ACS Omega
·
2024
·
IF 3.7
Yang Xie,Peng Li,Dong Fu,Fan Yang,Xin Sui,Bo Huang,Jiaying Liu,Jialong Chi
Cannabidiol (CBD) has demonstrated its potential to enhance depression treatment through various biological pathways. However, the application potential of CBD is significantly impeded by its polymorphic nature, limited water solubility, and hepatic first-pass metabolism. To improve chemical stability and water solubility, nanostructured lipid carriers loaded with CBD (CBD-NLCs) were developed using a hot-melt emulsification method and optimized by response surface methodology (RSM). The process parameters were optimized using a four-factor and three-level Box–Behnken experimental design consisting of 29 experiments. The CBD-NLCs were formulated and characterized, demonstrating desirable properties, including a mean particle size of 54.33 nm, a PDI value of 0.118, a zeta potential of −29.7 mV, and an impressive encapsulation efficiency rate of 87.58%. The nanoparticles were found to possess an approximately spherical shape, as revealed by scanning and transmission electron microscopy. The stability studies have demonstrated that CBD-NLCs effectively mitigated the photodegradation of CBD and exhibited a stable behavior for 42 days when stored. The CBD-NLCs displayed a biphasic release profile characterized by an initial burst release (over 50% of CBD released within 20 min) followed by a subsequent gradual and sustained release, aligned with first-order kinetics and Fickian diffusion. These findings demonstrate the potential suitability of this formulation as a carrier for CBD in food fortification and pharmaceutical applications.
研究领域:
药剂学
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纳米技术
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药物递送系统
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生物药剂学
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DOI
PubMed
高影响因子
Pharmaceutics
·
2021
·Vol. 13
·期 9
·1415
·
IF 6.321
Shanshan Chen,Changping Deng,Wenyun Zheng,Shihui Li,Yuping Liu,Tong Zhang,Chen Zhang,Yunhui Fu,Hui Miao,Fuzheng Ren,Xingyuan Ma
Cannabidiol (CBD), a primary bioactive phytocannabinoid extracted from hemp, is reported to possess potent anti-tumorigenic activity in multiple cancers. However, the effects of CBD on bladder cancer (BC) and the underlying molecular mechanisms are rarely reported. Here, several experiments proved that CBD promoted BC cells (T24, 5637, and UM-UC-3) death. For example, T24 cells were treated with 12 µM CBD for 48 h, flow cytometry analysis demonstrated that early and late apoptotic cells were accounted for by 49.91%, indicating CBD enhanced cell apoptosis ability. To deeper explore molecular mechanisms, the CBD-treated T24 cell transcriptome libraries were established. KEGG analysis implied that the significantly changed genes were enriched in the PI3K/Akt pathway. qRT-PCR and Western blot assays verified that CBD regulated BC cells growth and migration and induced apoptosis by inactivating the PI3K/Akt pathway. Meanwhile, the developed chitosan to wrap CBD-loaded PLGA nanoparticles can significantly enhance the adhesion of the material to the mouse bladder wall, and the binding efficiency of mucin to chitosan-PLGA nanoparticles reached 97.04% ± 1.90%. In summary, this work demonstrates that CBD may become a novel reliable anticancer drug and the developed intravesical adhesion system is expected to turn into a potential means of BC chemotherapy drug delivery.Keywords:cannabidiol (CBD);bladder cancer (BC);RNA sequencing;PI3K/Akt;chitosan;CBD-loaded PLGA
研究领域:
肿瘤学
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药理学
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分子生物学
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药物递送系统
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DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2024
·
IF 18.5
Zhenghao Liu,Yiming Li,Zijing Chen,Chengyu Tan,Xiangjin Du,Fubo Tian,Jiangjian Shi,Huijue Wu,Yanhong Luo,Dongmei Li,Qingbo Meng
Tin oxide (SnO 2 ) based on chemical bath deposition method (CBD-SnO 2 ) is considered as an ideal electron transporting layer for perovskite solar cells (PSCs), however, the research on precise regulation toward CBD-SnO 2 layer is lacking. Here, the study introduces a multifunctional molecule, potassium 2-(N-morpholino)ethanesulfonate (MES-K), on the surface of CBD-SnO 2 layer to synergistically modify the buried interface between the SnO 2 and perovskite. It is found that MES-K introduction can passivate interfacial defects, favor the perovskite crystal growth, and improve carrier transportation. 25.14% efficiency of small-size perovskite solar cells has been achieved with 24.45% efficiency of 1 cm 2 perovskite devices, with negligible hysteresis. Besides, unencapsulated devices based on CBD-SnO 2 can maintain > 95% of its initial efficiency after 2000 h storage at ambient environment, and > 90% after 1000 h LED illumination.
研究领域:
材料科学
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能源技术
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化学工程
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DOI
高影响因子
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
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2021
·Vol. 127
·期 7
·1-8
·
IF 2.584
Zhang Junlin,Wang Yunfan,Zhou Biao,Cao Hongyuan,Yang Xiutao,Li Bing,Zhang Jingquan,Feng Lianghuan,Zeng Guanggen,Zhong Zhengxiang,Ghali Mohsen,Karazhanov Smagul
In this work, CdS thin films were deposited on glass/fluorine-doping tin oxide (FTO) substrates by low-cost chemical bath deposition (CBD), followed by annealing with CdCl 2 -doping (Cl-doping) to fabricate resistive-type photodetectors (PDs) with a vertical structure of glass/FTO/CBD-CdS:Cl/electrode. The effect of annealing with Cl-doping (AwCl) on the various properties of films and the photodetection performance of PDs were systematically characterized by special testing methods. The results revealed that the surface morphology and crystal structure of CBD-CdS:Cl films were improved, accompanied by an enhancement of hexagonal phase (002) crystal plane (wurtzite structure), and the optical bandgap of films can be adjusted between 2.43 and 2.26 eV while the electron activation energy of the films was reduced from 75.9 to 10.3 meV after AwCl. Furthermore, the light responsivity of CBD-CdS:Cl PDs were 0.57, 0.59 and 1.67 A/W under 365, 400 and 530 nm illumination at a bias of −2.0 V, respectively, and the detectivity of photons at corresponding wavelengths were 3.7 × 10 8 , 3.9 × 10 8 and 1.08 × 10 9 Jones. Meanwhile, the PDs showed optimized repeatability and improved sensitivity under periodic illumination. The above results demonstrated that the CBD-CdS:Cl PDs with a vertical structure developed in this work had good detection performance at certain characteristic wavelengths.
研究领域:
材料科学
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光电技术
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DOI
高影响因子
JOURNAL OF THE AMERICAN OIL CHEMISTS SOCIETY
·
2013
·Vol. 91
·期 1
·55-62
·
IF 1.592
Qin Xiao-Li,Huang Hui-Hua,Lan Dong-Ming,Wang Yong-Hua,Yang Bo
Typoselectivity of crude CBD-T1 lipase ( Geobacillus sp. T1 lipase fused with a cellulose binding domain) was investigated. Multi-competitive reaction mixtures including a set of n -chain fatty acids (C8:0, C10:0, C12:0, C14:0, C18:1 n-9, C18:2 n-6 and C18:3 n-3) and tripalmitin-enriched triacylglycerols were studied in hexane. The crude CBD-T1 lipase discriminated strongly against C18:1 n-9 [competitive factor ( α ) = 0.23] and showed the highest preference for C8:0 ( α = 1). Utilizing the catalytic properties of crude CBD-T1 lipase, acidolysis of soybean oil with C8:0 was selected as a model reaction to investigate the ability of the lipase to produce MLM-type (medium-long-medium) structured lipids. Several reaction parameters (added water amount, reaction temperature, substrate molar ratio and reaction time) examined for incorporating C8:0 into soybean oil, the optimum conditions were: 1:3 (soybean oil/C8:0) of molar ratio, 3 mL of hexane, 50 °C of temperature, 48 h of reaction time, 20 % of crude CBD-T1 lipase (w/w total substrates), and 7.5 % of water (w/w enzyme). Under these conditions, the incorporation of C8:0 was 29.6 mol%. The results suggest that crude CBD-T1 lipase, which showed different fatty acid specificity profiles, is a potential biocatalyst for the modification of fats and oils.
研究领域:
生物化学
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食品科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2022
·Vol. 33
·期 8
·5564-5574
·
IF 2.779
Li Zhen,Chen Yingying,Lang Haoze,Wan Jianghong,Gao Yan,Dong Haitao,Zhang Xiaoke,Feng Wenran
The ternary Pb–SnSe thin films were prepared using chemical bath deposition (CBD) and sensitized with iodine. The chemical formula of the films was recognized as Pb 0.8 Sn 0.2 Se, according to the stoichiometric ratio. The films are both centered cubic crystal structure and show preferred orientation in PbSe (200). The optical band gap ( E g ) is found to decrease after sensitization, due to the impurity energy levels created by PbI 2 . The photoelectric performance of the Pb 0.8 Sn 0.2 Se thin films is significantly improved after iodine sensitization. Accordingly, the resistance change rate, i.e., the photoelectric sensitivity is enhanced over 35%, which is over 161% for more than 4 on/off cycles. The density of states (DOS) of Pb 0.8 Sn 0.2 Se is calculated using the first-principle method. The calculation shows that the I dangling bond in sensitized Pb 0.8 Sn 0.2 Se introduces a large DOS inside the band gap and causes the narrowing of the band gap.
研究领域:
材料科学
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半导体物理
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光电化学
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DOI
高影响因子
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
·
2026
·
IF 3.4
Qurat Ul Ain Haidery,Bo Han,Rashid Saeed,Chenyue Yan,Xingyuan Ma,Wenyun Zheng
Cannabidiol (CBD), a non-psychoactive terpenophenolic compound derived from Cannabis sativa , exhibits broad-spectrum pharmacological activities but is highly susceptible to oxidative, photolytic, and thermal degradation, making it challenging to preserve and use in therapeutics. Therefore, this study compares the preservation efficiency of a powder-based hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion-complex system for cannabinoid stability and solubility and medium-chain triglyceride (MCT) oil, a common lipid-based carrier in commercial formulations. Formulation characterizations, including CBD content (HPLC), color change, solvent residues, moisture, particle size, and zeta potential, were measured. DPPH experiments revealed that the HP-β-CD complex exhibited higher antioxidant activity (89.2%, EC₅₀ = 45.3 µg/mL) than the MCT oil system (83.6%, EC₅₀ = 58.7 µg/mL), with ascorbic acid serving as the control (EC₅₀ = 12.4 µg/mL). Additionally, photostability testing (8000 lux) demonstrated superior CBD retention in the HP-β-CD complex (>90%) compared with MCT oil (∼20%), indicating substantial light-induced degradation in the oil system. HP-β-CD complex retained 92–93% CBD (k = 0.0084 week⁻¹; t₁/₂ = 82.5 weeks) versus 88% in MCT oil. At 40 °C, HP-β-CD complex preserved 86–87% CBD. GC-FID/GC-MS showed that HP-β-CD powder preserved CBD with only trace degradation (<0.1–1.0%). In contrast, MCT oil produced higher cannabinoid by-products (0.1–6.21%), and greater antioxidant degradation (2.5–8.6% vs 0.5–2.1%). The results suggested that CBD degradation follows matrix-dependent kinetics, with cyclodextrin encapsulation significantly reducing the apparent degradation rate constants relative to oil-based solubilization under identical stress conditions.
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PubMed
高影响因子
OPTICS COMMUNICATIONS
·
2015
·
IF 1.449
Yibing Lin,Yu Lin,Yongming Meng,Yongguang Tu,Xiaolong Zhang
SnO 2 nanoparticles were synthesized by hydrothermal method and applied to photo-electrodes of quantum dots-sensitized solar cells (QDSSCs). After sensitizing SnO 2 films via CdS quantum dots , CdSe quantum dots was decorated on the surface of CdS/SnO 2 photo-electrodes to further improve the power conversion efficiency. CdS and CdSe quantum dots were deposited by successive ionic layer absorption and reaction method (SILAR) and chemical bath deposition method (CBD) respectively. Scanning electron microscopy (SEM), transmission electron microscopy (TEM) and X-ray diffraction (XRD) were used to identify the surface profile and crystal structure of SnO 2 photo-electrodes before and after deposited quantum dots. After CdSe co-sensitized process, an overall power conversion efficiency of 1.78% was obtained in CdSe/CdS/SnO 2 QDSSC, which showed 66.4% improvement than that of CdS/SnO 2 QDSSC.
研究领域:
材料科学
·
能源技术
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产品关联
DOI
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2022
·
IF 6.449
Hang Li,Qing-Sheng Zhao,Li-Wei Wang,Sen-Lin Chang,Pei-Dong Wang,Bing Zhao
Cannabidiol (CBD) is an important natural compound of hemp. Cyclodextrin-assisted extraction of CBD from hemp leaves was optimized by single-factor experiments and response surface methodology . The highest extraction yield of CBD was 1.075 ± 0.012 mg/g and the recovery yield was 87.19 % using dimethyl-β-cyclodextrin (DM-βCD), which showed that the extract had a higher proportion of CBD. The optimal conditions were as follows: extraction temperature was 40 ℃, liquid-to-solid ratio was 25.17 mL/g, extraction time was 74.4 min, mass ratio of DM-βCD to hemp leaves was 1.17, and ethanol concentration was 60 %. Different characterizations demonstrated that complexation of DM-βCD promoted CBD extraction and increased the proportion of CBD in the extract. The cumulative release rate of CBD (67.98%) from the extract by DM-βCD-assisted extraction (DAHE) was much higher than that (2.62%) without DM-βCD-assisted extraction (HE). The permeability, bioactivity, and stability of DAHE were also better than that of HE. The better results of DAHE could be due to the inclusion by DM-βCD and the higher proportion of CBD. In conclusion, DM-βCD-assisted extraction was an appropriate method for CBD extraction and the obtained extract with higher CBD proportion and better bioactivity and stability could be applied in many fields.
研究领域:
药学
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化学工程
·
植物化学
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产品关联
DOI
高影响因子
Materials Today Chemistry
·
2022
·
IF 7.613
G. Zhong,C. Tong,X. Liu,J. Fan,X. Xiong,P. Chen,A. Zhu,R. Yu,B. Liu
The emergence and spreading of methicillin-resistant Staphylococcus aureus ( MRSA ) have become one of the main reasons for the surgical failure even for the death. Thus, there is an urgent need to develop efficient antimicrobial alternatives for eradicating it so as to improve the therapy efficiency of related diseases. Although the synthesized metal nanoparticles showed the MRSA -killing function in vitro , their biosafety in vivo application is still in controversy due to the potential toxicity and induced multidrug resistance. Recently, plant natural compounds with high antibacterial activity and special mechanisms different from antibiotics have attracted wide interest for developing new anti- MRSA regents. In this work, new nanocomplexes of [email protected] @CBD based on natural compounds of cannabidiol (CBD) and chitosan (Chi) were designed for eradicating MRSA . In vitro results demonstrate that [email protected] @CBD NPs plus laser irradiation can efficiently kill MRSA by inducing bacterial surface perforation, content leakage, ROS production, and ATP reduction. In vivo results show that the combination of [email protected] @CBD NPs plus laser can effectively remove bacteria and accelerate wound healing of MRSA -infected normal and diabetes mellitus mice by up-regulating VEGF and CD31. Moreover, [email protected] @CBD NPs possessing excellent biocompatibility and ultra-low toxicity in vitro significantly delayed the time for multidrug-resistance induction, comparing with silver nanoparticles. In our point, the “green therapeutics” against MRSA show great potential in clinical application.
研究领域:
纳米技术
·
药学
·
微生物学
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生物医学工程
·
糖尿病研究
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DOI
高影响因子
EXPERIMENTAL NEUROLOGY
·
2023
·
IF 5.3
Kechun Chen,Bingtian Xu,Xuan Xiao,Lu Long,Qian Zhao,Zicen Fang,Xingxing Tu,Jiakang Wang,Jiangping Xu,Haitao Wang
We have previously demonstrated that treatment with cannabidiol (CBD) ameliorates mitochondrial dysfunction and attenuates neuronal injury in rats following cerebral ischemia . However, the role of CBD in the progression of ischemic stroke-induced inflammation and the molecules involved remain unclear. Here, we found that CBD suppressed the production of interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α), reduced the activation of microglia , ameliorated mitochondrial deficits, and decreased the phosphorylation of nuclear factor κ-B (NF-κB) in BV-2 cells subjected to oxygen-glucose deprivation/reoxygenation (OGD/R). Cyclin-dependent kinase regulatory subunit 1B (CKS1B) expression was decreased in BV-2 cells following OGD/R and this reduction was blocked by treatment with CBD. Knockdown of CKS1B increased the activation of microglia and enhanced the production of IL-1β and TNF-α in BV-2 cells treated with CBD. Moreover, CKS1B knockdown exacerbated mitochondrial deficits and increased NF-κB phosphorylation. CBD treatment also ameliorated brain injury, reduced neuroinflammation , and enhanced the protein levels of mitochondrial transcription factor A and CKS1B in rats following middle cerebral artery occlusion/reperfusion. These data identify CKS1B as a novel regulator of neuroinflammation; and reveals its involvement in the anti-inflammatory effects of CBD. Interventions targeting CKS1B expression are potentially promising for treating in ischemic stroke.
研究领域:
神经科学
·
药理学
·
分子生物学
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
MATERIALS RESEARCH BULLETIN
·
2016
·
IF 2.435
Xiaowei Li,Ruixue Chen,Huidong Sui,Xiaoxian Yuan,Meng Li,Kun Yang,Ling Li,Wenming Zhang,Yucang Zhang
Flower-like NiO nanoparticles was successfully synthetized by homogeneous precipitation. A novelty modified (CH 3 ) 4 N) 2 S/((CH 3 ) 4 N) 2 S n electrolyte was introduced in solar cell successfully and NiS was used as the counter electrode. Moreover, CdSe sensitized p-type NiO was synthesized by chemical bath deposition (CBD) in a precursor solution to ensure the nanosized flower-like NiO films obtain a better uniformity and high penetration. Meanwhile, a series of parallel experiment were designed to investigate the effect of different CdSe deposition layers on the photoelectric characteristic of the cell. The result showed that when the film was eight layers, the maximum efficiency of 1.06% had been achieved, with a significantly open circuit voltage ( V oc ) of 0.755 V, a fill factor (ff) of 0.27% and a short circuit current density ( J sc ) of 5.21 mA cm −2 .
研究领域:
材料科学
·
光伏技术
·
纳米技术
·
电化学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）