AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
·
2025
·
IF 4.7
Jianing Li,Letian He,Wenling Wang,Siyu Wang,Dan Zhang,Liyun Liang,Guangping Song,Yijian Zhang,Shaoqing Yu,Lei Wang,Qiuying Han,Shaoyi Huang,Sen Li,Haiqing Tu,Zengqing Song,Huaibin Hu,Huiyan Li,Yang Yang,Min Wu
As the largest secondary lymphoid organ, the spleen plays a crucial role in initiating and sustaining immune responses against blood-borne pathogens through antigen capture and delivery. It is innervated by both autonomic and sensory nerves, which allows for neural modulation of its immune responses. The intricate spatial structure and precise coordination between immune and neural components is essential for proper splenic function, necessitating three-dimensional (3D) imaging to reveal its architecture. However, the dense fibrous capsule and exceptionally rich vasculature of the spleen pose significant challenges for achieving comprehensive 3D visualization of the entire organ. Here, we systematically evaluated and compared five cutting-edge tissue clearing approaches—ImmuView, FLASH, SHANEL, advanced CUBIC, and Ce3D—for their effectiveness in rendering the spleen transparent for multiplexed antibody staining and high-resolution 3D imaging. Our results indicated that SHANEL provided the clearest visualization of essential splenic neural and immune components. Meanwhile, advanced CUBIC achieved the greatest labeling efficacy for immune cells, albeit with slightly reduced transparency. Importantly, our study marked the first application of these optimized protocols to human spleen tissue, successfully revealing the highly organized immune cell zones and neural networks with enhanced clarity. Notably, we identified the nociceptive sensory innervation within human spleen tissue for the first time. Collectively, these findings establish optimal imaging strategies for visualizing splenic immune cells and neural structure in both murine and human tissues, providing profound insights into the intricate neuroimmune interactions and their pivotal roles in the immune functions of the spleen.
研究领域:
免疫学
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神经科学
·
医学影像学
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DOI
PubMed
高影响因子
CRYSTAL GROWTH & DESIGN
·
2023
·
IF 3.8
Xuefang Lu,Richeng Lin,Siqi Zhu,Xiaoyu Song,Cunhua Xu,Feng Huang,Wei Zheng
Boron isotope-containing semiconductors with many novel physical properties have attracted extensive research interest in the areas such as device thermal management, optical components, and neutron detection. However, the existence of strong intrinsic covalent bonding leads to the high-temperature and high-pressure growth conditions of the single crystals of B-compound semiconductors, which has been a great bottleneck limiting their development. Here, high-quality monoisotopic cubic 10BP single crystals at a millimeter scale of approximately 1 mm were grown by a multistep ripening method based on the gas–liquid–solid principle for crystal growth. Structural and morphological analyses have shown that the 10BP single crystals prepared by this method possess a single cubic phase and high crystalline quality. The isotopic effect gives rise to the shift of characteristic peaks in the Raman spectrum. Besides, results obtained through reflection spectrum, photoluminescence (PL), and theoretical calculations demonstrate that 10BP is a semiconductor with an indirect band gap beyond 2 eV. All of these findings can prove that the multipart maturation method is a feasible way to synthesize high-quality 10BP single crystals, which provides a novel and competitive route for the study of isotopic c-BP and the growth of large-sized crystals.
研究领域:
材料科学
·
半导体物理
·
晶体生长
·
同位素工程
·
光电子学
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DOI
高影响因子
BULLETIN OF MATERIALS SCIENCE
·
2024
·Vol. 47
·期 4
·1-9
·
IF 1.9
Xiao Changjiang,Zheng Haoyu,Tao Hongjun,Ma Jinming,Zhang qunfei,Tang Lihui
Polycrystalline cubic boron nitride (PcBN) composites were prepared through high-temperature and high-pressure (HTHP) sintering process. Cubic boron nitride (cBN) powders with particle sizes of 0.2, 1, 3, and 8 μm were selected as raw materials, and Al-Co-TiN was employed as a binder. The effect of particle size of initial cBN powders on the microstructure, relative density, flexural strength, microhardness, fracture toughness and abrasive ratio of sintered PcBN composite were systematically studied. The results showed that synthesized products were mostly made of cBN, TiN, AlN, TiB 2 and CoN phases. The mechanical properties of sintered PcBN composites first increased and then decreased with a reduction in the particle size of cBN powders. When the particle size of initial cBN powder was 1 µm, the binder was observed to be evenly distributed around the cBN grains in the sintered product. Moreover, there was a close bonding between cBN grains and the binder in the sintered product when the particle size of initial cBN powders was 1 µm, consequently, the optimal mechanical properties were achieved. The maximum values for relative density, flexural strength, microhardness, fracture toughness and abrasive ratio were 99.1%, 607 MPa, 47.06 GPa, 6.52 MPa·M 1/2 and 7125, respectively.
研究领域:
材料科学
·
机械工程
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DOI
高影响因子
CRYSTENGCOMM
·
2019
·Vol. 21
·期 9
·1389-1396
·
IF 3.382
Zhuo Chen,Lvming Dong,Hanchuan Tang,Yan Yu,Lei Ye,Jianfeng Zang
One-dimensional all-inorganic halide perovskites have emerged as one of the most prominent materials in the application of optoelectronic devices due to their remarkable properties such as a low number of defects, morphological anisotropy, mechanical flexibility and fast charge transfer capability. Particularly, cubic (α) phase CsPbI3 has the narrowest band gap of 1.73 eV among all-inorganic lead halide perovskites, exhibiting the greatest potential in solar cell applications. However, the direct synthesis of room temperature stabilized α-CsPbI3 nanowires is challenging and remains unfulfilled because the synthesis reaction usually involves a phase change process, resulting in an undesired orthorhombic (δ) phase with a wider bandgap of 2.82 eV. Here, we report a low-temperature approach to directly synthesize highly stabilized α-CsPbI3 nanowires. Low reaction temperature, capping ligand protection, and extended growth time are employed to successfully grow α-CsPbI3 nanowires. The as-synthesized α-CsPbI3 nanowires are 10–20 μm in length and 5–80 nm in diameter. The X-ray diffraction (XRD), photoluminescence (PL), and UV-vis absorption results verify that these cubic phase nanowires maintain excellent stability at room temperature for 90 days. The CsPbI3 nanowires show a PL peak located at around 685 nm and the UV-vis absorption spectrum further reveals that the band gap is about 1.77 eV. The excellent optical properties of the phase-stable CsPbI3 nanowires offer great potential in the field of optoelectronic devices.
研究领域:
材料科学
·
光电子学
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DOI
高影响因子
CHEMISTRY OF MATERIALS
·
2014
·
IF 8.535
Junli Wang,Weiling Fan,Juan Yang,Zulin Da,Xiaofei Yang,Kangmin Chen,Huan Yu,Xiaonong Cheng
First-order solid–solid phase transition of crystalline solids at the nanoscale has attracted an increasing interest in solid-state physics and chemistry, which can be used to alter the properties of materials without changing chemical compositions. Herein, we report the results of our comparative studies on phase transitions between tetragonal (t), orthorhombic (β), and cubic (α) polymorphs in Ag2Se nanocrystals. A significant discrepancy in stability and phase transition behavior is determined for t-Ag2Se nanocrystals, which were prepared separately by two different methods. Differential scanning calorimetry (DSC) and variable-temperature XRD studies reveal that the t-Ag2Se nanocrystals prepared by the oleylamine (OLA)-mediated method show a highly temperature- and time-sensitive metastability and undergo a t → β → α → β phase transition during the thermal cycling, in which the t → β transition is exothermic and irreversible, whereas the β → α transition is reversible. Similarly, the reversible β → α structure transition is detected in the β-Ag2Se nanocrystals, which were also prepared using the OLA-mediated method with different post-treatment manners and stabilized conditions. In contrast, the t-Ag2Se nanocrystals prepared by the PVP-assisted solvothermal method are more stable and exhibit a direct, reversible t → α phase transition without undergoing the β phase; however, when heated to a high temperature, for example, ≥250 °C, the stability of the t phase and the reversibility of the t → α transition will be destroyed due to the sintering and size increase of the sample, which is confirmed by the determination of the t → α → β phase transition in the DSC cycle. The formation of the t phase is attributed to the α → t structure transformation with the temperature cooled from synthetic temperatures (160–220 °C) to room temperature. Moreover, the reasons for the difference in the stabilities and phase transitions of t-Ag2Se nanocrystals prepared in our two methods are discussed based on the influences of size, surface (or shape), and defects on the thermodynamics and kinetics of a solid–solid structure transformation.
研究领域:
材料科学
·
纳米技术
·
固体化学
·
相变
·
热力学
·
晶体学
✓ 已验证
DOI
高影响因子
Nano Research
·
2020
·Vol. 13
·期 7
·1920-1927
·
IF 8.183
Chan Yat Tung,Siddharth Kumar,Shao Minhua
As a promising fuel candidate, ammonia has been successfully used as anode feed in alkaline fuel cells. However, current technology in catalysts for ammonia electro-oxidation reaction (AOR) with respect to both cost and performance is inadequate to ensure large scale commercial application of direct ammonia fuel cells. Recent studies found that alloying Pt with different transition metals and controlling the morphology of catalysts can improve the AOR activity, and thus potentially can solve the cost issue. Herein, (100)-terminated Pt-M nanocubes (M = 3d-transition metals Fe, Co, Ni, Zn) are synthesized via wet-chemistry method and their catalytic activities toward AOR are evaluated. The addition of Fe, Co, Ni and Zn elements can enhance the AOR activity due to decrease in oxophilicity of platinum and bifunctional mechanism. Pt-Zn exhibits the maximum mass activity and specific activity with values of 0.41 A/mg Pt and 1.69 mA/cm 2 that are 1.6 and 1.8 times higher than Pt nanocubes, respectively. Pt-Fe, Pt-Co and Pt-Ni nanocubes also illustrate higher mass and specific activities compared to Pt nanocubes.
研究领域:
材料科学
·
电化学
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DOI
高影响因子
Asian Journal of Pharmaceutical Sciences
·
2017
·Vol. 12
·期 6
·580-585
·
IF 0
Shijie Wei,Jingbo Ren,Ning Li,Wuzhen Huo,Chongkai Gao
An LCC delivery system for Fenofibrate (Fen) was developed to improve its poorly oral bioavailability. Fen-LCC preparation methods were screened, and the prepared Fen-LCC was then characterized by a polarizing microscope and transmission electron microscopy (TEM). The spray drying technique was selected to dry and solidify particles into powder. The in vitro release of Fen-LCC was measured and in vivo pharmacokinetic experiments were carried out on rats after oral administration. Particles prepared through the high-temperature input method exhibited structural characteristics of LCC, and re-dissolved particles maintained the same features. The LCC delivery system can significantly improve in vitro release outcomes. After oral administration, AUCs of the suspension and LCC systems were measured at 131.6853 µg⋅h/ml and 1435.72893 µg⋅h/ml, respectively. The spray drying process presented here better maintains cubic structures, and the LCC system significantly improves bioavailability levels.
研究领域:
药剂学
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药物递送系统
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纳米医学
·
药代动力学
·
药物代谢
✓ 已验证
DOI
ACS Applied Energy Materials
·
2022
·
IF 6.959
Dong Xie,Yi Chang,Tao Liu,Zhili Li,Jun Luo
Owing to their superior plastic deformability and tunable electrical and thermal transport properties, semiconducting silver chalcogenides exhibit unique advantages in the application of flexible thermoelectrics. In this work, we report the discovery of ductile Ag2S0.4(Se0.6Te0.4)0.6 with a cubic structure. Due to the alloying effect, the high-temperature body-centered cubic structure is stabilized at room temperature for Ag2S0.4(Se0.6Te0.4)0.6, which is of vital importance for practical applications. The cubic Ag2S0.4(Se0.6Te0.4)0.6 shows plastic deformability comparable to that of α-Ag2S, while the dimensionless thermoelectric figure of merit zT is only ∼0.06 due to its overhigh carrier concentration. A small amount of excessive Se [Ag2S0.4(Se0.6Te0.4)0.6 + ySe (y = 0, 0.02, 0.03, 0.04, 0.05)] is added to reduce the carrier concentration and improve the thermoelectric properties. Owing to the effectively optimized carrier concentration, the thermoelectric power factor of the sample with y = 0.04 reaches 6.2 and 7.5 μW cm–1 K–2 at, respectively, 300 and 350 K, showing promising potential for near-room-temperature applications. Combined with the decreased total thermal conductivity, the zT values of the samples with y = 0.04 and 0.05 reach ∼0.3 at 300 K, which is five times that of Ag2S0.4(Se0.6Te0.4)0.6. This study provides helpful guidance for the design of ductile silver chalcogenide semiconductors with stable and improved thermoelectric properties.
研究领域:
材料科学
·
热电学
·
无机化学
·
半导体
·
柔性电子学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 74
·70124-70132
·
IF 3.289
T. M. Chen,J. Xiao,G. W. Yang
Inorganic artificial enzymes have been developed as potential candidates to naturally occurring enzymes, and three inorganic enzyme mimics, noble metals, metal oxides and carbon materials, have been reported so far. Here, we reported the inorganic enzyme mimic of nitride-based materials. We demonstrated that cubic boron nitride (c-BN) as an enzyme mimic showed intrinsic peroxidase-like activity towards classical colorimetric substrates in the presence of hydrogen peroxide (H2O2). The Michaelis–Menten kinetics studies indicated that the catalytic efficiency of c-BN is superior to its natural peroxidase counterparts. We also established that the peroxidase-like activity of c-BN is induced by catalyzing the decomposition of H2O2 and generating hydroxyl radicals (˙OH). Based on the color reaction, a strategy was developed for H2O2 and glucose quantitative detection with high sensitivity. A reactor was constructed by entrapping c-BN in a porous platform and the peroxidase mimic immobilization for removal of organic pollutants was successfully conducted. Additionally, c-BN can be re-used up to 5 times and retain its catalytic activity after incubation at extremes of pH and temperature. These findings open the door for the application of c-BN as a catalyst and the development of nitride-based materials in the enzyme-mimics field.
研究领域:
材料科学
·
生物催化
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xiaobing Jili,Libin Gao,Jinxu Liu,Minghao Liu,Bowen Deng,Hongwei Chen,Jihua Zhang
The multi-layer ceramic capacitor (MLCC) is prepared with Bi 1.5 MgNb 1.5 O 7 (BMN) pyrochlores, which has medium dielectric constant, large dielectric tunability, and especially the very small dielectric loss. The multilayer ceramic capacitors with Bi 1.5 MgNb 1.5 O 7 as the dielectric material are prepared by a tape-casting method. The dielectric constant of the BMN thick film was observed to be superior to that of the bulk material, indicating its potential application in electronic devices. The increase in dielectric constant during the preparation of multilayer ceramic capacitors was explained by investigating the interdiffusion between the ceramic thick films and the electrodes. The BMN thick films and Ag 0.7 /Pd 0.3 electrodes showed a dense microstructure and serial interfaces when sintering at 1050 °C for 1.5 h. The capacitor exhibited good temperature stability with a dielectric constant temperature coefficient of −249.94 ppm/°C, a relative dielectric constant of 216, and a dielectric loss of 0.00036. Provides insights for the development and optimization of high-performance dielectric tunable electronic device.
研究领域:
材料科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
RARE METAL MATERIALS AND ENGINEERING
·
2016
·
IF 0.236
Guo Haiying,Jiao Tifeng,Zhang Qingrui,Li Adan,Gao Faming
A simple hydrothermal synthesis method has been designed for the controllable synthesis of cubic α -Fe 2 O 3 nanoparticles. Structural and morphological characterizations of the synthesized products were investigated by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction (XRD). The size range of the cubic α -Fe 2 O 3 particles is 130–150 nm. Results indicate that the α -Fe 2 O 3 nanoparticles can be used as an efficient photocatalysts for photocatalytic degradation of Rhodamine B in the presence of hydrogen peroxide, which may provide the design and development of high-efficiency visible-light photocatalysts for removing toxic dyes from industrial wastewater with a new way and basis.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
SOLID STATE SCIENCES
·
2018
·
IF 1.861
Kun Chai,Hongyi Li,Mingyuan Zhu,Bin Dai
By the introduction of Rb + with large ionic radius and rigid SiO 4 unit into borate , a noncentrosymmetric crystal, RbBSi 2 O 6 polymorph has been obtained. Its structure was determined by single crystal X-ray diffraction technique , and it can be described as a three dimensional (3D) framework constructed by the Si/BO 4 tetrahedra via corner-sharing O atoms, the Rb atoms reside in the tunnels and large cavities of the 3D framework. In addition, the optical properties of RbBSi 2 O 6 and CsBSi 2 O 6 , including IR spectra , UV–Vis–NIR diffuse reflectance spectra, have been reported in this work. Both RbBSi 2 O 6 and CsBSi 2 O 6 reveal short deep ultraviolet (UV) cutoff edges (below 180 nm and 185 nm, respectively), so they may have potential application in deep UV fields. Furthermore, the first-principle theoretical studies on band structure and density of states have also been performed for RbBSi 2 O 6 .
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DOI
高影响因子
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