Ningning Dong,Lifa Ge,Pei Chen,Wei Wang,Fatang Tan,Xinyun Wang,Xueliang Qiao,Po Keung Wong
Stable, cheap and environmentally friendly CaO 2 was widely used to remediate environmental pollution, especially in advanced oxidation process (AOP) systems. However, its non-radical activation was still a huge challenge. In this study, the non-radical activation of CaO 2 nanoparticles was realized by MgNCN/MgO composites for efficient remediation of organic and heavy metal-contaminated wastewater. The presented CaO 2 -based AOP system exhibited excellent degradation performance towards tetracycline (TC) and methylene blue (MB) over a broad pH range, accompanied with the weak influences of common coexisting anions and natural water sources. Singlet oxygen ( 1 O 2 ) was verified as the dominant active species for organics degradation, and the coordination between MgNCN and MgO in MgNCN/MgO composites played a crucial role in the non-radical activation of CaO 2 nanoparticles. More importantly, the AOP system could not only degraded effectively organic pollutants, but also remove simultaneously heavy metal ions in wastewater. 100 mg/L CaO 2 and MgNCN/MgO could successfully remediate the complex pollution consisting of 10 mg/L MB and 100 mg/L Cd 2+ . Furthermore, the degradation intermediates of MB and the solid residues after treating pollutants were analyzed in detail to reveal the degradation process and conversion products.
Photodynamic therapy (PDT) has been rapidly developed as an effective therapeutic approach in clinical settings. However, hypoxia seriously limits the effectiveness of PDT. Here, we report a porphyrin-based metal–organic framework combined with hyaluronate-modified CaO2 nanoparticles (PCN-224-CaO2-HA) to target and enhance PDT efficacy. CaO2 reacts with H2O or weak acid to produce O2, overcoming the hypoxia problem. Hyaluronate protects CaO2 and specifically targets the CD44 receptor, which is highly expressed on tumor cell membranes, performing targeted therapy. After PDT treatment in vitro, the survival rates of 4T1 and MCF-7 tumor cells were 14.58% and 22.45%, respectively. The fluorescence imaging showed that PCN-224-CaO2-HA effectively aggregated in the tumor after 12 h of its intravenous injection into tumor-bearing mice. PCN-224-CaO2-HA exhibited efficacious tumor growth inhibition via enhanced PDT. Overall, this nanosystem providing in situ oxygen production was successfully used for targeted PDT with a significantly enhanced therapeutic efficacy in vitro and in vivo.
Tianqi Liu,Yanfang Sun,Guohua Jiang,Wenjing Zhang,Rui Wang,Lei Nie,Amin Shavandi,Khaydar E. Yunusov,Uladzislau E. Aharodnikau,Sergey O. Solomevich
Diabetes chronic wound is a severe and frequently occurring medical issue in patients with diabetes that often leads to more serious complications. Microneedles (MNs) can be used for wound healing as they can effectively pierce the epidermis and inject drugs into the wound tissue. However, common MN patches cannot provide sufficient skin adhesion to prevent detachment from the wound area. Inspired by the barb hangnail microstructure of porcupine quills, a porcupine quill-like multilayer MN patch with an adhesive back patching for tissue adhesion and diabetic wound healing was designed. Sodium hyaluronate-modified CaO 2 nanoparticles and metformin (hypoglycemic agent) were loaded into the polycaprolactone tips of MNs, endowing them with exceptional antibacterial ability and hypoglycemic effect. A flexible and adhesive back patching was formed by polyacrylamide-polydopamine/Cu 2+ composite hydrogel, which ensures that the MN patches do not peel off from the application sites and reduce bacterial infection. The bioinspired multilayer structure of MN patches exhibits satisfactory mechanical and antibacterial properties , which is a potential multifunctional dressing platform for promoting wound healing. Statement of significance The porcupine quill-like microneedles (MNs) with PAM-PDA/Cu 2+ (PPC) composite hydrogel back patching have been fabricated, which can enhance the adhesion property of MNs to the skin through a physical interlock of multilayer MNs and chemical bonding of hydrogel patching. CaO 2 -HA NPs and metformin were loaded into the polycaprolactone tips of MNs, endowing them with the exceptional antibacterial ability and hypoglycemic effect, which could accelerate diabetic wound healing. As a safe and effective strategy in transdermal delivery of drugs, the as-fabricated flexible multilayer MN patch with good antibacterial, hypoglycemic, and biocompatibility has been used to promote the healing of diabetic wound by releasing oxygen and inhibiting inflammation at the wound site.
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