SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2012
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IF 2.098
Lun Wang,Fei Yuan,Hong-Qi Chen,Bo Ling,Juan Xu
A novel flow injection nanocrystals (NCs) chemiluminescence (CL) analysis method has been established for the determination of estradiol, estriol and estrone based on the enhancement of CdTe NCs–KMnO 4 CL reaction catalyzed by sodium hexametaphosphate. Glutathione (GSH)-capped CdTe nanocrystals were synthesized in aqueous medium, and the CdTe NCs emitted at around 555 nm was selected as the light emitter in CdTe NCs–KMnO 4 chemiluminescence (CL) system. It has been found that sodium hexametaphosphate (SHMP) enhanced the CL of the CdTe NCs–KMnO 4 system and estrogens increased these CL signals again in near neutral solution. UV–visible spectra, photoluminescence (PL) spectra, transmission electron microscopy (TEM) and CL spectra were used to characterize CdTe nanoparticles and investigate the mechanism of the CL reaction. On the basis of the enhancement, a novel flow-injection CL method has been established for the determination of estrogens. Under the optimum experimental conditions, three linear relationships were obtained. The method described is simple, sensitive, and has been successfully utilized for the determination of estrogens in tap water samples.
研究领域:
分析化学
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环境科学
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生物医学
✓ 已验证
DOI
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 129
·106599-106606
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IF 3.84
Hucheng Zhang,Huili Wang,Kelu Du,Xinxin Ma,Jianji Wang
Assembling ultra-small nanoparticles into nanosized colloidal nanocrystal clusters (CNCs) to create novel collective properties still poses tremendous challenges. This work reports the fabrication of photoluminescent CdTe CNCs on the nanoscale and their thermo-responsive properties. Diblock copolymers of poly(N-(2-aminoethyl) acrylamide-b-N-isopropylacrylamide) (PNAEAM-b-PNIPAM) were synthesized and employed as self-assembling actuators of CNCs. The side chains of PNAEAM blocks act as efficient anchors to capture CdTe nanocrystals via surface ligand identification. The thermo-sensitive PNIPAM blocks serve as the protection layer of CNCs and the trigger to turn off/on the photoluminescence CNCs during heating/cooling cycles. The [HS–C10mim]+ ligands with smart noncovalent interactions on the as-prepared nanocrystals render the CNCs rapid and reversible thermo-response performances. These make the CNCs an excellent thermo-responser, and offer a new controllable self-assembly route for designing and engineering multifunctional nanosized CNCs.
研究领域:
材料科学
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纳米技术
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化学工程
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Xuwen Gao,Xiaoxuan Ren,Yaojia Ai,Mengwei Li,Bin Zhang,Guizheng Zou
Multiplexed gene assay for simultaneously detecting the multi-targets of nucleic acids is strongly anticipated for the accurate diseases diagnosis and prediction, and all commercial available gene assays for IVD are a kind of single-target assay. Herein, a dual-potential encoded and coreactant-free electrochemiluminescence (ECL) strategy is proposed for the multiplexed gene assay, which can be conveniently carried out by directly oxidizing the same luminescent tag of dual-stabilizers-capped CdTe nanocrystals (NCs). The CdTe NCs linked with sulfhydryl-RNA via Cd−S bond merely exhibits one ECL process around 0.32 V with a narrow triggering-potential-window of 0.35 V, while CdTe NCs linked with amino-RNA via amide linkage solely gives off one ECL process around 0.82 V with a narrow triggering-potential-window of 0.30 V. Multiplexing ECL of both sulfhydryl-RNA-functionalized CdTe NCs and amino-RNA-functionalized CdTe NCs can be utilized to simultaneously detect the open reading frame 1ab (ORF1ab) and the nucleoprotein (N) genes without crosstalk , in which ECL of sulfhydryl-RNA-functionalized CdTe NCs can dynamically determine ORF1ab from 200 aM to 10 fM with a limit of detection (LOD) of 100 aM, while ECL of amino-RNA-functionalized CdTe NCs can linearly detect N gene from 5 fM to 1 pM with a LOD of 2 fM. Post-engineering CdTe NCs with RNA in a labeling-bond engineering way would provide a potential-selective and encoded ECL strategy for multiplexed gene assay with one luminophore.
研究领域:
生物技术
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分析化学
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医学诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Progress in Natural Science-Materials International
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2021
·
IF 3.607
Jiaojiao Zheng,Bing Bai,Qiumei Di,Zhuoli Jiang,Meng Xu,Jiatao Zhang
In II-VI group, the doping in CdTe nanocrystals (NCs) is more difficult than other chalcogenides. In this communication, CdTe nanocrystals containing Cu impurities were carefully synthesized based on controlled reverse cation exchange process between as-prepared Cu 7 Te 5 nanocubes and Cd 2+ ions. By well-defined Cu 7 Te 5 nanocubes, the obtained CdTe NCs kept the original morphology. The concentration of Cu impurities in CdTe NCs was controlled by the regulation such reverse cation exchange. Additionally, the regulation from band gap (BG) photoluminescence (PL) to the coexistence of the bandgap emission, dopant emission, and surface-state emission was realized. This tailoring from undoped to doped emission in the case of Cu impurities is helpful to study the Cu related doping in telluride NCs.
研究领域:
材料科学
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纳米技术
✓ 已验证
DOI
高影响因子
Journal of the American Chemical Society
·
2025
·
IF 15.6
Shangxin Lin,Chuanzhong Yan,Jie Zhu,Yida Lu,Xiaogang Peng
With CdTe nanocrystals as a model system, we discover a new synthetic strategy for control of size and size distribution of colloidal semiconductor nanocrystals in both nucleation and growth stages. Especially in the nucleation stage, an in situ-formed cadmium complex with approximately one alkanoate and one alkylphosphonate ligand enables both high-yield nucleation by reacting the reactive cadmium-carboxylate bond with Te precursors and efficient size control by immediate passivation with the close-proximity alkylphosphonate ligand from the same complex. Conversely, control on size distribution during either homoepitaxial or heteroepitaxial growth requires reactive cadmium (or zinc) alkanoates as the cationic precursors with a minimum concentration of alkylphosphonate ligands in the novel synergistic solvents. This new strategy not only yields monodisperse CdTe and CdTe/ZnSe core/shell nanocrystals with unprecedented optical quality but also provides a much-needed alternative route for synthesizing monodisperse semiconductor nanocrystals, which is commonly hindered by the growth barrier of the dense ligand monolayer.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MATERIALS CHEMISTRY AND PHYSICS
·
2014
·
IF 2.129
Yongqiang Cao,Ning Liu,Ping Yang,Ruixia Shi,Qian Ma,Aiyu Zhang,Yuanna Zhu,Junpeng Wang,Jianrong Wang
The polyvinylpyrrolidone (PVP) hybrid luminescent micro-/nanofibers doped with the novel hybrid SiO 2 -coated CdTe nanocrystals (HS-CdTe NCs) have been fabricated for the first time via the electrospinning technique. The morphologies and photoluminescence (PL) emissions of HS-CdTe/PVP micro-/nanofibers prepared by doping the HS-CdTe NCs with the different PL peak wavelength (571, 616, and 643 nm) in PVP fibers were investigated by optical and PL microscope. The results revealed that all the HS-CdTe/PVP hybrid fibers showed an ultralong length for several hundreds of micrometers and a relatively uniform diameter of 1000 ∼ 1200 nm. The hybrid fibers displayed a wavelength-tunable PL emission, determining by the PL of doped HS-CdTe NCs. Moreover, similar to the original PL properties of HS-CdTe NCs before the electrospinning, the HS-CdTe/PVP fibers also showed a series of superior PL properties, such as narrow and symmetry PL spectrum, high, and uniform brightness. For comparison purpose, we also prepared three CdTe/PVP hybrid fibers by doping the 553 nm, 600 nm, and 633 nm PL-emitting CdTe NCs respectively in PVP electrospinning fibers. The characterization results showed that, the obtained three CdTe/PVP hybrid fibers had a basically satisfactory micro-/nanofiber morphology with a long length and relatively uniform diameter, but all the fibers exhibited very weak PL emissions. The enormous contrast in PL properties between HS-CdTe/PVP and CdTe/PVP fibers should mainly be ascribed to the different connection modes of ligands with the NCs and the passivation effect of inert hybrid silica shell on HS-CdTe. It is hopeful that the high luminescent HS-CdTe/PVP micro-/nanofibers with the tunable PL peak wavelength would be a good candidate in the optical sensor , light-emitting devices (LEDs), nanometer-scale waveguides , and the other related photonic materials.
研究领域:
材料科学
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光学工程
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纳米技术
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2015
·
IF 2.711
Chunxiao Qiu,Youhong Xing,Wenming Yang,Zhiping Zhou,Yingchun Wang,Hong Liu,Wanzhen Xu
Twenty molecular dynamics (MD) simulations of molecular imprinting prepolymerization systems had been performed to optimize the imprinting shell of the fluorescent sensor. The results revealed that the system with a Bisphenol A (BPA): 3-aminopropyltriethoxysilane (APTES): tetraethylorthosilicate (TEOS) mole ratio of 10:15:60 had the most stable template (T)-functional monomer (FM) cluster. Correspondingly, five kinds of imprinted and non-imprinted polymers were synthesized to assess the reliability and validity of the simulation results. Hybrid SiO 2 -coated CdTe NCs (HS-QD) were synthesized by a simple reflux procedure including a sol-gel reaction that resulted in the formation of a hybrid SiO 2 layer with CdS-like clusters on a CdTe core. Based on the optimal component ratio of the prepolymerization system, MIP shells were anchored on the surface of HS-QD to build a fluorescent MIP sensor. A linear relationship between relative fluorescence intensity and the concentration of BPA had been obtained covering the concentration range of 0.05–10 μmol L −1 with a limit of detection of 6 nmol L −1 . The feasibility of the fluorescent sensor was successfully evaluated through the analysis of BPA in river water and milk. The recoveries are above 96.31%, and the relative standard deviation (RSD) ranged from 1.55% to 2.78%.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
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2020
·
IF 0
Yun Shan,Hong-Lin Zhang,Yuan Zhu,Ying Wang,Huaju Song,Chuanguo Shi
An electrochemiluminescent immunosensor is constructed for the detection of diethylstilbestro (DES) on the basis of amplified quenching of electrochemiluminescence (ECL) from CdTe nanocrystal (NC)/reduced graphene oxide (rGO) composite films by antibody (Ab) against DES-modified SiO2 nanoparticles (Ab@SiO2). In this immunosensing system, CdTe NC/rGO composite films act as solid supporters for both DES and ECL emitters, which generate a 100-fold stronger ECL emission than CdTe NC films because the presence of rGO can lower the potential barrier, facilitate charge transfer, suppress nonradiative Auger recombination, and make the electron trap states fill more efficiently. On the composite films, the immobilized ovalbumin-modified DES (OVA-DES) competes with free target DES to bind Ab@SiO2. As a result, the number of formed OVA-DES-Ab@SiO2 immunocomplexes is inversely related to that of target DES. Using an ECL quenching maximum at blank as a calculation benchmark, the ECL intensity increment of the immunosensor and the concentration of target DES show a linear range of 0.002–2 ng/mL (R2 = 0.996) with a detection limit of 0.001 ng/mL (signal/noise = 3). This immunosensor, of good selectivity and stability, was used to detect beef samples, with recoveries at a scope of 93.2%–105.0%.
研究领域:
分析化学
·
生物医学工程
✓ 已验证
产品关联
DOI
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Xuwen Gao,Kena Fu,Li Fu,Huaisheng Wang,Bin Zhang,Guizheng Zou
Novel optical labels for biosensing in near-infrared (NIR) region (especially between 800 and 900 nm) are arousing much attention for higher penetrating capability, less scattering and lowered autofluorescent background. Herein, a water-soluble electrochemiluminophore with effective electrochemiluminescence (ECL) around 815 nm is developed via doping dual-stabilizers-capped CdTe nanocrystals (NCs) with Co 2+ species in a growth-doping way. The Co 2+ -doped CdTe NCs not only can preserve the highly-passivated surface states of dual-stabilizers-capped CdTe NCs, but also exhibit efficient red-shifted photoluminescence (PL) and ECL into the promising optical NIR window of 800–900 nm. A spectrum-based ultrasensitive NIR ECL immunosensor is consequently fabricated with the Co 2+ -doped CdTe NCs as tags for the first time, which can selectively and sensitively determine human carcinoembryonic antigen with a wide linearity range from 1 fg/mL to 10 pg/mL and a low limit of detection at 0.2 fg/mL (S/N = 3). This work opens a way to screen novel NIR electrochemiluminophore as well as to modulate the ECL performance of NCs via surface doping and engineering.
研究领域:
材料科学
·
纳米技术
·
分析化学
·
生物传感器
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2023
·
IF 7.4
Xuwen Gao,Xiaoxuan Ren,Yaojia Ai,Mengwei Li,Bin Zhang,Guizheng Zou
Coreactant-free electrochemiluminescence (ECL) is promising for removing the exogenous effects of coreactant and simplify the operation procedures and setups of commercialized ECL bioassays. Herein, an electrosterically involved strategy for achieving a low-triggering-potential (+0.21 V vs Ag/AgCl) and coreactant-free ECL from dual-stabilizer-capped CdTe nanocrystals (NCs) is proposed with mercaptopropionic acid (MPA) and hexametaphosphate (HMP) as the capping agents of luminophores. Upon employing the CdTe NCs as the ECL tag for the immunoassay, all the tags in the bioconjugates of the CdTe NCs and the secondary antibody (Ab2|CdTe) as well as in the final achieved sandwich-type immunocomplexes can exhibit efficient coreactant-free ECL with an electrosterically involved triggering potential nature. The bioconjugates of Ab2|CdTe with Ab2 no more than 30 kDa, such as the thyroid stimulating hormone (30 kDa) and the recombinant pro-gastrin releasing peptide (ProGRP, 14 kDa), merely exhibit coreactant-free ECL around +0.24 V, while bioconjugates of Ab2|CdTe with an Ab2 beyond 30 kDa only give off coreactant-free ECL around +0.82 V. Due to the further enhanced electrosteric effect in sandwich-type immunocomplexes, only the ECL immunosensor with ProGRP as the target can give off coreactant-free ECL around +0.24 V. The electrosterically involved and coreactant-free ECL of CdTe NCs is consequently utilized to sensitively and selectively determine the molecular protein ProGRP, which demonstrates a wide linearity range from 0.1 to 2000 pg/mL and a low limit of detection at 0.05 pg/mL (S/N = 3). This low-triggering-potential and coreactant-free combined ECL platform indicates that engineering the surface of CdTe NCs with a protein can improve the performance of ECL tags in a protein-weight-involved electrosterical way.
研究领域:
分析化学
·
生物化学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2024
·
IF 6.7
Xiaoxuan Ren,Zhijian Tian,Xuwen Gao,Yaojia Ai,Mengwei Li,Bin Zhang,Guizheng Zou
Chemiluminescence (CL), especially commercialized CL immunoassay (CLIA), is normally performed within the eye-visible region of the spectrum by exploiting the electronic-transition-related emission of the molecule luminophore. Herein, dual-stabilizers-capped CdTe nanocrystals (NCs) is employed as a model of nanoparticulated luminophore to finely tune the CL color with superior color purity. Initialized by oxidizing the CdTe NCs with potassium periodate (KIO4), intermediates of the reactive oxygen species (ROS) tend to charge CdTe NCs in both series-connection and parallel-connection routes and dominate the charge-transfer CL of CdTe NCs. The CdTe NCs/KIO4 system can exhibit color-tunable CL with the maximum emission wavelength shifted from 694 nm to 801 nm, and the red-shift span is over 100 nm. Both PL and CL of each of the CdTe NCs are bandgap-engineered; the change in the NCs surface state via CL reaction enables CL of each of the CdTe NCs to be red-shifted for ∼20 nm to PL, while the change in the NCs surface state via labeling CdTe NCs to secondary-antibody (Ab2) enables CL of the CdTe NCs-Ab2 conjugates to be red-shifted for another ∼20 nm to bare CdTe NCs. The CL of CdTe753-Ab2/KIO4 is ∼791 nm, which can perform near-infrared CL immunoassay and semi-automatically determined procalcitonin (PCT) on commercialized in vitro diagnosis (IVD) instruments.
研究领域:
纳米技术
·
分析化学
·
生物医学工程
·
临床诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）