Current Optics and Photonics
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2025
·Vol. 9
·期 3
·224-232
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IF 0.8
Junfeng Wang,Junfeng Wang,Wenpeng Liu,Shoujun Ding,Shoujun Ding,Guihua Sun,Gang Liu
A series of x at% Sm3+ (x = 0.5, 1, 3, 5, 8, 10) doped ScTaO4 phosphors were prepared using a high-temperature solid-state method. The synthesized samples were structurally characterized by using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy, and the diffraction data were fitted to the full spectrum. At the same time, the electronic structure (energy band and state density) and differential charge of the ScTaO4 host material were calculated. The results showed that ScTaO4 has a direct band gap with a width of 4.14 eV. The effect of Sm3+ ion doping concentrations on the emission spectrum was further explored, and the 3 at% Sm3+ ion doping concentration was selected to have the best luminescence effect. In addition, we measured the temperature-changing spectrum of the 3 at% Sm3+ doped sample in the temperature range of 300–510 K to evaluate the thermal stability of its photoluminescence spectrum. At 390 K, the emission peak intensity at 610 nm of the 3 at% Sm3+ doped sample was still 79.55% of that at room temperature, showing excellent thermal stability. At the same time, we explored the temperature quenching mechanism of the material and fitted the variable temperature spectrum to obtain the activation energy (E
a) of the phosphor as 0.187 eV. The results show that Sm3+:ScTaO4 orange-red phosphor is expected to be used in the field of white LED lighting.Published by the Optical Society of Korea under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
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高影响因子
Biomolecules & Therapeutics
·
2020
·
IF 3.47
Zhenling Zhang,Qiuping Zhang,Fang Li,Yi Xin,Zhijun Duan
The mitogen-activated protein kinase (MAPK) pathway controls intestinal epithelial barrier permeability by regulating tight junctions (TJs) and epithelial cells damage. Heme oxygenase-1 (HO-1) and carbon monoxide (CO) protect the intestinal epithelial barrier function, but the molecular mechanism is not yet clarified. MAPK activation and barrier permeability were studied using monolayers of Caco-2 cells treated with tissue necrosis factor α (TNF-α) transfected with FUGW-HO-1 or pLKO.1-sh-HO-1 plasmid. Intestinal mucosal barrier permeability and MAPK activation were also investigated using carbon tetrachloride (CCl 4 ) administration with CoPP (a HO-1 inducer), ZnPP (a HO-1 inhibitor), CO releasing molecule 2 (CORM-2), or inactived-CORM-2-treated wild-type mice and mice with HO-1 deficiency in intestinal epithelial cells. TNF-α increased epithelial TJ disruption and cleaved caspase-3 expression, induced ERK, p38, and JNK phosphorylation. In addition, HO-1 blocked TNF-α-induced increase in epithelial TJs disruption, cleaved caspase-3 expression, as well as ERK, p38, and JNK phosphorylation in an HO-1-dependent manner. CoPP and CORM-2 directly ameliorated intestinal mucosal injury, attenuated TJ disruption and cleaved caspase-3 expression, and inhibited epithelial ERK, p38, and JNK phosphorylation after chronic CCl 4 injection. Conversely, ZnPP completely reversed these effects. Furthermore, mice with intestinal epithelial HO-1 deficient exhibited a robust increase in mucosal TJs disruption, cleaved caspase-3 expression, and MAPKs activation as compared to the control group mice. These data demonstrated that HO-1-dependent MAPK signaling inhibition preserves the intestinal mucosal barrier integrity by abrogating TJ dysregulation and epithelial cell damage. The differential targeting of gut HO-1-MAPK axis leads to improved intestinal disease therapy.
研究领域:
胃肠病学
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细胞生物学
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分子生物学
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药理学
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PubMed
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ACS Nano
·
2024
·
IF 15.8
Zhengxi Wang,Xudong Zhang,Quan Liu,Xianli Hu,Jiawei Mei,Jun Zhou,Xianzuo Zhang,Dongdong Xu,Wanbo Zhu,Zheng Su,Chen Zhu
There is an increasingly growing demand to balance tissue repair guidance and opportunistic infection (OI) inhibition in clinical implant surgery. Herein, we developed a nanoadjuvant for all-stage tissue repair guidance and biofilm-responsive OI eradication via in situ incorporating Cobaltiprotoporphyrin (CoPP) into Prussian blue (PB) to prepare PB-CoPP nanozymes (PCZs). Released CoPP possesses a pro-efferocytosis effect for eliminating apoptotic and progressing necrotic cells in tissue trauma, thus preventing secondary inflammation. Once OIs occur, PCZs with switchable nanocatalytic capacity can achieve bidirectional pyroptosis regulation. Once reaching the acidic biofilm microenvironment, PCZs possess peroxidase (POD)-like activity that can generate reactive oxygen species (ROS) to eradicate bacterial biofilms, especially when synergized with the photothermal effect. Furthermore, generated ROS can promote macrophage pyroptosis to secrete inflammatory cytokines and antimicrobial proteins for biofilm eradication in vivo. After eradicating the biofilm, PCZs possess catalase (CAT)-like activity in a neutral environment, which can scavenge ROS and inhibit macrophage pyroptosis, thereby improving the inflammatory microenvironment. Briefly, PCZs as nanoadjuvants feature the capability of all-stage tissue repair guidance and biofilm-responsive OI inhibition that can be routinely performed in all implant surgeries, providing a wide range of application prospects and commercial translational value.
研究领域:
生物医学工程
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纳米技术
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组织工程
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免疫学
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传染病学
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高影响因子
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