ENVIRONMENTAL RESEARCH
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2025
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IF 7.7
Zhongqi Dai,Yu Zhang,Meng Dong,Yanchao Chai,Jilong Ren,Lei Wang,Cui Han
The novel brominated flame retardant 1, 2-bis (2,4,6 tribromophenoxy) ethane (BTBPE) has been widely used since the mid-1970s and detected in the aquatic environment and organisms; however, little information is available regarding its biotoxicity. In this study, the life-history parameters, transcriptomic regulation, multi-generational offspring size, and population dynamics of rotifers were determined in response to BTBPE (0, 0.01, 1, and 100 μg/L). The results showed that BTBPE (>1 μg/L) significantly increased the pre-reproductive time, shortened both reproduction periods and the lifespan, and decreased the total number of rotifer offspring. Transcriptomic analysis revealed that the expression of key genes involved in the pathways of citrate cycle, 2-oxocarboxylic acid metabolism, carbon metabolism, and propanoate metabolism was affected. Moreover, BTBPE has transgenerational effects on rotifers, the size of the F1 to F5 generations decreased significantly in response to BTBPE. Finally, the population density in the 100 μg/L BTBPE treatment group was significantly reduced by 30 % compared to the control group, suggesting that the population growth of rotifers was inhibited by BTBPE exposure. The findings of this study indicate that BTBPE has effects on the individual reproduction, population growth, offspring quality, and energy metabolism of rotifers. These findings highlighted the potential impacts of BTBPE on dominant zooplankton species, providing useful baseline information for evaluating the potential ecological risk of novel brominated flame retardant.
研究领域:
生态毒理学
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环境科学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL POLLUTION
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2017
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IF 5.099
Man Ren,Hao Zeng,Ping-An Peng,Hui-Ru Li,Cai-Ming Tang,Jian-Fang Hu
Polybrominated dibenzo- p -dioxins (PBDDs) and hydroxylated polybrominated diphenyl ethers (OH-PBDEs) can be formed from bromophenols (BPs) by thermal degradation , biosynthesis or phototransformation. However, it is unknown whether PBDDs and OH-PBDEs can be formed during the chemical production processes that utilize BPs as raw materials. 2,4,6-tribromophenol (2,4,6-TBP) is an important raw material for the synthesis of 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE), a novel brominated flame retardant . In this study, PBDDs, polybrominated dibenzofurans (PBDFs) and OH-PBDEs have been identified and quantified in commercially available BTBPE and 2,4,6-TBP. Furthermore, their formation as unintentional by-products during the laboratory synthesis of BTBPE from 2,4,6-TBP and 1,2-dibromoethane in the presence of sodium carbonate has also been investigated. 2,3,7,8-substituted PBDDs and PBDFs (2,3,7,8-PBDD/Fs) were undetectable in commercial samples of BTBPE and present in low levels (nanogram per gram) in 2,4,6-TBP. Two tetrabrominated dibenzo- p -dioxins (TeBDDs), namely 1,3,6,8- and 1,3,7,9-TeBDD, and three hydroxylated pentabrominated diphenyl ethers (OH-pentaBDEs), namely 4′-OH-BDE121, 2′-OH-BDE121, and 6′-OH-BDE100, were identified or tentatively identified, and quantitatively estimated to be at concentrations in the range of undetectable to several thousands of nanograms per gram in commercial BTBPE and 2,4,6-TBP. TeBDDs and OH-pentaBDEs were formed as by-products from 2,4,6-TBP during BTBPE synthesis. Further studies need to be conducted in order to determine whether PBDD/Fs and OH-PBDEs are also formed during the industrial synthesis of other chemical compounds that utilize BPs as raw materials or intermediates.
研究领域:
环境科学
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毒理学
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化学
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产品关联
DOI
PubMed
高影响因子
ENVIRONMENTAL TOXICOLOGY
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2021
·Vol. 36
·期 8
·1674-1682
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IF 4.119
Jun Shi,Xueting Wang,Lulu Chen,Huiping Deng,Min Zhang
Brominated flame retardants (BFRs), such as, 1,2,5,6-tetrabromocyclooctane (HBCD), 1,2-dibromo-4-(1,2-dibromopropyl)cyclohexane (TBECH), and 1 1,2-bis-(2,4,6-tribromophenoxy)ethane (BTBPE), have garnered increasing attention due to their potent biological effects. In the present study, the toxicity of HBCD, TBECH, and BTBPE in human vascular endothelial cells (ECs) was explored. The data showed that HBCD, TBECH, and BTBPE induced cytotoxicity, namely dose–dependent cell viability reduction, cell membrane permeability and apoptosis increase, migration, and lumen formation inhibition. Moreover, HBCD was found to be more toxic than BTBPE or TBECH. Exposure to HBCD, TBECH, and BTBPE led to the production of reactive oxygen species, mitochondrial superoxide generation, and mitochondrial membrane potential collapse, implying that reactive stress caused the cytotoxicity. The ATP content, glutathione content, superoxide dismutase, and MDA activities were reduced, indicating that mitochondrial dysfunction may be the key mechanisms responsible for apoptosis. The present study suggested that mitochondria are a new target of BFRs in ECs and further deepened our understanding of the developmental toxicity of BFRs.
研究领域:
毒理学
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细胞生物学
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环境健康
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）