SEPARATION AND PURIFICATION TECHNOLOGY
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2023
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IF 8.6
Wenbei Chen,Huixian Liu,Yuting Chen,Jian Ke,Xin Qiu,Jianqiu Chen,Yibing Ji
Membrane separation technology has infinite potential to produce optically pure drugs. However, there are still challenges regarding chiral membranes, such as the single separation object, poor mechanical properties, and constrained relationship between permeability and enantioselectivity. To improve the membrane properties, heptakis (6-amino-6-deoxy)- β -CD-modified carboxyl-functionalized COF (TpBD-Am7CD) was introduced as a chiral functional material for the preparation of a TpBD-Am7CD stainless steel I-Net cellulose acetate membrane (COF/SSCAM) via interfacial polymerization. Using tryptophan as the template molecule, the membrane preparation and filtration conditions were optimized to achieve maximum enantioselectivity. The optimized COF/SSCAM achieved a better enantiomeric excess percentage (e.e.% = 100.00%) and solute permeation flux (J S = 37 × 10 −6 mol m −2 h −1 ) for racemic tryptophan than the support membrane, which was attributed to the enantioselectivity and hydrophilicity of TpBD-Am7CD. Moreover, COF/SSCAM achieved enantiomeric separation of racemates of propranolol, warfarin, atenolol, and metoprolol, and the e.e.% values were 39.51%, 5.60%, 16.04%, and 3.09%, respectively. In addition, the chiral recognition mechanism was investigated by molecular docking simulation.
研究领域:
材料科学
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生物医学工程
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化学工程
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产品关联
DOI
高影响因子
Journal of Functional Biomaterials
·
2024
·Vol. 15
·期 7
·185
·
IF 5
Yu Wu,Sen Xu,Fengjuan Ding,Weibing Zhang,Haiyan Liu
In this work, a new type of FE-1 COF material is prepared by a reversible imine condensation reaction with diaminoferrocene and diaminodiformaldehyde as materials. The material is connected by imine bonds to form a COF skeleton, and the presence of plenty of nitrogen-containing groups gives the material good hydrophilicity; the presence of metal Fe ions provides the material application potential in the enrichment of phosphopeptides. According to the different binding abilities of N-glycopeptide and phosphopeptide on FE-1 COF, it can simultaneously enrich N-glycopeptide and phosphopeptide through different elution conditions to realize its controllable and selective enrichment. Using the above characteristics, 18 phosphopeptides were detected from α-casein hydrolysate, 8 phosphopeptides were detected from β-casein hydrolysate and 21 glycopeptides were detected from IgG hydrolysate. Finally, the gradual elution strategy was used; 16 phosphopeptides and 19 glycopeptides were detected from the α-casein hydrolysate and IgG hydrolysate. The corresponding glycopeptides and phosphopeptides were identified from the human serum. It proves that the FE-1 COF material has a good enrichment effect on phosphopeptides and glycopeptides.
研究领域:
分析化学
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蛋白质组学
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生物化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2014
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IF 3.552
Juan Li,Xiaodan Yang,Chiyao Bai,Yin Tian,Bo Li,Shuang Zhang,Xiaoyu Yang,Songdong Ding,Chuanqin Xia,Xinyu Tan,Lijian Ma,Shoujian Li
A novel COF-based material (COF-COOH) containing large amounts of carboxylic groups was prepared for the first time by using a simple and effective one-step synthetic method, in which the cheap and commercially available raw materials, trimesoyl chloride and p -phenylenediamine, were used. The as-synthesized COF-COOH was modified with previously synthesized 2-(2,4-dihydroxyphenyl)-benzimidazole (HBI) by “grafting to” method, and a new solid-phase extractant (COF-HBI) with highly efficient sorption performance for uranium(VI) was consequently obtained. A series of characterizations demonstrated that COF-COOH and COF-HBI exhibited great thermostabilities and irradiation stabilities. Sorption behavior of the COF-based materials toward U(VI) was compared in simulated nuclear industrial effluent containing UO 2 2+ and 11 undesired ions, and the UO 2 2+ sorption amount of COF-HBI was 81 mg g −1 , accounting for approximately 58% of the total sorption amount, which was much higher than the sorption selectivity of COF-COOH to UO 2 2+ (39%). Batch sorption experiment results indicated that the uranium(VI) sorption on COF-HBI was a pH dependent, rapid (sorption equilibrium was reached in 30 min), endothermic and spontaneous process. In the most favorable conditions, the equilibrium sorption capacity of the adsorbent for uranium could reach 211 mg g −1 .
研究领域:
化学
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环境科学
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核能技术
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
·
IF 16.744
Ying Tang,Shanliang Jiang,Wenyuan Li,Syed Jalil Shah,Zhenxia Zhao,Lie Pan,Zhongxing Zhao
Construction of highly-active nanozymes featuring merits of enzymes and nanomaterials is challenging for biomimetic catalysis. Herein, “confined coordination” strategy was proposed to engineer a novel laccase-nanozyme supported on mesoporous COF-OMe (Cu-Cys@COF-OMe) for the effective degradation of phenolic pollutants. In-situ L -Cysteine modification and confined Cu-coordination implanted unique Cys-multicopper (Cu + /Cu 2+ ) cluster in COF-OMe mesopores, and engineered biomimetic active pockets to which achieved efficient synergistic diffusion-adsorption-catalysis. Cu-Cys@COF-OMe realized 1.9 times higher enzymatic activity than that of laccase and 2.1–17.0 times higher monatomic copper activity than that of reported state-of-the-art laccase nanozymes, respectively. Besides, Cu-Cys@COF-OMe displayed catalytic merits of nano-materials over laccase, which demonstrated enhanced catalytic activity with temperature and excellent stability under variable reaction conditions. Cu-Cys@COF-OMe nanozyme exhibited 1.4 times faster degradation kinetics (of laccase) for phenolic pollutants, which was further intensified (3.4 times) after exposure to NaCl. This work opens a promising avenue for better design of laccase nanozymes to realize effective phenolic pollutants degradation for large-scale applications.
研究领域:
环境科学
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生物化学
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DOI
高影响因子
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