BIOMEDICAL MICRODEVICES
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2021
·Vol. 23
·期 4
·1-7
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IF 2.838
Yao Yin,Fan Yiqiang
This study proposed a rapid and low-cost fabrication method for open-channel hydrogel-based microfluidic devices using CO 2 laser ablation. The agarose hydrogel substrate was prepared with agarose gelation in DI water upon microwave heating, then a commercial CO 2 laser system was used for the direct laser ablation of microchannels on the surface of agarose hydrogel substrate, the hydrophilic nature of the microchannels fabricated on hydrogel substrate enables the self-driven of the liquid inside the microchannels with capillary force. The profiles of the laser ablated microchannels on agarose hydrogel substrate with various laser power and scan speed were studied in detail. Due to the loss of water when exposed to the atmosphere, significant deformation of the fabricated microchannels was observed, and the profile change was recorded for 48 h for comparison. An easy-to-access storage method of hydrogel-based microfluidic device in DI water was also proposed in this study. Unlike compact silicon or polymer-based microfluidic devices, the hydrogel is formed by cross-linked polymer chains filled with water, for a better understanding of the diffusion of small molecules into the bulk hydrogel material during fluid propagation inside the microchannel, the Nile red fluorescent was added into the liquid and the diffusion across the hydrogel-based microchannels with time was measured and discussed in this study. Several open-channel agarose hydrogel-based microfluidic devices were fabricated in this study for the demonstration of the proposed fabrication method. The CO 2 laser ablation approach for agarose hydrogel-based microfluidic devices has the advantages of rapid processing time, low-cost, highly biocompatible, and self-driven without pumps and could have wide application potentials in biological and medical fields.
研究领域:
微流控
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生物医学工程
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材料科学
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激光技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2019
·
IF 4.959
Yang Hu,Haiyan Liu,Xin Zhou,Haobo Pan,Xiuping Wu,Noureddine Abidi,Yongjun Zhu,Jinhui Wang
Bacterial cellulose (BC) is a bio-derived polymer, and it has been considered as an excellent candidate material for tissue engineering. In this study, a crossed groove/column micropattern was constructed on spongy, porous BC using low-energy CO 2 laser photolithography. Applying the targeted immobilization of a tetrapeptide consisting of Arginine-Glycine-Aspartic acid-Serine (H-Arg-Gly-Asp-Ser-OH, RGDS) as a fibronectin onto the column platform surface, the resulting micropatterned BC (RGDS-MPBC) exhibited dual affinities to fibroblasts and collagen. Material characterization of RGDS-MPBC revealed that the micropattern was built by the column part with size of ~100 × 100 μm wide and ~100 μm deep, and the groove part with size of ~150 μm wide. Hydrating the MPBC did not result in the collapse of the integrity of the micropattern, suggesting its potential application in a highly hydrated wound environment. Cell culture assays revealed that the RGDS-MPBC exhibited an improved cytotoxicity to mouse fibroblasts L929, as compared to the pristine BC. Meanwhile, it was observed that the RGDS-MPBC was able to guide the ordered aggregation of human skin fibroblast (HSF) cells on the column platform surface, and no HSF cells were found in the groove channels. Over time, it was found that a dense network of collagen was gradually established across the groove channels. Furthermore, the in-vivo animal study preliminarily demonstrated the scar-free healing potential of the micropatterned BC materials. Therefore, this RGDS-MPBC material exhibited its advantages in guiding cell migration and collagen distribution, which could present a prospect in the establishment of “basket-woven” organization of collagen in normal skin tissue against the formation of dense, parallel aggregation of collagen fibers in scar tissue toward scar-free wound healing outcome.
研究领域:
组织工程
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生物医用材料
·
伤口愈合
✓ 已验证
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Tingxue Fang,Jiawei Wang,Zongxuan Bai,Yuhao Wang,Nan Wang,Dong Xiang,Kedi Cai
It remains critical and challenging to synthesize non-noble metal catalysts with excellent hydrogen evolution reaction (HER) activity in a wide pH range. High-temperature pyrolysis is one of the main methods for catalyst synthesis but can be time-consuming and leads to agglomeration easily. In view of this, molybdenum carbide and molybdenum nitride composite (MoC@MoN) was prepared via CO2 laser irradiation technology. The catalytic activity of the as-prepared catalysts can be effectively regulated by controlling the usage of Na2MoO4·2H2O and the applied CO2 laser power. In acidic and alkaline media, the as-prepared MoC@MoN requires an overpotential of only 63 mV and 34 mV, respectively, at a current density of 10 mA cm–2 and exhibits considerable electrochemical and structural durability, making it a suitable candidate for hydrogen production in a wide pH range. Theoretical calculations reveal the surface adsorption and desorption properties of reactive hydrogen and confirm the energetically favorable hydrogen spillover on the heterostructured MoC@MoN interface. The construction of the heterostructured interface enhances the activation of H2O* and further decreases the energy barrier of H2O* dissociation, thereby promoting the Volmer step and the H* supply for HER on the MoC@MoN interface. The integration of efficient H* adsorption on MoN and easy desorption on MoC effectively accelerates the Tafel step and hydrogen spillover, resulting in excellent HER performance of MoC@MoN. The strategy presented in this paper may offer a unique and viable approach for designing and synthesizing high-performance, low-cost HER catalysts, applied in a wide pH range.
研究领域:
电化学
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催化
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材料科学
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纳米技术
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表面科学
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能量转换
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Kang Xue,Huaiyu Li,Lun Pan,Yiran Liu,Xiangwen Zhang,Ji-Jun Zou
With the continuous development of advanced fuel and engine technology, the boundary between liquid and solid fuel is more and more blurred, so the development of new solid-liquid two-phase fuels has become a major opportunity and challenge. Herein, two kinds of [email protected] energetic particles ( [email protected] and [email protected] ) were fabricated by an in-situ electrostatic self-assembly method. The thermal property, ignition and combustion performances of [email protected] are characterized by TG-DSC, CO 2 laser ignition and constant-volume combustion experiments. The results show that the initial exothermic temperature of [email protected] and [email protected] are reduced by about 60 and 110 °C, respectively, compared with nAl (579.6 °C). Moreover, [email protected] has a lower ignition delay time, higher peak pressure, and faster pressurization rate than nAl, especially [email protected] and [email protected] The combustion process of [email protected] is proposed, which can be obviously enhanced by regulating the interfacial reaction and the generation of microexplosions. In the ignition experiment of nanofluid fuel, [email protected] energetic particles exhibit the bifunction characteristics, which can simultaneously improve the ignition and combustion performances of solid-phase nAl particles and liquid-phase hydrocarbon fuel. This work provides a new strategy for advanced aerospace fuel by introducing MOF shells to construct bifunctional energetic particles with enhanced ignition and combustion properties.
研究领域:
材料科学
·
化学工程
·
航空航天工程
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
CARBON
·
2020
·
IF 8.821
Lijun Cao,Shuairu Zhu,Baohai Pan,Xinyan Dai,Weiwei Zhao,Yuan Liu,Weiping Xie,Yongbo Kuang,Xiaoqing Liu
The stability and durability of laser-induced graphene (LIG) patterns embedded in polymer substrates are significant for their practical application. However, most of currently reported LIG precursors are facing the dilemma of weak structural controllability, poor resistance to acid/base, or bad processability . In this work, we efficiently converted the synthesized poly (Ph-ddm) into LIG using a straightforward CO 2 laser, aiming to find a potential LIG precursor with excellent durability under harsh conditions. The graphene structure of obtained LIG was confirmed by Raman spectra , scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray photoelectron spectroscopy (XPS). Results indicated that the poly (Ph-ddm)-based LIG showed a low sheet resistance of 35 Ω/sq as well as a high specific surface area of 883 m 2 /g. And due to the superior properties of poly (Ph-ddm), the LIG patterns exhibited excellent resistance to strong acid/base solutions and high adhesion on the substrate, which ensured their stable application under severe conditions. Besides, potential application of as-prepared LIG was demonstrated in well-performed supercapacitors and electrode for water splitting in an alkaline medium . Based on the results in this work, polybenzoxazine could be a promising precursor for stable and durable LIG preparation.
研究领域:
材料科学
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纳米技术
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电化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）