CHEMICAL ENGINEERING JOURNAL
·
2020
·
IF 10.652
Biao-Qi Chen,Ranjith Kumar Kankala,Yang Zhang,Shu-Ting Xiang,Han-Xiao Tang,Qi Wang,Da-Yun Yang,Shi-Bin Wang,Yu Shrike Zhang,Gang Liu,Ai-Zheng Chen
In an attempt to attain synergistic therapeutic benefits and address various intrinsic limitations of the highly efficient black phosphorus quantum dots (BPQDs), we fabricated poly( L -lactide)-poly(ethylene glycol)-poly( L -lactide) triblock copolymer (PLLA-PEG-PLLA)-based nanocomposites co-loaded with BPQDs and gambogic acid (GA) using the supercritical carbon dioxide (SC-CO 2 ) technology to achieve photoacoustic (PA) imaging-guided synergistic chemo-photothermal therapy. On the one hand, BPQDs displayed near-infrared (NIR)-induced hyperthermia through the high photothermal conversion efficiency. On the other hand, the NIR-responsive release of GA facilitated early apoptosis through specific binding to stress-induced overexpression of heat shock protein (HSP)-90 for combating thermoresistant tumor cells. GA significantly promoted the photothermal therapy (PTT) efficiency by enhancing both early and late apoptosis of BPQDs. Moreover, the encapsulation of BPQDs in the polymer significantly improved their chemical as well as photothermal stabilities. Our findings suggested that these nanocomposites fabricated using the eco-friendly supercritical fluid (SCF) technology provided good protection to the biodegradable BPQDs, offering a great potential towards cancer ablation through augmented synergistic effects.
研究领域:
癌症治疗
·
纳米技术
·
生物医学工程
·
材料科学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2024
·
IF 8.5
Jiayi Wang,Shufang Zhou,Futai Lu,Shuo Wang,Qiliang Deng
Active antibacterial materials play an important role in solving food safety problems caused by pathogen contamination. In this study, a composite active antibacterial material with the synergistic antibacterial effectiveness of photothermal, photodynamic and the surface charge of polyphenols was developed, where the multi-porous polyphenol functionalized metal–organic frameworks (ZIF-8-TA) were used as the framework carrier, and black phosphorus quantum dots (BPQDs) were used as the photosensitive source. The resulted ZIF-8-TA/PBQDs possesses excellent photothermal conversion efficiency (27.92%), photodynamic performance and surface charge, and these factors ensure the outstanding broad-spectrum antibacterial performance (100%). Multifunctional characteristics and excellent biocompatibility endow the materials with vast potential for foodstuff packaging. The results showed that the composite antibacterial film produced by doping ZIF-8-TA/PBQDs into chitosan could effectively prolong the shelf life of foodstuff compared with commercial membrane. The successful implementation of this research provides a new idea for controlling microbial contamination and developing multifunctional antibacterial materials.
研究领域:
食品科学
·
材料科学
·
微生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2025
·Vol. 23
·期 1
·1-19
·
IF 12.6
Ai Li,Liu Zhijuan,Li Ran,Hu Ying,Li Yongxia
Background Lung adenocarcinoma, the most common type of non-small cell lung cancer (NSCLC), is a leading cause of cancer-related deaths globally due to its high incidence and treatment difficulty. Despite recent advancements in treatment methods, the prognosis for patients with advanced disease remains poor. Studies have shown that targeting mitophagy, the selective clearance of damaged mitochondria, can influence the sensitivity of cancer cells to treatment. Methods In this study, we designed and synthesized BPQDs@Lipo-YSA, a novel nanomaterial, aimed at specifically inducing mitophagy in lung adenocarcinoma cells. The nanomaterial was characterized using techniques such as transmission electron microscopy (TEM) and dynamic light scattering (DLS). The ability of BPQDs@Lipo-YSA to induce mitophagy was evaluated using Western blot, immunofluorescence, and flow cytometry. Additionally, in vitro and in vivo experiments were conducted to investigate the impact of BPQDs@Lipo-YSA on lung adenocarcinoma cells through the induction of immunogenic cell death (ICD). Results Experimental results showed that BPQDs@Lipo-YSA effectively induced mitophagy in lung adenocarcinoma cells by activating the PRKN/AKT1 pathway. More importantly, this induction of mitophagy significantly enhanced the cytotoxic effect on lung adenocarcinoma cells. In animal models, BPQDs@Lipo-YSA, by inducing ICD, markedly inhibited tumor growth and extended survival. Conclusions This study reveals the potential value of BPQDs@Lipo-YSA in lung adenocarcinoma treatment through the induction of mitophagy and ICD. This finding provides theoretical and technical support for the development of new therapeutic strategies for lung adenocarcinoma.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Zhichao Hu,Jiaqi Lu,Annan Hu,Yongjiang Dou,Sheng Wang,Dihan Su,Wang Ding,Ruixian Lian,Shunyi Lu,Lan Xiao,Yu-Lin Li,Jian Dong,Jian Zhou,Xuyong Yang,Libo Jiang
Bone regeneration following the removal of tumor tissues remains a major clinical challenge for the treatment of bone defects, in which materials with combinatory bone repair and osteolytic metastasis therapy is considered as a promising solution. Herein, a highly strong delignified wood/regenerated silk fibroin (RSF) hydrogel scaffold integrated with black phosphorus quantum dots (BPQDs) encapsulated by poly (lactic-co-glycolic acid) (PLGA) was engineered to realize efficient mechanical supporting, bone regeneration, and tumor therapy. Following delignification, the white wood (WW) scaffold significantly improved the mechanical properties of RSF composite hydrogel, with the elastic modulus in the L-direction and R-direction of 300 MPa and 3.3 MPa, and compression modulus in the L-direction of 9.3 MPa. Moreover, the WW/RSF hydrogel scaffold with BPQD/PLGA nanospheres effectively promoted the proliferation, migration, and osteogenic differentiation of bone mesenchymal stem cells and enhanced osteogenesis in vivo . Compared with the vertical implantation method, better bone regeneration was observed in parallel implantation system parallel to bone shaft. Importantly, the BPQDs in the hydrogel scaffolds could inhibit osteoclast differentiation and exhibit photothermal effects against metastatic tumor in the spine. Our data provide promising evidence for the potential therapeutic application on bone regeneration and ablation of bone metastasis.
研究领域:
生物医学工程
·
材料科学
·
组织工程
·
癌症治疗
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2022
·
IF 6.51
Yingjie Yu,Bingkai Wang,Miao Sun,Yunchang Zhang,Lei Hou,Sizhen Wang,Tianheng Chen,Feng Yang,Zhiqiang Ma
Photothermal therapy (PTT) is becoming increasing prevalent in clinic for eradicating the primary tumor and improving cancer patients’ compliance. However, photothermal resistance and distal metastasis still haunt the tumor treatment with PTT. Herein, on the basis that histone deacetylase acetylase inhibitor (HDACis) could activate the expression of anti-tumor gene and accelerate the differentiation and apoptosis of tumor cells, we propose that HDACis supplementing PTT could overcome those obstacles with appropriate drug-controlled release strategy. Thus, we fabricated a nano-complex of lysosomal activable vorinostat (SAHA) carrier-prodrug encapsulating black phosphorus quantum dots (BPQDs@PPS) to counter those challenges in PTT. With spherical morphology and favorable bio-safety, BPQDs@PPS could release BPQDs and Vorinostat spontaneously in lysosome, not only effectively inhibiting tumor growth, but also reversing tumor thermotolerance and metastasis within a PTT procedure. Especially, both western blot and immunofluorescence analysis validate that Vorinostat enables PTT to reverse tumor thermotolerance and distal metastasis by down-regulation of HSP70 and up-regulation of H3. Therefore, this research not only reveals the mechanism how HDACis supplement PTT in reversing tumor thermotolerance and metastasis, but also provides a promising prospect to upgrade clinical photothermal therapy.
研究领域:
肿瘤学
·
纳米医学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2025
·
IF 5.7
Yanning Qu,Beibei Lou,Jie Ren,Yuan Yu,Lin Liao,Dongfeng Sun,Ru Yan,Xinyang Zhang,Shihu Lei
Quantum dot-based materials exhibit unique photocatalytic performance, however inefficient electron transfer and weak visible light absorption negatively affect the results. In this study, a hollow TiO 2 /black phosphorus quantum dot (BPQDs) composite with cavity reflection associated oriented electron transfer effects was developed for photocatalytic hydrogen (H 2 ) production. The H 2 evolution rate of TiO 2 /BPQDs composite is 19 times higher than that of BPQDs and 2.3 times higher than that of TiO 2 . BPQDs were demonstrated that effectively loaded into both external and internal layers of TiO 2 , the UV-Vis diffuse reflectance spectra revealed an increased light absorption capacity of the material after BPQDs loading. Photoelectric tests and density functional theory calculations demonstrated improved electron transfer ability of the composite. The research expands the design methods for BP-based composites, providing new insights into heterojunction enhanced efficiency for solar energy conversion.
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
Nature Communications
·
2016
·Vol. 7
·期 1
·1-13
·
IF 11.329
Shao Jundong,Xie Hanhan,Huang Hao,Li Zhibin,Sun Zhengbo,Xu Yanhua,Xiao Quanlan,Yu Xue-Feng,Zhao Yuetao,Zhang Han,Wang Huaiyu,Chu Paul K.
Photothermal therapy (PTT) offers many advantages such as high efficiency and minimal invasiveness, but clinical adoption of PTT nanoagents have been stifled by unresolved concerns such as the biodegradability as well as long-term toxicity. Herein, poly (lactic-co-glycolic acid) (PLGA) loaded with black phosphorus quantum dots (BPQDs) is processed by an emulsion method to produce biodegradable BPQDs/PLGA nanospheres. The hydrophobic PLGA not only isolates the interior BPQDs from oxygen and water to enhance the photothermal stability, but also control the degradation rate of the BPQDs. The in vitro and in vivo experiments demonstrate that the BPQDs/PLGA nanospheres have inappreciable toxicity and good biocompatibility, and possess excellent PTT efficiency and tumour targeting ability as evidenced by highly efficient tumour ablation under near infrared (NIR) laser illumination. These BP-based nanospheres combine biodegradability and biocompatibility with high PTT efficiency, thus promising high clinical potential.
研究领域:
生物医学工程
·
纳米技术
·
癌症研究
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2021
·
IF 9.229
Hui Zhang,Zhuohao Zhang,Han Zhang,Canwen Chen,Dagan Zhang,Yuanjin Zhao
The in-depth development of biological materials, especially natural polymer materials, has injected strong vitality into clinical wound treatment. Here, a new type of controllable responsive microparticles composed of several natural polymer materials was presented for drug release and wound healing. These hybrid microparticles consisted of silk fibroin, gelatin, agarose, and black phosphorus quantum dots (BPQDs) and were loaded with growth factors and antibacterial peptides. Under near-infrared (NIR) irradiation, BPQDs could absorb the NIR light and increase the temperature of the microparticles to the melting point of gelatin. When the gelatin started to melt, the encapsulated drugs were gradually released because of the reversible phase transformation. Both in vitro and in vivo experiments have demonstrated that the BPQD-laden microparticles with a NIR-responsive feature could achieve the desired controllable release of growth factors to promote neovascularization formation. In addition, because antibacterial peptides were also mixed with the secondary hydrogel and encapsulated in the scaffolds, the microparticles are imparted with the antibacterial ability during storage and usage. These characteristics of BPQD-laden natural protein hybrid microparticles make them ideal for drug delivery and wound healing.
研究领域:
生物医学工程
·
材料科学
·
制药学
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yanning Qu,Jie Ren,Dongfeng Sun,Yuan Yu
Black phosphorus quantum dots (BPQDs)-based materials possess excellent photocatalytic efficiency; however, they often present a loss of photo-induced carriers and random active sites in electron transfer of heterojunctions , thus restricting the enhancement of hydrogen (H 2 ) evolution and their potential application. In this study, a micro-nano ZnIn 2 S 4 /BPQDs (MN-ZISBP) composite is constructed to enable specific orientation and self-distribution of photoelectrons transferred from ZnIn 2 S 4 (ZIS) to BPQDs. The relationship between photoelectron transfer and H 2 evolution efficiency is investigated via experiments and density functional theory (DFT) calculations. MN-ZISBP with a nanorod-like structure presents an H 2 evolution rate of 1207 μmol/g/h and is higher than that of the sheet-shaped (S-ZISBP, 1023 μmol/g/h) and flower-like composites (F-ZISBP, 744 μmol/g/h) under visible light irradiation. The MN-ZISBP composite with a lower conduction band level and larger specific surface area increases the number of active sites on BPQDs via “self-distribution” for H 2 evolution. Finally, the electron transfer direction and bonding orbitals of MN-ZISBP are calculated using the work function and density of states results to verify the above conclusions. The novel construction technique and photocatalytic mechanism of MN-ZISBP reported in this study provide significant insights into the BPQDs-based photocatalysts for H 2 evolution.
研究领域:
材料科学
·
能源科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
·
2024
·Vol. 22
·期 1
·1-20
·
IF 10.6
Li Tan,Zhang Xingyu,Shi Chengyu,Liu Qiao,Zhao Yuetao
Combination of tumor immunotherapy with photothermal therapy (PTT) is a feasible tactic to overcome the drawback of immunotherapy such as poor immune response. Via triggering the immunogenic cells death (ICD), PTT can stimulate the activity of immune cells, but meanwhile, the level of adenosine is elevated via the CD73-induced decomposition of ATP which is overexpressed accompanying with the PTT process, resulting in negative feedback to impair the immune stimulation. Herein, we developed a novel biomimetic photothermal nanodrug to specifically block CD73 for inhibition of adenosine production and more efficient priming of the suppressive immune microenvironments. The nanodrug, named as AptEM@CBA, is constructed by encapsulation of photothermal agent black phosphorus quantum dots (BPQDs) and selective CD73 inhibitor α, β-Methyleneadenosine 5′-diphosphate (AMPCP) in chitosan nanogels, which are further covered with aptamer AS1411 modified erythrocyte membrane (EM) for biomimetic camouflage. With AS1411 induced active targeting and EM induced long blood circulation time, the enrichment of the nanodrug tumor sites is promoted. The photothermal treatment promotes the maturation of dendritic cells. Meanwhile, the release of AMPCP suppress the adenosine generation via CD73 blockade, alleviating the impairment of adenosine to dendritic cells and suppressing regulatory T cells, synergically stimulate the activity of T cells. The combination of CD73 blockade with PTT, not only suppresses the growth of primary implanted tumors, but also boosts strong antitumor immunity to inhibit the growth of distal tumors, providing good potential for tumor photoimmunotherapy.
研究领域:
纳米技术
·
癌症免疫治疗
·
光热疗法
·
药物递送系统
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Jun Zhang,Lei Su,Zhinan Liu,Jincheng Tang,Lichen Zhang,Ziang Li,Dong Zhou,Zhuo Sun,Kun Xi,Peirong Lu,Guohua Deng
Following an ocular chemical injury, the release of neutrophil extracellular traps (NETs) triggers an innate immune cascade fibrotic effect involving macrophages (Mø), which limits corneal repair. However, the interplay and mechanisms between NETs and macrophages, as well as the coordination between the innate immunity and corneal repair, remain challenging issues. Using a co-culture system, we report that chemical stimulation exacerbates the accumulation of reactive oxygen species (ROS) within the polymorphonuclear neutrophils, leading to NET formation and the activation of M2 macrophages, ultimately inducing pathological fibrosis of the ocular surface through the IL-10/STAT3/TGF-β1/Smad2 axis. Inspired by the locally formed acidic microenvironment mediated by innate acute inflammatory stimulation, we further integrate sericin with oxidized chitosan nanoparticles loaded with black phosphorus quantum dots (BPQDs) using Schiff base chemistry to construct a functional pH-responsive hydrogel. Following corneal injury , the hydrogel selectively releases BPQDs in response to the acidic environment, inhibiting the innate immune cascade fibrosis triggered by the PMN-ROS-NETs. Thus, corneal pathological fibrosis is alleviated and reshaping of the ocular surface takes place. These results represent a refinement of the mechanism of inherent immune effector cell interactions, and provide new research ideas for the construction of nano biomaterials that regulate pathological fibrosis.
研究领域:
生物材料
·
免疫学
·
眼科
·
组织工程
·
纳米技术
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）