PHARMACOLOGICAL RESEARCH
·
2022
·
IF 10.334
Jiale Zhu,Zhiwei Jin,Lei Yang,Caili Zhao,Jianping Hu,Jinhu Chen,Yubao Han,Pei Yu,Jun Luo,Lingyi Kong,Chao Zhang
Promoting angiogenesis in the ischemic penumbra is a well-established method of ischemic stroke treatment. Ginkgolide B (GB) has long been recognized for its neuroprotective properties following stroke. As previously reported, it appears that stroke-induced neurogenesis and angiogenesis interact or are dependent on one another. Although the pharmacodynamic effect of GB on cerebral blood flow (CBF) following ischemic stroke has been reported, the molecular mechanism underlying this effect remains unknown. As such, this study sought to elucidate the pharmacodynamic effects and underlying mechanisms of GB on post-stroke angiogenesis. To begin, GB significantly increased the proliferation, migration, and tube formation capacity of mouse cerebral hemangioendothelioma cells (b.End3) and human umbilical vein endothelial cells (HUVEC). Additionally, GB significantly improved angiogenesis after oxygen-glucose deprivation/reperfusion (OGD/R) in endothelial cells. The dynamics of CBF, brain microvascular neovascularization and reconstruction, and brain endothelial tissue integrity were examined in middle cerebral artery occlusion (MCAO) mice following GB administration. Through label-free target detection techniques, we discovered for the first time that GB can specifically target Creatine Kinase B (CKB) and inhibit its enzymatic activity. Additionally, we demonstrated through network pharmacology and a series of molecular biology experiments that GB inhibited CKB and then promoted angiogenesis via the CCT/TRiC-SK1 axis. These findings shed new light on novel therapeutic strategies for neurological recovery and endothelial repair following ischemic stroke using GB therapy.
研究领域:
神经学
·
药理学
·
分子生物学
·
细胞生物学
·
卒中研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICS EXPRESS
·
2023
·Vol. 31
·期 15
·24914-24925
·
IF 3.8
Zitong Liu,Le Zhang,Le Zhang,Le Zhang,Le Zhang,Jian Kang,Jian Kang,Tianyuan Zhou,Tianyuan Zhou,Shiwei Chen,Shiwei Chen,Peng Yang,Bingheng Sun,Yang Li,Hao Chen,Hao Chen,Hao Chen
Ceramic phosphors are widely considered the next-generation phosphor material for white LED/LD lighting, and a wide spectrum is a key factor in improving the CRI of lighting sources. In this paper, a novel, to our knowledge, barcode-structured YAG:Ce/YAG:Ce,Mn ceramic phosphor was designed and fabricated. The lighting sources with the CRI value of 73.5 and 68.9 were obtained under the excitation of blue LEDs and blue LDs, respectively. Simultaneously, thanks to the effective supplementary emission from a red LD, the CRI of the ceramic-based lighting source reached 81.8 under blue LD excitation. Specifically, the microstructure and luminescent property of ceramic phosphors with different thicknesses and ion doping concentrations were systematically studied. Besides, by changing the blue power from 0.52 W to 2.60 W, the CCT of the laser lighting source with the encapsulation of optimized YAG:Ce/YAG:Ce,Mn ceramic phosphors ranged from 3928 K to 5895 K, while the CRI always maintained above 80. The above results indicate that barcode-structured Ce:YAG/Ce,MnYAG ceramic phosphor is a candidate to achieve a high CRI and ican be applied to various lighting occasions.
研究领域:
材料科学
·
光学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DALTON TRANSACTIONS
·
2021
·Vol. 51
·期 2
·645-654
·
IF 4.39
Qinghong Meng,Guoying Zhao,Qi Zhu,Xiaodong Li,Xudong Sun,Ji-Guang Li
Synergistic doping of the metastable Gd3Al5O12:Ce garnet with a Ca2+/Hf4+ pair and Sc3+ to form Gd2.97−xCaxHfxScyAl3O12:0.03Ce (x = 0.5–2.0, y = 0.0–1.5, x + y = 2.0) solid solution was conducted for the structural stabilization and photoluminescence manipulation. The site selection of Ca2+/Hf4+/Sc3+ dopants and the effects of doping on the crystal structure, local coordination, band structure and Ce3+ luminescence were revealed in detail with the results of XRD, Rietveld refinement, TEM, and UV-Vis/photoluminescence spectroscopy. A decrease in Ca2+/Hf4+ and an increase in the Sc3+ content were observed to shrink the lattice, widen the bandgap of the garnet host, red-shift the excitation/emission wavelength, broaden the emission band and shorten the fluorescence lifetime of Ce3+. The spectral changes were rationalized by considering the local coordination and crystal field splitting of the Ce3+ 5d energy level. Application of typical Gd0.97Ca2Hf2Al3O12:0.03Ce (x = 2.0, y = 0) cyan and Gd2.47Ca0.5Hf0.5Sc1.5Al3O12:0.03Ce (x = 0.5, y = 1.5) greenish-yellow phosphors in w-WLED lighting produced low correlated color temperatures of ∼3842 and 3514 K, high color rendering indices of ∼88 and 93 and favorable luminous efficacies of ∼32.9 and 14.7 lm/W under the excitation of 395 nm n-UV and 450 nm blue LED chips, respectively.
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2017
·
IF 6.216
Sai Lin,Mengyuan Chen,Ziwei Wang,Yijun Zhang,Rongrong Yuan,Xiaojuan Liang,Weidong Xiang,Yongqiang Zhou
Multicolor luminescent carbon dots (Cdots) are of immense importance nowadays, while it still a challenge to construction of full-color light-emitting Cdots and their efficient solid-state materials. Here in, we fabricated a facile method to synthesize multicolor Cdots by adjustment of the reaction temperature. Although all samples showed uniform distribution of particles size and similar graphite structure, the surface chemical composition gradually varied among Cdots, especially the oxygen contents and nitrogen contents. Detailed material characterization has revealed that this tunable emission is results from the changes of the chemical composition. It is believed that the surface oxidation become more severe at high temperature, resulting in the formation of higher oxygen and nitrogen, which are responsible for the long-wavelength emission. Meanwhile, flexible solid-state materials were successfully created by combination of organosilane (OSi) and Cdots, which can be used to prevent the aggregation-induced solid-state fluorescence quenching. Finally, red Cdots/OSi was stacked on the Y 3 Al 5 O 12 :Ce 3+ (Ce 3+ : YAG) phosphor-in-glass (Ce-PiG) via tape-casting technology. Then, warm white light-emitting diodes (WLEDs) were constructed by these materials and GaN chips. As the Cdots increases, the correlated color temperature (CCT) decreases while the color rendering index (CRI) increases, and the color coordinates shift towards the red region. The resulting color converting material produced a warm white by adjusting red Cdots content, which will be a promising candidate for applications in the warm WLED.
研究领域:
材料科学
·
光电技术
·
纳米技术
·
照明工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2019
·
IF 10.159
Guojun Zhou,Xingxing Jiang,Maxim Molokeev,Zheshuai Lin,Jing Zhao,Jing Wang,Zhiguo Xia
Finding new low-dimensional metal halides with broad-band emission is attracting interest in single-component phosphor for white light-emitting diodes (WLEDs). The full-spectrum white light still remains a challenge as found in the two-dimensional hybrid material (C6H18N2O2)PbBr4 exhibiting the intrinsic free exciton (FE) and broad-band self-trap exciton (STE) emission upon 365 nm ultraviolet excitation, and a combined strategy has been proposed through doping the Mn2+ ions enabling a superposition of multiple emission centers toward the ultra-broad-band warm white light. The occupation of Mn2+ in (C6H18N2O2)PbBr4 has been discussed, and optical investigations verify that the warm white-light emission of Mn2+-doped (C6H18N2O2)PbBr4 originates from the coupling effects of the FE, STEs, and the 4T1–6A1 transition of the doped Mn2+. When the concentration of Mn2+ is 5%, the emission spectrum of the phosphor covers all visible-light areas with a full width at half maximum (FWHM) of about 230 nm. The high Ra (84.9) and warm light CCT (3577 K) values of the as-fabricated WLED lamp demonstrate that (C6H18N2O2)Pb1–xMnxBr4 can be promising as single-component white-light phosphor in solid-state lighting. Our work could provide a new understanding and perspective about hybrid metal halides for designing superior phosphor toward single-component white emission.
研究领域:
材料科学
·
光电
·
固态照明
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2021
·
IF 3.599
Pinyi He,Su Yang,Xinghua Liu,Yongzhen Yang,Jingxia Zheng,Xuguang Liu,Bingshe Xu
Green-emitting graphene quantum dots (GQDs) with a high crystallization degree were prepared by a two-step solvothermal method . Owing to the co-doping of nitrogen and oxygen, carbonyl and amide groups were introduced into GQDs. The quantum yield (QY) of GQD solution is up to 47.09%, which is higher than that of other GQDs synthesized by top-down methods. Since GQD solution exhibits concentration-dependent photoluminescence (PL) properties, green, yellow, and orange emissions were realized by adjusting GQD concentration. A high concentration (no less than 6.0 mg mL −1 ) GQD solution was mixed with KH-792 to form a yellow-emitting fluorescent film with an excellent fluorescence and thermal stability, which was used as color converters and combined with 405 nm laser diodes (LDs) to realize the devices with white laser-emitting. The Commission Internationale de L'Eclairage (CIE) coordinate of the laser device is (0.34, 0.39), the correlated color temperature (CCT) is 5288 K, and the color rendering index (CRI) is 70. This work provides an advanced way for the development of laser fluorescent materials.
研究领域:
材料科学
·
光电技术
·
光子学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2024
·
IF 3.3
Ruifeng Liu,Yunluo Wang,Haoming Qin,Xuchang He,Shihao Ge,Jianghua Wu,Tianrui Zhou,Tingting Ye,Zesen Gao,Futing Sun,Jingshan Hou,Yihui He,Lianjun Wang,Haijie Chen,Wan Jiang
Lead-free halides, with the advantages of non-toxicity and high stability, have broad application prospects. Here, we studied the synthesis and luminescent properties of the Sb-doped Rb 2 ZnCl 4 and explored their utilizations for white light-emitting diode (WLED) and X-ray detection. The as-synthesized Rb 2- x Zn 1- x Sb x Cl 4 single crystals exhibit bright red emission centered at 740 nm with a large full width at half maximum (FWHM) of 220 nm, and the maximum photoluminescence quantum yield (PLQY) is determined to be 59.7 % for the sample with x = 0.01. The assembled WLED achieves a high color rendering index (CRI) of 93.6 and a low correlated color temperature (CCT) of 3755 K. Under continuous X-ray irradiation for 600 s at a dose rate of 26.5 Gy min −1 , the irradiation luminescence intensity of Rb 1.99 Zn 0.99 Sb 0.01 Cl 4 did not decrease, indicating that the single crystal has a high tolerance to X-ray irradiation. Our work demonstrates that Zn halides are also a promising lead-free family for multiple optoelectronic applications.
研究领域:
材料科学
·
光电子学
·
光子学
·
辐射检测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2023
·
IF 3
Yuhan Chen,Nian Yin,Yunfei Wang,Shanjun Gao,Chunhui Shen
A novel bio-based carbon forming agent (Mg@PA-CS) containing P and N elements was were synthesized using the complexation characteristics of chitosan (CS) and phytate (PA). The flame retardant behavior of poly(lactic acid) (PLA)/Mg@PA-CS/APP composites (addition of 20 wt% of different ratios of Mg@PA-CS and APP to polylactic acid composites) were investigated by the limiting oxygen index (LOI), vertical burning test (UL-94), cone calorimetry test (CCT), and thermogravimetric analysis (TGA). Due to the biphasic flame retardant and synergistic effect, since the 20 wt% flame retardant system (Mg@PA-CS:APP = 1:2), PLA composites passed the UL-94 test V-0 rating, reached 34% LOI value. The peak heat release rate (PHRR) and total heat release rate (THR) were reduced to 1/2 of the pure PLA, char residue could be as high as 11.49% at 800°C. Moreover, the flame-retardant mechanism of PLA composites during thermal decomposition was analyzed using a scanning electron microscope (SEM) and the coupling techniques of TGA linked with FT-IR (TG-FTIR).
研究领域:
材料科学
·
高分子科学
·
消防安全工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Xiao-Fei Wang,Gui-Gen Wang,Jia-Bing Li,Zheng Liu,You-Xiao Chen,Long-Fei Liu,Jie-Cai Han
Herein we first report new chlorine-doped graphene quantum dots (Cl-GQDs) that can be used in solid-state white-light-emitting diodes (WLEDs). The Cl-GQDs with a mean size of 1.53 nm are obtained by one-step hydrothermal method using β-cyclodextrin and hydrochloric acid as the source materials. The PL emission spectra of the Cl-GQDs show an excitation-wavelength-dependent behavior in the range from 300 to 380 nm excitation. Under UV irradiation, the Cl-GQDs can direct emit white light. Given that they are worth using in light-conversion, Cl-GQDs embedded solid composite film (Cl-ESCF), based on silicon resin as host material, is successfully fabricated by solution-processing approach. The freestanding Cl-ESCF has high transparency and flexibility, excellent photostability and temperature resistance, and retains its optical properties in the solid state. In order to realize its potential, the Cl-ESCF converted remote UV-pumped WLED is demonstrated. The results verify that the Cl-GQDs can be homogeneously dispersed within solid matrix without obvious aggregation so that a uniform and defect-free natural white light can be obtained. In addition, our WLED possesses favorable white-light characters with the CIE of (0.33, 0.34), moderate CCT of 5653 K, and high CRI of 87.6, as well as good color and LED stability. This single-phase rare-earth-free white-luminescent Cl-GQDs may be not only expected to prevent the drawbacks of multicolor phosphors, thereby generating high-quality white emission, but also identified to be a green alternative for conventional emitters.
研究领域:
材料科学
·
纳米技术
·
光电
·
光子学
✓ 已验证
产品关联
DOI
高影响因子
Materials
·
2018
·Vol. 11
·期 1
·111
·
IF 2.467
Hongda Chen,Jihui Wang,Aiqing Ni,Anxin Ding,Xia Han,Ziheng Sun
In order to improve the efficiency of intumescent flame retardants (IFRs), a novel macromolecular charring agent named poly(ethanediamine-1,3,5-triazine-p-4-amino-2,2,6,6-tetramethylpiperidine) (PETAT) with gas phase and condense phase synergistic flame-retardant capability was synthesized and subsequently dispersed into polypropylene (PP) in combination with ammonium polyphosphate (APP) via a melt blending method. The chemical structure of PETAT was investigated by Fourier transform infrared spectroscopy (FTIR), and1H nuclear magnetic resonance (NMR) spectroscopy. Thermal properties of the PETAT and IFR systems were tested by thermogravimetric-derivative thermogravimetric analysis (TGA-DTG) and thermogravimetry–Fourier transform infrared spectroscopy (TG-FTIR). The mechanical properties, thermal stability, flame-retardant properties, water resistance, and structures of char residue in flame-retardant composites were characterized using tensile and flexural strength property tests, TGA, limiting oxygen index (LOI) values before and after soaking, underwritten laboratory-94 (UL-94) vertical burning test, cone calorimetric test (CCT), scanning electron microscopy with energy dispersive X-ray spectrometry (SEM-EDXS), and FTIR. The results indicated that PETAT was successfully synthesized, and when the ratio of APP to PETAT was 2:1 with 25 wt % loading, the novel IFR system could reduce the deterioration of tensile strength and enhance the flexural strength of composites. Meanwhile, the flame-retardant composite was able to pass the UL-94 V-0 rating with an LOI value of 30.3%, and the peak of heat release rate (PHRR), total heat release (THR), and material fire hazard values were considerably decreased compared with others. In addition, composites also exhibited excellent water resistance properties compared with traditional IFR composites. SEM-EDXS and FTIR analyses of the char residues, as well as TG-FTIR analyses of IFR were used to investigate the flame-retardant mechanism of the APP/PETAT IFR system. The results indicated that the efficient flame retardancy of PP/IFR composites could be attributed to the synergism of the free radical-quenching and char layer-protecting mechanisms in the gas phase and condense phase, respectively.
研究领域:
材料科学
·
高分子化学
·
消防安全工程
·
分析化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）