ChemNanoMat
·
2021
·Vol. 7
·期 4
·457-466
·
IF 3.154
Shouning Yang,Yuyan Xue,Yanmin Zhang,Sijia Lu,Junli Wu,Lin Yang,Huayan Yang,Shaoning Yu
Graphical CaCO 3 -encapsulated Bi 2 S 3 nanorods targeted to mitochondria are reported for efficient photothermal cancer therapy. Photothermal therapy (PTT) is a light-triggered therapeutic method showing great promise in cancer treatment. For safe and effective PTT, minimal invasion and high specificity are needed. Mitochondria have been recognized as an attractive target to enhance the therapeutic efficacy of cancer treatment. Here, we present a unique type of CaCO 3 -encapsulated Bi 2 S 3 nanorods (Bi 2 S 3 @CaCO 3 NRs) for improving PTT therapeutic efficacy based on a novel mitochondria-targeted strategy. Such NRs with Bi 2 S 3 NRs as the photothermal agent, carboxylated short-chain PEG as bridging group and CaCO 3 as pH responsive surface coating showed not only remarkable promotion of cancer uptake efficiency, but also enhanced mitochondria targeting ability. The significant improvement of phototherapeutic efficacy of Bi 2 S 3 @CaCO 3 suggests that our mitochondria-targeting strategy is a reliable and useful method for efficient cancer therapy.
研究领域:
生物医学工程
·
肿瘤学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS RESEARCH BULLETIN
·
2013
·
IF 1.913
Huan-Huan Huang,Jun Chen,Yuan-Zheng Meng,Xiao-Quan Yang,Ming-Zhen Zhang,Yong Yu,Zhi-Ya Ma,Yuan-Di Zhao
Owing to the high X-ray absorption, Bi 2 S 3 nanocrystals are widely used as CT contrast agents. Here, we prepared uniform Bi 2 S 3 nanorods via a hot injection method using bismuth (III) chloride, sulfur and oleyl amine. The resulting nanocrystals were coated with tetraethylorthosilicate (TEOS) and 2-[methoxy(polyethyleneoxy)propyl]yrimethoxysilane (PEG-silane) for the biological utility. X-ray diffraction (XRD) and transmission electron microscopy (TEM) results showed that the Bi 2 S 3 nanorods had an orthorhombic structure with the length of 14 nm and the diameter of 7 nm, respectively. Composite nanoparticles (0.0226 M) gave a CT number at 550 (HU), which was higher than that of the commercial available iobitridol CT contrast agent. Furthermore, cell experiments revealed that Bi 2 S 3 composite nanoparticles had a low cytotoxicity with a concentration up to 0.01 M of Bi for 24 h.
研究领域:
材料科学
·
医学影像学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Huanshun Yin,Bing Sun,Yunlei Zhou,Mo Wang,Zhenning Xu,Zhengliang Fu,Shiyun Ai
In this work, we fabricated a novel photoelectrochemical immunosensor for assay of DNA methylation , where Bi 2 S 3 nanorods were used as photoelectric conversion material, MBD1 protein (a kind of methyl bonding domain protein) was used as DNA methylation recognizing unit, anti-his tag antibody was used to further inhibit the photocurrent and increase the detection sensitivity. The results demonstrated that Bi 2 S 3 possessed excellent photoelectron property. The detection conditions, such as Bi 2 S 3 concentration, MBD1 protein concentration, incubation time of MBD1 protein, antibody concentration and antibody incubation time, were optimized. Under optimal experimental conditions, the photocurrent variation was proportional to the logarithm of methylated target DNA concentration from 10 −9 to 10 –13 M with detection limit of 3.5×10 –14 M ( S / N =3). Moreover, the immunosensor presented high detection specificity, even distinguishing single-base mismatched sequence.
研究领域:
生物化学
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2016
·Vol. 19
·期 4
·727-733
·
IF 3.849
Huan Yu,Junli Wang,Tingting Wang,Hongsong Yu,Juan Yang,Guiwu Liu,Guanjun Qiao,Qing Yang,Xiaonong Cheng
A facile colloidal chemistry method is reported for synthesis of uniform Bi2S3 nanorods in a mixed solution of oleylamine with other organic amines including n-dodecylamine (C12), n-octylamine (C8), and n-hexylamine (C6). The nanorod length can be tuned through the carbon-chain length of these amines and importantly multigrams of Bi2S3 nanorods can be readily synthesized in a single scaled-up batch. Current–voltage (I–V) measurements showed that the Bi2S3 nanorods, obtained from both the small and large-scale batches or ones with different chain-length amines, exhibit fast light response characteristics (at the sub-second scale) with an obviously enhanced photocurrent (or photoconductivity) under broad-spectrum white light or monochromatic visible light of different wavelengths. The as-obtained nanorods, as determined by time-dependent current (I–t) curves, also exhibit excellent photoresponsive stability and reproducibility with the on–off switch of light. The photoconductivity enhancement in the Bi2S3 nanorods is assigned to the efficient electron–hole pair separation due to a hole-trapping mechanism. These results indicate the promising potential of Bi2S3 nanorods for optoelectronic device applications including photodetection (sensing), optical switch, photocatalysis, and photovoltaics within the visible spectrum range.
研究领域:
材料科学
·
纳米技术
·
光电子学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Energy Storage
·
2025
·
IF 9.8
Qianshi Wang,Chao Gu,Gang Liu,Xinmei Liu,Limin Dong,Yuhan Li,Mingyang Wu
In this study, we presented a mild hydrothermal method for preparing Bi 2 S 3 nanorods with varying bismuth-to‑sulfur ratios and systematically investigated the influence of these different ratios on its supercapacitor's performance. We adjusted the sulfur vacancy concentration in Bi 2 S 3 by different bismuth to sulfur ratios and found that the concentration of sulfur vacancy in Bi 2 S 3 reached a maximum at the bismuth to sulfur ratio of 1:12. At a Bi:S molar ratio of 1:12, the synthesized Bi 2 S 3 –3 demonstrated a high discharge capacity of 233.1C g −1 under 1 A g −1 current density. Notability, Bi 2 S 3 –3 maintains 67.4 % capacity retention after 10,000 cycles at 10 A g −1 , demonstrating exceptional cycling stability. When configured in a hybrid supercapacitor (Bi 2 S 3 –3//AC), the device achieves energy densities and power densities of 23.78 Wh kg −1 and 798.58 W kg −1 , respectively, showcasing its practical energy storage capabilities. Even at a current density of 10 A g −1 , the system maintained a capacity retention rate of 87.5 % and a coulomb efficiency of 99.1 % after 10,000 cycles of charge and discharge. The improved performance of the supercapacitor can be attributed to the introduction of more sulfur vacancies, which increases the number of active sites within the Bi 2 S 3 framework, significantly improves the charge transfer dynamics, and promotes the charge transfer between Bi 2 S 3 and electrolyte. This work provides new insights into improving the performance of supercapacitors through defect engineering modification of transition metal sulfides.
研究领域:
材料科学
·
电化学
·
纳米材料
·
能源存储
·
无机功能材料
·
电化学储能
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2024
·Vol. 35
·期 5
·1-10
·
IF 2.8
Kan Hao,Yang Wenhao,Guo Zilong,Li Min
Bismuth sulfide (Bi 2 S 3 ) is known for its remarkable sensitivity and stability, making it as an ideal material for gas sensor. Here, we present a highly sensitive room-temperature NO 2 gas sensor by controlling the Bi 2 S 3 nanorods morphology through hot injection method with varying Bi/S ratios (Bi/S = 1, Bi/S = 2, Bi/S = 4). The as-synthesized samples were subsequently spin-coated onto ceramic substrates to fabricate chemo-resistive gas sensors. TEM and XPS analyses revealed that with the increasing Bi/S ratio in the precursors leading to the nanorods aspect ratios enhancing and the generation of S vacancies facilitating. As a result, Bi 2 S 3 nanorods with a Bi/S ratio of 4 exhibited higher carrier mobility and provided more accessible sites for gas molecules. The optimal sensor (Bi/S = 4) showed an impressive response of 12.2 for 10 ppm NO 2 , which is 4 times higher than the device of Bi/S = 1. It also demonstrated a fast response/recovery time of 39 s/696 s and a lower detection limit down to 120 ppb. These findings highlight the excellent gas sensitivity performance of Bi 2 S 3 nanorods at room temperature and their potential for the development of energy-efficient and cost-effective gas sensors.
研究领域:
材料科学
·
纳米技术
·
气体传感器
·
环境监测
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2020
·
IF 4.389
Shouning Yang,Yanmin Zhang,Sijia Lu,Lihong Liu,Lin Yang,Yuming Guo,Shaoning Yu,Huayan Yang
One of the main diseases contributing to human death are malignant tumors. Phototherapy is a promising approach for cancer therapy, and functional nanoparticles with targeting ligands are commonly used to improve the therapeutic efficiency. However, recent studies have shown that nanoparticles in contact with a biological fluid can rapidly form a “protein corona” on their surface, which will remarkably decrease the targeting ability. Here, we describe the preparation of hybrid nanomaterials with Bi 2 S 3 nanorods as the core, and fluorescein-isothiocyanate and folic acid-modified human serum albumin (HSA-FITC-FA) as the shell. By using fluorescent binding label (FITC) and imaging techniques, we discovered the image of the cell lysosomes, indicating that the photothermal therapy agent was predominantly targeted to and accumulated in lysosomes. Combined with photothermal therapy agent (Bi 2 S 3 nanorods) and targeting ligand (FA), the obtained product shows enhanced photothermal therapy under near-infrared region laser irradiation. Additionally, SDS-PAGE shows that the modified HSA shell could remarkably reduce the reabsorption of protein corona from blood serum, minimized the adverse effect of protein corona on targetability. Taken together, the results indicate that our strategy has the potential for preparing efficient photothermal nanomaterials with image-guided subcellular organelle-targeting cancer cell ablation ability.
研究领域:
纳米技术
·
癌症治疗
·
生物成像
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2018
·
IF 6.042
Lin Cui,Juan Hu,Meng Wang,Xing-kang Diao,Chen-chen Li,Chun-yang Zhang
We demonstrate for the first time the development of a mimic peroxidase- and bismuth sulfide (Bi2S3) nanorod-based photoelectrochemical (PEC) biosensor for signal-on detection of polynucleotide kinase (PNK) on the basis of manganese-based mimic enzyme (MnME) catalytic precipitation. We use the hybrid film which consists of Bi2S3 nanorods and Au nanoparticles (AuNPs) as the immobilization matrix of capture probe. The capture probe on the modified electrode can specifically hybridize with the MnME@AuNPs-labeled signal probe to form the double-stranded DNA (dsDNA), generating a PEC biosensor. In the absence of PNK, MnME may stimulate the mimic enzyme catalytic precipitation onto the electrode surface, blocking the interfacial electron transfer and eventually leading to a low PEC signal. While in the presence of PNK, the dsDNA is phosphorylated and subsequently cleaved by lambda exonuclease to release the MnME@AuNPs conjugates from the electrode, leading to the decrease of catalytic precipitation on the surface of electrode and consequently the production of a high PEC signal. Notably, the MnME can be easily synthesized and possesses higher catalytic activity than the manganese-based mimic enzyme. This signal-on PEC biosensor exhibits high sensitivity with a detection limit of 1.27 × 10–5 U mL–1 and an extrembly large dynamic range of 5 orders of magnitude. Moreover, it can be applied for the screening of PNK inhibitors and accurate quantification of PNK activity in cancer cell extracts.
研究领域:
生物化学
·
分析化学
·
生物传感器
·
癌症诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Bing Sun,Fengmin Qiao,Lijian Chen,Zhen Zhao,Huanshun Yin,Shiyun Ai
A universal and effective photoelectrochemical (PEC) immunosensing device was fabricated on an indium tin oxide (ITO) electrode for sensitive and specific detection of subgroup J of avian leukosis virus (ALVs-J) based on a signal-on strategy. Bismuth sulfide (Bi 2 S 3 ) nanorods , with good morphology , high crystallinity and differentiated PEC properties, were selected as the photoelectrochemical species and synthesized by a facile hydrothermal method . On the basis of alkaline phosphatase catalytic chemistry to in situ produce ascorbic acid for electron donating, an enhanced photocurrent was obtained. Due to the dependence of the photocurrent signal on the concentration of generated electron donor , an exquisite immunosandwich protocol was successfully constructed for PEC detection of ALVs-J with a linear range from 10 2.14 to 10 3.65 TCID 50 /mL. The detection limit was 10 2.08 TCID 50 /mL ( S / N =3), and high stability and specificity were obtained. The strategy provides a fast and sensitive method for ALVs-J analysis and opens a general format for future development of PEC immunoanalysis.
研究领域:
病毒学
·
光电化学
·
免疫学
·
分析化学
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Guowen Qian,Tianci Wen,Yang Shuai,Xiongting Wu,Zhikui Zeng,Shuping Peng,Cijun Shuai
Photodynamic antimicrobial therapy via producing ROS based on light-responsive nanoparticles has attracted worldwide attention because of the high selectivity and low side effects. However, biofilms and bacterial membranes provide a natural barrier to prevent the penetration of ROS, which impairs the photodynamic antibacterial efficiency of nanoparticles. Photothermal therapy is an effective strategy against biofilms and bacterial membranes because high temperature can destroy the biofilm structure and enhance the membrane permeability. Herein, Bi2S3 nanorods were anchored on the surface of zinc-doped g-C3N4 (ZnCN) nanosheets to construct a ZnCN-Bi2S3 nanocomposite; then, it was incorporated into poly-l-lactic acid and prepared into scaffolds by the selective laser sintering technology. Bi2S3 nanorods not only endowed the scaffold with an excellent photothermal property but also strengthened the photodynamic effect of ZnCN nanosheets after forming the nanocomposite. The results showed that this nanocomposite had a lower recombination rate of photogenerated electron–hole pairs and produced higher photocurrent compared to those of the g-C3N4 nanosheets and Bi2S3 nanorods. The scaffold destroyed the biofilm and elevated the bacterial membrane permeability significantly and finally achieved 98.5% antibacterial rate for Staphylococcus aureus and 96.3% antibacterial rate for Pseudomonas aeruginosa. Encouragingly, the scaffold could also promote chondrogenic differentiation because of the continuous release of Zn ions. The scaffold containing ZnCN-Bi2S3 nanocomposites possessed excellent antimicrobial and cartilage regeneration functions, which displayed great potential in treating tracheal injuries.
研究领域:
纳米技术
·
材料科学
·
生物医学工程
·
抗菌治疗
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2013
·
IF 5.437
Huanshun Yin,Mo Wang,Yunlei Zhou,Xiaoyan Zhang,Bing Sun,Guihua Wang,Shiyun Ai
A novel signal “on” type of photoelectrochemical biosensor for microRNA-21 hybridization detection was fabricated, where Bi 2 S 3 nanorods were used as photoactive material with a maximum adsorption at 450 nm visible light, hairpin-structure DNA as detecting probe, streptavidin as signal capturing unit and biotin functionalized ascorbic acid loaded apoferritin as signal amplification unit. Hybridization between the probe and the target microRNA-21 was confirmed by the increased photocurrent of the biosensor after electron donor of ascorbic acid was introduced into the detection buffer by digesting the apoferritin by trypsase, indicating that this method could be used fProd. Type: FTPor quantitative measurements , and the discrimination of the complementary from mismatched microRNA-21. Under the optimal detection conditions, the photoelectrochemical biosensor displayed a linear range of 1–5000 fM and a low detection limit of 0.35 fM for microRNA-21 determination. Moreover, the down-regulated expression of microRNA-21 in poultry cells and tissues infecting with avian leukosis viruses was confirmed by directly detecting microRNA-21 in extracted total RNA. This proposed strategy may open a new avenue for the applications of photoelectrochemical biosensor for oligonucleotides detection using visible light irradiation , which could largely reduce the destructive effect of UV light on biomolecules .
研究领域:
生物传感器
·
纳米技术
·
分子生物学
·
分析化学
·
病毒学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2014
·Vol. 182
·期 1
·241-248
·
IF 3.719
Wang Mo,Yang Zhiqing,Guo Yunlong,Wang Xinxu,Yin Huanshun,Ai Shiyun
We demonstrate a photo-electrochemical biosensor for the sensitive and specific detection of microRNA using Bi 2 S 3 nanorods as a photoactive material and streptavidin as the unit that inhibits photocurrent. Bi 2 S 3 nanorods were synthesized hydrothermally in organic phase and displayed excellent light-to-current conversion efficiency. The Bi 2 S 3 was deposited on an indium tin oxide (ITO) slice and then modified with gold nanoparticles onto which biotinylated hairpin probe DNA was deposited as a monolayer. Following hybridization between the biotinylated probe DNA and the target microRNA, the stem-loop structure of the probe DNA was unfolded and the biotin directed outwards into the solution. Streptavidin was then added to bind to biotin via the strong streptavidin-biotin interactions. This causes the photocurrent of the modified ITO to decrease due to steric hindrance that blocks the transfer of electrons from added ascorbic acid to the surface of the electrode. The method has a detection limit as low as 3.5 fM of microRNA and can excellently discriminate even singly mismatched microRNA. The method was successfully applied to investigate the effect of abscisic acid on the expression level of microRNA-159a in seeds of Arabidopsis thaliana . We conclude that the assay presented here has a large potential as a method for quantification of microRNA and for studying the epigenetic regulation of flowering plants.
The photocurrent generation and decrease mechanism of the PEC biosensor.
研究领域:
生物传感器
·
光化学
·
纳米技术
·
分子生物学
·
植物科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）