INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Shenglong Shang,Yu Zheng,Luyao Wei,Jie Liu,Ping Zhu
Green and low carbon development has become an unstoppable mainstream of the global and forced a trend of developing biomass fibers with high performance. Alginate fiber is an important component of marine biobased fibers that has gained widespread interest recently. However, applications of alginate fiber are facing challenges because of its limited mechanical properties. Here, we developed a novel design to prepare structurally enhanced alginate fibers alginate fiber by constructing multiple Ca 2+ crosslinked and interpenetrating networks in alginate chains. Through the synergistic effect of two biocompatible polymers, the entanglement of alginate chains was improved and the viscosity was controlled at a certain level which would not affect the fiber forming. The as-spun alginate fibers without further stretching possess a breaking strength of 265.7 MPa, elongation at break of 19.6 %, outperforming most alginate fibers enhanced by adding reinforcement additives. Improving the intermolecular entanglement to enhance the mechanical properties paves a new way for fabricating high-performance alginate fibers.
研究领域:
生物材料
·
高分子科学
·
纤维素化学
·
生物医学工程
·
绿色化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2017
·Vol. 6
·期 4
·1403-1411
·
IF 8.867
Junwei Yang,Haian Xie,Hao Chen,Zhuqun Shi,Tao Wu,Quanling Yang,Chuanxi Xiong
Flexible and eco-friendly dielectric materials with high energy density and breakdown strength have promising applications in energy storage devices. Here, cellulose nanofibril/boron nitride nanosheet nanocomposite films were fabricated from 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized cellulose nanofibrils (TOCNs) and hexagonal boron nitride nanosheets (BNNSs) in aqueous dispersions. The obtained TOCN/BNNS nanocomposites were further cross-linked by immersion in aqueous CaCl2 solution to improve their properties. The maximum discharged energy density of the finally prepared composite film was 3.9 J cm−3 with only 4 vol% of BNNSs at 380 MV m−1, achieving greater enhancement than the neat TOCN film with a low energy density of 0.1 J cm−3 at 50 MV m−1. It is much higher than the previously reported highest energy density of biopolymer-based composites (0.81 J cm−3) and also higher than that of the commercially available best dielectric polymer BOPP (2 J cm−3). Moreover, the nanocomposite films exhibited excellent mechanical flexibility and significantly improved thermal stability (100 °C increase in thermal decomposition temperature).
研究领域:
材料科学
·
纳米技术
·
能源存储
·
复合材料
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Yanjun Yang,Mengli Yu,Yulin Mo,Yue Cheng,Bin Huang,Weilin Wang,Maomao Zhu,Xiaobin Jia,Liang Feng,Bing Yang
Licorice is not only a widely used food, but also a classic tonic Chinese medicine, which mainly contains glycyrrhiza polysaccharides (GP) and flavonoids with excellent anti-inflammatory and antioxidant pharmacological activities. In this study, a neutral homogeneous polysaccharide (GP1–2) was isolated from Glycyrrhiza uralensis Fisch. However, its gelation behavior and properties have yet to be comprehensively studied. In this study, a Ca 2+ cross-linked physical hydrogel based on neutral GP1–2 (GP1–2-Ca 2+ ) is fabricated. The ability of metal ions to cross-linked gelation with GP1–2 is explored with respect to the polysaccharide concentrations, ion species, and pH environments. The pH range of Ca 2+ cross-linked with GP1–2 to form hydrogel is 8 to 10, and the gelation concentration ranges from 20.0 % to 50.0 % w / v . Subsequently, the properties of the GP1–2-Ca 2+ hydrogels are investigated using rheological measurements, scanning electron microscopy, free radical scavenging, MTT assays, healing capability, and enzyme-linked immunosorbent assays. The results reveal that the structure of GP1–2 presents an irregular porous structure, however, the physical gel formed after cross-linking with Ca 2+ microscopically showed a globular porous structure with uniform distribution, suggesting that this structure characteristic may be used as a carrier material for drug delivery. Meanwhile, the GP1–2-Ca 2+ hydrogel also possessed extraordinary viscoelasticity, cytocompatibility, antioxidant properties, anti-inflammatory activity, and ability to promote wound healing. Furthermore, the potential of GP1–2-Ca 2+ hydrogels as drug delivery materials was validated by using rhein as a model drug for encapsulation, it is demonstrated that its cumulative release behavior of GP1–2-Ca 2+ is pH-dependent. All in all, this study reveals the potential application of natural polysaccharides in drug delivery, highlighting its dual roles as carrier materials and bioactive ingredients.
研究领域:
药学
·
材料科学
·
生物技术
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Huilin Chen,Ran Xu,Enyu Xu,Yan Chen,Chunyu Niu,Yin Chen
Polysaccharides have garnered significant attention as potential nanoparticle carriers for targeted tumor therapy due to their excellent biodegradability and biocompatibility . Polyguluronic acid (PG) is a homogeneous acidic polysaccharide fragment derived from alginate, which is found in brown algae , possesses excellent bioactivities, unique properties. This study explored the immunomodulatory activity of PG and developed PG-based nanogels through modified disulfide bonds and Ca 2+ dual crosslinking. We characterized their structure, assessed their drug-loading and release properties, and ultimately validated both the safety of the nanocarrier and the in vitro anti-tumor efficacy of the encapsulated drug. Results indicated that PG significantly enhanced the proliferative activity and phagocytosis of RAW264.7 cells while promoting reactive oxygen species (ROS) production and cytokine secretion. The study identified TLR4 as the primary receptor for PG recognition in RAW264.7 cells. Furthermore, PG-based drug-carrying nanogels were prepared, exhibiting uniform sizes of about 184 nm and demonstrating exceptional encapsulation efficiency (82.15 ± 0.82 %) and drug loading capacity (8.12 ± 0.08 %). In vitro release experiments showed that these nanogels could responsively release drugs under conditions of high glutathione (GSH) reduction, facilitating drug accumulation at tumor sites and enhancing therapeutic efficacy. This research not only expands the application of PG in drug delivery systems but also provides valuable insights into leveraging natural immunomodulatory polysaccharides as carriers for targeted drug delivery .
研究领域:
药学
·
纳米技术
·
免疫学
·
生物医学工程
·
药物递送
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）