ACS Nano
·
2024
·
IF 15.8
Yanzhi Dong,Gang Shu,Yibo Wei,Jinbin Pan,Dong Li,Shao-Kai Sun
Tantalum (Ta) emerges as a promising element for advanced computed tomography (CT) imaging probes owing to its high X-ray attenuation coefficient and excellent biocompatibility. Nevertheless, the synthesis of renally clear Ta-based imaging probes through simple methods remains a significant challenge. Herein, we introduce a simple and gram-scale approach for the synthesis of renal-clearable Ta nanodots with high water solubility for CT imaging in vivo. The Ta nanodots, coordination polymers, are fabricated via coordination reactions involving Ta(OH)5, citric acid (CA), and hydrogen peroxide. The Ta nanodots exhibit an ultrasmall hydrodynamic diameter (2.8 nm), high water solubility (1.88 g/mL, 688 mg Ta/mL), superior X-ray absorption capacity, gram-scale production capability (>10 g in lab synthesis), renal-clearable ability, and good biocompatibility. The Ta nanodots possess superior CT imaging efficacy across diverse tube voltages, enabling highly sensitive gastrointestinal CT imaging, renal CT imaging, and CT angiography (CTA). Moreover, Ta nanodots maintain robust CT imaging capabilities even at high X-ray energies, and Ta nanodots-based spectral CT achieves metallic artifacts-minimized CTA. The proposed Ta nanodots present substantial potential as a potent CT imaging probe for diagnosing various diseases.
研究领域:
医学影像学
·
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Chunmei Yang,Didi Gu,Xin Zhu,Pan Han,Liping Pan,Xiaoling Che,Xinyao Chen,Qiuyu Meng,Guidong Dai,Lu Yang
Spectral CT can overcome the shortcomings of conventional CT, however, clinically used iodized contrast agents are not ideal for spectral CT imaging, which calls for the development of novel contrast agent with high attenuation coefficient. In this study, a small molecule lanthanide chelate Ytterbium-tetraazacyclododecane-1,4,7,10-tetraacetic acid (Yb-DOTA) was prepared by a simple and green one-step method, and it had multi-advantages such as good stability, excellent biocompatibility and high performance of spectral CT imaging in vitro and in vivo. In addition, Yb-DOTA had more prominent ability to visualize renal tissue, GI tract, the heart and venous system in both conventional and spectral CT imaging compared with clinical iohexol. Moreover, higher tissue contrast and enhanced sensitivity were achieved at high monochromatic energies (70–150 keV) after Yb-DOTA administration, indicating its superior spectral CT imaging performance. Yb-DOTA is expected to be a novel contrast agent to enhance the diagnostic sensitivity and accuracy.
研究领域:
医学影像学
·
分子影像
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry B
·
2016
·Vol. 4
·期 6
·1090-1099
·
IF 4.872
Yao Yu,Youshen Wu,Jiajun Liu,Ke Li,Daocheng Wu
To improve the computed tomography (CT) imaging ability and the toxicity of gold nanoparticles (AuNPs), hydrophilic dopamine (DPA)-coated gold nanoparticle (AuNP) (MSA AuNPs@DPA) aggregates (42 ± 2.65 nm) were obtained by assembling MSA AuNPs@DPA (5–6 nm) with the use of polyethyleneimine (PEI). They rapidly degraded into MSA AuNPs@DPA with PEI in blood. The acute toxicity test showed that the maximum tolerated doses of MSA AuNPs@DPA and MSA AuNPs@DPA aggregates were larger than 4.8 and 4.6 g kg−1, respectively, which are much higher doses than those of the commonly used citric acid-stabilized AuNPs (CA AuNPs) (2.97 g kg−1). The metabolic test in vivo showed that the elimination rates of MSA AuNPs@DPA aggregates and MSA AuNPs@DPA were 0.848 and 0.955, respectively. Most of the aggregates were eliminated by the kidney after 5 days and excreted by urine, whereas CA AuNPs remained in vivo and concentrated in some organs. The t0.5 values of MSA AuNPs@DPA and MSA AuNPs@DPA aggregates were 24.28 and 43.68 h, respectively, meaning that MSA AuNPs@DPA aggregates had a much longer circulation time. Similarly, the CT absorption value of MSA AuNPs@DPA aggregates was much higher than that of the commonly used nonionic iodinated CT contrast agent iohexol and CA AuNPs at the same concentration. Thus, MSA AuNPs@DPA aggregates possess characteristics such as ease of fabrication, long circulation time, hypotoxicity, and excellent CT absorption value, which suggest their great potential applications in vivo.
研究领域:
生物医学工程
·
纳米医学
·
影像学
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION
·
2021
·Vol. 336
·期 4
·364-375
·
IF 2.656
Alida M. Bailleul,Jing Lu,Zhiheng Li
Iodine-based contrasting agents for computed tomography (CT) have been used for decades in medicine. Agents like Lugol's iodine enhance the contrasts between soft tissues and mineralized (skeletal) tissues. Because a recent study on extant avian heads showed that iodine–ethanol (I 2 E) is a better contrast enhancer overall than the standard Lugol's iodine, here, we tested if I 2 E could also enhance the CT contrasts of two fossilized skeletal tissues: bone and calcified cartilage. For this, we used a partial ankle joint from an extinct pheasant from the Late Miocene of Northwest China (Linxia Basin). The pre-staining CT scans showed no microstructural details of the sample. After being immersed into a solution of 1% I 2 E for 8 days and scanned a second time, the contrasts were drastically enhanced between the mineralized tissues (bony trabeculae and calcified cartilage) and the sediments and minerals inside vascular spaces. After three other staining-scanning cycles in 2%, 3%, and 6% I 2 E solutions, the best contrasts were obtained after immersion in 6% I 2 E for 7 days. Energy Dispersive Spectroscopy showed that iodine was preferentially absorbed by the mineralized tissues and the minerals in the vascular spaces, but not by the sediments. This method not only effectively increased the contrasts of two different fossilized skeletal tissues, it was also non-destructive and reversible because part of the fossil was successfully de-stained after a few days in pure ethanol. These preliminary results indicate that iodine-ethanol has the potential to be used widely in vertebrate paleontology to improve CT imaging of fossilized tissues. Research Highlights We immersed the partial ankle joint of a fossil bird from the Miocene of China into solutions of iodine-ethanol. The CT contrasts of the fossilized bony trabeculae and the calcified cartilage were positively enhanced; in a reversible and non-destructive manner.
研究领域:
古生物学
·
医学影像学
✓ 已验证
DOI
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Jinmei Song,Yuhong He,Haijing Hu,Mingbian Li,Chenglong Li,Bai Yang,Haotong Wei
Computed tomography (CT) imaging has emerge as an effective medical diagnostic technique due to its rapid and 3D imaging capabilities, often employing indirect imaging methods through scintillator materials. Arraying scintillators that can confine light scattering to enable high-resolution CT imaging remains an area of ongoing exploration for emerging perovskite scintillators. Here an anti-scattering cesium lead bromide (CsPbBr 3 ) scintillator array embedded within a polyurethane acrylate matrix for CT imaging using a cost-effective solution-processed method is reported. Due to the large refractive index contrast between the scintillator and matrix, photon propagation can be well confined within the CsPbBr 3 scintillator array to significantly suppress the light scattering and enhance the light collection efficiency by nearly two times compared to the monolithic film. Furthermore, the scintillator array exhibits low-dosage and high-resolution CT imaging capability by reconstructing a 3D tooth image with a good spatial resolution of 20.1 lp cm −1 at a low effective dose of 0.22 mSv. This work highlights that the CsPbBr 3 scintillator array is a highly promising candidate for CT imaging.
研究领域:
医学影像
·
材料科学
·
放射学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMATERIALS
·
2012
·
IF 7.404
Han Wang,Linfeng Zheng,Chen Peng,Mingwu Shen,Xiangyang Shi,Guixiang Zhang
We report a new usage of folic acid-modified dendrimer-entrapped gold nanoparticles (Au DENPs-FA) as nanoprobes for in vitro and in vivo targeted computed tomography (CT) imaging of human lung adencarcinoma. In this study, Au DENPs prepared using amine-terminated generation 5 poly(amidoamine) dendrimers as templates were covalently linked with FA, followed by an acetylation reaction to neutralize the remaining dendrimer surface amines. The formed Au DENPs-FA was used for both in vitro and in vivo targeted CT imaging of human lung adencarcinoma cells (SPC-A1 cells) and the xenograft tumor model, which express folic acid receptors (FAR) verified by immunohistochemical staining. Micro-CT images show that SPC-A1 cells can be detected under X-ray after incubation with the Au DENPs-FA in vitro and the xenograft tumor model can be imaged after intravenous, intratumoral, and intraperitoneal administration of the particles. Transmission electron microscopy data confirm that the Au DENPs-FA is able to be uptaken dominantly in the lysosomes of the cells. Combined morphological observation of cells after Hematoxylin and Eosin staining, MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay of cell viability , and flow cytometric analysis of cell cycle and apoptosis show that the Au DENPs-FA does not affect cell morphology , viability, and cell cycle and apoptosis, indicating their good biocompatibility at the given concentration range. These findings suggest that the developed Au DENPs-FA have a great potential to be used as imaging probes for targeted CT imaging of human lung adencarcinoma.
研究领域:
医学影像学
·
纳米医学
·
肿瘤学
✓ 已验证
DOI
PubMed
高影响因子
Materials Research Express
·
2019
·Vol. 6
·期 9
·095005
·
IF 1.449
Hui-Li Zhu,Qing-Yuan Cheng,Mei-Yan Liao,Zhi-Ling Zhang,Wei-Guo Cai,Jiao-Jiao Ma,Meng-Ying Sun,Ming-Xia Yu,Zhi-Quan Tian,Dai-Wen Pang
Ultra-small Bi2S3 nanoparticles are potential contrast agents for high-sensitive CT imaging. However, the expensive and harmful synthesis process limited their further application. Herein, an economical and low-toxic process was developed by employing S powders as sulfur precursors for large-scale preparation of ultra-small Bi2S3 nanoparticles. The as-prepared ultra-small Bi2S3 nanoparticles were modified with amine-terminated poly(ethylene glycol) (PEG) to produce water-soluble contrast agents. In vitro experiment results suggested that the ultra-small Bi2S3-PEG nanoparticles were low cytotoxic and superior contrast agents. In vivo experiments demonstrated that the ultra-small Bi2S3-PEG nanoparticles were preferred contrast agents for long-term and high-sensitive CT imaging.
研究领域:
医学影像学
·
纳米医学
·
生物材料
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2025
·
IF 12.9
Yuping Zhang,Jianqi Deng,Mingbin Lang,Gang Shu,Jinbin Pan,Cai Zhang,Ran Cheng,Shao-Kai Sun
High atomic number elements-based X-ray computed tomography (CT) contrast agents offer a promising solution to address the inherent deficiencies of FDA-approved iodine contrast agents. However, they face substantial challenges in balancing imaging performance, safety, and large-scale production for clinical translation. Herein, inspired by the history of clinical gadolinium- and iodine-based contrast agents, we report a large-scale approach for synthesizing non-ionic bismuth (Bi) chelate for high-performance CT imaging in vivo . Bi-HPDO3A can be easily obtained from low-cost precursor within 4 steps at 6 g-scale. The non-ionic macrocyclic structure endows it with low osmolality, low viscosity, high stability, good renal clearable capability and biocompatibility. Additionally, Bi-HPDO3A realizes superior imaging performance across various in vivo applications, including gastrointestinal imaging, renal imaging, and computed tomography angiography (CTA). Especially, Bi-HPDO3A exhibits superior spectral imaging capability owing to the high K-edge of element Bi, achieving metal artifact-free CTA in vivo . The proposed Bi-HPDO3A that balances overall performance can serve as a high-performance CT contrast agent with potential for clinical translation.
研究领域:
医学影像学
·
放射医学
·
药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2017
·
IF 7.504
Yanyan Cui,Jian Yang,Qunfang Zhou,Ping Liang,Yaling Wang,Xueyun Gao,Yongtian Wang
Albumin-stabilized Ag nanodots (ANDs) are prepared by a one-step biomineralization method. The highly crystallized nanodots have ultrasmall sizes (approximately 5.8 nm) and robust X-ray attenuation (5.7313 HU per mM Ag). The unlabeled ANDs are directly excreted from the body via the urine after in vivo X-ray computer tomography (CT) imaging application. ANDs could be used as CT imaging agents and effective photothermal therapy agents. Tumor growth inhibition reaches 90.2% after photothermal treatment with ANDs. ANDs are promising tools for in vivo CT imaging and clearable near-infrared-triggered theranostic agents.
研究领域:
医学影像学
·
纳米医学
·
生物材料学
✓ 已验证
DOI
PubMed
高影响因子
Journal of Nanomaterials
·
2016
·
IF 1.758
Xiaochao Qu,Xiaoxiao Li,Jingning Liang,Yanran Wang,Muhan Liu,Jimin Liang
Gold nanomaterials as computed tomography (CT) contrast agents at lower X-ray dosage to get a higher contrast have advantages of longer imaging time and lower toxic side effects compared to current contrast agents. As a receptor for Cyclo (Arg-Gly-Asp-D-Phe-Lys) (RGD) peptide, integrin is overexpressed on some tumor cells and tumor neovasculature. In this paper, we conjugated the RGD peptide on the surface of gold nanorods (AuNRs), designated as RGD-AuNRs, a promising candidate in applications such as tumor targeting and imaging capability for micro-CT imaging. Integrin -positive U87 cells and integrin -negative HT-29 cells were chosen to establish animal models relatedly and then texted the tumor targeting ability and imaging capability of RGD-AuNRs in vitro and in vivo. The MTT assay and stability measurement showed that RGD-conjugation eliminated their cytotoxicity and improved their biocompatibility and stability. Dark-field imaging of U87 cells and HT-29 cells testified the binding affinities and uptake abilities of RGD-AuNRs, and the results showed that RGD-AuNRs were more specifical to U87 cells. The enhanced micro-CT imaging contrast of intramuscular and subcutaneous injection illustrated the feasibility of RGD-AuNRs to be contrast agents. Furthermore, the micro-CT imaging of targeting U87 and HT-29 tumor models verified the targeting abilities of RGD-AuNRs.
研究领域:
医学影像学
·
纳米生物学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
BIOMATERIALS
·
2016
·
IF 8.387
Ang Li,Xiang Li,Xujiang Yu,Wei Li,Ruyi Zhao,Xiao An,Daxiang Cui,Xiaoyuan Chen,Wanwan Li
In this work, we report a successful synthesis of copper bismuth sulfide nanorods (NRs) with broad and strong photoabsorption ranging from ultraviolet (UV) to near-infrared (NIR) wavelengths, which can be used as a 1064 nm-laser-driven photothermal agent with the photothermal conversion efficiency of 40.7%, noticeably higher than most of the reported PTT agents working in NIR-II window. The as-prepared PEGylated Cu 3 BiS 3 NRs were used as photoacoustic imaging (PAI) and CT imaging agents due to their strong NIR absorption and large X-ray attenuation coefficient of bismuth. We are the first to demonstrate that a small quantity of PEGylated Cu 3 BiS 3 NRs in tumors can concentrate radiation energy and trigger mild PTT under NIR-II irradiation and thus, these particles could be used as a novel, synergistic thermoradiotheraputic agent that enhances the efficacy of radiotherapy .
研究领域:
生物医学工程
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2016
·Vol. 63
·期 12
·977-984
·
IF 0.879
Rongjin Sun,Ting Yin,Peng Huang,Guo Gao,Joseph George Shapter,Yulan Shen,Jingjing Zhang,Daxiang Cui
In this paper, we report the development of a facile one-pot hydrothermal method for the controlled synthesis of monodispersed BaGdF 5 :Yb/Er nanoparticles for computed tomography (CT) and magnetic resonance (MR) imaging. The as-prepared nanoparticles have uniform size with a diameter of 20–25 nm. MTT tests show that the cell viability surpasses 90% even with a concentration of nanoparticles of 500 µg/mL, suggesting that the as-prepared BaGdF 5 :Yb/Er nanoparticles possess low toxicity. For both BaGdF 5 :Yb/Er nanoparticles and iopromide, the Hounsfield unit (HU) values increase with the their concentration. The slope of BaGdF 5 :Yb/Er nanoparticles is about 26.47, which is much higher than that of iopromide (16.98), indicating a better CT imaging effect. Interestingly, we find that the synthesized BaGdF 5 :Yb/Er nanoparticles exhibit paramagnetism. Our in vitro and in vivo imaging experiments demonstrate that the synthesized monodispersed BaGdF 5 :Yb/Er nanoparticles can serve as effective contrast agents for CT and MR imaging.
研究领域:
材料科学
·
医学影像学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）