CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Haoyu Wang,Ping Han,Ying Yu,Shaolong Han,Yue Qiao,Yuehan Li,Bin Sun,Zheng Gu
Conductive hydrogels have been extensively investigated and demonstrate promising applications in wearable and flexible sensors. However, their broader implementation in this field is hindered by the insufficient strain sensitivity, susceptibility to mechanical damage with limited self-recovery, and inadequate adhesion to human skin. Herein, we present a multifunctional MXene/TA@CNC electronic hydrogel patch (MTC e-patch) by integrating highly conductive two-dimensional (2D) transition metal carbides (MXene) and tannic acid-coated carboxylated cellulose nanocrystals (TA@CNC) with polyvinyl alcohol and borax. And dynamic three-dimensional (3D) network is formed through synergistic dynamic hydrogen bonding and dynamic borate ester linkages. The incorporation of TA@CNC effectively prevents the oxidation of MXene, thereby extending the operational lifespan of hydrogels. The flexible covalent crosslinked network, combined with the rigidity of TA@CNC, imparts the MTC e-patch with excellent electrical conductivity (1.62 S/m), superior mechanical strength (≈1.35 MPa, 930 %), robust adhesiveness (≈28 kPa), and high self-healing capability (92 %). The rapid (161 ms) and sensitive (Gauge factor = 4.39) sensing performance of the developed wearable sensor enables the precise detection of subtle human motions, such as swallowing, throat vibrations during speech, and pen strokes during writing. Even when damaged, the sensor continues to provide stable signal output, demonstrating significant potential for applications in smart wearables, electronic skins, and human–machine interfaces.
研究领域:
材料科学
·
柔性电子
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Shuang Zheng,Lin Ding,Feilong Hu,Yong Zhang,Zhaofeng Ouyang,Shujuan Yang
In this work, the novel metal organic frameworks/multi-branched nanocellulose (Ni-Zn MOF@Multi CNC) fillers with different three-dimensional nanostructures are fabricated via two in-situ growing strategies, which were blended into Polyether sulfone (PES) matrix to construct composite ultrafiltration (UF) membranes. Furthermore, the effects of two structures of fillers on construction and performance of composite membranes are detailed investigated here. The results confirmed that the obtained PES composite membranes exhibited excellent permeability and selectivity because of the ultra-high hydrophilicity, abundant pores, and more negative charge of Ni-Zn MOF@Multi CNC fillers. Besides, compared with nanosphere structure of Ni-Zn MOF@Multi CNC, the nanoflower filler could provide more pores and cavities to enable higher water permeance, and more active surface charge (more -COO- groups) to increase protein rejection. The Ni-Zn MOF@Multi CNC 0.05 /PES membrane showed an 83 % higher permeance (up to 1151.00 L/m 2 h) and greatly improved BSA rejection (99 %). The Ni-Zn MOF@Multi CNC 0.05 /PES membrane has been successfully applied to different wastewater treatment, and shows expectant ultrafiltration performance.
研究领域:
材料科学
·
环境工程
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 12
·1-11
·
IF 5.833
Wang Xiao,Liao Xiaochen,Zhang Bingjian,Zhang Mengmeng,Mei Lisha,Wang Fangwai,Chen Siyu,Qiao Xiuwen,Hong Chenglin
Abstract Carcinoembryonic antigen levels in the human body reflect the conditions associated with a variety of tumors and can be used for the identification, development, monitoring, and prognosis of lung cancer, colorectal cancer, and breast cancer. In this study, an amperometric immunosensor with CuCo/carbon nanocubes (CuCo/CNC) as the signal label is constructed. The bimetal-doped carbon skeleton structure has a high specific surface area and exhibits good electrocatalytic activity. In addition, Au/g-C 3 N 4 nanosheets (Au/g-C 3 N 4 NSs) are used to modify the substrate platform, facilitating the loading of more capture antibodies. The reaction mechanism was explored through electrochemical methods, X-ray powder diffraction, X-ray photoelectron spectroscopy, and other methods. Kinetic studies have shown that CuCo/CNC have good peroxidase-like activity. In addition, the electrocatalytic reduction ability of CuCo/CNC on hydrogen peroxide can be monitored using amperometric i – t curve (− 0.2 V, vs. SCE), and the response current value is positively correlated with the CEA antigen concentration. The prepared electrochemical immunosensor has good selectivity, precision, and stability. The dynamic range of the sensor was 0.0001–80 ng/mL, and the detection limit was 0.031 pg/mL. In addition, the recovery and relative standard deviation in real serum samples were 97.7–103 % and 3.25–4.13 %, respectively. The results show that the sensor has good analytical capabilities and can provide a new method for the clinical monitoring of CEA. Graphic abstract
研究领域:
生物医学工程
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肿瘤学
·
分析化学
✓ 已验证
DOI
高影响因子
Artificial Cells Nanomedicine and Biotechnology
·
2018
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IF 3.026
Zhifang Zheng,Yishu Liu,Wenhua Huang,Yunfei Mo,Yong Lan,Rui Guo,Biao Cheng
Diabetic foot ulcers (DFUs) are a threat to human health and can lead to amputation and even death. Recently neurotensin (NT), an inflammatory modulator in wound healing, was found to be beneficial for diabetic wound healing. As we demonstrated previously, polylactide–polyglycolide (PLGA) and cellulose nanocrystals (CNCs) (PLGA/CNC) nanofiber membranes show good cytocompatibility and facilitate fibroblast adhesion, spreading and proliferation. PLGA/CNC nanofiber membranes are novel materials that have not been used previously as NT carriers in diabetic wounds. This study aims to explore the therapeutic efficacy and possible mechanisms of NT-loaded PLGA/CNC nanofiber membranes in full-thickness skin wounds in spontaneously diabetic mice. The results showed that NT could be sustained released from NT-loaded PLGA/CNC composite nanofiber membranes for 2 weeks. NT-loaded PLGA/CNC composite nanofiber membranes induced more rapid healing than other control groups. After NT exposure, the histological scores of the epidermal and dermal regeneration and the ratios of the fibrotic area to the whole area were increased. NT-loaded PLGA/CNC composite nanofiber membranes also decreased the expressions of the inflammatory cytokines IL-1β and IL-6. These results suggest that NT-loaded PLGA/CNC composite nanofiber membranes for sustained delivery of NT should effectively promote tissue regeneration for the treatment of DFUs.
研究领域:
生物医学工程
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药剂学
·
伤口愈合
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2023
·Vol. 61
·期 20
·2451-2461
·
IF 3.4
Jingda Huang,Shite Lin,Yipeng Liang,Enfu Wang,Yu Miao,Wenbiao Zhang,Kuichuan Sheng
It is still a serious challenge to construct a water-soluble polymer-based air filtration membrane with high efficiency and good mechanical properties by electrospinning. In the study, using polyvinyl alcohol (PVA) and polyacetylimide (PEI) as the main materials, both nanocellulosic crystal (CNC) and zinc oxide (ZnO) as the synergistic reinforcers and methyltrimethoxysilane (MTMS) as the hydrophobic modifier, the electrospun PVA/PEI/CNC/ZnO composite nanofibrous membrane with dual air filtration mechanisms was established. One of the mechanisms was the interception of the three-dimensional network structure built by the composite nanofibrous membrane, the other was the electrostatic adsorption provided by CNC. Based on the dual air filtration mechanisms, the filtration efficiency of particulate matter 2.5 (PM2.5) reached 98.20%. Moreover, the composite nanofibrous membrane displayed a good thermal stability and could still maintain more than the filtration efficiency of 83% and low-pressure drop after treatment at 200 °C for 1 h. Moreover, the composite nanofibrous membrane could still maintain the filtration efficiency (97.3%) and low-pressure drop (110.7 Pa) after five washing cycles after filtration, reflecting good reusability. Interestingly, the PVA/PEI/CNC/ZnO composite nanofibrous membrane was simple to produce and demonstrated excellent filtration efficiency, as well as excellent thermal stability, which could be an effective barrier against PM2.5 invasion. Graphical
研究领域:
材料科学
·
环境科学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2022
·
IF 4.326
Yasi Abi,Weiye Li,Zhihong Chang
A new type of humidification membrane for proton exchange membrane fuel cells composed of polyether-block polyamide (PEBAX) 3533, polyacrylic acid (PAA), and cellulose nanocrystals (CNCs) was fabricated using the electrospinning method. CNCs were used to improve the hydrophilicity of the membrane, and PAA was used to improve the spinnability of the material. Using a scanning electron microscope, the morphology of PEBAX/PAA/CNC composite fiber membranes (CFMs) and electrospun fibers was investigated. Through X-ray diffraction analysis and the tests of water vapor permeability, air permeability, and water contact angles, the effects of CNCs on membrane properties were investigated. The results showed that the addition of CNCs improved the hydrophilicity and crystallinity of the CFM; while the air barrier properties of the CFM improved, the water vapor permeability coefficient of the membranes decreased. When the content of CNCs was 4.8 wt %, the vapor/air selectivity reached the highest value of (2.20 ± 0.05) × 104, which was 14% more than that of the fiber membrane without CNCs.
研究领域:
材料科学
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能源工程
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燃料电池技术
✓ 已验证
产品关联
DOI
高影响因子
DRUG DELIVERY
·
2016
·
IF 4.843
Jiang Ni,Fengchun Tian,Fatima Zohra Dahmani,Hui Yang,Deren Yue,Shuwang He,Jianping Zhou,Jing Yao
The low oral bioavailability of numerous drugs has been mostly attributed to the significant effect of P-gp-mediated efflux on intestinal drug transport. Herein, we developed mixed polymeric micelles (MPMs) comprised of curcumin-carboxymethyl chitosan (CNC) conjugate, as a potential inhibitor of P-gp-mediated efflux and gastrointestinal absorption enhancer, and low-molecular-weight heparin-all-trans-retinoid acid (LHR) conjugate, as loading material, with the aim to improve the oral absorption of P-gp substrate drugs. CNC conjugate was synthesized by chemical bonding of curcumin (Cur) and carboxymethyl chitosan (CMCS) taking advantage of the inhibition of intestinal P-gp-mediated secretion by Cur and the intestinal absorption enhancement by CMCS. The chemical structure of CNC conjugate was characterized by 1H NMR with a degree of substitution of Cur of 4.52–10.20%. More importantly, CNC conjugate markedly improved the stability of Cur in physiological pH. Cyclosporine A-loaded CNC/LHR MPMs (CsA-CNC/LHR MPMs) were prepared by dialysis method, with high drug loading 25.45% and nanoscaled particle size (∼200 nm). In situ single-pass perfusion studies in rats showed that both CsA + CNC mixture and CsA-CNC/LHR MPMs achieved significantly higher Ka and Peff than CsA suspension in the duodenum and jejunum segments (p < 0.01), which was comparable to verapamil coperfusion effect. Similarly, CsA + CNC mixture and CsA-CNC/LHR MPMs significantly increased the oral bioavailability of CsA as compared to CsA suspension. These results suggest that CNC conjugate might be considered as a promising gastrointestinal absorption enhancer, while CNC/LHR MPMs had the potential to improve the oral absorption of P-gp substrate drugs.
研究领域:
药学
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药物递送系统
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药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Jimin Li,Hongjie Wang,Tian Liu,Usama Shakeel,Jiaqi Guo,Wenyuan Zhu,Igor S. Makarov,Mohammad Rizwan Khan,Huining Xiao,Junlong Song
Cellulose nanocrystals (CNCs) have garnered attention for their renewable and reactive nature, yet CNC allomorph II (CNC-II) remains underexplored compared to the extensively studied CNC-I. This study bridges this gap by introducing a two-step carboxylamine condensation strategy to conjugate poly(ethylene glycol) (PEG) onto CNC-II via ethylenediamine, leveraging the high topochemical reactivity of CNC-II. Utilizing bicarboxylate-capped PEG as a probe, quartz crystal microbalance with energy dissipation (QCM-D) assays revealed a significant reactivity increase of 16.99 % in PEG grafting for CNC-II compared to CNC-I. Furthermore, a temperature-responsive CNC-II conjugate (CF4-II) was synthesized by grafting the thermosensitive polymer F124 (a block copolymer composed of PEO and PPO segments), demonstrating its utility in stabilizing Pickering emulsions for the temperature-controlled release of ibuprofen. The results of the in vitro release of ibuprofen encapsulated in CF4-II emulsions show that the release rate is more than quadrupled as the temperature increased from 37 °C to 40 °C, indicating that it is a promising smart drug carrier for fever management. These findings not only underscore the potential of CNC-II as a superior substrate for topological chemical reactions but also pave the way for the development of advanced materials and nanodevices with enhanced functionality and responsiveness.
研究领域:
纳米技术
·
高分子科学
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药剂学
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材料科学
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化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CELLULOSE
·
2023
·Vol. 30
·期 15
·9607-9623
·
IF 5.7
Wang Zhile,Yu Dehai
The photocatalytic degradation of organic pollutants represents an efficacious, energy-conserving, and eco-friendly methodology. MIL-101 is a porous crystalline material composed of metal ions (or metal clusters) and organic linkers. As a prominent metal-organic framework material, MIL-101 exhibits remarkable thermal and chemical resilience, rendering it ideal for diverse applications encompassing gas storage, separation, and catalytic processes. However, its potency in the degradation of dye molecules is impeded by its innate hydrophobicity and predisposition to precipitate in aqueous solutions. In this study, MIL-101(Fe)/cellulose nanocrystal (CNC) hybrid nanoparticles (MCs) with high photocatalytic activity were prepared by in situ growth. Owing to their unique amphiphilicity and interfacial adsorption, the Pickering emulsions stabilised by MCs showed uniform particle size and stability. The MCs were uniformly adsorbed at the oil–water interface of the emulsion and dispersed in the water phase through a three-dimensional network with clusters. This facilitated complete contact of the MCs with pollutants, thereby significantly increasing the photocatalytic efficiency. The tuneable wettability of MIL-101(Fe) induced by CNCs considerably affected the stabilization and photocatalytic degradation performance. In the presence of 0.5 wt% CNCs, the MCs had a three-phase contact angle of 92°, resulting in the highest photocatalytic degradation rate and emulsion stability of the samples studied herein. An emulsion was produced with a constant emulsification index of 100% by using 0.4 wt% MCs and an oil-phase volume fraction of approximately 0.2. The MC-stabilised emulsion system exhibited high photocatalytic degradation efficiency for Rhodamine B. Moreover, the MCs could be recycled several times while ensuring a degradation efficiency within an acceptable range. Herein we introduce a new approach for improving and fabricating green, sustainable photocatalysts for the degradation of organic pollutants in aqueous systems.
研究领域:
环境科学
·
材料科学
·
纳米技术
·
催化
·
水处理
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2023
·
IF 5.2
Kang Li,Yutong Wen,Yuanyuan Song,Na Qi,Ying Li
Facing the increasingly serious water pollution problem, photocatalytic method has been recognized as one of the best solutions due to its convenience, efficiency and low consumption. Graphitic carbon nitride (g-C 3 N 4 ), a metal-free and visible light-responsive photocatalyst , has shown great potential in the photocatalytic treatment of water pollution. This study describes a novel bottom-up strategy for constructing visible light-responsive photoactive nanocomposite g-C 3 N 4 /CNC/PAM aerogel with the g-C 3 N 4 uniformly loaded throughout a polymeric network, perfect mechanical property and high performance in treating wastewater containing organic/heavy metal compound contaminants. Aldehyde-modified negatively charged natural nanoparticle cellulose nanocrystal (CNC-CHO) was used to achieve uniform dispersion of g-C 3 N 4 , and also participate in the subsequent formation of aerogel through chemical crosslinking with photoinitiated polyacrylamide (PAM) catalyzed by g-C 3 N 4 without additional crosslinkers. The optimized porous structure of the prepared aerogel ensured high swelling rate of up to 2500%, excellent pollutant adsorption performance and high light transmittance , thus achieved high removal rate and removal efficiency for different types of pollutants including organic dyes (RhB, MB and CR) and heavy metal Cr(VI). The removal efficiency could get 99% for RhB (5 mg/L) in 6 h, and 95% for Cr (VI) (10 mg/L) in 100 min under visible light . Further more, the aerogel showed excellent mechanical stability and reusability, with no loss in activity observed after over 5 cycles of dye degradation .
研究领域:
环境科学
·
材料科学
·
化学工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Polymers
·
2021
·Vol. 13
·期 19
·3417
·
IF 4.329
Xinhui Wang,Na Wang,Baoming Xu,Yili Wang,Jinyan Lang,Junliang Lu,Guorong Chen,Heng Zhang
Different modification process routes are used to improve the modified cellulose nanocrystalline (MCNC) with higher fatty acid by esterification reaction and graft polymerization to obtain certain hydrophobic properties. Two preparation methods, product structure and surface activity, are compared and explored. Experimental results show that the modified product is still at the nanometer level and basically retains the crystal structure of the raw cellulose nanocrystalline (CNC). The energy consumption of the two preparation methods is low; however, the esterification method with co-reactant requires short reaction time, and the degree of substitution of the product is high. The modified product prepared by grafting polymerization method has a high HLB value and amphiphilicity, which can effectively reduce the surface tension of water. Therefore, it can be used as a green and environmentally friendly surface-active substance.Keywords:CNC;esterification reaction;graft copolymerization;hydrophobic modification
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2022
·Vol. 14
·期 19
·4231
·
IF 4.967
Xu Li,Meijuan Cao,Shasha Li,Luhai Li,Yintang Yang,Ruping Liu,Zhicheng Sun,Lixin Mo,Zhiqing Xin,Yinjie Chen,Yaling Li,Yi Fang,Yuansheng Qi
A simple and novel method for the deposition of polypyrrole (PPy) and cellulose nanocrystal (CNC) composites on different fiber substrates by reactive ink-jet printing was proposed. PPy/CNCs composites were successfully prepared, and the surface resistance of conductive layer deposited on different fiber substrates is the least when the monomer concentration is 0.6 M. PPy/CNCs were deposited on polyethylene terephthalate (PET) to form a conductive layer by adding polyvinyl alcohol (PVA), and the optimum sintering temperature is 100 °C (monomer/PVA ratio 4.0, conductivity 0.769 S cm−1). The PPy/CNCs conductive layer deposited on the paper has the lowest surface resistance and the best adhesion, and the surface resistance of PPy/CNCs conductive layer decreases first and then increases with the increase of sulfonate concentration. Moreover, the volume of anion in sulfonate will affect the arrangement and aggregation of PPy molecular chain in composite materials. Appropriate sulfonate doping can improve the conductivity and stability of conductive paper, and the maximum conductivity is 0.813 S cm−1. Three devices based on PPy/CNCs conductive paper were proposed and fabricated. Therefore, this ink-jet printing provides a new method for the preparation of conductive materials, sensors, energy storage and electromagnetic shielding, etc.Keywords:PPy;CNC;fiber substrate;conductivity;ink-jet printing
研究领域:
材料科学
·
纳米技术
·
电子学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）