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SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY · 2019 · IF 2.931

Highly selective ratiometric fluorescent probes for the detection of Fe3+ and its application in living cells

Chunqing Li,Qi Sun,Qiang Zhao,Xinjian Cheng

It’s of vital importance to detect heavy metals in environment and living cells. In this work, four near-infrared regions boron dipyrromethene (BODIPY) probes (QBPH, PBPH, QBP and PBP) are constructed based on two BODIPY precursors (QB, PB) for sensing of Fe 3+ . As expected, these four probes exhibit obvious colorimetric and ratiometric response to Fe 3+ . In addition, QBP and PBP display highly sensitive and selective performance for detection of Fe 3+ . More importantly, QBP and PBP are successfully applied to near infrared imaging and detection of Fe 3+ in living A549 cells; it indicates that these novel designed probes could be a useful tool for the studies of Fe 3+ in living cells.

研究领域: 生物化学 · 分析化学 · 细胞生物学

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JOURNAL OF MATERIALS SCIENCE · 2024 ·Vol. 59 ·期 41 ·19628-19641 · IF 3.5

BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection

Song Shuang,Yang Na,Nawaz Muhammad Azhar Hayat,He Di,Han Wenzhao,Sun Baosheng,Steinmann Casper,Qi Hong,Li Ying,Shen Xiande,Yu Cong

Drug-resistant bacterial wound infections have become a major threat to human health worldwide, and there is an urgent need to develop a new generation of antibacterial agents to replace conventional antibiotics. In this work, we proposed an efficient nanoplatform that combines photothermal therapy (PTT) and light-triggered release of nitric oxide (NO) to combat bacteria. A multifunctional nanoplatform (BBDH NPs) based on a BODIPY probe, NO thermal responsive donor [ N , N ′-di-sec-butyl- N , N ′-diniroso-1,4-phenylenediamine (BNN6)], and a PEGylated polymer was prepared with a nanoprecipitation method. BBDH NPs represent a one-two punch against bacterial infections, combining potent photothermal therapy and the controlled release of NO, enabling rapid and efficient eradication of gram-negative and gram-positive bacteria. Histological analysis on a mouse model demonstrates that wounds treated with BBDH NPs and 685 nm laser irradiation have completed re-epithelialization, significant collagen deposition, and a number of hair follicle formation. BBDH NPs also exhibit a remarkable therapeutic effect on wounds infected with methicillin-resistant Staphylococcus aureus (MRSA). These results highlight that the proposed synergistic antibacterial strategy can be used as a potential therapeutic tool in drug-resistant, bacterial-infected wounds. Graphical

研究领域: 生物医学工程 · 纳米医学 · 感染性疾病

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Highly selective ratiometric fluorescent probes for the detection of Fe3+ and its application in living cells

BODIPY-based nanoparticles for highly efficient photothermal/gas synergistic therapy against drug-resistant bacterial infection