DESALINATION
·
2024
·
IF 8.3
Jiayu Luo,Zhengshuo Zhan,Yang Lei
Electrochemically mediated precipitation is promising for cooling water softening. However, the performance of this strategy is limited by the requirement of sufficient cathode surface area. To overcome this limitation, we propose using three-dimensional (3D) cathodes, which provide more deposition sites than two-dimensional (2D) cathodes under the same dimension. We systematically evaluated the softening performance of the 3D cathode as a function of applied current density, electrode spacing, electrode size , and Ca 2+ /HCO 3 − molar ratio in water samples. The results suggest both cathode size and current intensity affect softening performance, while a lower electrode gap reduces cell voltage and energy consumption without lowering softening performance. In actual phosphonates containing cooling water, electrochemical softening with 3D Ni foam removes 65.5% Ca and 35.5% Mg in 8 h electrolysis at 80 A/m 2 . We further confirmed the long-term stability of 3D system over 100 days of continuous flow operation with >50% hardness removal from synthetic solutions. The cell voltage remains relatively stable despite pronounced scaling deposition (up to 2 cm thickness). Collectively, the 3D foam cathode greatly enhances the softening performance and ensures long-term operation without maintenance. These findings are expected to provide valuable insights for the future scaling-up of 3D electrodes in water softening.
研究领域:
环境工程
·
水处理
·
电化学
✓ 已验证
产品关联
DOI
高影响因子
Case Studies in Thermal Engineering
·
2023
·
IF 6.8
Huan Li,Xiaoyang Yu,Ke Qiu,Bing Bo,Qian Li,Shouxiang Lu
The active ingredients for aqueous film-forming foam (AFFF) are supplied as a concentrate, and the water used to dilute AFFF concentrates generally come from water sources around the fire site including seawater and river water. However, the effects of salt in water on fire-extinguishing performance of AFFF remain unclear. In this paper, we investigated the relationship between the interfacial properties, foam stability, and fire-extinguishing performance of three homemade AFFFs (nonionic AFFF APG , amphoteric AFFF CAB and anionic AFFF SDS ) and four commercial AFFFs. The seawater, firefighting water from different regions of China and deionized water were used to dilute AFFF concentrates. The results showed that AFFF APG and AFFF CAB had a better performance than AFFF SDS in resisting the negative effects of salts on interfacial properties and foaming ability. In the fire-extinguishing tests, we found that dilution of AFFF with water samples containing high concentrations of Ca 2+ and Mg 2+ would weaken the fire-extinguishing performance. The traditional indicators characterizing the properties of foam (surface tension, liquid drainage rate, and spreading coefficient) could not explain the trend of fire extinguishing performance. The stability of AFFF in the presence of oil could be used to explain the difference in fire-extinguishing time of AFFF.
研究领域:
火灾科学
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化学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2021
·
IF 7.514
Zhiwen Qi,Xingying Xue,Hao Zhou,Hua Yuan,Wenjun Li,Guliang Yang,Pujun Xie,Chengzhang Wang
To valorise olive mill wastewater phenols (OPs) potentially applied in food preservation, a novel stable and regularly spherical OPs-AgNPs ( D avg = 78 nm) were successfully assembled in aqueous solution under the optimized conditions (pH 8.0, 5 mM AgNO 3 , 35C and 30 min). The results of antimicrobial zone diameters indicated that 50 μg/mL of promising OPs-AgNPs presented excellent antimicrobial effects. Especially, the cell wall damages of E. coli ATCC 23,815 were caused when OPs-AgNPs concentration was exceeded its MIC (8.58 μg/mL). Also, a significant down-regulating of the Ca 2+ -ATPase activity in E. coli was revealed, and the intracellular Ca 2+ concentrations were thus decreased from 12.5 to 1.35 µg/mL after a treatment for 3 h. The apoptosis level of E. coli was significantly increased more than the control (55.13% of OPs-AgNPs vs 9.90% of control). In sum, OPs exerts enhanced antimicrobial function via penetrating cell membrane and targeting Ca 2+ -ATPase after chelated with AgNPs.
研究领域:
环境科学
·
材料科学
·
微生物学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
PLoS One
·
2018
·Vol. 13
·期 5
·e0197934
·
IF 2.766
Xi Chen,Long-Yun Li,Jin-Lan Jiang,Kai Li,Zhen-Bo Su,Fu-Qiang Zhang,Wen-Jing Zhang,Guo-Qing Zhao
In this study, we investigated the relationship between propofol and autophagy and examined whether this relationship depends on ER stress, production of ROS (reactive oxygen species), and disruption of calcium (Ca 2+ ) homeostasis. To this end, we measured C2C12 cell apoptosis in vitro , along with Ca 2+ levels; ROS production; and expression of proteins and genes associated with autophagy, Ca 2+ homeostasis, and ER stress, including LC3 (microtubule-associate protein 1 light chain 3), p62, AMPK (adenosine 5’-monophosphate (AMP)-activated protein kinase), phosphorylated AMPK, mTOR (the mammalian target of rapamycin), phosphorylated mTOR, CHOP (C/BEP homologous protein), and Grp78/Bip (78 kDa glucose-regulated protein). We found that propofol treatment induced autophagy, ER stress, and Ca 2+ release. The ratio of phosphorylated AMPK to AMPK increased, whereas the ratio of phosphorylated mTOR to mTOR decreased. Collectively, the data suggested that propofol induced autophagy in vitro through ER stress, resulting in elevated ROS and Ca 2+ . Additionally, co-administration of an ER stress inhibitor blunted the effect of propofol.
研究领域:
药理学
·
细胞生物学
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分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
IET Nanobiotechnology
·
2023
·
IF 2.3
Xiu Han,Yan Lu,Zhaoluo Xu,Yanan Chu,Xueping Ma,Haiping Wu,Bingjie Zou,Guohua Zhou
Currently, organic solvents are necessary for the preparation of anionic liposomes for siRNA delivery. The removal of organic solvent is time-consuming and the residual organic solvent is not only a hidden danger, but also affects the stability of anionic liposomes. Glycerol, which is physiologically compatible and does not need to be removed, is used to promote the dispersion of lipids and the formation of anionic liposomes. Additionally, the preparation process is simple and not time-consuming. The results showed that anionic liposomes, which were typically spherical with a particle size of 188.9 nm were successfully prepared with glycerol. And with the help of Ca 2+ , siRNA was encapsulated in anionic liposomes. The highest encapsulation efficiency at 2.4 mM Ca 2+ reached 91%. And the formation of calcium phosphate could promote the endosomal escape of siRNA effectively. The results from cell viability showed that the anionic liposomes had no obvious cytotoxicity. It was also verified that anionic liposomes could improve the resistance of siRNA against degradation. Additionally, siRNA delivered by anionic liposomes could play an effective role in knockout. Therefore, anionic liposomes prepared with glycerol will be a safe and effective delivery platform for siRNA and even other nucleic acid drugs.
研究领域:
药剂学
·
纳米技术
·
药物递送系统
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of the Taiwan Institute of Chemical Engineers
·
2018
·
IF 3.849
Jie Gao,Lizhe Yang,Yingying Liu,Fengli Shao,Qianjiahua Liao,Jingge Shang
Nano scale zerovalent iron (nZVI) used in waste water treatment can be more effective when modified with sulfur. In this study, we synthesized biochar-supported sulfide-modified nZVI (S-nZVI/BC) and characterized it using X-ray diffraction, X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. Our results reveal that sulfidation resulted in the formation of FeS on the surface of S-nZVI/BC. The Cr(VI) removal efficiency and capacity of the above composite were investigated as a function of initial solution pH/Cr(VI) concentration, reaction time, and presence of background ions (Ca 2+ and SO 4 2– ). Batch experiments revealed that solution pH had a significant impact on Cr(VI) removal capacities, with the maximum observed at pH 2.5. From a kinetic viewpoint, Cr(VI) removal was best described by a pseudo-second-order model. Importantly, the scavenger reaction was significantly promoted in the presence of SO 4 2– , being slightly inhibited by Ca 2+ and dissolved oxygen. Thus, the sulfidised nanohybrids exhibited excellent Cr(VI) removal performance, being well suited to the remediation of Cr(VI)-polluted water.
研究领域:
环境科学
·
材料科学
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Colloid and Interface Science Communications
·
2022
·
IF 5.633
Yong-Hong Gao,Kuo Zhang,Meng-Ru Ding,Xue-Feng Gong,Hui Cao,Lei Wang
Binding-induced fibrillogenesis (BIF) peptides have a promising future in biomedicine due to the processiblity in situ in vivo, which bind to a specific trigger and in situ self-assemble into nanofibrous structures (BIF process) with excellent physical/biological functions. Alkyl chains in BIF peptides as hydrophobic tails have an important effect on self-assembly behaviors of BIF peptides. Herein, BIF peptides (trigger: Ca 2+ or integrin) with different hydrophobic alkyl chains are designed to explore the influence of hydrophobicity on self-assembly behaviors of BIF peptides (Abbreviation as BIF 4 , BIF 8 , and BIF 16 for 4, 8, 16 carbons of alkyl chains). It is found that BIF peptides with weak hydrophobicity (BIF 4 ) do not form fibrous structure upon binding to Ca 2+ , but in nanoparticle formulation. While with strong hydrophobicity, BIF 16 initially self-assemble into nanoparticles, which further bind to Ca 2+ and self-assemble into nanofibers with a β-sheet conformation. As a result, when incubated with HUVECs overexpressing integrins on surfaces, BIF 4 were internalized as nanoparticles without BIF process, but BIF 16 performed BIF process and attached on cell surfaces. This study provides experimental evidences of the hydrophobicity effect on self-assembly behavior of BIF peptides and directs applications of BIF peptides with controllable self-assembly
研究领域:
生物物理学
·
纳米技术
·
生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Materials Technologies
·
2023
·
IF 6.8
Yang Song,Qiang Zhang,Yuxuan Li,Jiaxu Lin,Jin-Ming Lin
The loss of plasma membrane integrity poses a serious threat to cells, and the plasma membrane repair mechanism is vital to cell survival. To investigate the plasma membrane repair mechanism, a method for causing controllable plasma membrane injury on single cells and the visualization of the plasma membrane repair process are proposed. A microregion with harmful chemicals is created by open microfluidic probe, which is applied to target single cells for injury. The injury time is precisely controlled by simply moving the target cells in and out of the microregion. Wound-repair process caused by injury is analyzed by fluorescence imaging in real time, revealing the repair kinetics at the single cell level. Using this method, the effect of external conditions (Ca 2+ , Mg 2+ , glucose) on plasma membrane repair in single cells is studied and the dynamics of intracellular species (Ca 2+ ) is monitored. Meanwhile, cellular heterogeneity of plasma membrane repair is revealed. This method provides a precise way to induce chemical plasma membrane injury at the single-cell level, which is a promising tool to study the mechanism of plasma membrane repair.
研究领域:
细胞生物学
·
生物物理学
·
微流控技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Ruijun Zhang,Wenqian Zhu,Jiayu Tian,Shanshan Gao,Bart Van der Bruggen
Reverse osmosis is an effective seawater desalination way extending the available sources of fresh water, but challenged by the gypsum scaling. Herein, D (+)-glucosamine (DGA) was rationally selected and utilized to prepare a novel polyesteramide (PEA) NF membrane that can reject SO 4 2− but release Ca 2+ . Then it was employed in the pretreatment of seawater reverse osmosis to spatially isolate SO 4 2− and Ca 2+ , thus removing the “foundation” for forming gypsum. Compared to the referenced NF270, the optimized sample denoted as DGA-PEA-NF has a looser structure with stronger negative charge, as well as a higher resistance to both organic fouling and chlorine attack. During the pretreatment of seawater, both the water permeability and SO4 2− /Ca 2+ selectivity of the DGA-PEA-NF membrane were much higher than those of NF270; the seawater permeance and SO 4 2− /Ca 2+ selectivity of DGA-PEA-NF were 10.25 L m −2 ·h −1 ·bar −1 and 7.62, respectively, while those of NF270 were only 5.11 L m −2 ·h −1 ·bar −1 and 2.08. Consequently, the DGA-PEA-NF membrane effectively reduced the gypsum scaling both in NF and RO stages rather than just transferring the fouling problem forwards to NF stage. The implementation of this research is expected to provide guidance for a targeted fabrication of NF membranes, as well as support for the sustainable development of seawater desalination.
研究领域:
材料科学
·
环境工程
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2021
·
IF 7.328
Yujie Zhang,Chuanfeng An,Yang Zhang,Haoyue Zhang,Abdullah Faqeer Mohammad,Qiao Li,Weijian Liu,Fei Shao,Jiayi Sui,Changle Ren,Kai Sun,Fang Cheng,Jia Liu,Huanan Wang
Cell microenvironment is a collection of dynamic biochemical and biophysical cues which functions as the key factor in determining cell behavior. Encapsulating single cell into micrometer-scale hydrogels which mimics the cell microenvironment can be used for single cell analysis, cell therapies, and tissue engineering. Here, we developed a microfluidics-based platform to engineer the niche environment at single cell level using alginate microgels crosslinked by different metal ions to regulate stem cell behavior for bone regeneration. Specifically, we revealed that Ca 2+ in the engineered microenvironment promoted osteogenic differentiation of encapsulated stem cells and substantially accelerated the matrix mineralization compared to Sr 2+ in vitro . However, the superior osteoinductive capacity of Ca 2+ compared with Sr 2+ led to comparable bone healing in a rat bone defect model. This attributed to Sr 2+ in microgels to inhibit the osteoclast activity and bone resorption after implantation. In summary, the present study demonstrates metal ions as a critical factor in the environmental cues to affect cell behavior and influence the efficacy of stem cell-based therapy in tissue regeneration, and provides new insights to engineer an expecting microenvironment for regenerative medicine.
研究领域:
组织工程
·
干细胞生物学
·
再生医学
·
生物医学工程
✓ 已验证
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2022
·Vol. 32
·期 38
·2204794
·
IF 19.924
Han Yang,Zheyan Qian,Jiajia Wang,Jianyou Feng,Chengqiang Tang,Liyuan Wang,Yue Guo,Ziwei Liu,Yiqing Yang,Kailin Zhang,Peining Chen,Xuemei Sun,Huisheng Peng
Electrophysiology and neurochemicals such as Ca 2+ , K + , and Na + on the cerebral cortex can synergistically reflect the neurophysiological states. Transparent electrodes have been reported to record electrocorticography (ECoG) and image Ca 2+ on the cerebral cortex surface. However, Ca 2+ imaging is unable to track extracellular changes correlated with neural activities such as anesthesia, and imaging techniques to monitor K + and Na + are yet unavailable. Here, a flexible multifunctional electrode (FME) based on carbon nanotube array is presented to record ECoG and extracellular ions of Ca 2+ , K + , and Na + . The FME exhibits both lower impedance and higher capacitance than that of conventional gold electrodes. It simultaneously shows stable ion-sensing performance and long-term biocompatibility. The FME realizes multi-model recording of ECoG and extracellular ions on the cerebral cortex surface of rats, providing an effective detection method for brain science.
研究领域:
神经科学
·
生物医学工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Food Bioscience
·
2018
·
IF 2.371
Guan Wang,Manman Liu,Liwei Cao,Jirawat Yongsawatdigul,Shanbai Xiong,Ru Liu
The effect of NaCl (0.1 − 3.0 M) on self-assembly of silver carp myosin at 4 °C was investigated in terms of microstructure, conformation, intermolecular interactions, and particle size distribution. During setting at 4 °C, the self-assembly of myosin showed an obvious concentration dependence. At low concentrations (<0.3 M), myosin assembled into filaments mainly through rod-rod ionic linkages, and showed significantly (P < 0.05) higher turbidity and lower solubility than at ≥0.3 M. The addition of NaCl (0.3 − 0.6 M) led to the extension and dissolution of myosin by interfering with electrostatic interactions. The myosin assemblies gradually became smaller and more uniform. The solubility and Ca 2+ -ATPase activity reached a maximum at 0.6 M NaCl. When the concentrations increased to >1.0 M, myosin further assembled into filaments dominated by hydrophobic interactions. Both rod-rod and head-head interactions contributed to the myosin filaments at high concentrations (1.0 − 3.0 M). The solubility and uniformity of the myosin assemblies decreased as the NaCl concentration increased from 1.0 to 3.0 M.
研究领域:
食品科学
·
蛋白质化学
·
生物物理学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）