TALANTA
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2024
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IF 5.6
Xianhong Wang,Jiuying Cui,Qinghua Gong,Lu Zheng,Dandan Liu,Guangming Nie
A novel electrochemiluminescence (ECL) sensor for the detection of Hg 2+ is constructed based on the synthesized cerium stannate/poly(5-formylindole) (Ce 2 Sn 2 O 7 /P5FIn) composite and multiple DNA signal amplification techniques, including strand displacement amplification (SDA) reaction and hybridization chain reaction (HCR). On the one hand, the combination of Ce 2 Sn 2 O 7 and P5FIn improves the electrochemical reaction rate between Ce 2 Sn 2 O 7 and the co-reactant, and significantly enhances the ECL signal. On the other hand, compared to P5FIn, Ce 2 Sn 2 O 7 /P5FIn has a larger specific surface area to facilitate the effective fixation of hairpin DNA H1. The target Hg 2+ is bound to the DNA strand (mDNA) rich in thymine bases (T) by T-Hg 2+ -T. Subsequently, with the assistance of polymerase (phi29 DNA) and restriction endonuclease (Nt. Bbv CI), strand displacement amplification (SDA) reaction is triggered to generate a large number of simulated target (MT). Hairpin DNA H1 captures MT, which then further triggers a hybridization chain reaction (HCR) to produce long strand DNA (dsDNA) rich in cytosine. Finally, a large amount of Ag + is introduced through C–Ag + -C, which is used as a co-reaction accelerator of Ce 2 Sn 2 O 7 –K 2 S 2 O 8 system to significantly enhance the ECL signal strength. Under optimal conditions, the constructed ECL sensor can detect Hg 2+ in a wide linear response range of 1.0 fM-100 nM, with a detection limit of 0.30 fM. The sensor also has high sensitivity and good applicability in the detection of seawater samples.
研究领域:
分析化学
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环境科学
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2023
·Vol. 11
·期 12
·2754-2761
·
IF 7
Yu Ji,Shuang He,Yang Chen,Pei Zhang,Jing Sun,Ya Li,Kaida Kuang,Nengqin Jia
A sensitive dual-signal electrochemiluminescence (ECL) immunosensor was proposed based on Ru(bpy)32+@HKUST-1/TPA and Ce2Sn2O7/K2S2O8 probes for detecting the NT-proBNP biomarker of heart failure. HKUST-1 with a high specific surface area facilitates the loading of more Ru(bpy)32+, effectively improving the anodic signal intensity, while the emerging Ce2Sn2O7 emitter displays a potential-matching cathodic emission with moderate intensity. Two ECL probes were characterized with field emission scanning electron microscopy, X-ray diffraction, XPS, FT-IR spectroscopy and UV-Vis diffuse reflectance spectroscopy. This dual-signal immunosensor has a wide linear range (5 × 10−4–1 × 104 ng mL−1) and a low quantitative detection limit, simultaneously showing high sensitivity, stability and reproducibility, as well as the detection capability of actual serum samples. This dual signal-calibrated immunoassay platform not only reduces the false positive rate of detection results but also provides a promising method for the early diagnosis of heart failure.
研究领域:
生物医学工程
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分析化学
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心血管疾病诊断
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Materials Technologies
·
2025
·
IF 6.2
Mathankumar Ganesan,Jin Li,Tongheng Cheng,Fei Wang
Pyrochlore-based metal oxide nanocomposites offer an attractive pathway for developing next-generation gas sensors by exploiting interfacial charge transfer and band engineering. Here, we report for the first time the use of Ce 2 Sn 2 O 7 /TiO 2 nanocomposites for ultra-trace NH 3 detection at room temperature. The materials are synthesized via a facile hydrothermal route and systematically evaluated against common volatile organic compounds, including ethanol, acetone, methanol, n-butanol, isopropanol, and triethanolamine. The Ce 2 Sn 2 O 7 /TiO 2 heterojunction demonstrated outstanding selectivity toward NH 3 , with the optimized CeTi2 sensor delivering an ultrahigh response of 83.8% to 100 ppm, a rapid response time of 12 and 5 s, and an exceptionally low detection limit of 2 ppb under ambient conditions (25°C). At 100°C, the prepared CeTi2 sensor displays a gas sensing response of 82.1% towards 100 ppm of NH 3 . Beyond sensitivity, the device exhibited excellent repeatability and long-term stability, and ensured reliable operation under realistic environments. Mechanistic analysis revealed that the Ce 2 Sn 2 O 7 /TiO 2 interface induces strong surface band bending and remarkably accelerates charge transport and reversible adsorption–desorption dynamics. This work establishes Ce 2 Sn 2 O 7 /TiO 2 as a pioneering platform for ppt-level NH 3 detection, offering a powerful combination of selectivity, stability, and energy-efficient operation for environmental monitoring and industrial safety.
研究领域:
材料科学
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气体传感技术
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纳米材料
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环境监测
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微机电系统（MEMS）
✓ 已验证
产品关联
DOI
高影响因子
IEEE SENSORS JOURNAL
·
2025
·
IF 4.5
Mathankumar Ganesan,Jin Li,Fei Wang
In this study, we report the synthesis of a MoS2/Ce2Sn2O7 composite via a simple hydrothermal method. The selectivity of the as-fabricated sensors was systematically evaluated against a range of volatile organic compounds, including ethanol, acetone, methanol, n-butanol, isopropanol, and triethanolamine. Notably, the MoS2/Ce2Sn2O7 heterojunction exhibited superior selectivity for NH3 gas at room temperature, with the MoCe3 sample showing an impressive response of 87.3% to 100 ppm of NH3. Furthermore, the MoCe3 sensor displayed a rapid response time of 40 s and an ultra-low detection limit of 50 ppt. The sensors demonstrated excellent repeatability, stability, and humidity resistance when exposed to NH3, with the MoCe3 sensor particularly excelling at lower concentrations at room temperature. The MoCe3 sample also exhibited low activation energy (5 kJ/mol) and enhanced surface band bending compared to other sensors. The gas adsorption/desorption behaviors and the underlying gas sensing mechanisms were systematically explored, highlighting the transition between n-type and p-type phases. The dual-mode sensing capability of the MoS2/Ce2Sn2O7 composite, operational at both room and lower temperatures, opens up diverse applications ranging from environmental monitoring to industrial safety.
研究领域:
材料科学
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传感器技术
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纳米材料
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气体传感
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环境监测
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工业安全
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）