ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
·
2021
·
IF 6.291
Ren Zhou,Ming Xia,Lei Zhang,Wei Cheng,Jia Yan,Yu Sun,Yan Wang,Hong Jiang
Exposure to many kinds of bisphenols (BPs) is common, and the effects of BP mixtures may differ from those of individual BPs. Therefore, evaluating combined exposure effects is necessary. Our study evaluated the individual and combined exposure effects of bisphenol A (BPA), bisphenol S (BPS) and bisphenol AF (BPAF) on embryonic development using an embryonic stem cell test (EST) and a concentration additive (CA) model at relatively high doses to uncover the interaction model of the three BPs. Environmentally relevant concentrations were then used to evaluate the possible effects of the individual and combined BPs at actual human exposure levels. Exposure to relatively high-dose BPA, BPS and BPAF inhibited embryonic stem cell differentiation into cardiomyocytes and exhibited weak embryo toxicity. Individually, BPA, BPS and BPAF inhibited endoderm, mesoderm and ectoderm marker expression but enhanced pluripotency marker expression. Combined exposure to BPs had an additive effect on cardiomyocyte differentiation and embryonic stem cell proliferation based on the CA model. Environmentally relevant individual or combined BP doses (10 ng/ml individual BPA, BPS and BPAF doses or 1 ng/ml and 10 ng/ml BP mixture doses) failed to cause oxidative stress, DNA damage or apoptosis changes in stem cell differentiation. The cardiomyocyte differentiation ratio also did not change significantly. Individual and combined exposure to environmentally relevant BP doses led to a significant increase in collagen expression. BPAF and the combination of BPs increased the type 1 collagen level, while the combination also increased the type 3 collagen level, which may be related to p38 pathway activation. The p38 pathway inhibitor SB203580 inhibited the increase in collagen during cardiomyocyte differentiation caused by low-dose BPs. These results suggest that relatively high-dose BPs in combination have an additive effect on cardiomyocyte differentiation. Low-dose BPs individually and in combination may affect cardiomyocyte collagen through the p38 pathway.
研究领域:
毒理学
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发育生物学
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细胞生物学
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环境科学
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DOI
PubMed
高影响因子
Bioactive Materials
·
2023
·
IF 18.9
Yizheng Li,Chengde Liu,Xitong Cheng,Jinyan Wang,Yue Pan,Cheng Liu,Shouhai Zhang,Xigao Jian
Currently, many cancer patients with bone defects are still threatened by tumor recurrence, postoperative bacterial infection, and massive bone loss. Many methods have been studied to endow bone implants with biocompatibility, but it is difficult to find an implant material that can simultaneously solve the problems of anticancer, antibacterial and bone promotion. Here, a multifunctional gelatin methacrylate/dopamine methacrylate adhesive hydrogel coating containing 2D black phosphorus (BP) nanoparticle protected by polydopamine (pBP) is prepared by photocrosslinking to modify the surface of poly (aryl ether nitrile ketone) containing phthalazinone (PPENK) implant. The multifunctional hydrogel coating works in conjunction with pBP, which can deliver drug through photothermal mediation and kill bacteria through photodynamic therapy at the initial phase followed by promotion of osteointegration. In this design, photothermal effect of pBP control the release of doxorubicin hydrochloride loaded via electrostatic attraction. Meanwhile, pBP can generate reactive oxygen species (ROS) to eliminate bacterial infection under 808 nm laser. In the slow degradation process, pBP not only effectively consumes excess ROS and avoid apoptosis induced by ROS in normal cells, but also degrade into PO 4 3− to promote osteogenesis. In summary, nanocomposite hydrogel coatings provide a promising strategy for treatment of cancer patients with bone defects.
研究领域:
生物材料
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癌症治疗
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组织工程
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抗菌材料
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骨再生
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DOI
PubMed
高影响因子
PROCESS SAFETY AND ENVIRONMENTAL PROTECTION
·
2026
·
IF 7.8
Ju Shen,Zejun Wang,Zeyang Li,Linghao Meng,Jin Yan,Qiuhui Qian,Xuedong Wang,Huili Wang
Herein, we compared the developmental and neurotoxic effects of Bisphenol S (BPS) and Tetrabromobisphenol S (TBBPS) on zebrafish embryos at their environmentally relevant concentrations. Both compounds induced dose-dependent malformations like delayed hatching, shortened somites, spinal curvature, and brain deformities. TBBPS was significantly more toxic (LC₅₀ = 5.73 mg/L) than BPS (LC₅₀ = 65.2 mg/L), with the 24-48 hours post-fertilization window being most sensitive. TBBPS caused more spinal/circulatory defects, while BPS induced more eye/pericardial issues. Target prediction identified 228 genes for BPS and 165 for TBBPS, both enriched in FoxO, P53, and hormone signaling. BPS primarily affected MAPK and neurotrophin pathways, whereas TBBPS targeted PI3K-Akt and receptor-mediated carcinogenesis pathways. Both triggered brain/spinal oxidative stress, reduced neurogenesis, increased apoptosis, and impaired neurotransmission, evidenced by decreased serotonin (5-HT) and suppressed acetylcholinesterase (AChE) activity, leading to abnormal behavior. Hub gene analysis revealed distinct mechanisms: BPS disrupted neuronal proliferation via genes like Cdk2 , Cdk6 , Tyms; TBBPS interfered with the cell cycle via Plk4, Ccnb2. RT-qPCR confirmed these differences. TBBPS exhibits stronger developmental and neurotoxicity than BPS, indicating bromination significantly increases toxicity, providing a basis for environmental risk assessment of bisphenol analogs.
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高影响因子
ENVIRONMENTAL RESEARCH
·
2024
·
IF 7.7
Xiaolong Rong,Ying Han,Hao Dai,Haixia Jiang,Yingang Xue
Black phosphorus nanosheets (BPNS), a novel two-dimensional nanomaterial, find extensive applications in the field of photocatalysis. With the prohibition of bisphenol A (BPA), the utilization of bisphenol S (BPS), which is more resistant to degradation than BPA, has been steadily increasing. In this study, few-layer BPNS was prepared using an improved liquid-phase exfoliation method, showcasing its commendable specific surface area and notable adsorption capacity. Subsequently, a new type of nanocomposite material, BPNS-Cadmium sulfide (CdS), was hydrothermal synthesized involving BPNS and CdS. We conducted comparative assessments of BPNS, CdS, and their composite materials to identify the most efficient catalysts. Ultimately, we found that the composite material BPNS-CdS exhibited the highest capability for degrading BPS in an alkaline environment, achieving an impressive degradation rate of 86.9%. Notably, the degradation rate remained higher in an acidic environment compared to a neutral one. Through Electron Spin Resoance (ESR) experiments, it is revealed that BPNS-CdS, when exposed to visible light, generates •O 2 − , •OH, and h + as confirmed. Additionally, we tested and validated the carrier separation and migration abilities of BPNS-CdS while also calculating the band gap for each material. Building upon these results, a possible photocatalysis mechanism experiment was proposed. Finally, the degradation products were analyzed using High-Performance Liquid Chromatography-Mass Spectrometry (HPLC-MS) and put forth a plausible pathway for the BPS degradation, and it was found that 4-Phenolsulfonic acid, Ethyl protocatechuate and Isophthalic acid are the main intermediates of BPS. This study contributes to a deeper understanding of the synergy between non-metallic catalysts like BPNS and metal catalysts like CdS. It also offers new insights into the degradation mechanisms and pathways for BPS.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2023
·Vol. 33
·期 18
·2214126
·
IF 19
Kai Zheng,Jiaxiang Bai,Wanling Chen,Yaozeng Xu,Huilin Yang,Wei Li,Penghui Li,Liping Tong,Huaiyu Wang,Paul K. Chu,Dechun Geng
Osteoporotic fracture, which is a clinical complication of osteoporosis featured with the imbalance of bone homeostasis. Non-surgical intervention is frequently required post-operatively to ameliorate the fracture healing. Nevertheless, current non-surgical therapies are mostly performed in a non-targeted manner without giving enough consideration to the pathological characteristics of osteoporosis. Therefore, it is highly desirable to develop an optimal strategy for promoting fracture healing under osteoporotic conditions. In this study, a multifunctional therapeutic nanoplatform is designed to work in conjunction with near-infrared irradiation. Specifically, poly (lactic-co-glycolic acid) (PLGA) is functionalized with alendronate (ALE) and black phosphorus nanosheets (BPs) together with melatonin (MT) molecules are encapsulated by PLGA-ALE to produce the multifunctional BPs/MT@PLGA-ALE nanospheres. In this structure, BPs degrade gradually and deliver mild photothermal effects to facilitate bone regeneration, whereas MT has the dual-capability of suppressing osteoclastogenesis and promoting osteogenesis. Moreover, ALE endows the nanoplatform with the reliable bone-targeting capacity to improve the therapeutic effects. The combination of BPs/MT@PLGA-ALE nanospheres and photothermal therapy significantly improve post-surgical healing of osteoporotic fracture by modulating the tumor necrosis factor and cell death-related signaling pathways. This study reveals a promising strategy to treat osteoporotic fracture and broadens the application of nanomaterials in the biomedical field.
研究领域:
生物医学工程
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纳米技术
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骨科
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药学
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DOI
高影响因子
ENVIRONMENT INTERNATIONAL
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2021
·
IF 9.621
Cuicui Guo,Feng Ren,Jing Jin,He Zhang,Longxing Wang,Haijun Zhang,Jiping Chen
Bisphenols (BPs) are widely used in consumer products, and human exposure to BPs is nearly ubiquitous. However, human biomonitoring data are scarce, especially for children. In this study, we quantified eight BPs in the serum of 345 children from a typical coastal city in China. Bisphenol A (BPA), bisphenol F (BPF), and bisphenol S (BPS) were frequently detected (63% BPA, 68% BPF, 43% BPS), with geometric mean (GM) concentrations of 1.6, 0.08, and 0.04 ng/mL, respectively. The other five BPs had low detection frequencies (<5%). The distribution of BPA, BPF, and BPS in children’s serum samples was independent of sex whereas the concentrations of BPS and BPF both significantly increased with age ( P < 0.01). The GM values of estimated daily intake for BPA and BPS were 0.61 and 0.014 μg/kg body weight (bw)/day, respectively, indicating a relatively higher exposure risk of BPA in comparison with BPS. Compared with the population with euthyroid or nonhyperthyroid thyroid dysfunction, children with hyperthyroidism suffered higher exposure to BPA. By multiple linear regression analysis, thyroid-stimulating hormone showed a significantly negative relationship with log 10 -BPA concentration for euthyroid children ( R 2 = 0.477, P < 0.001), whereas a significantly positive correlation ( R 2 = 0.753, P = 0.033) was found for hyperthyroid children.
研究领域:
环境健康
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毒理学
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内分泌学
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公共卫生
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
·
2025
·Vol. 39
·期 6
·e70303
·
IF 2.8
Hongyu Zhang,Guoshun Lin,Yang Yang,Yifei Wang,Xiushuo Yang,Guige Hou,Zhenbo Wang,Qingguo Meng,Yun Hou
Hydroxytyrosol (HT), a primary phenolic compound in olive oil, exhibits antioxidant and antiapoptotic effects in various cell types, including cardiomyocytes and human umbilical vein endothelial cells. Contrastingly, bisphenol S (BPS) is known to induce apoptosis in myocardial and endothelial cells via oxidative stress. BPS increases reactive oxygen species (ROS) production and reduces the viability of hippocampal HT22 cells. In this study, we explored whether HT could protect neurons from BPS-induced oxidative stress and apoptosis. Our results showed that HT effectively inhibited oxidative stress responses in the brains of BPS-treated mice and significantly decreased ROS production in BPS-treated HT22 and PC12 cells. Additionally, HT reduced BPS-induced neuronal apoptosis in the cortical regions of mice as well as in HT22 and PC12 cells. Further analysis revealed that BPS activates the NF-κB signaling pathway, a key mediator of oxidative stress and neuronal apoptosis, while HT counteracted these effects. In summary, this study demonstrates the antioxidant and antiapoptotic properties of HT in BPS-exposed neurons. These findings provide compelling experimental evidence supporting the potential dietary inclusion of HT-rich compounds to alleviate oxidative stress-related neuronal damage. Summary HT showed neuroprotection in BPS-treated in mice, HT22 and PC12 cells. HT attenuates oxidative stress in BPS-treated in mice, HT22 and PC12 cells. HT inhibits NF-κB activity in BPS-treated in HT22 and PC12 cells.
研究领域:
神经生物学
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药理学
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毒理学
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DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2026
·
IF 5.2
Yunjia Yang,Yi Yang,Yixing Feng,Qian Jiang,Jing Zhang
Hydroxylated, glucuronide and sulfate metabolites were firstly identified in vitro . • A sensitive LC-MS/MS method was established for metabolite Semi-quantification. • Recombinant human UGT/SULT isoforms mediating DBSP metabolism were identified. • DBSP shows higher unconjugated forms and longer elimination in rat plasma than BPS. • Provide insights into the biomonitoring and toxicological assessment of DBSP. The widespread use of structural analogs to replace the endocrine-disrupting chemicals bisphenol A (BPA) and bisphenol S (BPS) has become a growing concern for both the environment and human health. As a novel BPS derivative, 2,4-bis(phenylsulfonyl)phenol (DBSP) has been frequently detected in environmental samples and human biological matrices; however, the biotransformation and toxicokinetic behavior of DBSP remain uncharacterized. To address these gaps, liquid chromatography coupled with high-resolution mass spectrometry (HRMS) was used in this study to identify DBSP metabolites from human liver microsomes/cytosolic fractions in vitro . For the first time, oxidative metabolites, as well as glucuronide and sulfate conjugates of DBSP, were identified, and a corresponding LC–MS/MS semiquantitative method was established. Further phenotyping assays using recombinant human UGT and SULT isoforms revealed that UGT1A3, UGT1A8, UGT1A9 and UGT1A1 exhibited high glucuronidation activity toward DBSP, while SULT1E1, SULT1A1, and SULT1B1 played major roles in DBSP sulfation. Pharmacokinetic analysis in rats after a single oral dose (100 μg/kg) further underscores the importance of phase II conjugation in DBSP metabolism. Compared with that of BPS, the proportion of free forms of DBSP in plasma was greater (77.0 ± 6.2%), and its elimination half-life (10.7 h) was longer, suggesting potential toxicological risk. These findings provide a critical foundation for future biomonitoring and toxicological assessments of DBSP. Download: Download high-res image (136KB) Download: Download full-size image
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高影响因子
Water
·
2020
·Vol. 12
·期 5
·1317
·
IF 2.544
Yan Zhang,Zhili Ni,Jie Yao
The electrochemical oxidation processes have attracted tremendous attention on the destruction of toxic and non-biodegradable organics. A series of neodymium (Nd)-doped PbO2electrodes (Ti/PbO2-Nd) were synthesized through a pulse electrodeposition method, and its activity of bisphenol S (BPS) removal was further examined. The morphologies and structures were characterized by the X-ray diffraction (XRD), scanning electron microscopy (SEM) and an energy dispersive spectrometer (EDS). The performance, energy consumption and mechanism of electrochemical oxidation of BPS by Ti/PbO2-Nd electrode were also discussed. Compared to the traditional Ti/PbO2electrode, the Ti/PbO2-Nd enables finer crystal particles, facilitating the oxygen evolution overpotential (OEP) from 1.41V to 1.55V and the generation of hydroxyl radicals (•OH). Moreover, lower duty cycles during the preparation of the electrode also contribute to the tapering size of crystals. The results show that the Ti/PbO2-Nd electrode exhibits relatively high activity in the anodic oxidation of BPS. Over 95% of BPS could be removed with the current density of 15 mA cm−2. Moreover, the energy consumption of BPS degradation on Ti/PbO2-Nd electrode is 60.26 kWh m−3, much lower than that on Ti/PbO2electrode (95.45 kWh m−3). To conclude, the Ti/PbO2-Nd electrode has been proven to be a promising material for BPS removal.Keywords:bisphenol S;electrochemical degradation;Ti/PbO2-Nd electrode;mechanism;duty cycle
研究领域:
环境科学
·
电化学
·
材料科学
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Zarfashan Shahid,Bairong Fu,Saima Rehman,Zia Ahmad,Jiping Chen,Xianbo Lu
Bisphenol compounds, including BPA and BPS, are significant pollutants found in the environment, food, and daily necessities. They pose various adverse effects, including estrogenic, immunotoxic, metabolic, and reproductive toxicity, which severely threaten human health and ecological safety. Achieving simultaneous rapid detection of BPA and BPS is still very challenging due to their similar structures and co-existence in actual samples at ultratrace level. This study addresses the problem of developing an effective method for the rapid detection of BPA and BPS simultaneously. A new electrochemical nanosensor based on ionic liquid (IL) coupled Zr-MOF@GO was developed for ultrasensitive real-time detection of BPA and BPS. The Zr-MOF@GO/IL nanocomposite features a custom-built structure with an ordered framework, abundant pores, and highly coupled interfaces. The experimental findings demonstrate that the introduction of IL enhances the conductivity and dispersibility of the nanocomposite, improves the absorption capability for target bisphenols, and significantly improves the detection limit and linear range of the Zr-MOF@GO based electrochemical sensor. The sensor demonstrated wide linear ranges with detection limits of 5.5 nmol/L for BPA and 7.1 nmol/L for BPS (S/N = 3), respectively. Comparative studies revealed that the detection limits of the Zr-MOF@GO/IL-based sensor improved by an order of magnitude compared to the Zr-MOF@GO-based sensor. Additionally, the sensor exhibited superior analytical performance regarding reproducibility, stability, and selectivity. This study investigated the capability and synergy of IL coupled high-valent stable transition metal Zr IV -based MOFs in electrochemical sensing for the first time. This development sets a new benchmark in non-enzymatic electrochemical sensing, establishing the Zr-MOF@GO/IL-based sensor as a promising platform for the individual or simultaneous rapid detection of bisphenols in actual samples.
研究领域:
环境科学
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分析化学
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材料科学
·
纳米技术
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产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Mengqiong Zhang,Guowen Wang,Jiping Chen,Xianbo Lu
Bisphenol compounds (BPA, BPS, BPAF, etc.) are one class of the most important and widespread pollutants that poses severe threat to human health and the ecological environment. Because of the presence of multiple bisphenols in environmental and food samples, it is urgent and challenging to develop a rapid and cheap technique for simultaneously detecting BPA and its analogues. In this study, a series of M - N -C (M = Cu, Mg, Ni, Co, Fe, K) single-atom nanozymes (SAzymes) were created by simulating the structure of natural enzyme molecules, which were used as novel sensing platform for the fabrication of electrochemical sensors. Through systematic screening and characterization, it was interestingly discovered that the electrochemical sensor based on Cu- N -C SAzymes exhibited the best sensing performance for bisphenols among all SAzymes, which catalyzed not only BPA like tyrosinase, but also showed excellent catalytic capacity beyond tyrosinase (tyrosinase has no catalytic activity for BPS, BPAF, etc.), and achieved potential-resolved simultaneous rapid detection of BPA, BPS and BPAF. Further structure-activity relationship and catalytic mechanism characterizations of Cu- N -C SAzymes revealed that the presence of single atom Cu was predominantly in the form of Cu + and Cu 2+ , which were anchored onto graphene nanosheet support through four coordination bonds with pyridinic N and pyrrolic N and acted as highly efficient active centers for electrocatalytic oxidation of bisphenols. The developed electrochemical sensing method exhibited excellent selectivity, sensitivity, and reliability for the rapid detection of multiple bisphenols in actual samples.
研究领域:
分析化学
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环境科学
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材料科学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Yao Liu,Runzi Zhang,Xiaoyu Yang,Li Tang,Bing Shao,Yi He,Xiao Yang
With the growing public concern over environment and food safety, the detection of trace amounts of bisphenols S (BPS) becomes crucial. In this work, an ultrasensitive surface-enhanced Raman scattering (SERS) biosensor was developed based on hydrogen-bonded organic frameworks@horseradish peroxidase (HOFs@HRP) and hollow bowl-shaped SERS substrates (AFRNBs@AuNPs) for the detection of BPS. Due to the excellent biocompatibility and mild synthesis conditions, HOFs had been utilized as protective matrices for HRP, effectively preserving its enzymatic activity. Furthermore, hollow bowl-like morphology AFRNBs@AuNPs were successfully prepared as efficient SERS substrate. When BPS was present, the stronger affinity between BPS and its aptamer triggered a displacement reaction, allowing HOFs@HRP to bind with AFRNBs@AuNPs, thereby enabling the catalytic conversion of TMB into oxTMB and generating a detectable Raman signal. Accordingly, the biosensor exhibited a detection limit of 1.28 × 10 −12 M. This method pioneers a new approach for trace BPS detection, demonstrating broad application prospects.
研究领域:
分析化学
·
环境科学
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食品安全
·
生物传感
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纳米材料
·
分子生物学
·
转化医学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）