CHEMICAL ENGINEERING SCIENCE
·
2023
·
IF 4.7
Ye Zhaochun,Yao JiaCheng,Zheng Wen,Yuan Wenhui,Guan Jianyu,Li Li,Xiao Hong
Octafluoropropane (C 3 F 8 ) is a kind of super greenhouse gas, and the low concentration of octafluoropropane makes it difficult to be adsorbed and removed. In this study, a series of Co-doped MOFs (Co x Cr-MIL-101) have been successfully synthesized using a hydrothermal method without the addition of strong acids such as HF. The structural properties of the prepared Co x Cr-MIL-101 are characterized using SEM, XRD, nitrogen adsorption desorption test, etc. The adsorption properties of C 3 F 8 are measured by single-component isothermal adsorption experiments and fixed bed adsorption breakthrough experiments. The adsorption mechanism was investigated via the adsorption theory models. The results show that the introduction of cobalt ions can effectively improve the adsorption capacity of MIL-101, among which the Co 0.2 Cr-MIL-101 exhibits the best adsorption performance. The C 3 F 8 equilibrium adsorption capacity reaches 0.077 mmol/g at 298 K and 180 Pa, which is 3.03 times that of the pristine MIL-101 and the dynamic adsorption capacity is 20.710 mmol/g (298 K, 1.2 L/min), which is 9.37 times that of the pristine MIL-101. Inspiringly, the IAST separation selectivity of C 3 F 8 /N 2 at 100 kPa is up to 146.7, which is 14.3 times that of the pristine MIL-101. More importantly, the co-modified adsorbent showed better thermal stability and cyclic stability. In addition, Co 0.2 Cr-MIL-101 fits the Freundlich isothermal adsorption model, and the adsorption mechanism analysis shows that the high adsorption capacity of Co 0.2 Cr-MIL-101 benefits from the unique pore structure and abundant active sites of the modified MOFs.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Acta Biomaterialia
·
2021
·
IF 8.947
Jiameng Gao,Jingjing Liu,Zheying Meng,Yanming Li,Yuping Hong,Lirui Wang,Lan He,Bing Hu,Yuanyi Zheng,Tianliang Li,Daxiang Cui,E. Shen
Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks specific treatment. Fibroblast growth factor 21 (FGF21) has been proved to have cardioprotective effect in DCM. However, the insufficient cardiac delivery effect of FGF21 limits its application in DCM. Therefore, to improve the therapeutic efficacy of FGF21 in DCM, an effective drug delivery system is urgently required. In this study, perfluoropropane (C 3 F 8 ) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles (CPPNBs) were synthesized via double-emulsion evaporation and FGF21 was efficiently absorbed ( [email protected] ) via the electrostatic incorporation effect. [email protected] could effectively deliver FGF21 to the myocardial tissue through the cavitation effect under low-frequency ultrasound (LFUS). The as-prepared [email protected] could efficiently load FGF21 after doping with the cationic polymer PEI, and displayed uniform dispersion and favorable biosafety. After filling with C 3 F 8 , [email protected] could be used for distribution monitoring through ultrasound imaging. Moreover, [email protected] significantly downregulated the expression of ANP, CTGF, and caspase-3 mRNA via the action of LFUS owing to increased FGF21 release, therefore exhibiting enhanced inhibition of myocardial hypertrophy, apoptosis, and interstitial fibrosis in DCM mice. In conclusion, we established an effective protein delivery nanocarrier for the diagnosis and prophylactic treatment of DCM. Statement of significance Diabetic cardiomyopathy (DCM) is a serious cardiac complication of diabetes that currently lacks effective clinical treatments. Fibroblast growth factor 21 (FGF21) can protect cardiomyocytes from diabetic damage, but insufficient cardiac drug delivery limits the application of FGF21 in DCM. In this study, perfluoropropane (C3F8) and polyethylenimine (PEI)-doped poly (lactic-co-glycolic acid) (PLGA) nanobubbles loaded with FGF21 ( [email protected] ) were developed for the prophylactic treatment of DCM. [email protected] could effectively deliver the FGF21 to the myocardial tissue through the cavitation effect of low-frequency ultrasound (LFUS). Our results indicated that [email protected] combined with LFUS could significantly down-regulate the expressions of ANP, CTGF, and caspase-3 mRNA, and as a result, it prevented the myocardial hypertrophy, apoptosis, and interstitial fibrosis of DCM mice. Overall, we established an effective protein delivery nanocarrier for the diagnosis and prophylactic treatment of DCM.
研究领域:
药剂学
·
心脏病学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Scientific Reports
·
2018
·Vol. 8
·期 1
·1-18
·
IF 4.122
Du Jing,Li Xiao-Yu,Hu He,Xu Li,Yang Shi-Ping,Li Feng-Hua
Molecularly-targeted contrast enhanced ultrasound (US) imaging is a promising imaging strategy with large potential for improving diagnostic accuracy of conventional US imaging in breast cancer detection. Therefore, we constructed a novel dual-targeted nanosized US contrast agent (UCA) directed at both vascular endothelial growth factor receptor 2 (VEGFR2) and human epidermal growth factor receptor 2 (HER2) based on perfluoropropane (C 3 F 8 )-filled poly(lactic-co-glycolic acid) (PLGA) (NBs) for breast cancer detection. In vitro , single- or dual-targeted PLGA NBs showed high target specificities and better effects of target enhancement in VEGFR2 or HER2-positive cells. In vivo , US imaging signal in the murine breast cancer model was significantly higher ( P < 0.01) for dual-targeted NBs than single-targeted and non-targeted NBs. Small animal fluorescence imaging further confirmed the special affinity of the dual-targeted nanosized contrast agent to both VEGFR2 and HER2. Immunofluorescence and immunohistochemistry staining confirmed the expressions of VEGFR2 and HER2 on tumor neovasculature and tumor cells of breast cancer. In conclusions, the feasibility of using dual-targeted PLGA NBs to enhance ultrasonic images is demonstrated in vitro and in vivo . This may be a promising approach to target biomarkers of breast cancer for two site-specific US molecular imaging.
研究领域:
医学影像
·
肿瘤学
·
药剂学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADSORPTION SCIENCE & TECHNOLOGY
·
2025
·
IF 3.2
Yao JiaCheng,Li Li,Yuan Wenhui
Octafluoropropane (C3F8) is widely used as etching agent in refrigeration, air conditioning and semiconductor industries. However, due to its long lifespan and strong infrared absorbing ability, once C3F8 is emitted, the atmospheric radiation absorbing ability will be permanently altered, which will result in a serious greenhouse effect. Therefore, the efficient removal technology of C3F8 is crucial in protecting the environment and alleviating the greenhouse effect. In this work, a series of X-ETS-4 (X: Mg, Ca, Sr, Ba) molecular sieves were synthesized by solvothermal and ion-exchange method. The morphology and structure of the prepared X-ETS-4 were characterized by FT-IR, XRD, and SEM, etc. The adsorption performance of the X-ETS-4 on C3F8 are determined by fixed-bed adsorption breakthrough experiments and single-component isothermal adsorption experiments. The adsorption mechanism was investigated using different adsorption theoretical models. The results show that Ba-ETS-4 exhibits high adsorption capacity and high adsorption selectivity for C3F8, achieving C3F8 adsorption separation at very low concentration (C3F8/N2 volume ratio = 1:400). The saturated adsorption capacity of Ba-ETS-4 on C3F8 reaches 155.17 mg/g (298 K, 170 kPa), which is 15.49 times more than that of Na-ETS-4. In addition, the ideal adsorption solution theory (IAST) separation selectivity of C3F8/N2 reaches 341–941 in the pressure range of 0–170 kPa.
✓ 已验证
DOI
高影响因子
Materials
·
2026
·Vol. 19
·期 4
·753
·
IF 3.7
Ziyang Yang,Xicheng Sun,Wenhui Yuan,Li Li
Highlights What are the main findings? A green acid-free route produces MIL-101/GO-0.1, enabling superior C 3 F 8 capture. The content of graphene oxide affects the adsorption properties of the composite material. MIL-101/GO-0.1 achieved a record-breaking IAST separation selectivity of 17,069 for C 3 F 8 /N 2 . What are the implications of the main findings? Overcome the current technical bottleneck of low C 3 F 8 adsorption capacity. Green synthesis coupled with high adsorption capacity opens up possibilities for industrial applications. This provides insights for future research into the adsorption and separation of C 3 F 8 . As a perfluorinated compound with a high global warming potential, octafluoropropane (C 3 F 8 ) needs to be efficiently separated from industrial waste gas, but separating it from nitrogen at low concentrations is highly challenging. To address the common drawback of using corrosive acids in conventional MIL-101(Cr) synthesis, this study developed a green, acid-free solvothermal method for preparing graphene oxide (GO)-modified MIL-101(Cr) composites (MIL-101/GO). By systematically varying the GO doping, the optimal composite (MIL-101/GO-0.1) exhibited breakthrough adsorption performance: its equilibrium adsorption capacity for C 3 F 8 reached 210 mg/g in fixed-bed breakthrough experiments. The predicted C 3 F 8 adsorption selectivity relative to N 2 reached 17,069, ranking among the highest values reported for adsorbents, indicating a significant performance enhancement over the pristine MIL-101(Cr). Mechanistic analysis reveals that graphene oxide not only increases specific surface area and micropore volume but also enhances dispersion forces, substantially boosting affinity for C 3 F 8 . Additionally, the composite exhibits outstanding cycling stability and thermal stability. This study provides a novel eco-friendly synthetic strategy for high-performance metal–organic frameworks and offers a highly promising candidate material for industrial-scale fluorocarbon recovery.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 22
·6447-6459
·
IF 7.59
Yi Lin,Ju Huang,Yinyin Chen,Ziwei Wen,Yang Cao,Liang Zhang,Tao Cai,Chaoqun Yu,Xuemei He
Accurate sentinel lymph node (SLN) identification is an important prerequisite for sentinel lymph node biopsy (SLNB). However, existing SLN mapping techniques, mainly imaging-guided methods, are severely restricted by the high cost of the instruments, harmful radiation or unsatisfactory imaging depths. Herein, we prepared a new ultrasound contrast agent by filling perfluoropropane (C3F8) into chitosan polyacrylic acid nanobubbles for precise SLN identification. The obtained ultrasound contrast agent, coined C3F8–CS-PAA nanobubbles, presents a nanometer size with a diameter of approximately 120 nm. The C3F8–CS-PAA nanobubbles of desirable size are able to enter lymphatic vessels and accumulate in the sentinel lymph node to enhance ultrasound imaging. As a result, the injection of C3F8–CS-PAA nanobubbles can remarkably enhance the ultrasound imaging lymph system, providing image guidance for sentinel lymph node biopsy. Furthermore, it was shown that such C3F8–CS-PAA nanobubbles can effectively permeate into the tumor region via the tumor-enhanced permeability and retention (EPR) effect to enhance tumor ultrasound imaging for monitoring tumorigenesis. This work highlights a novel nanoscale ultrasound contrast agent for the lymphatic system and tumor imaging, with great promise for subsequent studies and clinical applications.
研究领域:
医学影像
·
纳米技术
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Medicine Reports
·
2014
·Vol. 11
·期 3
·1885-1890
·
IF 1.484
Cui-Wei Wang,Shi-Ping Yang,He Hu,Jing Du,Feng-Hua Li
The present study aimed to prepare perfluoropropane (C3F8)-filled poly(lactic-co-glycolic acid) (PLGA) nanoparticles and investigate the feasibility of using PLGA nanoparticles as an ultrasound contrast agent. The PLGA nanoscale ultrasound contrast agent was prepared using a modified double-emulsion solvent evaporation method. Camphor in the form of a sublimable porogen was added to render the nanoparticles hollow and enable C3F8 gas introduction. Various physicochemical properties of PLGA nanoparticles, including morphology, size and dispersion, were analyzed by electron microscopy and dynamic laser scattering. In vitro ultrasound imaging of C3F8-filled PLGA nanoparticles was also investigated under various imaging conditions. Further in vivo ultrasound imaging was conducted on male rats following intratesticular injection of PLGA nanoparticles. C3F8-filled PLGA nanoparticles with a mean diameter of 152.0±58.08 nm were obtained. Electron microscopy revealed spherical-shaped nanoparticles with smooth surfaces, a capsular morphology and a large hollow within. In vitro ultrasound imaging of hollow PLGA nanoparticles indicated marked signal enhancement. Local intensity of the acoustical signal continued to increase during PLGA-nanoparticle injection into the testicle and the ability of hollow PLGA nanoparticles to enhance ultrasound imaging in vivo was demonstrated. The enhancement image of testicular tissue following injection with C3F8-filled PLGA nanoparticles was sustained for a minimum of five minutes. In conclusion, the hollow C3F8-filled PLGA nanoparticles were demonstrated to have potential for applications as a novel ultrasound contrast agent.
研究领域:
医学影像学
·
材料科学
·
药剂学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）