Selective conversion of glycerol to lactic acid requires the synergistic activation of C–H, C–O, and O–H. Herein, we report an inexpensive Fe–Cr/TiO2 catalyst that achieves lactic acid formation with a high selectivity of 60.5%. By changing the Fe/Cr ratios and reduction temperatures, the structures of Vő and Vő-OH were altered, which determined the overall oxidation–dehydration–isomerization process. The in situ ATR-IR experiments confirmed the activation of glycerol by adsorbing the primary −OH, and a series of control experiments verified that Fe was responsible for the cleavage of C–H and O–H, while CrOx catalyzed the activation of C–O and C–H. This work designs a hydrothermal catalyst with multifunctional ability, which may guide the rational catalyst design for the selective oxidation of glycerol to lactic acid.
Xiuzheng Zhuang,Jianguo Liu,Yangqi Ji,Xiaojun Wu,Xinghua Zhang,Lungang Chen,Qi Zhang,Longlong Ma
Summary Pharmaceutical synthesis keeps close ties with the development of heterogeneous catalysts ; in this work, we report a facile way to prepare cobalt nanoparticles encapsulated by a graphene-shelled matrix, whose catalytic activity for a wide range of primary amines is proved to be broadly effective. As determined by its structural features, such a graphene-shelled matrix is characterized by surface defects such that inner metallic atoms are individually pulled outside by the divacancy sites; as a result, the delivery of metallic sites facilitates the easy substitution of the –NH 2 moiety toward functionalized and structurally diverse molecules by directly activating the C=O or C–N bonds in varied substrates, providing cost-effective access to numerous amines and other precursors for more complex drug products. In addition, the performance of this catalyst in a continuous test can reach at least 180 h without any loss of efficiency, which can be mainly ascribed to the protection of graphene-shelled structures.
危险品化学品经营许可证（带存储）