JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2021
·
IF 3.981
Qikang Tian,Qianqian Han,Xin Zhu,Lan Zhang,Kun Chen,Zhishen Xie,Pan Wang,Xiangxiang Wu,Zhenqiang Zhang,Huahui Zeng
Celastrol is a promising drug candidate for treating diet-induced obesity, but the cytotoxicity and poor water solubility limit its clinical application. We prepared a novel celastrol conjugate (Cel-CMCS) with excellent water solubility (33.94 mg/mL), and then investigated its anti-obesity and toxic activities in diet-induced obese mice. Just as the parent celastrol, Cel-CMCS reduced body weight and body fat mass in an equally effective manner, but with lower toxicity. Collectively, Cel-CMCS provides a possible solution for the treatment of obesity in humans. In addition, the present study provided a practical experience of the development of carboxymethyl chitosan-based delivery system for poorly water-soluble drugs.
研究领域:
药学
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生物医学
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DOI
高影响因子
AAPS PHARMSCITECH
·
2025
·Vol. 26
·期 4
·1-17
·
IF 4
Luo Zhilin,Sun Yao,Cai Shihao,Liu Hongting,Zhao Conglu,Xu Xiang,Xu Aiguo,Zhou Honggang,Yang Cheng,Gu Xiaoting,Ai Xiaoyu
Idiopathic Pulmonary Fibrosis (IPF) is a rare and serious chronic interstitial lung disease that may endanger the lives of patients. The median survival time of patients with idiopathic pulmonary fibrosis is short, and the mortality rate is higher than that of many types of cancer. At present, pirfenidone (PFD) and nintedanib (NDNB) have been approved by FDA for IPF, but they can only delay the process of pulmonary fibrosis and cannot cure the disease. Therefore, it is urgent to develop other drugs with the effect of improving pulmonary fibrosis. Ellagic acid (EA) can inhibit the Wnt-signaling pathway and has an effect in treating pulmonary fibrosis induced by bleomycin (BLM) in mice. However, its solubility is poor, resulting in its low bioavailability and limited therapeutic benefits, so its clinical application has been limited. Herein, based on the characteristics of nano-drug lung delivery system, chitosan (CS) was selected as the carrier, and ellagic acid-loaded chitosan nanoparticles (EA-CS-NPs) were prepared by ionic gelation method. The EE% and DL% of prepared EA-CS-NPs was 73.73 ± 4.52% and 6.23 ± 1.09%, the particle size was 119.6 ± 5.51 nm (PDI = 0.234 ± 0.017), the zeta potential was 29.833 ± 0.503 mV. The morphology of the nanoparticles was observed by TEM microscope, which was round, uniform dispersion, indicating that the preparation process is stable and feasible. The toxicity experiment showed that EA-CS-NPs maintained 80% cell viability, significantly higher than that of the NDNB group, indicating lower toxicity and better inhibitory effects on TGF-β1-stimulated MLg and NIH-3T3 cells. Wound healing assay results showed that the inhibitory effect of EA-CS-NPs on cell migration was more pronounced than that of EA in the same amount of EA-containing drugs. Drug uptake experiments revealed that EA-CS-NPs significantly enhanced drug uptake in MLg and NIH-3T3 cells. In vivo , Cy7-CS-NPs exhibited higher fluorescence intensity in rat lungs compared to Cy7 solution, indicating better lung retention. The in vivo efficacy test showed that compared with the EA group, EA-CS-NPs could better reduce the area of pulmonary fibrosis and collagen deposition, improve lung function, and have a longer retention time in the lung. In summary, our results revealed that EA-CS-NPs may be a good choice for the treatment of pulmonary fibrosis. Graphical
研究领域:
药剂学
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呼吸病学
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纳米医学
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DOI
PubMed
高影响因子
Gels
·
2022
·Vol. 8
·期 5
·307
·
IF 4.432
Zhichuan Tang,Zhengsong Qiu,Hanyi Zhong,Yujie Kang,Baoyu Guo
The problem of wellbore stability has a marked impact on oil and gas exploration and development in the process of drilling. Marine mussel proteins can adhere and encapsulate firmly on deep-water rocks, providing inspiration for solving borehole stability problem and this ability comes from catechol groups. In this paper, a novel biopolymer was synthesized with chitosan and catechol (named “SDGB”) by Schiff base-reduction reaction, was developed as an encapsulator in water-based drilling fluids (WBDF). In addition, the chemical enhancing wellbore stability performance of different encapsulators were investigated and compared. The results showed that there were aromatic ring structure, amines, and catechol groups in catechol-chitosan biopolymer molecule. The high shale recovery rate demonstrated its strong shale inhibition performance. The rock treated by catechol-chitosan biopolymer had higher tension shear strength and uniaxial compression strength than others, which indicates that it can effectively strengthen the rock and bind loose minerals in micro-pore and micro-fracture of rock samples. The rheological and filtration property of the WBDF containing catechol-chitosan biopolymer is stable before and after 130 °C/16 h hot rolling, demonstrating its good compatibility with other WBDF agents. Moreover, SDGB could chelate with metal ions, forming a stable covalent bond, which plays an important role in adhesiveness, inhibition, and blockage.
研究领域:
石油工程
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生物材料科学
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2018
·
IF 6.434
Kexin Wang,Hui Ma,Shengyan Pu,Chun Yan,Miaoting Wang,Jing Yu,Xiaoke Wang,Wei Chu,Anatoly Zinchenko
Easy-to-obtain magnetic bentonite-chitosan hybrid beads (Bn-CTS) were prepared by immobilizing bentonite within a porous structure of chitosan beads to achieve a hybrid adsorption effect for the removal of cesium ion (Cs + ) from water. The hybrid adsorbent, which had a porous structure and abundant binding sites contributed by both chitosan and bentonite, ensured superb adsorption characteristics. The paramagnetic character of the beads enabled their facile separation for recycling. The chitosan/bentonite ratio, pH and contact time were optimized to achieve the optimal Cs + efficiency, and the adsorption kinetics and isotherms were thoroughly discussed. The adsorption kinetics obeyed the pseudo-second-order model, and the best fitted equation for equilibrium data was the Langmuir isotherm model. The maximum adsorption capacity of the bentonite-chitosan beads was 57.1 mg g −1 . The adsorbent had excellent selectivity towards Cs + adsorption in the presence of abundant cations (Li + , Na + , K + and Mg 2+ ). The adsorbent was able to be recycled by treating the beads with 0.1 mol L −1 of MgCl 2 to quantitatively desorb Cs + from the beads. Overall, the magnetic bentonite-chitosan beads can be used as a highly efficient adsorbent for radioactive waste disposal and management.
研究领域:
环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
International Journal of Nanomedicine
·
2021
·
IF 6.4
Qiangqiang Wang,Xiaoke Sun,Xin Huang,Jianmei Huang,Muhammad Waqqas Hasan,RuoFeng Yan,Lixin Xu,Xiaokai Song,Xiangrui Li
Background Hepatocellular carcinoma-associated antigen 59 (HCA59) from excretory/secretory products of Haemonchus contortus is known to have the ability to modulate the functions of host cells. However, its immunogenicities using different nanoparticles adjuvants remain poorly understood. Purpose The study aimed to select an efficient nanoparticle antigen delivery system, which could enhance the immune responses of Haemonchus contortus HCA59 in mice. Methods Here, the immune responses induced by the recombinant protein of HCA59 (rHCA59) with poly-D,L-lactide-co-glycolide (PLGA) nanoparticles, Chitosan nanoparticles, mixture of PLGA and Chitosan nanoparticles (rHCA59-Chitosan-PLGA), and Freund’s complete adjuvant were observed, respectively, in mice. Cytokine and antibody levels induced by different groups were detected by ELISA assay. The effects of lymphocyte proliferations on different groups were examined using CCK-8 kit. Phenotypes of T cells and dendritic cells were analyzed by flow cytometry. Results On day 14 post vaccination, levels of IgM, IgG1, IgG2a, IFN-γ, IL-4, and IL-17 were significantly increased in the groups immunized with rHCA59 encapsulated with nanoparticles. After mice were vaccinated with rHCA59 loaded with Chitosan/PLGA nanoparticles, lymphocytes proliferated significantly. Additionally, the percentages of CD4 + T cells (CD3 + CD4 + ), CD8 + T cells (CD3 + CD8 + ), and dendritic cells (CD11c + CD83 + , CD11c + CD86 + ) were obviously up-regulated in the mice immunized with nanoparticles, especially in the rHCA59-Chitosan-PLGA antigen delivery system group. Conclusion The findings of this research demonstrated that rHCA59-Chitosan-PLGA antigen delivery system could induce higher immune responses in mice model and indicated that rHCA59 might be a good candidate molecule to develop nanovaccines against Haemonchus contortus in future study.
研究领域:
寄生虫学
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免疫学
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疫苗研究
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DOI
PubMed
高影响因子
FOOD CHEMISTRY
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2025
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IF 9.8
Xiaojing Ma,Jiachen Lv,Jiale Fu,Hongshun Hao,Jingran Bi,Hongman Hou,Gongliang Zhang
In this study, phenethyl isothiocyanate nanoemulsion (PNE) was formulated for creating composite films with pectin and chitosan. Two types of PNE/pectin/chitosan (PNE-PC) films (PNE-PC1, PNE-PC2) were made by introducing PNE into films with different pectin/chitosan (PC) contents. Compared to PC films, PNE-PC films showed greater hydrophilicity and improved elongation at break, with Fourier transform infrared spectroscopy, X-ray and microstructural observations confirming PNE's good compatibility within the film matrices. The PNE-PC2 film exhibiting a cumulative release of 55.3 % of PNE over 72 h and confirmed to inhibit Staphylococcus aureus for up to 48 h. Furthermore, beef covered with PNE-PC2 film showed lower total viable count compared to uncovered and polyethylene-covered groups. The film also stabilized beef pH and maintained total volatile basic nitrogen values within a safe range. It effectively suppressed sulfide production, preventing undesirable odors and extending beef shelf life, demonstrating the potential of PNE-PC films for food packaging applications.
研究领域:
食品科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2012
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IF 3.07
Yuxi Liu,Jing Yang,Ziqi Zhao,Junjie Li,Rui Zhang,Fanglian Yao
With natural polysaccharides carrageenan (Car) and chitosan (Cs) as the polyanion and polycation, respectively, multilayer hollow nanocapsules have been fabricated via sequential layer-by-layer (LbL) electrostatic self-assembly from the sacrificed templates nanospheres (SiO 2 –NH 2 ). The LbL assembly process with the polysaccharides on SiO 2 –NH 2 core was followed by ζ -potential and size analysis. The fabrication of (Car/Cs) x nanocapsules and the removing of the SiO 2 –NH 2 core templates were confirmed by TGA and EDS analysis. The morphology of SiO 2 (Car/Cs) x nanospheres and (Car/Cs) x nanocapsules were observed by TEM analysis. The size analysis of (Car/Cs) x nanocapsules indicated that the cyst wall thickness and cavity volume of the nanocapsules are pH and ionic strength dual responsive. Due to the biocompatibility of the natural polysaccharides carrageenan and chitosan and the responsiveness of nanocapsules to pH and ionic strength, the (Car/Cs) x multilayer nanocapsules are expected to be used as nanoreactors or nanocontainers to control the synthesis, encapsulation, and releasing behaviors of bioactive molecules.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Chanchal Kumar Kundu,Zhiwei Li,Xiaohong Li,Zhijun Zhang,Yuan Hu
A plant derived bio-macromolecule namely lignin (L) and a green phosphorus compound like phytic acid (PA) were functionalized with graphene oxide (GO) and subsequently, used to enhance the flame retardant properties of polyamide 66 (PA66) fabrics in a one pot deposition method. Meanwhile, we also considered pure phytic acid and one more bio-derived charring agent like chitosan (CS) to formulate a series of GO-based flame retardant finishing by altering the applied compounds in the formulation. The applied finishing with a minimum loading % (i.e., less than 10%) rarely altered the physical properties (i.e., color, handle and tensile strength , etc.) of treated textiles while provided enhanced thermal stability and added flame retardancy. Thus, a significant increase in limiting oxygen index (LOI) by 27% was received for the GO-lignin and GO-phytic acid modified fabric sample (i.e., PA66-A), indicating the supremacy of graphene-based compound. Furthermore, a substantial reduction in the peak heat release rate (pHRR) by 25% was also noticed for the fabric sample treated with GO-lignin, chitosan and phytic acid (i.e., PA66-D). Additionally, the as prepared finishing exhibited a considerable level of wash durability as a maximum reduction of pHRR by 17% was retained even after 5 washing cycles.
研究领域:
材料科学
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纺织工程
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生物化学
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DOI
PubMed
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 80
·76855-76860
·
IF 3.289
Chao Yang,Haodao Mo,Limin Zang,Jian Chen,Zhenqiang Wang,Jianhui Qiu
An attapulgite@chitosan (ATP@CS) nanocomposite was prepared by coating chitosan onto naturally needle-like nanoscale attapulgite clay. The nanocomposite was characterized by scanning electron microscopy, Fourier transform infrared spectroscopy and thermogravimetric analysis. Cellulase was covalently immobilized on this ATP@CS support using glutaraldehyde activation method and compared to (3-aminopropyl) triethoxysilane modified ATP (ATP–APTES) support. The amount of cellulase on the ATP@CS and ATP–APTES was 88.3 and 76.5 mg g−1, respectively. The reusability and effects of pH and temperature on activity were studied. The ATP@CS immobilized cellulase exhibited higher pH and thermal stability as well as good reusability compared to the ATP–APTES immobilized cellulase and the free cellulase. The immobilized cellulase samples were also utilized to hydrolyze wheat straw to evaluate their potentially practical applications.
研究领域:
生物化学
·
材料科学
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产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2022
·
IF 10.723
Yanhui Kong,Wenjing Zhang,Tian He,Xue Yang,Wanghua Bi,Jiwei Li,Wenzhe Yang,Weichao Chen
Wound infection and inflammation hinder the process of wound healing and bother human beings chronically. As a naturally degradable macromolecule , chitosan (CS) has been widely used in antibacterial wound dressings. However, the antibacterial property of chitosan is inhibited by its water insolubility. In this study, we prepared a bilayered asymmetric nanofibrous membrane with the hydrophilic CS/chitosan oligosaccharide (COS) nanofibrous membrane as the bottom layer and the hydrophobic polycaprolactone (PCL) nanofibrous membrane as the top layer. Results showed that incorporating COS improved the CS membrane's wettability, and adding 0.5 % COS increased the inhibition zone diameter of Escherichia coli and Staphylococcus aureus by 23 % and 26 %, respectively. Moreover, the PCL layer could prevent the adhesion of water and bacteria. The PCL-CS/COS 0.5% membrane showed relatively good mechanical properties, excellent water absorptivity (460 %), and appropriate cytocompatibility. This asymmetric wettable membrane has a massive potential to serve as a new antibacterial dressing for wound healing.
研究领域:
生物材料
·
组织工程
·
伤口愈合
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生物医学材料
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
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2026
·
IF 4.6
Li Xuan-Ran,Sun Xiao-Han,Tian Hua-Feng,Lu Ang
Ionic thermoelectric gels based on the Soret effect play an important role in realizing the efficient conversion of thermal and electrical energy, which is crucial for renewable energy utilization and efficient energy management. In this study, chitosan hydrogels were fabricated by complexation of chitosan and various metal ions via a freeze-casting approach for unitization as ionic thermoelectric materials. Various aggregate structures, including loosely fibrous networks, oriented porous structures, and lamellar porous structures, were obtained owing to the different interactions between chitosan and metal ions. As a result of the synergy of both the aggregate structure and intermolecular interaction, the as-prepared chitosan hydrogels demonstrated wide thermoelectric coefficient ranging from +1.6 mV·K −1 to −18.4 mV·K −1 , which can be achieved by simply involving different metal ions. The present work not only demonstrates the correlation between gel structure, intermolecular interactions, and thermoelectric performance, but also provides a simple approach for the fabrication and regulation of natural polymer-based thermoelectric materials.
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DOI
高影响因子
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2017
·
IF 4.159
Jinyu Li,Guoxin Tan,Bingchao Cheng,Dandan Liu,Weisan Pan
To facilitate the hydrophobic drugs modeled by coumarin-6 (Cou-6) acrossing the cornea to the anterior chamber of the rabbit eye, chitosan (CS) derivatives including chitosan-N-acetyl- l -cysteine (CS-NAC), chitosan oligosaccharides (COS) and carboxymethyl chitosan (CMCS) modified nanostructured lipid carriers (NLCs) were designed and characterized. We found that, with similar size distribution and positive charges, different CS derivatives based on NLCs led to distinctive delivery performance. In vivo precorneal retention study on rabbits revealed that these CS derivatives coating exhibited a stronger resistant effect than Cou-6 eye drops and Cou-6-NLC (P < 0.05), moreover, the AUC (0−∞) , C max and MRT (0−∞) of them followed the sequence of CMCS-Cou-6-NLC < COS-Cou-6-NLC < CS-NAC-Cou-6-NLC. Confocal laser fluorescence microscopy (CLSM) for in vitro corneal penetration study showed that COS-, and CS-NAC-coated NLCs penetrated through the whole corneal epithelium barrier (about 40 μm), while CMCS failed to significantly enhance the intraocular drug penetration as expected, displayed a negligible fluorescence at 30 μm deep. In addition, penetration through the intact cornea was achieved and the penetration levels through the ocular tissues were increased thoroughly for the COS and CS-NAC coating ones compared with CMCS-NLC (P < 0.05), and successfully reduced the conjunctival-to-corneal permeability ratio (ratio (C - S/C) ) thus resulted in a higher bioavailability, which was confirmed by ex vivo fluorescence imaging on ocular tissues. In summary, CS-NAC-NLC and COS-NLC are promising ocular drug delivery systems to achieve prolonged precorneal retention, higher corneal permeability and enhanced ocular bioavailability. And comparatively speaking, CS-NAC-NLC possesses the highest potential for ocular drug delivery.
研究领域:
药剂学
·
眼科研究
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）