Journal of Materials Chemistry B
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2024
·Vol. 12
·期 25
·6128-6136
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IF 6.1
Dandan Ding,Shushan Mo,Qishan Li,Fei Wang,Xueyi Wang,Caiwen Ou,Zhenhua Li
Boron neutron capture therapy (BNCT) is an emerging approach for treating malignant tumors with binary targeting. However, its clinical application has been hampered by insufficient 10B accumulation in tumors and low 10B concentration ratios of tumor-to-blood (T/B) and tumor-to-normal tissue (T/N). Herein, we developed fluorinated BPA derivatives with different fluorine groups as boron delivery agents for enabling sufficient 10B accumulation in tumors and enhancing T/B and T/N ratios. Our findings demonstrated that fluorinated BPA derivatives had good biological safety. Furthermore, fluorinated BPA derivatives showed improved 10B accumulation in tumors and enhanced T/B and T/N ratios compared to the clinical boron drug fructose-BPA (f-BPA). In particular, in B16-F10 tumor-bearing mice, fluorinated BPA derivatives met the requirements for clinical BNCT even at half of the clinical dose. Thus, fluorinated BPA derivatives are potentially effective boron delivery agents for clinical BNCT in melanoma.
研究领域:
肿瘤学
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药理学
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放射医学
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DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
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IF 5.4
Hong Zhao,Yuqi Yang,Man Zhou,Lihui Xu,Hong Pan,Qun Yang,Zaisheng Cai
Anti-fog glass can solve the safety problems caused by glass fogging in a wide range of applications. However, its durability is still insufficient under actual application conditions such as high humidity, friction and scratches, et al. Therefore, this work copolymerised hydrophilic chain segments N-hydroxyethyl acrylamide (HEAA) containing -OH and water-resistant -NH-CO-, hydrophobic chain segments butyl acrylate (BA) and a “bridging agent” 4-benzoylphenyl acrylate (BPA) into a trimeric anti-fog coating. And, -OH was introduced to the glass surface by a simple plasma treatment. The BPA was covalently linked with hydrophilic and hydrophobic polymers HEAA/BA through a free-radical polymerisation reaction of double-bonded to form a covalent carbon chain. Meanwhile, it covalently combined with the -OH on the glass surface. BPA formed a stable link between the anti-fog coating and the glass substrate. Thus, the coating was resistant to 400 cycles of sand abrasions and can lift up to 1500 g. The -NH-CO- in HEAA and BA significantly increased the water resistance of the coating which can be immersed in water for 120 h. The -OH in HEAA not only given the coating excellent anti-fogging properties, but also enabled it to self-heal quickly within 10 s. The durable anti-fog coatings prepared in this work have great potential for practical applications.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Guoliang Cao,Qiao Li,Rupeng Wang,Chengyu Wang,Xiaoguang Duan,Shih-Hsin Ho
The advancement and exploitation of modern industry has a significant and far-reaching impact on water environment, prompting to development of advanced technologies for the filtration of oil/water emulsion mixtures and purification of soluble organic contaminants. However, bifunctional materials capable of continuously filtrating multiphase emulsion mixtures and degrading soluble organic contaminants from wastewater are still a concerning issue. Herein, a dual prewetted underwater superoleophobic and underoil superhydrophobic microalgae residue membrane (DMRM) hybrid was developed, which demonstrated outstanding performance in the filtration of multiphase emulsion mixtures and catalytic degradation of microplastics-released BPA. The combination of underoil superhydrophobic oil-containing region (OCR) with underwater superoleophobic water-containing region (WCR) in an integrated membrane promoted successive filtration of multiphase emulsion mixtures. Additionally, DMRM serves as a high-performance carbocatalyst for peroxydisulfate (PS) activation of rapid elimination of BPA. The reagents used in the integrated DMRM/PS system were optimized in a safety dose evaluation by the osteoblasts viability. Hence, the presented results will inspire the future comprehensive environmentally friendly treatment of wastewater with integrated systems and advanced membrane technology.
研究领域:
环境科学
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材料科学
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催化化学
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DOI
高影响因子
Biosensors-Basel
·
2022
·Vol. 12
·期 6
·367
·
IF 5.743
Rui-Hong Ye,Jin-Yang Chen,Di-Hui Huang,Yan-Jun Wang,Sheng Chen
The electronic conductive metal-organic frameworks (EC-MOFs) based on a single ligand are not suitable for the accurate detection of bisphenol A (BPA) due to the limitations of their electron-transfer-based sensing mechanism. To overcome this drawback, we developed EC-MOFs with novel dual-ligands, 2,3,6,7,10,11-hexahydroxy-sanya-phenyl (HHTP) and tetrahydroxy 1,4-quinone (THQ), and metal ions. A new class of 2D π-conjugation-based EC-MOFs (M-(HHTP)(THQ)) was synthesized by a self-assemble technique. Its best member (Cu-(HHTP)(THQ)) was selected and combined with reduced graphene (rGO) to form a Cu-(HHTP)(THQ)@rGO composite, which was thoroughly characterized by X-ray diffraction, field scanning electron microscopy, and energy-dispersive X-ray spectroscopy. Cu-(HHTP)(THQ)@rGO was drop-cast onto a glassy carbon electrode (GCE) to obtain a sensor for BPA detection. Cyclic voltammetry and electrochemical impedance tests were used to evaluate the electrode performance. The oxidation current of BPA on the Cu-(HHTP)(THQ)@rGO/GCE was substantially higher than on unmodified GCE, which could be explained by a synergy between Cu-(HHTP)(THQ) (which provided sensing and adsorption) and rGO (which provided fast electron conductivity and high surface area). Cu-(HHTP)(THQ)@rGO/GCE exhibited a linear detection range for 0.05–100 μmol·L−1of BPA with 3.6 nmol·L−1(S/N = 3) detection limit. We believe that our novel electrode and BPA sensing method extends the application perspectives of EC-MOFs in the electrocatalysis and sensing fields.
研究领域:
材料科学
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分析化学
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环境科学
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DOI
高影响因子
DENTAL MATERIALS
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2024
·
IF 4.6
Negar Mahmoudi Meimand,James Kit Hon Tsoi,Michael Francis Burrow,Jingwei He,Kiho Cho
Objective The commonly used base monomer utilized in resinous commercial dental restorative products is bis-GMA which is derived from bisphenol-A (BPA) - a well-known compound which may disrupt endocrine functions. To address concerns about its leaching into the oral environment and to optimize the quality of dental composites , a BPA-free alternative base monomer , fluorinated urethane dimethacrylate (FUDMA), was designed by modifying a UDMA monomer system. Methods Nine groups of composites were prepared by mixing the base monomers and TEGDMA in a ratio of 70/30 wt% to which were added silanized glass particles (mean diameter: 0.7 µm) in 3 different volume fractions (40, 45, and 50 vol%). Bis-GMA and UDMA base monomers were used as control groups in the same ratios. Various properties including degree of conversion (DC), flexural strength (FS) and flexural modulus (FM), water sorption (WS), solubility (SL), surface hardness and roughness, and initial adhesion property against S.mutans were investigated. One-way analysis of variance followed by Bonferroni test at α = 0.05 was used to analyze the results. Results A significant difference in FS between FUDMA-based composite with 40 vol% filler (120.3 ± 10.4 MPa) and Bis-GMA-based composite with the same filler fraction (105.8 ± 10.0 MPa) was observed but there was no significant difference among other groups. The UDMA based group exhibited the highest WS (1.3 ± 0.3 %). Bis-GMA showed greater initial bacterial adhesion but was not statistically different from the other groups (p = 0.082). Significance FUDMA-based resin composites exhibit comparable mechanical and bacterial adhesion properties compared with Bis-GMA and UDMA-based composites. The FUDMA composites show positive outcomes indicating they could be used as substitute composites to Bis-GMA-based composites.
研究领域:
牙科学
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材料科学
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生物医学工程
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DOI
PubMed
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2021
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IF 3.228
Qin Wang,Qing Chang,Mei Sun,Chenghao Liu,Jiahui Fan,Yijun Xie,Xiaoyong Deng
The complex combined effects of nanoparticles and environmental pollutants in the aqueous environment will inevitably affect aquatic ecosystem and human life. Bisphenol A (BPA) is listed as a typical kind of endocrine disruptors , there is little research about the joint toxicity of co-exposure of SiO 2 nanoparticles (NPs) and BPA. In this study, fluorescent ultra-small SiO 2 NPs (US-FMSNs) around 6.3 nm were synthesized and investigated for their combined effects with BPA on zebrafish during the early developmental stages within 4–168 h post fertilization (hpf). The results showed that US-FMSNs could accumulate in the chorion , abdomen and intestine in zebrafish. In addition, the different concentration (0.1, 1, 10 μg/mL) of BPA and US-FMSNs (200 μg/mL) demonstrated strong impact on multiple toxic endpoints at four periods (72, 96, 120, 168 hpf). We found US-FMSNs had no significant toxic effect on zebrafish, while BPA (10 μg/mL) showed a degree of developmental toxicity . Compared with single BPA (10 μg/mL) exposure, combined exposure enhanced the developmental toxicity of zebrafish, including increased mortality, decreased hatching rate and body length, and decreased activity of total superoxide dismutase (T-SOD) and increased malondialdehyde (MDA) levels. Our results indicated that US-FMSNs and BPA induced oxidative stress , and the effect of the co-exposure was less than that of single exposure (10 μg/mL). This study hereby provides a basis for the potential ecological and health risks of SiO 2 NPs and BPA exposure.
研究领域:
环境科学
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毒理学
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水生生态学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Yuanyuan Liu,Yihan Liu,Linyan Gu,Juan Han,Wenjing Zhi,Yun Wang,Lei Wang
Encapsulating enzyme within MOF (enzyme-MOF) gives rise to new opportunity to improve the fragility of enzyme, but practical application of enzyme-MOF composite is far from being realized. The development of a novel enzyme-MOF composite system should simultaneously guarantee the enhanced activity and controllably complete recycling, and only in this way can we efficiently and economically utilize the enzyme-MOF composite. Herein, we addressed all these fundamental limitations of current enzyme-MOF composite by establishing aptamer-functionalized enzyme-MOF composite (HRP-ZIF-8@P1). HRP-ZIF-8@P1 relied on automatic structure switch of aptamer-target binding and aptamer-cDNA (complementary DNA) hybridization, achieving effectiveness in self-enriching substrate around HRP-ZIF-8@P1 to boost enzymatic activity first, subsequently hybridizing spontaneously with magnetically controllable cDNA sequence (Fe 3 O 4 @P3) to completely recover the HRP-ZIF-8@P1, where preferentially capturing substrate could further induce the release of the hybridized HRP-ZIF-8@P1 for automatically starting the cyclic enzyme catalysis. A 5.6-fold enhancement in the catalytic efficiency for BPA degradation was endowed, and 94.7% catalytic activity was retained for 8 consecutive degradations of BPA, both of which were even more significant than HRP-ZIF-8. Additionally, remarkable stability of HRP-ZIF-8@P1 was afforded by dual-layer protection of ZIF-8 and P1 in denaturing conditions. Taking the possibility of discovering an aptamer for any target into account, the aptamer-functionalized enzyme-MOF composites provide a generic and simple guide for simultaneously boosting enzymatic activity and controllably full recycling the enzyme-MOF systems, accelerating their commercial utilizations.
研究领域:
材料科学
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生物技术
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环境化学
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2023
·
IF 15.1
Fangxin Deng,Qingze Chen,Yanping Zhu,Xiaoliang Liang,Runliang Zhu,Yunfei Xi
Although various strategies have been developed to boost the reactivity of heterogeneous Fenton catalysts, integrating multiple strategies in one catalyst to achieve high Fenton reactivity is still a challenge. To tackle this issue, the ball-milled peat and magnetite (Mag) composites were hydrothermally treated to synthesize novel heterogeneous Fenton catalyst (i.e., Mag-HTP) for bisphenol A (BPA) removal. The degradation efficiency of BPA (30 mg/L) by H 2 O 2 (2 mmol/L) activated with 50 %Mag-HTP (0.2 g/L) was above 98% within 120 min at initial pH 3. The calculated degradation rate constant of Mag-HTP was 0.0873, which was 20.6 folds higher than that of Mag; moreover, it possessed high reactivity over a wide pH range (3–7) with low H 2 O 2 dosage (0.5–2 mM), and high reaction stability (eight cycles with degradation rate over 95%). The multiple reactive mechanisms were validated: (1) NMR/XPS spectra, H 2 O 2 decomposition, and HO production experiments proved the HTP as an electron donor could directly reduce Fe(III); (2) C-V curves proved the formed C-O-Fe bonds could lower the Fe(II)/Fe(III) redox potential; (3) Raman/EIS spectra, Tafel plot, and radical scavenging tests proved that HTP could serve as an electron shuttle for transferring electrons from H 2 O 2 to Fe(III); (4) NMR spectra proved the formed C-O-C bonds on HTP could function as the dual-reaction-center in Fenton reaction. These multiple mechanisms collectively contributed to the high reactivity of Mag-HTP in the Fenton reaction. Therefore, Mag-HTP shows great potential for practical applications in wastewater treatment and soil remediation due to its cost-effectiveness, easy separation, and high Fenton reactivity.
研究领域:
环境科学
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化学工程
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产品关联
DOI
高影响因子
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
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2021
·
IF 6.291
Ren Zhou,Ming Xia,Lei Zhang,Wei Cheng,Jia Yan,Yu Sun,Yan Wang,Hong Jiang
Exposure to many kinds of bisphenols (BPs) is common, and the effects of BP mixtures may differ from those of individual BPs. Therefore, evaluating combined exposure effects is necessary. Our study evaluated the individual and combined exposure effects of bisphenol A (BPA), bisphenol S (BPS) and bisphenol AF (BPAF) on embryonic development using an embryonic stem cell test (EST) and a concentration additive (CA) model at relatively high doses to uncover the interaction model of the three BPs. Environmentally relevant concentrations were then used to evaluate the possible effects of the individual and combined BPs at actual human exposure levels. Exposure to relatively high-dose BPA, BPS and BPAF inhibited embryonic stem cell differentiation into cardiomyocytes and exhibited weak embryo toxicity. Individually, BPA, BPS and BPAF inhibited endoderm, mesoderm and ectoderm marker expression but enhanced pluripotency marker expression. Combined exposure to BPs had an additive effect on cardiomyocyte differentiation and embryonic stem cell proliferation based on the CA model. Environmentally relevant individual or combined BP doses (10 ng/ml individual BPA, BPS and BPAF doses or 1 ng/ml and 10 ng/ml BP mixture doses) failed to cause oxidative stress, DNA damage or apoptosis changes in stem cell differentiation. The cardiomyocyte differentiation ratio also did not change significantly. Individual and combined exposure to environmentally relevant BP doses led to a significant increase in collagen expression. BPAF and the combination of BPs increased the type 1 collagen level, while the combination also increased the type 3 collagen level, which may be related to p38 pathway activation. The p38 pathway inhibitor SB203580 inhibited the increase in collagen during cardiomyocyte differentiation caused by low-dose BPs. These results suggest that relatively high-dose BPs in combination have an additive effect on cardiomyocyte differentiation. Low-dose BPs individually and in combination may affect cardiomyocyte collagen through the p38 pathway.
研究领域:
毒理学
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发育生物学
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细胞生物学
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环境科学
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产品关联
DOI
PubMed
高影响因子
CHEMOSPHERE
·
2024
·
IF 8.1
Jingyuan Yue,Xiaojin Hu,Huijun Xie,Zhen Hu,Haiming Wu,Jian Zhang,Bo Sun,Lushan Wang
Bisphenol A (BPA) in seawater tends to be deposited in coastal sediments. However, its degradation under tidal oscillations has not been explored comprehensively. Hydroxyl radicals (·OH) can be generated through Fe cycling under redox oscillations, which have a strong oxidizing capacity. This study focused on the contribution of Fe-mediated production of ·OH in BPA degradation under darkness. The removal of BPA was investigated by reoxygenating six natural coastal sediments, and three redox cycles were applied to prove the sustainability of the process. The importance of low reactivity Fe(II) in the production of ·OH was investigated, specifically, Fe(II) with carbonate and Fe(II) within goethite, hematite and magnetite. The degradation efficiency of BPA during reoxygenation of sediments was 76.78–94.82%, and the contribution of ·OH ranged from 36.74% to 74.51%. The path coefficient of ·OH on BPA degradation reached 0.6985 and the indirect effect of low reactivity Fe(II) on BPA degradation by mediating ·OH production reached 0.5240 obtained via partial least squares path modeling (PLS-PM). This study emphasizes the importance of low reactivity Fe(II) in ·OH production and provides a new perspective for the role of tidal-induced ·OH on the fate of refractory organic pollutants under darkness.
研究领域:
环境科学
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化学
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海洋科学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2020
·Vol. 27
·期 14
·17290-17302
·
IF 3.056
Ma Lin,Yu Haiyang,Wang Xu,Li Dan,Zhang Yumin,Pei Xiucong,Duan Zhiwen,Ma Mingyue
The effect of prenatal bisphenol A (BPA) exposure is increasingly concerned. We investigated the effect of maternal BPA exposure during pregnancy on male offspring and its potential mechanism. Thirty pregnant Sprague Dawley (SD) rats were randomly divided into exposed and control groups. At PND56, the number of sperm, luteinizing hormone, and testosterone in the BPA-exposed group decreased, and testicular tissue structure was damaged in offsprings. At GD20, the miRNA profile in the testis of male offspring was examined and the expression levels of 28 deregulated miRNAs were validated by qRT-PCR. We found that miR-361-5p , miR-203a-3p , and miR-19b-2-5p had significantly different expression levels in the testis. These results suggest that maternal exposure to BPA can lead to differential changes in progeny miRNAs, which will provide direction for future in-depth mechanisms of reproductive injury.
研究领域:
生殖生物学
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毒理学
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分子生物学
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内分泌学
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产品关联
DOI
PubMed
高影响因子
COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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2023
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IF 3.9
Lin Duan,Haoyang Deng,Qianqing Zhang,Peijie Gao,Lang Wu
Bisphenol A (BPA) and fluoroquinolone antibiotics (FQs) have been detected frequently in aquatic environments. Studies have shown that high levels of BPA and FQs exposure have adverse effects on chondrogenesis in young terrestrial vertebrates. However, little is known about their combined toxicity to bone metabolism. Here, we evaluated the single and combined effects of BPA and norfloxacin (NOR, a typical species of FQs) at an environmentally relevant level (1 μg/L) on early skeletal development in zebrafish. We found that both individual and combined BPA and NOR exposure resulted in poor embryo quality and decreased calcium-phosphorus ratio. The malformation increased after exposure to BPA and NOR, and craniofacial cartilage ossification was delayed. At the molecular level, the transcriptions of genes related to ossification were down-regulated significantly, and the lysine oxidase activity decreased. Hence, we infer that an environmentally relevant concentration of BPA and NOR have adverse effects on early skeletal development in fish. In addition, combined exposure to BPA and NOR seems to have an antagonistic effect on early skeletal development.
研究领域:
环境科学
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毒理学
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发育生物学
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水生生态学
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产品关联
DOI
PubMed
高影响因子
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