Arabian Journal of Chemistry
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2023
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IF 6
Xucong Huang,Zhenghua Wu,Yanchao Liu,Mengqi Jia,Wenjuan Zhao,Shuowen Wang,Xinhui Jiang,Yuefen Lou,Guorong Fan
A simple, sensitive, and rapid LC-MS/MS method for the simultaneous determination of BIC, the M7 and M8 active metabolites in SD rat plasma was developed. After salting-out assisted liquid–liquid extraction (SALLE) with 5 M ammonium acetate solution, the sample was analyzed on a Sciences column (C18 3.0 × 100 mm, 3 μm) using a gradient elution at 40 ℃ within 7 min. The assay displayed excellent linearity in the range of 4–2000 ng/mL for M7 and BIC, and 1–500 ng/mL for M8. The results of this method exhibited that the precision, accuracy, matrix effect, recovery, and stability of BIC, M7 and M8 met all requirements for the quantitation in plasma samples. The pharmacokinetic result showed that the AUC (0→t) was calculated as 383.1 ± 164.4 (ng/mL·h) for BIC, and 5627 ± 1261 (ng/mL·h) for M7 after oral administration with BIC. Compared with BIC group, the pharmacokinetic parameters in BIC-NPs group were improved. Augmentation in AUC (0→t) (3.02-fold) and t 1/2 (1.43-fold) for BIC. Meanwhile, double peak phenomenon was observed on the mean plasma concentration–time curves of M7 in BIC and BIC-NPs group. In conclusion, both BIC and BIC-NPs were metabolized to abundant M7 in SD rat, which would provide a basis for researching the treatment mechanism of liver injury.
研究领域:
药物代谢
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药理学
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分析化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
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IF 13.2
Fuqian Hei,Yimin Zhang,Nannan Xue,Hong Liu
Tackle the problems of slow V 2+ /V 3+ reaction kinetics and severe hydrogen evolution side reactions of vanadium redox flow batteries (VRFB), this research proposes a strategy rooted in synergistic modification of graphite felt (GF) with Bi and N. Through high-temperature carbonization, bismuth atoms decomposed from bismuth nitrate react with the nitrogen formed from 2-methylimidazole to establish strong Bi N and Bi C coordination bonds at the GF interface. This process constructs a highly active bismuth-based composite electrode (1BiGF) that significantly Improves the activity of the V 2+ /V 3+ redox pair while simultaneously increasing the hydrogen evolution potential, effectively suppressing hydrogen evolution side reactions. Batteries incorporating 1BiGF as the negative electrode deliver an energy efficiency of 80.26 % at a current density of 220 mA cm −2 , outperforming the GF electrodes(74.32 %). The peak power density of the 1BiGF electrode increased by 6.7 % compared to the original GF (780.3 vs. 731.36 mW cm −2 ). Furthermore, after 600 cycles at a current density of 220 mA cm −2 , the 1BiGF electrode exhibited an energy efficiency retention rate of 98.2 %, demonstrating excellent long-term stability. This research focuses on developing high-performance VRFB negative electrodes by leveraging the synergistic action of N doping and Bi-based catalysis, thereby broadening the application scope of Bi-based composite electrodes in VRFBs.
研究领域:
储能
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电化学
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材料科学
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可再生能源技术
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DOI
高影响因子
MOLECULES
·
2019
·Vol. 24
·期 7
·1265
·
IF 3.06
Qingkui Fang,Quan Zu,Xiude Hua,Pei Lv,Wanwen Lin,Dahe Zhou,Zihan Xu,Jiarui Fan,Xiaohan Li,Haiqun Cao
A sensitive biotinylated indirect competitive enzyme-linked immunosorbent assay (Bic-ELISA) was developed to detect acetamiprid pesticides in pollen, based on the heterogeneous coating antigen and biotinylated anti-acetamiprid monoclonal antibody. Under optimized experimental conditions, the detection limit for the Bic-ELISA was 0.17 ng/mL and the linear range was 0.25–25 ng/mL. The cross-reactivities could be regarded as negligible for the biotinylated antibodies with their analogues except for thiacloprid (1.66%). Analyte recoveries for extracts of spiked pollen (camellia pollen, lotus pollen, rape pollen) ranged from 81.1% to 108.0%, with intra-day relative standard deviations (RSDs) of 4.8% to 10.9%, and the average reproducibility was 85.4% to 110.9% with inter-assay and inter-assay RSDs of 6.1% to 11.7%. The results of Bic-ELISA methods for the Taobao’s website samples were largely consistent with HPLC-MS/MS. Therefore, the established Bic-ELISA methods would be conducive to the monitoring of acetamiprid in pollen.Keywords:pollen;acetamiprid;pesticide;heterogeneous coating antigen;biotinylated mAb;Bic-ELISA
研究领域:
分析化学
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环境科学
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农业科学
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DOI
PubMed
高影响因子
IONICS
·
2024
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IF 2.4
Wang Haoxiang,Wei Xiuxia,Shao Fenjuan,He Yuyang,Luo Yuting,Sun Yiwei,Xu Dongpo
As a broad-spectrum antibiotic, tetracycline (TC) is commonly employed in veterinary drugs for treating numerous diseases. Nevertheless, its residue in food and water sources poses a significant threat. Hence, there is a substantial need for a rapid, inexpensive, and simple method to detect TC in water systems. In this study, a nanocomposite sensor based on gold-modified bismuth carbide (BiC) nanofibers and connected with a TC aptamer is proposed for the detection of tetracycline. The carbonized nanofibers offer a large surface area and excellent conductivity. Gold nanoparticles (AuNPs) on the surface of BiC nanomaterials enhance the electrochemical detection performance and also serve as the binding site for the TC aptamer. The surface morphology and structure of the modified electrodes are characterized by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The electrochemical performance of BiC@Au@Apta is evaluated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Under optimal conditions, BiC@Au@Apta has a wide detection range (0.001–100 µM) and a limit of detection (LOD) of 2.92 nM. It also exhibits good anti-interference ability, repeatability (RSD = 2.75–2.78%), and stability ( I = 97.30%). Additionally, BiC@Au@Apta can be utilized to detect TC in milk samples.
研究领域:
分析化学
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环境科学
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生物传感技术
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9.1
Jiayi Ge,Chaochao Lai,Tongtong Zhang,Meifei Chen,Xintao Zhou,Zhongqiu Luo,Zuqiang Huang,Yanjuan Zhang,Xiunan Cai
Precise engineering of interfacial electron transfer is pivotal for advancing photocatalytic performance. Herein, a metallic Bi-bridged, Bi-vacancy-rich Bi@Bi V -Bi 2 O 3 /CN S-scheme heterojunction featuring orchestrated interfacial charge transport is designed. Bi vacancies in Bi 2 O 3 acts as an efficient hole extraction agent, driving the directional migration of photogenerated holes, while the in-situ generated metallic Bi establishes a rapid electron transfer channel via Bi C interfacial bonding to concentrate electrons onto the CN substrate. Notably, the p-orbital hybridization of Bi with the p orbitals of C modulates the local electronic structure, synergistically enhancing interfacial electron dynamics. X-ray absorption spectroscopy confirms the formation of Bi C with strong electronic coupling, while density functional theory (DFT) calculations reveal directed charge migration at the Bi@Bi V -Bi 2 O 3 and CN interfaces. This dual-channel synergistic mechanism achieves highly efficient spatial separation of charge carriers while preserving highly reductive electrons and highly oxidative holes, providing an ideal platform for photocatalytic hydrogen evolution and organic pollutant degradation. Benefiting from the engineered interfacial pathways, Bi@Bi V -Bi 2 O 3 /CN achieves superior photocatalytic degradation of antibiotic, with a tetracycline (TC) degradation rate constant (0.019 min −1 ) and a hydrogen production rate (2903.30 μmol g −1 h −1 ) reaching 5.8 and 12.1 times that of pristine CN, respectively. This work provides novel insights and a theoretical foundation for designing efficient S-scheme photocatalysts with dual-functional capabilities for pollutant degradation and clean energy production.
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高影响因子
Advanced Science
·
2023
·Vol. 10
·期 7
·2206236
·
IF 15.1
Zichen Wang,Jiacheng Sun,Jiye Li,Lang Wang,Zishun Li,Xiaorui Zheng,Liaoyong Wen
Bound states in the continuum (BICs) have a superior ability to confine electromagnetic waves and enhance light–matter interactions. However, the quality-factor of quasi-BIC is extremely sensitive to structural perturbations, thus the BIC metasurfaces usually require a very-high precision nanofabrication technique that greatly restricts their practical applications. Here, distinctive 2.5D out-of-plane architectures based plasmonic symmetry protected (SP)-BIC metasurfaces are proposed, which could deliver robust quality factors even with large structural perturbations. The high-throughput fabrication of such SP-BIC metasurfaces is realized by using the binary-pore anodic aluminum oxide template technique. Moreover, the deep neural network (DNN) is adapted to conduct multiparameter fittings, where the 2.5D hetero-out-of-plane architectures with robust high quality-factors and figures of merit are rapidly predicted and fabricated. Finally, owning to its large second-order surface sensitivity, the desired 2.5D hetero-out-of-plane architecture demonstrates a detection limit of endotoxin as low as 0.01 EU mL -1 , showing a good perspective of biosensors and others.
研究领域:
光学
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光子学
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材料科学
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人工智能
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纳米制造
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DOI
PubMed
高影响因子
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