ACS ES&T Engineering
·
2023
·
IF 7.1
Dazhong Yang,Qiuyue Ge,Xuezhen Feng,Ranhao Wang,Shangying Li,Wenfei Wei,Renji Zheng,Juan Zhang,Hong Chen
Herein, we developed a universal “soil for soil remediation” strategy to utilize soil resources for cation-/anion-type heavy-metal-contaminated soil remediation. The representative natural soils fetched from 12 different areas in China have been universally converted into Fe2O3-CAN (hydroxycancrinite) zeolite composite materials. Furthermore, we discover that due to the presence of exchangeable Na+ and OH– in CAN channels together with the intrinsic surface adsorption function of Fe2O3-CAN, Fe2O3-CAN holds distinctive cation/anion dual ion-exchange functions and strong adsorption capacity, which could synergistically remediate cation-/anion-type HM-contaminated soil. When 25 g/kg Fe2O3-CAN is added into Cd/As polluted soil (100–200 ppm), Cd2+ and AsO2– in soil could be immobilized simultaneously and the Cd/As bioaccumulation in the harvested vegetables is dramatically suppressed with reduction ratios of 48.1–67.0%, effectively reducing the HM enrichment in the phytosphere. Overall, this work confirms the high universality of Fe2O3-CAN synthesis using different types of natural soils and demonstrates that the as-synthesized Fe2O3-CAN composite material can be further effectively used for soil remediation. The “soil for soil remediation” strategy developed here could improve the flexibility and economy of soil remediation, which can be extended to a broad range of locations worldwide.
研究领域:
环境科学
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土壤学
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材料科学
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产品关联
DOI
高影响因子
INORGANIC CHEMISTRY
·
2025
·
IF 4.7
Hongwei Zheng,Xiaoming Wang,Chenchen Cao,Wen Li,Leiming Fang,Tianhui Liu,Hengwei Wei,Jiangbo Lu,Jie Su,Yingxia Wang,Zupei Yang,Huan Jiao
In this study, we synthesized the first CAN (cancrinite)-typed zeolite-like oxonitridosilicates, Ln5Ca9O2(SiNO3)[Si12N24] (Ln = La and Ce). The crystal structure of La5Ca9O2(SiNO3)[Si12N24] was determined through single-crystal X-ray diffraction (SCXRD) data and neutron powder diffraction (NPD) data refinement. The compound crystallizes in hexagonal space group P63mc (No. 186) with a = 12.9875(2) Å, c = 5.2072(1) Å, and Z = 1. The anionic framework of La5Ca9O2(SiNO3)[Si12N24] is entirely constructed from [SiN4] tetrahedra, forming larger-sized composite building units, t-can and t-ato. The Ca2+ cations in the t-can cage contribute to balancing the charge difference originating from N3– substitution for O2– in La5Ca9O2(SiNO3)[Si12N24], which was revealed by the charge density difference calculation. The Ce3+-doped La5Ca9O2(SiNO3)[Si12N24] shows a broad-band orange-red emission peaking at λ = 630 nm under UV light excitation.
研究领域:
材料科学
·
化学
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产品关联
DOI
PubMed
高影响因子
Antioxidants
·
2023
·Vol. 12
·期 3
·679
·
IF 7
Tong Zhu,Jingjing Song,Bin Gao,Junjie Zhang,Yabei Li,Zhaoyang Ye,Yuxiang Zhao,Xiaogang Guo,Feng Xu,Fei Li
Myocardial fibrosis progression and imbalanced redox state are closely associated with increased extracellular matrix (ECM) stiffness. Candesartan (CAN), an angiotensin II (Ang II) receptor inhibitor, has shown promising anti-fibrosis and antioxidant efficacy in previous cardiovascular disease studies. However, the effect of ECM stiffness on CAN efficacy remains elusive. In this study, we constructed rat models with three different degrees of myocardial fibrosis and treated them with CAN, and then characterized the stiffness, cardiac function, and NADPH oxidase-2 (NOX2) expression of the myocardial tissues. Based on the obtained stiffness of myocardial tissues, we used polyacrylamide (PA) gels with three different stiffness to mimic the ECM stiffness of cardiac fibroblasts (CFs) at the early, middle, and late stages of myocardial fibrosis as the cell culture substrates and then constructed CFs mechanical microenvironment models. We studied the effects of PA gel stiffness on the migration, proliferation, and activation of CFs without and with CAN treatment, and characterized the reactive oxygen species (ROS) and glutathione (GSH) levels of CFs using fluorometry and scanning electrochemical microscopy (SECM). We found that CAN has the best amelioration efficacy in the cardiac function and NOX2 levels in rats with medium-stiffness myocardial tissue, and the most obvious anti-fibrosis and antioxidant efficacy in CFs on the medium-stiffness PA gels. Our work proves the effect of ECM stiffness on CAN efficacy in myocardial anti-fibrosis and antioxidants for the first time, and the results demonstrate that the effect of ECM stiffness on drug efficacy should also be considered in the treatment of cardiovascular diseases.Keywords:myocardial fibrosis;candesartan (CAN);extracellular matrix (ECM);oxidative stress;scanning electrochemical microscopy (SECM)
研究领域:
心脏病学
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药理学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2020
·
IF 7.727
Yuan He,Zhuyifan Ye,Xinyang Liu,Zhengjie Wei,Fen Qiu,Hai-Feng Li,Ying Zheng,Defang Ouyang
Nanocrystals have exhibited great advantage for enhancing the dissolution rate of water insoluble drugs due to the reduced size to nanoscale. However, current pharmaceutical approaches for nanocrystals formulation development highly depend on the expert experience and trial-and-error attempts which remain time and resource consuming. In this research, we utilized machine learning techniques to predict the particle size and polydispersity index (PDI) of nanocrystals. Firstly, 910 nanocrystal size data and 341 PDI data by three preparation methods (ball wet milling (BWM) method, high-pressure homogenization (HPH) method and antisolvent precipitation (ASP) method) were collected for the construction of the prediction models. The results demonstrated that light gradient boosting machine (LightGBM) exhibited well performance for the nanocrystals size and PDI prediction with BWM and HPH methods, but relatively poor predictions for ASP method. The possible reasons for the poor prediction refer to low quality of data because of the poor reproducibility and instability of nanocrystals by ASP method, which also confirm that current commercialized products were mainly manufactured by BWM and HPH approaches. Notably, the contribution of the influence factors was ranked by the LightGBM, which demonstrated that milling time, cycle index and concentration of stabilizer are crucial factors for nanocrystals prepared by BWM, HPH and ASP, respectively. Furthermore, the model generalizations and prediction accuracies of LightGBM were confirmed experimentally by the newly prepared nanocrystals. In conclusion, the machine learning techniques can be successfully utilized for the predictions of nanocrystals prepared by BWM and HPH methods. Our research also reveals a new way for nanotechnology manufacture.
研究领域:
药学
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纳米技术
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人工智能
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产品关联
DOI
PubMed
高影响因子
FISH & SHELLFISH IMMUNOLOGY
·
2023
·
IF 4.7
Yihan Yu,Dandan Tian,Sanghyok Ri,Tongchol Kim,Kwangjin Ju,Jiongming Zhang,Shuangshuang Teng,Weixia Zhang,Wei Shi,Guangxu Liu
Although accumulating data demonstrated that gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter , plays an important regulatory role in immunity of vertebrates, its immunomodulatory function and mechanisms of action remain poorly understood in invertebrates such as bivalve mollusks . In this study, the effect of GABA on phagocytic activity of hemocytes was evaluated in a commercial bivalve species, Tegillarca granosa . Furthermore, the potential regulatory mechanism underpinning was investigated by assessing potential downstream targets. Data obtained demonstrated that in vitro GABA incubation significantly constrained the phagocytic activity of hemocytes. In addition, the GABA-induced suppression of phagocytosis was markedly relieved by blocking of GABA A and GABA B receptors using corresponding antagonists. Hemocytes incubated with lipopolysaccharides (LPS) and GABA had significant higher K + -Cl - cotransporter 2 (KCC2) content compared to the control. In addition, GABA treatment led to an elevation in intracellular Cl − , which was shown to be leveled down to normal by blocking the ionotropic GABA A receptor. Treatment with GABA A receptor antagonist also rescued the suppression of GABA A receptor-associated protein ( GABARAP ), KCC , TNF receptor associated factor 6 ( TRAF6 ), inhibitor of nuclear factor kappa-B kinase subunit alpha ( IKKα ), and nuclear factor kappa B subunit 1 ( NFκB ) caused by GABA incubation. Furthermore, incubation of hemocytes with GABA resulted in a decrease in cAMP content, an increase in intracellular Ca 2+ , and downregulation of cAMP-dependent protein kinase ( PKA ), calmodulin kinase II ( CAMK2 ), calmodulin ( CaM ), calcineurin ( CaN ), TRAF6 , IKKα , and NFκB . All these above-mentioned changes were found to be evidently relieved by blocking the metabotropic G-protein-coupled GABA B receptor. Our results suggest GABA may play an inhibitory role on phagocytosis through binding to both GABA A and GABA B receptors, and subsequently regulating corresponding downstream pathways in bivalve invertebrates.
研究领域:
免疫学
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分子生物学
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海洋生物学
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无脊椎动物生理学
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产品关联
DOI
PubMed
高影响因子
Cannabis and Cannabinoid Research
·
2023
·
IF 3.8
Mengxue He,Aiyang Liu,Jiachen Shi,Yong-Jiang Xu,Yuanfa Liu
Introduction: Cannabidiol (CBD) has important pharmacological activity, which includes antispasmodic, antioxidant, antithrombotic, and antianxiety properties. CBD has been applied as a health supplement to atherosclerosis. However, CBDs effect on gut microbiota and metabolic phenotype is unclear.Materials and Methods: We constructed a high production of cardiovascular risk factors, such as trimethylamine-N-oxide (TMAO) and phenylacetylglutamine (PAGln), in a mouse model using Clostridium sporogenes colonization. We used 16S ribosomal RNA (rRNA) gene sequencing and ultra-high performance liquid chromatography-quadrupole time-of flight mass spectrometry-based metabolomics to evaluate the effect of CBD on gut microbiota and plasma metabolites.Results: CBD decreased the levels of creatine kinase (CK), alanine transaminase (ALT), and low-density lipoprotein cholesterol and markedly increased high-density lipoprotein cholesterol. Furthermore, CBD treatment increased the abundance of beneficial bacteria, which include Lachnospiraceae_NK4A136 and Blautia in the gut, but it decreased the levels of TMAO and PAGln in the plasma.Conclusion: CBD might have beneficial effects for cardiovascular protection.
研究领域:
药理学
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微生物组学
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代谢组学
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产品关联
DOI
PubMed
高影响因子
ADVANCED MATERIALS
·
2025
·
IF 26.8
Tongtong Zhou,Yan Wang,Jiulong Zhou,Lifeng Yao,Ke He,Lixun Chen,Song Zhang,Hong Liu,Xiaodong Chen,Shuxun Cui
Inorganic hydrogels have great potential in many applications as sustainable materials, but lack flexibility due to rigid network structures. Here, a novel strategy is proposed—an inorganic polymer hydrogel, prepared by crosslinking long-chain polyphosphate (LPP) with M 2+ ions (Ca 2+ , Mn 2+ , Mg 2+ , Ni 2+ ), which effectively address the rigidity and fragility issues commonly associated with traditional inorganic gels. With the most stable hydration shell among those ions, Ni 2+ tends to interact indirectly with LPP through hydrogen bonds rather than coordination bonds. The unique Ni 2+ -phosphate interaction endows the Ni-LPP hydrogels with ultrahigh elongation at break (≈15 000×). Further experiments reveal that the Ni 2+ -phosphate motif can be applied to other hydrogels as an extension enhancement factor. The highly extensible, good conductive (1.06 ± 0.08 S m −1 ), self-healing (within 30 s and without stimulation), arbitrarily shapeable, and nonflammable Ni-LPP inorganic hydrogel indicates a bright future in flexible electronics, environmental remediation, and beyond.
研究领域:
材料科学
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高分子化学
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无机化学
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软物质物理
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柔性电子学
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环境修复
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2018
·
IF 6.735
Hao Zhang,Jianquan Luo,Sushuang Li,John M. Woodley,Yinhua Wan
The presence of micropollutants in water results in serious effects on public health and aquatic ecosystems. Biocatalytic membrane technology has shown great potential for micropollutant removal. However, the efficiency and stability still need to be further improved. In this work, we introduced graphene oxide (GO) and GO derivates into a biocatalytic membrane by reverse filtration and co-deposition methods respectively, in order to explore the role of GO in the biocatalytic membrane. The enrichment effect and catalytic functions of GO improved both the activity and stability of the laccase. Although the bisphenol A (BPA) removal efficiency was not promoted with such a GO-based biocatalytic membrane under flow-through mode, the incorporation of GO in the membrane increased the enzyme loading and its storage stability, which has great potential in BPA detection. Apart from offering a novel strategy to prepare GO-based biocatalytic membranes for micropollutant removal and detection, this work further clarifies the interaction mechanism between GO, laccase and micropollutants, especially in a polymeric membrane matrix.
研究领域:
环境科学
·
生物技术
·
材料科学
✓ 已验证
DOI
高影响因子
Environmental Technology & Innovation
·
2021
·
IF 5.263
Zhixu Lu,Xuezhu Li,Xianjin Qi
Most current arsenic(As(V)) removal technologies are designed for low-As(V) wastewater. Consequently, the efficacy of treating high-As(V) wastewater with these technologies is generally unsatisfactory. Here, the Cobalt(Co)-loaded resin removal of As(V) in wastewater and its mechanism are discussed. Rapid adsorption and a slow equilibrium were achieved during the reaction, and the As(V) removal efficiency exceeded 99% within 0–30 min with an initial As(V) concentration of 100 mg/L. The adsorption capacity of the Co-loaded resin was as high as 116 mg/g. The Co-loaded resin has the best As(V) removal efficiency when the pH = 8. The adsorption kinetics of the Co-loaded resin material revealed the adsorption behavior. FTIR and XPS studies showed that As(V) was removed on the Co-loaded resin material, and As(V) was primarily removal through ion exchange adsorption and chemical co-precipitation. Thus, this Co-loaded resin material provides a simple and effective means to remove As(V) from high-As(V) wastewater.
研究领域:
环境科学
·
化学工程
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产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 44
·期 1
·194-199
·
IF 3.069
Wenda Wang,Xuerong Fan,Qiang Wang,Jin Xu,Lili Wang,Lipeng Liu,Xueming Bao
In this communication, acrylamide (AM) polymerisation to poly(acrylamide) was initiated by horseradish peroxidase (HRP) and acetylacetone (ACAC) without hydrogen peroxide (H2O2). Electron spin resonance (ESR) spectroscopy showed that free radicals of ACAC and AM were present in the reaction. Gel Permeation Chromatography (GPC), FT-IR, 1H-NMR and relative viscosity indicated that the product was PAM. Furthermore, the enzymatic cycling mechanism of the HRP–ACAC–H2O2 ternary system was also explained.
研究领域:
生物化学
·
高分子化学
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产品关联
DOI
高影响因子
FIRE SAFETY JOURNAL
·
2023
·
IF 3.1
Ying Zhang,Chuyuan Ma,Menglin Yang,Dachao Yuan,Kaixuan Tang,Changwei Li,Binbin Mao
The flammability and melt dripping illustrate polymer's fire risk. The high-efficiency thermal shielding effect of carbon nanotubes has been widely concerned to improve polymer's flame retardancy. However, the high thermal conductivity and wick effect of carbon nanotubes may enhance heat and mass transfer to promote fire development. A series of experiments about ignition, heat release, horizontal flame spread and dripping behaviors were carried out to comprehensively analyze the fire risk of polymer composite including polymethyl methacrylate (PMMA) and multi-walled carbon nanotubes (MWCNTs). The results showed after the addition of MWCNTs, the limiting oxygen index (LOI) increased from 18% to 20%, the peak of heat release rate (PHRR) decreased from 548 kW/m 2 to 372 kW/m 2 , and the flame spread rate (FSR) increased from 0.28 mm/s to 1.1 mm/s, respectively. These results indicate that MWCNTs decreased the ignition risk of PMMA and its heat generation, however, the fire growth rate increased sharply. That was due to the thermal shielding effect and the heat and mass transfer effect of the char layer, respectively. Therefore, the effects of MWCNTs addition on the fire risk of polymer composites need a comprehensive assessment of multiple factors including the fire growth risk.
研究领域:
材料科学
·
消防安全
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产品关联
DOI
高影响因子
CHEMICAL SENSES
·
2023
·
IF 3.5
He Yue,Chen Jianshe,Shi Weiyao,Shi Jingang,Ma Tian,Wang Xinmiao
While accumulating evidence implied the involvement of retro-nasal sensation in the consumption of nonvolatile taste compounds, it is still unclear whether it was caused by the taste compounds themselves, and if so, how can they migrate from the oral to nasal cavity. At first, we proposed aerosol particles as an alternative oral–nasal mass transfer mechanism. The high-speed camera approved that aerosol particles could be generated by the typical oral and pharynx actions during food oral processing; while the narrow-band imaging of nasal cleft and mass spectrometry of nostril-exhaled air approved the migration of aerosol within the oral–nasal route. Then, the “smelling” of taste compounds within the aerosol particles was testified. The four-alternative forced choices (4AFC) approved that the potential volatile residues or contaminants within the headspace air of pure taste solution cannot arouse significant smell, while the taste compounds embedded in the in vitro prepared aerosol particles can be “smelled” via the ortho route. The “smell” of sucrose is very different from its taste and the “smell” of quinine, implying its actual olfaction. The sweetness intensity of sucrose solution was also reduced when the volunteers’ noses were clipped, indicating the involvement of retro-nasal sensation during its drinking. At last, the efficiency of aerosol as a mechanism of oral–nasal mass transfer was demonstrated to be comparable with the volatile molecules under the experimental condition, giving it the potential to be a substantial and unique source of retro-nasal sensation during food oral processing.
研究领域:
食品科学
·
感官科学
·
神经生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）