (DI) water as the feed solution.
✓ 已验证
DOI
Blue-Green Systems
·
2019
·Vol. 1
·期 1
·86-101
·
IF 0
Zhao Jujiao,Quan Xie,Chen Shuo,Yu Hongtao
Electro-Fenton in neutral medium has attracted more and more attention since it can relieve the costs of H 2 O 2 storage and pH adjustment, which are the major disadvantages limiting the practical applications of Fenton reaction. The electrode with good performance for electrochemical H 2 O 2 production from O 2 in neutral medium is of great importance in electro-Fenton. Herein, the N-doped three-dimensional carbon foam (NCF) electrode was obtained by using melamine foam as precursor. The nitrogen functional groups and graphitization degree could be tailored by adjusting the carbonization temperature. NCF1000, the sample carbonized at 1,000 °C, presents the H 2 O 2 selectivity of 81.9%, which is the highest among those of other NCFs. The H 2 O 2 concentration in neutral medium on NCF1000 achieved 0.87 mmol L −1 at −0.6 V, which is 1.8, 2 and 2.6 times as much as those on graphite, carbon cloth and carbon felt. Using as cathode in electro-Fenton, NCF1000 exhibits the kinetic rate of 0.062 min −1 for phenol degradation, which is 4.1 times larger than that on graphite electrode. As well, the performance of NCF1000 shows no visible attenuation after ten times phenol removal experiments, demonstrating its good reusability. These results indicate the potential of NCF as a promising alternative for commercial carbon-based electrode in electro-Fenton.
研究领域:
环境科学
·
电化学
·
材料科学
·
水处理技术
✓ 已验证
DOI
BIOMACROMOLECULES
·
2023
·
IF 6.2
Qinghua Hou,Kun Liu,Chenxi Lian,Jiawei Liu,Wenying Wei,Tong Qiu,Honglian Dai
Bacterial infection, prolonged inflammation, and insufficient angiogenesis are the main challenges for effective wound repair. In this work, we developed a stretchable, remodeling, self-healing, and antibacterial multifunctional composite hydrogel for infected wound healing. The hydrogel was prepared using tannic acid (TA) and phenylboronic acid-modified gelatin (Gel-BA) through hydrogen bonding and borate ester bonds and incorporated iron-containing bioactive glasses (Fe-BGs) with uniform spherical morphologies and amorphous structures to achieve GTB composite hydrogels. On one hand, the chelation of Fe3+ in Fe-BGs with TA endowed the hydrogel with good photothermal synergistic antibacterial ability; on the other hand, the bioactive Fe3+ and Si ions contained in Fe-BGs can recruit cells and synergistically promote blood vessel formation. In vivo animal experiments showed that the GTB hydrogels remarkably accelerated infected full-thickness skin wound healing by improving granulation tissue formation, collagen deposition, and the formation of nerves and blood vessels while decreasing inflammation. This hydrogel with a dual synergistic effect and ″one stone, two birds″ strategy holds immense potential for wound dressing applications.
研究领域:
材料科学
·
生物医学工程
·
伤口愈合
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）