INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Yunxia Bai,Mei Li,Xuemei Liu,Jinyu Han,Xinli Zhu,Qingfeng Ge,Hua Wang
Photocatalytic CO2 reduction is a promising route to simultaneously address two critical issues related to the energy and environment. Herein, a direct Z-scheme photocatalytic system, Ti3+ defective TiO2/CdS nanoflowers, was fabricated to enhance the production of C1–C3 products from CO2 reduction. First, nanoflower-like TiO2 (NF-TiO2) is prepared using a TiB2 precursor to build in Ti3+ defects. Then, the NF-TiO2/CdS heterojunctions are constructed via the sulfurization of TiO2/Cd-MOF. Importantly, the optimal heterojunction photocatalyst NF-TiO2/CdS0.6 exhibits a highly promoted CO2 reduction activity not only for CO and CH4 but also for C2–C3 hydrocarbons. The cumulative yields of CO and CH4 are 1007.0 μmol/g and 83.5 μmol/g (2.5 h), respectively, and a yield of 55.3 μmol/g (2.5 h) of C2–C3 hydrocarbons is obtained. This enhanced yield of C1–C3 products is attributed to the synergistic effects of abundant Ti3+ defects that increase adsorption and activation of CO2, the large surface area that provides sufficient active sites, and a direct Z-scheme heterojunction with a good intimate contact interface that effectively separates charge carriers and accumulates electrons with strong reducibility. Moreover, the photoluminescence analysis of hydroxyl radicals was conducted to provide evidence for the direct Z-scheme mechanism. This work provides a facile method for the construction of a TiO2-based direct Z-scheme photocatalytic system for improving photocatalytic performance toward CO2 reduction.
研究领域:
材料科学
·
环境科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
·
2014
·
IF 2.302
An-Lin Zhang,Li-Wen Yang,Nian-Fa Yang,Jing Zhang
Several C 3 -symmetric trialkanolamines can be efficiently obtained via molecular sieve-assisted epoxide ring opening with ammonia in high yields (up to 90%) and regioselectivity up to 100%. These trialkanolamines were effective for the asymmetric alkynylation of aldehydes and the propargyl alcohols were obtained in high yields (up to 92%) and high enantiomeric excesses (up to 95%). The 1 H NMR spectra support that there could be a complex mixture of polynuclear Ti(IV)-based species form from the interaction of Ti(IV) with ligand.
研究领域:
有机化学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2023
·
IF 9.9
Yuqi Liu,Fuyan Kang,Chunyu Bi,Junming Shi,Guoyang Gao,Yulong An,Zhanhua Huang
The simultaneous reforming of biomass into high value-added chemicals and H 2 production by water splitting in a green and environmentally clean way is a very challenging task. Herein, we demonstrate the design of bifunctional Mn x Cd 1-x S photocatalyst with a controllable band gap by bandgap engineering. Bandgap engineering effectively regulates the oxidation and reduction capacity of materials. The design of photocatalysts with suitable conduction bands and valence bands makes the targeted conversion of xylose possible. Innovative conversion of xylose to glyceric acid, lactic acid, and propanoic acid. The optimized Mn 0.7 Cd 0.3 S catalyst showed excellent performance in the production of H 2 (14.06 mmol·g cat -1 ·h −1 , 29.9 times more than CdS and 351.5 times more than MnS), xylose conversion (90%), and C3 organic acid yield (59.2%) without cocatalyst and any scavengers under visible light irradiation. This work shows that a rational photocatalyst design can achieve efficient simultaneous production of high value-added chemicals and clean energy.
研究领域:
材料科学
·
环境科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ORGANIC & BIOMOLECULAR CHEMISTRY
·
2022
·Vol. 20
·期 7
·1510-1517
·
IF 3.89
Yang Liu,Meng Cao,Shangxi Zhang,Zhenxi Wang,Xin Dai,Xinde Jiang,Yucheng Dong,Jie Fu
A Brønsted acid catalyzed method for the construction of guaiazulenyl C3-functionalized indole derivatives is reported for the first time. The reactions proceeded smoothly at ambient temperature by using (±)-10-camphorsulfonic acid (CSA) as a catalyst, 2-indolylmethanols and guaiazulene as substrates, and the desired products were obtained in high yields with excellent regioselectivities.
研究领域:
有机化学
·
药物化学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2025
·
IF 8.3
Zhenjun Liu,Tianpei Yang,Yi Shen
The glycerol electrochemical oxidation (GEOR) represents a sustainable strategy for converting abundant biomass-derived feedstocks into high value-added chemicals. Herein, we prepared a series of Pt/Au/Ti catalysts via electrodepositing Pt nanoparticles (NPs) onto Au-sputtered Ti substrates (Au/Ti). The atomic Pt/Au ratio on the surface was engineered through pulse-deposition cycles. The structures of the catalysts were characterized by scanning electron microscopy, atomic force microscopy and X-ray diffraction, confirming that Pt NPs were uniformly deposited on the Au/Ti surface. Electrochemical evaluations demonstrated that the 10Pt/Au/Ti catalyst has superior GEOR performance in 1 M KOH solutions, achieving a peak current density of 13.16 mA cm −2 . Operando electrochemical impedance spectroscopy revealed that Au and Pt worked synergistically to promote the adsorption of adsorbed hydroxyl species ( OH ad ) and glycerol, thereby improving GEOR activity. Product analysis revealed that the 10Pt/Au/Ti catalyst yielded the highest glyceric acid selectivity of 93.6% at 0.9 V vs. RHE under alkaline conditions. This study provides an efficient strategy for the highly selective conversion of glycerol into high value-added C 3 products.
研究领域:
电催化
·
能源化学
·
环境科学
·
材料科学
·
可持续化学
✓ 已验证
产品关联
DOI
高影响因子
Molecular Catalysis
·
2023
·
IF 4.6
Liping Tan,Yamei Sun,Changjun Yang,Bingguang Zhang,Kejian Deng,Xiaofeng Cao,Yanchuan Guo
Photocatalytic selective oxidation of glycerol to value-added C 3 products is a promising strategy for the valorization of glycerol. In this work, an inorganic/organic composite material by integrating zinc oxide (ZnO) with iron thioporphyrazine (FePz) was prepared to act as photocatalyst for photocatalytic oxidation of glycerol in water. The effects of FePz surface modification on the physicochemical properties and photocatalytic performance of ZnO were systemically studied. More importantly, the integration of ZnO with FePz could markedly improve the visible light absorption ability and effectively promote the separation of photogenerated charges. Meanwhile, introducing FePz onto the ZnO surface was beneficial to the adsorption capacity of glycerol. Just because of this, ZnO/FePz composite exhibited excellent photocatalytic activity for oxidizing glycerol in water, C 3 products including glyceraldehyde and dihydroxyacetone were obtained from this composite photocatalytic system. Additionally, the active species responsible for glycerol oxidation were also determined.
研究领域:
材料科学
·
化学工程
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
BRAIN RESEARCH
·
2019
·
IF 2.929
Linjie Wei,Jianbo Zhang,Bo Zhang,Junjun Geng,Qiang Tan,Ling Wang,Zhi Chen,Hua Feng,Gang Zhu
Background Traumatic brain injury (TBI) leads to severe mortality and disability, in which secondary injury induced by complement activation plays an important role. TBI tends to be associated with more severe cerebral edema and worse neurological functional recovery if it occurs in high-altitude areas than in low-altitude areas. However, the underlying mechanism of this difference is unknown. Thus, we used cobra venom factor (CVF) to deplete complement C3 in simulated high-altitude areas to explore whether the differences in outcome at different altitudes are related to secondary injury caused by complement C3. Methods The weight-drop model was adopted to induce TBI in rats. Rats were randomly divided into the following groups: sham + saline (sham), high altitude + TBI + saline (HAT), high altitude + TBI + CVF (H-CVF), low altitude + TBI + saline (LAT), and low altitude + TBI + CVF (L-CVF). Brain contusion and edema volumes, brain water content, myelin basic protein (MBP) expression, tumor necrosis factor alpha (TNF-a) expression, interleukin 1 beta (IL1B) expression, mortality rate, neurological function, and complement component 3 (C3) mRNA expression were measured by techniques such as Evans blue fluorescence, Perls staining, TUNEL staining, ELISA, immunohistochemistry and Western blotting to evaluate correlations between complement activation and secondary injury. Results The activation of complement after TBI was significantly higher at high altitude than at low altitude. High-altitude TBI resulted in a leakier blood-brain barrier, more severe cerebral edema and higher mortality than low-altitude TBI did. In addition, high-altitude TBI tended to be associated with more MBP degradation, ferric iron deposition, neuronal apoptosis, and inflammatory factor deposition than low-altitude TBI. All of these effects of TBI were partially reversed by inhibiting complement activation using CVF. Conclusion Our study provided evidence that TBI at high altitude leads to severe edema and high mortality and disability rates. Complement C3 activation is one of the important factors contributing to secondary brain injury.
研究领域:
神经科学
·
免疫学
·
病理生理学
·
实验医学
✓ 已验证
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Shuai Kong,Liuhuimei Cheng,Junying Yan,Huiqing Liu,Ruirui Li,Baoying Wang,Yaoming Wang,Tongwen Xu
Metal alkoxides are widely applied in organic synthesis because of their solubility and volatility. However, conventional synthetic methods suffer from safety risks, harsh conditions, and low efficiency. This study reported the first evidence of isopropanol dissociation in a bipolar membrane and developed a green electrosynthesis route for lithium isopropoxide by taking advantage of isopropanol dissociation in bipolar membranes. We find that the threshold dissociation voltage of isopropanol was 53.4 V, which is significantly higher than that of water and C 1 /C 2 alcohols because of its low dielectric constant. To overcome high solution resistance, various electrolytes have been screened, with tetraethylammonium chloride resulting in an 88 % reduction in stack resistance. Under the optimized current of 6 mA·cm −2 with the BP-A configuration, lithium isopropoxide was synthesized with an energy consumption of 213 kWh·kg −1 and a current efficiency of 67 %. The product was characterized via FTIR and solid-state 7 L i NMR, confirming the successful formation of lithium isopropoxide. The technoeconomic analysis demonstrated that the bipolar membrane electrodialysis (BMED) process offers a cost-effective and energy-efficient alternative to traditional methods, with a production cost of $51.35/kg, which is significantly lower than that of the traditional synthesis route. This study expands the application of BMED in C 3 alcohols and offers theoretical and technical foundations for scalable and green production of metal alkoxides via alcohol dissociation.
研究领域:
有机合成
·
电化学
·
绿色化学
·
膜技术
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
NEUROCHEMICAL RESEARCH
·
2025
·Vol. 50
·期 5
·1-12
·
IF 3.8
Huang Manqian,Tang Meiling,Liu Lu
Epilepsy is a chronic neurological disorder featured by abnormal neural discharges that can lead to cognitive impairment. Salidroside (Sal), a biologically active component, protects neurons against various insults. The current study aims to explore the therapeutic potential of Sal in epilepsy and elucidate the mechanisms underlying its effects. We established a rat model of status epilepticus (SE) using pentylenetetrazol-kindling. SE rats were treated with Sal. Assessment of seizure latency and epileptic stage scores were performed. Cognitive function of rats was evaluated using a novel object recognition test and a Morris water maze test. Neuronal damage and hippocampal pathology were examined, alongside microglial and astrocyte activation, complement C3-C3a receptor (C3-C3aR) pathway involvement, and inflammatory factor levels. Sal prolonged seizure latency, decreased epilepsy stage scores, and improved cognitive performance compared to untreated SE rats. Furthermore, Sal suppressed the activation of C3-C3ar, microglia, and astrocytes, while decreasing the levels of inflammatory factors, which ameliorated hippocampal damage and neuronal loss. Sal may attenuate epilepsy and cognitive dysfunction by downregulating complement C3-C3aR pathway-mediated activation of microglia and astrocytes.
研究领域:
神经病学
·
药理学
·
神经药理学
·
免疫学
·
分子生物学
·
神经科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Peng Hu,Mingyuan Jiang,Jialang Hu,Long Li,Gui Shi,Lvming Jin,Yonggang Zhang,Chao Xiong,Hongbing Ji
The efficient separation and purification of natural gas (NG) represents a pivotal industrial procedure. Herein, we rationally designed a hierarchical-discrete MOF (denoted as 1a ) with molecular nanotraps that enable highly efficient C 3 H 8 capture and kinetic separation from light alkane mixtures (CH 4 /C 2 H 6 /C 3 H 8 ). N 2 adsorption analysis and pore visualization reveal hierarchically discrete pore geometries with ultra-submicroporous dimensions of 5.0 × 4.9 Å 2 and 8.3 × 8.2 Å 2 , effectively optimizing the formation of C 3 H 8 -selective molecular nanotraps while improving gas storage and diffusion kinetics through interconnected ultra-submicroporous channels. Significantly, 1a demonstrates exceptional separation performance, with IAST selectivity of equimolar C 3 H 8 /CH 4 and C 2 H 6 /CH 4 for 1a is 575.6 and 34.8 at zero coverage and 298 K, surpassing many well-known MOFs. Dynamic breakthrough experiments confirm the effective separation of ternary CH 4 /C 2 H 6 /C 3 H 8 mixtures and combined density functional theory (DFT) calculations, transient two-dimensional electron-density maps (2D-EDM),etc., reveal the molecular-level host–guest binding mechanisms. This work highlights the importance of multiscale pore cooperation for synergistically enhancing gas storage capacity and diffusion kinetics.
研究领域:
化学工程
·
材料科学
·
气体分离技术
·
纳米多孔材料
·
计算化学
✓ 已验证
产品关联
DOI
高影响因子
BIOMACROMOLECULES
·
2024
·
IF 5.5
Danyu Lv,Wanjun He,Wei Liu,Yuqiang Cheng,Yan Cui,Xiujuan Zhou,Yanwen Xue,Siming Yu,Ningjin Zhang,Hecheng Meng,Yongguang Guan,Jian-He Sun,Xian-Ming Shi
The γ-cyclodextrin (γ-CD) metal–organic frameworks (CD-MOF-1) consist of γ-CD and potassium (K+) ions through coordinating an eight-coordinated K+ ion with two C5-linked oxygen and C6-linked hydroxyl (C5–O/C6–OH) groups in the primary faces of adjacent γ-CD units and two C2- and C3-linked hydroxyl (C2–OH/C3–OH) groups in the secondary faces. Herein, we found polysaccharide gels with only C2–OH/C3–OH or C5–O/C6–OH groups in pyranoid rings can form four-coordinated K+ ions and then coordinate γ-CD in a KOH solution for CD-MOF-1 growth. Exposure of C2–OH/C3–OH or C5–O/C6–OH groups in polysaccharide gels is important to form active four-coordinated K+ ions. Mechanism supporting this work is that four-coordinated K+ ion sites are first formed after coordinating C2–OH/C3–OH groups in pectin and then coordinating C5–O/C6–OH groups in the primary faces of γ-CD units. Alternatively, four-coordinated K+ ions with C5–O/C6–OH groups in chitosan can coordinate the C2–OH/C3–OH groups in the secondary faces of γ-CD units. Mechanism of CD-MOF-1 growing on pectin and chitosan gels through the proposed four-coordinated K+ ions is also universally applicable to other polysaccharide gels with similar C2–OH/C3–OH or C5–O/C6–OH groups such as alginate gel. Based on this mechanism, we developed pectin and chitosan gel-based CD-MOF-1 composites and exemplified applications of them in antibacterial and organic dye removal. To help future research and applications of this mechanism, we share our theoretical assumption for further investigations that any matrices with an ortho-hydroxyl carbon chain or ortho-hydroxyl ether structures may form four-coordinated K+ ions for CD-MOF-1 growth. The proposed mechanism will broaden the development of novel CD-MOF-1 composites in various fields.
研究领域:
材料科学
·
化学
·
生物材料
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Translational Medicine
·
2024
·Vol. 22
·期 1
·1-19
·
IF 6.1
Pan Caizhe,Wei Hao,Chen Bi,Wu Lei,Song Jiayao,Zhang Qing,Wu Xinglong,Liang Guibai,Chen Wenhao,Wang Yingshuo,Xie Yicheng
Background Idiopathic pulmonary fibrosis (IPF) stands as a significant contributor to global mortality rates. Presently, there exists a dearth of effective anti-fibrotic treatments for this condition. While itraconazole (ITR) has exhibited potential in mitigating pulmonary fibrosis, its oral administration is hampered by unfavorable pharmacokinetics, which elevate the risk of adverse reactions, thus limiting its clinical utility. Methods An inhalable formulation of ITR were engineered which aimed at enhancing its pulmonary dispersion. First, pharmacokinetics were conducted to investigate the blood concentration and tissue residue of ITR after inhalation administration. In addition, bleomycin induced mouse pulmonary fibrosis model was used to compare the therapeutic effects of ITR administered by inhalation and intragastric administration. Finally, single-cell RNA sequencing (scRNAseq) was used to explore the mechanism of ITR inhalation administration. Results We found that a large amount of drugs accumulated in the lung tissue for a long time after inhalation administration, thus maximizing the therapeutic effect of drugs. Inhalation of ITR daily at for 21 days significantly attenuated bleomycin-induced lung fibrosis and inflammation in murine models. Additionally, our findings revealed that ITR inhalation diminished the proportion of diseased fibroblasts while promoting reparative fibroblast populations in the murine model. Furthermore, it effectively reversed the proportion of activated phagocytic macrophages. Mechanistically, ITR inhalation exerted its effects by regulating SPP1 and C3 signaling pathway pivotal in the interaction between phagocytic macrophages and diseased fibroblasts. Conclusions These insights into the molecular mechanisms underlying ITR’s therapeutic effects on IPF underscore the favorable pharmacokinetic profile conferred by inhalation, thus presenting a promising formulation poised for clinical translation.
研究领域:
呼吸病学
·
药理学
·
分子生物学
·
治疗学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）