Applied Materials Today
·
2020
·
IF 8.352
Zhen Wang,Shuanghu Wang,Kun Liu,Dongmei Fu,Yicheng Ye,Junbin Gao,Lu Liu,Daniela A. Wilson,Yingfeng Tu,Fei Peng
Here we present an anti-CD3 loaded PLGA/ALG/CHI Mg micromotor systems, with degradable constituents and Mg-water reaction propulsion, thus ensuring a superior biocompatibility. Porous hydrogel formed by ALG/CHI offers high capacity of antigen loading, along with biocompatibility. By efficient loading of anti-human CD3 as an antigen and activating the calcium ion channel of Jurkat T cell, vital for immunotherapy, the motor system extends the application scope of micro/nanomotor systems from cargo (drug) delivery to interaction with the biointerface and immune activity modulation.
研究领域:
生物医学工程
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免疫学
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材料科学
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DOI
高影响因子
Science Bulletin
·
2017
·
IF 4.092
Jie Xu,Zhenye Chen,Hongwen Zhang,Guibin Lin,Huaxiang Lin,Xuxu Wang,Jinlin Long
For a long time, there has been global concern over the environment and energy problems. Recently, the problems, which have brought about serious effect on the global living condition, have been in the “spotlight” and given impetus to the universal’s efforts to head for the same direction: stem the worst warming and strive for the renewable energy source . Hydrogen peroxide (H 2 O 2 ) is undoubtedly a good choice, which holds the promise as a clean, efficient, safe and transferrable energy carrier. Octahedral coordination polymer , Cd 3 (C 3 N 3 S 3 ) 2 , was found to be a robust photocatalyst for H 2 O 2 generation under visible light irradiation . To further improve the H 2 O 2 generation efficiency, adhering the octahedron to reduced graphene (rGO) was applied as the strategy herein. The study shows that by adhering Cd 3 (C 3 N 3 S 3 ) 2 to rGO , the formation of H 2 O 2 is 2.5-fold enhanced and its deformation is concurrently suppressed. This work not only demonstrates the effectiveness of adhering Cd 3 (C 3 N 3 S 3 ) 2 polymer to rGO for the improvement of the polymer’s photocatalytic performance, but also proposes a general way for the fabrication of graphene/coordination compound hybrids for maximizing their synergy.
研究领域:
材料科学
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环境科学
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能源科学
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产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2023
·Vol. 25
·期 12
·1775-1781
·
IF 3.1
Zhi-Hao Zhang,Jia-Lu Ge,Yan Li,Qing Li,Pin-Pin Ma,Xiao-Yan Tang,Wen-Hua Zhang,David J. Young
Developing porous materials for the efficient capture of I2 is relevant to the sequestration and storage of radioactive iodine towards clean nuclear energy. In this work, three topologically identical two-dimensional (2D) metal–organic frameworks (MOFs) [Cd3(BTB)2(Pz)4]·xSol. (2), [Cd3(BTB)2(3-PyCN)2(H2O)2]·xSol. (3), and [Cd3(BTB)2(4-PyCN)4]·xSol. (4) have been prepared by ligand exchange with [Cd3(BTB)2(DEF)4]·2(DEF)0.5 (1) via single-crystal to single-crystal transformations (H3BTB = benzene-1,3,5-tribenzoic acid; DEF = diethylformamide; Pz = pyrazine; 3-PyCN = 3-cyanopyridine; 4-PyCN = 4-cyanopyridine; xSol. = guest solvates). MOFs 1–4 feature linear Cd3 cluster secondary building units (SBUs) interconnected by BTB ligands, with each Cd3 unit also associated with four terminally bonded ligands bearing halogen bonding sites, viz. N(DEF) for 1, N(Pz) for 2, –CN(3-PyCN) for 3, and –CN(4-PyCN) for 4. MOFs 1–4 adsorbed I2 in the sequence 2 > 3 > 4 > 1 with a maximum uptake of 54.1 mg g−1 for 2.
研究领域:
材料科学
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核化学
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环境科学
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DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2022
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IF 9.136
Chumin Yan,Xiaoli Dong,Yu Wang,Nan Zheng,Hui Dang,Hongchao Ma,Xiufang Zhang
As an efficient and sustainable technology, photocatalysis driven by visible light has made great contributions to the removal of heavy metals from environment. In this work, a series of Cd 3 (TMT) 2 /CdS heterojunction composite photocatalysts were prepared by self-formation of CdS nanoparticles using an octahedral coordination polymer Cd 3 (C 3 N 3 S 3 ) 2 (denoted as Cd 3 (TMT) 2 ) as a precursor. The photocatalytic performance of Cd 3 (TMT) 2 /CdS heterojunction composites for Cr(VI) has been significantly improved under visible light irradiation owing to effective separation and migration of photoexcited charge carriers. Moreover, Cd 3 (TMT) 2 /CdS composites exhibited remarkable photocatalytic reduction performance of Cr(VI) solution with high concentration. This photocatalyst provides a novel route in the photoreduction of Cr(VI).
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
LANGMUIR
·
2024
·
IF 3.7
Qianrui Xu,Zhimin Zhao,Xinyu Chen,Wenqian Fan,Yong Jiang
Fe3O4 nanoparticles occupy a pivotal position in the realm of nanobiology due to their nontoxic, biocompatible, and superparamagnetic properties. This study examines the influence of surface modifiers on the properties of magnetic nanoparticles. Poly(methacrylic acid) (PMAA), poly(4-styrenesulfonic acid-co-maleic acid) sodium salt (PSSM), trisodium citrate (TSC), carboxymethylcellulose (CMC), and carboxymethylated-dextran 40 (CMD40) were introduced into a one-pot solvothermal method to synthesize magnetic nanoparticles. TEM, the 4-(bromomethyl)-6,7-dimethoxy coumarin (BMMC) absorption assay, and the Bradford method were employed to characterize the diameter, carboxyl content, and protein immobilization ability of the nanoparticles, respectively. The findings revealed that CMD40-modified magnetic nanoparticles (CMD40-MNPs) exhibited the highest carboxyl content and streptavidin (SA) immobilization content, reaching 6.5 × 10–7 mol/mg and 375 μg/mg, respectively. In contrast, CMC-modified magnetic nanoparticles displayed opposite trends. This is primarily attributed to dextran’s unique molecular structure, which enhances its water solubility and biocompatibility, thereby facilitating contact with Fe3O4 nanoparticles in aqueous solutions. CMD40-MNPs possess a saturation magnetization value of 60.90 emu/g and can be collected within (60 ± 5) s using a standard magnetic separator. Cytotoxicity assays demonstrated that CMD40-MNPs are nontoxic to cells. A cell sorting strategy utilizing the binding of SA-CMD40-MNPs and biotin antihuman CD3 antibody-modified cell suspensions was employed to isolate CD3+T cells. The results indicate that the purity and efficiency of targeted CD3+T cells are 85.2% and 61.5%, respectively.
研究领域:
纳米生物学
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生物医学工程
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Cancer
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2019
·
IF 3.182
Wanru Ma,Juan Ma,Ting Lei,Man Zhao,Man Zhang
To investigate whether CD155 is an attractive target for T cell-mediated immunotherapy against human bladder cancer, we examined the novel bispecific antibody anti-CD3 x anti-CD155 (CD155Bi-Ab) for its ability to redirect activated T cells (ATCs) to target bladder cancer cells was examined. Expression of CD155 was detected by flow cytometry on the surface of bladder cancer cells, including T24 and Pumc-91 cells, and their chemotherapeutic drug-resistant counterparts. ATCs generated from healthy donors were stimulated with anti-CD3 monoclonal antibody, anti-CD28 monoclonal antibody and interleukin-2 (IL-2) for 14 days. The cytotoxic activity of ATCs armed with CD155Bi-Ab against bladder cancer cells was detected by LDH and luciferase quantitative assay. Furthermore, ATCs generated from bladder cancer patients were also armed with CD155Bi-Ab to verity the cell killing by the same methods. In contrast to unarmed ATCs, CD155Bi-armed ATCs against bladder cancer cells were increased cytotoxic activity at effector/target (E/T) ratios of 5:1, 10:1, and 20:1, with more IFN-γ, TNF-α secreting. It is worth noting that in spite of the presence of immunosuppression in bladder cancer patients and the drug resistance in chemotherapeutic drug-resistant cancer cell lines, not only the anti-tumor effect of CD155Bi-armed ATCs generated from bladder cancer patients still showed significantly but only higher level of activation marker CD69 was expressed. Taken together, our results suggest that CD155 is an effective target for the CD155-positive bladder cancer. And CD155Bi-Ab-armed ATCs are promisingly to provide a novel strategy for current CD155-positive bladder cancer therapy.
研究领域:
肿瘤学
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免疫疗法
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分子生物学
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癌症研究
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DOI
PubMed
高影响因子
Frontiers in Immunology
·
2022
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IF 8.786
Zhang Nan,Gao Xiaochen,Zhang Weijia,Xiong Junyao,Cao Xiaojian,Fu Zhen F.,Cui Min
Japanese encephalitis virus (JEV) is one of the most important members of the flavivirus family. It is a typical zoonotic pathogen that has caused substantial social and economic losses worldwide. The relation between JEV-induced immunosuppression and inflammatory responses has not been thoroughly investigated. In this study, cells infiltrating the brain tissue of JEV-infected mice were mainly identified as monocytic myeloid-derived suppressor cells (M-MDSCs), which subsequently differentiated into CD3+ macrophages. Co-culture with T cells showed that both splenic M-MDSCs and brain infiltrated M-MDSCs isolated from JEV-infected mice inhibited T cell proliferation through ARG1 and iNOS. The splenectomy model revealed that JEV-induced M-MDSCs were mainly derived from bone marrow and migrated to the spleen and central nervous system (CNS). The results of the transcriptome analysis and IRF7-deficient mice indicated that the ZBP1-IRF7 signaling pathway stimulated by JEV RNA played a central role in the induction of M-MDSCs. M-MDSCs migrated into the CNS through the chemokine CCL2/N-CCL2 derived from astrocytes and brain infiltrated M-MDSCs differentiated into CD3+ macrophages through a mechanism mediated by M-CSF, IL-6 and IFN-γ in the brain microenvironment. These findings provide evidence for the mechanism that JEV regulates the differentiation of M-MDSCs and thereby exacerbates pathogenicity, which represents a potential therapeutic target for Japanese encephalitis (JE).
研究领域:
免疫学
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神经病毒学
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病毒学
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致病机制
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产品关联
DOI
PubMed
高影响因子
INORGANIC CHEMISTRY
·
2021
·
IF 5.165
Liling Cao,Shengzi Zhang,Dan Zhao,Bingxuan Li,Tao Yan,Guangsai Yang,Zheshuai Lin,Min Luo,Ning Ye
A new d10 transition-metal iodate fluoride, namely, Cd3(IO3)(IO4)F2·0.1CdO, was successfully designed and synthesized via the mid-infrared hydrothermal method. It crystallizes in the polar space group R3m and features the coexistence of the [IO3]− and [IO4]3– groups. Cd3(IO3)(IO4)F2·0.1CdO has a strong second-harmonic-generation response of about 3.0 times that of KDP(KH2PO4), large birefringence (0.133 at 546.1 nm), and a wide energy band gap (4.00 eV). In addition, the power laser damage threshold (LDT) measurement indicated that it possesses a high LDT of 84.29 MW/cm2, which is about 30 times that of AgGaS2. These superior properties showed that Cd3(IO3)(IO4)F2·0.1CdO may be an excellent nonlinear-optical crystal for visible and mid-infrared application.
研究领域:
材料科学
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光学
·
晶体学
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DOI
高影响因子
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
·
2021
·Vol. 2021
·期 44
·4566-4571
·
IF 2.524
Wen-Dong Yao,Mei Yan,Xiao-Hui Li,Wenlong Liu,Ru-Ling Tang
Graphical A novel transition metal tellurite phosphate Cd 3 (PO 4 )(TePO 6 ) features a new type of {[TePO 6 ] 3− } ∞ chain was obtained by solid-state reactions, and its electronic structure and optical properties are studied systematically. New inorganic crystals containing multiple anions have received extensive attensions recently in view of their abilities to be potential multifunctional materials. Among them, tellurite-phosphates with simple chemical components are relatively rarely studied. Here, one novel tellurite phosphate Cd 3 (PO 4 )(TePO 6 ) was obtained through conventional soild-state reaction, and it is the first tellurite-phosphate only possessing d 10 transition metal. It crystallizes in the monoclinic space group P 2 1 / c , and its structure features an interesting {[TePO 6 ] 3− } ∞ chain constructed by corner-sharing connected PO 4 and TeO 4 tetrahedra. Meanwhile, we obtained a new phase of Cd 3 (PO 4 ) 2 and Cd 1.725 Mg 1.275 (PO 4 ) 2 in the exploration of tellurite-phosphates, and they also crystalize in the centric space group P 2 1 / c . Crystal structures, theoretical calculations on their electronic structure and birefringence have been studied, together with the IR and UV-vis-NIR diffuse reflectance spectra.
研究领域:
材料科学
·
化学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
·
2020
·
IF 7.632
Zhiliang Guo,Qingchun Zhang,Zhi Cheng,Qiangqiang Liu,Jin Zuo,Bo Jin,Rufang Peng
In this work, a novel air-flow impacting (AFI) synthetic technique for mechanochemical synthesis of metal organic frameworks (MOFs) was reported for the first time, which is an alternative approach for conventional mechanochemical synthesis. The MOFs, Cd3(BTC)2 (BTC = 1,3,5-benzenetricarboxylate) and HKUST-1, were characterized by Fourier transform infrared spectroscopy, X-ray diffraction (XRD), thermogravimetric analysis, scanning electron microscopy, transmission electron microscopy, and energy dispersive X-ray spectroscopy. The results indicated that the MOFs were successfully prepared after 10 min at a feeding rate of 60 kg h–1, which exhibit a slightly better Brunauer–Emmett–Teller surface area and pore sizes compared to that of materials produced by the conventional solvothermal method. The space time yields (STYs) for AFI of up to 1.44 × 106 kg m–3 d–1 are one order of magnitude greater than STYs for twin screw extrusion. Furthermore, the kinetic analysis of Cd3(BTC)2 was carried out to study the reaction mechanisms by measuring the XRD of the products at different reaction times. It was found that the preparation of Cd3(BTC)2 belonged to the two-dimensional diffusion model. In general, the AFI method clearly enables the preparation of MOFs under solvent-free conditions and may also be applied in synthesis more generally.
研究领域:
材料科学
·
化学工程
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产品关联
DOI
高影响因子
JOURNAL OF NANOBIOTECHNOLOGY
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2026
·
IF 15
Xia Liu,Hui Li,Ningning Shan,Bingxin Guan,Yang Jiang,Chengyun Zheng,Leisheng Zhang,Dexiao Kong
Aplastic anemia (AA) is a debilitating disorder marked by bone marrow failure, frequently associated with dysregulated T cell activity. The present study explored the therapeutic potential of anti-CD3 antibody-modified calcium silicate nanoparticles loaded with novel 7H-pyrrolo[2,3-d]pyrimidine derivatives (antiCD3-pCaSiNP@NPDP) for AA treatment. Whole-transcriptome sequencing and bioinformatics analysis identified interleukin-2-inducible T-cell kinase (ITK) as a critical regulator of T cell function in AA. In vitro experiments demonstrated that ITK enhances T cell proliferation and promotes differentiation toward inflammatory subsets, thereby contributing to disease progression. The newly developed NPDP derivatives effectively inhibited ITK activity. Targeted delivery of NPDP via antiCD3-pCaSiNP nanoparticles selectively suppressed ITK expression in T cells, resulting in reduced inflammatory T cell proliferation and increased regulatory T cell populations. In an AA mouse model, administration of antiCD3-pCaSiNP@NPDP nanoparticles markedly improved hematopoietic recovery and immune balance. The findings indicate that nanoparticle-mediated ITK inhibition represents a promising therapeutic strategy for restoring immune and bone marrow function in AA.
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DOI
PubMed
高影响因子
BIOCONJUGATE CHEMISTRY
·
2024
·
IF 4
Yanian Xiong,Yingtung Lo,Huizhu Song,Jianzhong Lu
The penetration ability of visible light (<2 mm) and near-infrared (NIR) light (∼1 cm) remarkably impairs the therapeutic efficacy and clinical applications of photodynamic therapy (PDT). To address the limitation of light penetration depth, a novel self-luminescent bacterium, teLuc.FP-EcN, has been engineered through transfection of a fusion expression plasmid containing the luciferase gene teLuc and bright red fluorescent protein mScarlet-I into Escherichia coli Nissle 1917 (EcN). The engineered teLuc.FP-EcN can specifically target and colonize tumors without significant toxicity to the host. Acting as a continuous internal light source, teLuc.FP-EcN can activate the photosensitizer chlorin e6 (Ce6) to generate reactive oxygen species (ROS) and then effectively destroy tumor tissue from the inside. As a result, a significant reduction in tumor proliferation and extension of the overall survival in mouse tumor models has been observed. Furthermore, teLuc.FP-EcN-boosted PDT amplified its therapeutic effect by activating antitumor immune response, including the conversion of M2 macrophages into pro-inflammatory M1 macrophages, as well as an increase in the proportion of CD3+ T cells and a decrease in T-cell exhaustion. In conclusion, teLuc.FP-EcN can be used as an implantable light source for tumor phototherapy, which simultaneously possesses ROS generation and immune regulation.
研究领域:
生物技术
·
癌症研究
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治疗学
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免疫学
·
分子生物学
✓ 已验证
DOI
PubMed
高影响因子
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