JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2024
·
IF 5.8
Wenhao Dou,Daxin Li,Bingzhu Wang,Zhihua Yang,Dechang Jia,Ralf Riedel,Yu Zhou
The microstructural evolution of C sf /SiBCN composites and formation mechanism of the oxide layer after oxidation for 1–10 h at 1500 ℃ were studied. As the oxidation time increases to 10 h, the macrostructure of the porous C sf /MA-SiBCN composite collapses obviously, while the C sf /SiBCN composite densified via the polymer infiltration and pyrolysis (PIP) process maintains structural integrity due to the formation of the oxide layer with a tri-layer structure: the outermost loose layer mainly containing cristobalite, the dense interlayer of amorphous glass and the innermost layer of some unoxidized BN(C) and SiC grains embedded into the amorphous glass, which hinders the diffusion of oxygen.
研究领域:
材料科学
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复合材料
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氧化行为
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产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2024
·
IF 3.5
Wenhao Dou,Bingzhu Wang,Daxin Li,Haobo Jiang,Xiaoliang Sun,Ling Li,Yingying Wang,Zhihua Yang,Dechang Jia,Yu Zhou
To enhance the ablation resistance of porous C sf /MA–SiBCN composites, the polymer infiltration and pyrolysis (PIP) process is adopted to obtain layered C sf /SiBCN composites containing MA–SiBCN and PDCs–SiBCN. After ablation for 10 s, the ablative layer fails to remain on the C sf /MA–SiBCN surface with mass ablation rate of 0.062 g/s and linear ablation rate of 0.208 mm/s, while the dense C sf /SiBCN surface is covered by a dense and stable ablative layer mainly consisting of amorphous SiO 2 glassy phase due to the synergistic ablation effect of MA–SiBCN and PDCs–SiBCN, which could resist the intense scour by ablation flame and prevent internal corrosion, and thus the ablation resistance improves with a 37% decrease in mass ablation rate (0.039 g/s) and an 18% decrease in linear ablation rate (0.171 mm/s), respectively.
研究领域:
材料科学
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航空航天工程
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产品关联
DOI
高影响因子
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
·
2023
·
IF 5.7
Jun Lu,Dewei Ni,Bowen Chen,Feiyan Cai,Zou Xuegang,Xiangyu Zhang,Yusheng Ding,Shaoming Dong
Pitch-based short carbon fibres reinforced C sf /ZrB 2 -SiC composites were fabricated by direct ink writing of short carbon fibres, followed by slurry impregnation and reactive melt infiltration . Ablation behaviour of the C sf /ZrB 2 -SiC composite was studied by air plasma test. It is indicated that the skeleton of the oriented short carbon fibres provides heat diffusion channels. Consequently, temperatures at the ablation surface are as low as ∼1730 o C and ∼2000 o C respectively at 4 MW/m 2 and 5 MW/m 2 . The composite presents outstanding ablation-resistant performance with a linear recession rate of ∼ − 0.04 µm/s and mass recession rate of ∼ − 3.40 mg/s at 4 MW/m 2 , ∼ − 0.17 µm/s and ∼ 3.58 mg/s at 5 MW/m 2 . It is revealed that the fibres area and matrix area of the composite present different ablation mechanisms. The fibres area is ablated severely, while the matrix area presents excellent ablation-resistance with continuous ZrO 2 -SiO 2 protective layer.
研究领域:
材料科学
·
航空航天工程
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产品关联
DOI
高影响因子
Journal of Inflammation Research
·
2025
·
IF 4.1
Yuan Zhang,Longbin Huang,Ningning Yue,Zhiliang Mai,Chen Kong,Chengmei Tian,Dao-ru Wei,Jun Yao,Lisheng Wang,Defeng Li
Background Although cytokines have been implicated in the development of ulcerative colitis (UC), the potential mediating role of metabolite levels in this association remains unclear.Methods Utilizing data from genome-wide association studies (GWAS) encompassing 91 circulating cytokines, 1400 blood metabolites, and 178,689 UC cases, we performed a two-sample Mendelian randomization (MR) analysis to investigate the effect of metabolites mediated cytokines on the development of UC. A two-step MR analysis was conducted to quantitatively evaluate the mediation effect. Additionally, dextran sodium sulfate (DSS)-induced colitis mice were used to further confirm our results.Results Mendelian randomization (MR) analysis indicated that macrophage colony-stimulating factor (M-CSF) had a causal and positive relationship with aconitate (OR: 1.10, 95% CI: 1.00–1.20, p = 0.043, IVW beta 1 = 0.095). Moreover, MR analysis revealed that high level of aconitate were associated with reduced risk of UC (OR: 0.44, 95% CI: 0.24–0.80, p = 0.008, IVW beta 2 = −0.818). In addition, MR analysis showed M-CSF had an inverse correlation with the disease onset of UC (OR: 0.31, 95% CI: 0.15–0.80, p = 0.002, IVW beta all = −1.16). Furthermore, the mediation effect of aconitate mediated M-CSF on the risk of UC was −0.0777 (95% CI: −0.154 to −0.0018, p = 0.045), accounting for 6.69% of the total effect, and indicating a modest contribution to the protective effect of M-CSF against UC. Subsequently, as an in vivo validation model, DSS-induced colitis was employed to demonstrate that M-CSF treatment significantly ameliorated weight loss, disease activity index (DAI) scores, colon shortening, and histological damage. Additionally, M-CSF treatment also significantly reduced M1 macrophage infiltration, elevated levels of aconitate as well as itaconate, and decreased the levels of pro-inflammatory cytokines in colitis. These results demonstrated that aconitate inhibited the expression of pro-inflammatory cytokines through its enzymatic conversion into the immunometabolite itaconate by aconitate decarboxylase 1 (Acod1), and downregulated the levels of M1 macrophages, thereby ameliorating colitis.Conclusion These findings suggest that M-CSF is an important anti-inflammatory cytokine in UC, which may be a promising therapeutic target in the treatment of UC.
研究领域:
免疫学
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胃肠病学
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遗传学
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代谢组学
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炎症研究
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生物医学研究
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产品关联
DOI
PubMed
高影响因子
Frontiers in Bioengineering and Biotechnology
·
2020
·
IF 3.644
Jiang Qiongchao,Zeng Yunting,Xu Yanni,Xiao Xiaoyun,Liu Hejun,Zhou Boyang,Kong Yao,Saw Phei Er,Luo Baoming
Though radiofrequency ablation (RFA) is considered to be an effective treatment for hepatocellular carcinoma (HCC), but more than 30% of patients may suffer insufficient RFA (IRFA), which can promote more aggressive of the residual tumor. One possible method to counter this is to accurately identify the margin of the HCC. Colony-stimulating factor 1 receptor (CSF-1R) has been found to be restrictively expressed by tumor associated macrophages (TAMs) and monocytes which more prefer to locate at the boundary of HCC. Using biotinylation method, we developed a CSF-1R-conjugated nanobubble CSF-1R (NBCSF–1R) using a thin-film hydration method for margin detection of HCC. CSF-1R expression was higher in macrophages than in HCC cell lines. Furthermore, immunofluorescence showed that CSF-1R were largely located in the margin of xenograft tumor and IFRA models. In vitro, NBCSF–1R was stable and provided a clear ultrasound image even after being stored for 6 months. In co-culture, NBCSF–1R adhered to macrophages significantly better than HCC cells (p = 0.05). In in vivo contrast-enhanced ultrasound imaging, the washout half-time of the NBCSF–1R was significantly greater than that of NBCTRL and Sonovue® (p = 0.05). The signal intensity of the tumor periphery was higher than the tumor center or non-tumor region after NBCSF–1R injection. Taken together, NBCSF–1R may potentially be used as a non-invasive diagnostic modality in the margin detection of HCC, thereby improving the efficiency of RFA. This platform may also serve as a complement method to detect residual HCC after RFA; and may also be used for targeted delivery of therapeutic drugs or genes.
研究领域:
医学影像
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肿瘤学
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生物医学工程
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分子生物学
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2020
·Vol. 9
·期 1
·413-422
·
IF 11.301
Xiaohuan Chang,Junjie Fu,Dongxing Kou,Wenhui Zhou,Zhengji Zhou,Shengjie Yuan,Yafang Qi,Zhi Zheng,Sixin Wu
The introduction of alkali metal (AM) post-deposition treatment (PDT) has led to the consecutive breakthrough of world record efficiencies for Cu(In,Ga)Se2 photovoltaics. However, for the derivative Cu2SnZn(S,Se)4 (CZTSSe) solar cells, the corresponding verdict seems partially unjustified due to the difference in defect chemical environment and phase structure, and the most effective incorporation means of AMs is still a mystery. In this work, for the first time, we developed a dual AM synergistic incorporation strategy combining light and heavy AMs by post-depositing CsF after NaF-PDT to improve the efficiency of CZTSSe solar cells. The relevant microscopic-electrical advantages with regard to the different roles of NaF and CsF PDT are discussed in more detail. It was found that the Na atoms are randomly dispersed both in the grain interior (GI) and grain boundaries (GBs), significantly increasing the acceptor concentration and passivating the deep level defects to enhance the Voc. In contrast, the Cs atoms are mainly segregated at the GBs, primarily increasing the potential of the GBs and improving the FF. The prominent electric benefits of Cs at the GBs and Na in the GI finally increase the device efficiency from 10.12% to 12.16%. Our findings solve the difficulty in obtaining the available Voc and FF for future high efficiency research and should serve as a basis for the in-depth understanding of AM-PDT in kesterite photovoltaics.
研究领域:
材料科学
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光伏技术
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半导体物理
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产品关联
DOI
高影响因子
Pharmaceutics
·
2025
·Vol. 17
·期 3
·376
·
IF 5.5
Yuxing Zhang,Xixi Zou,Qiran Du,Xiaotao Dong,Uday Kumar Chinta,Ruyue Yu,Fei Wu,Tuo Jin
Objectives: Thermo-gelling hydrophilic polymers like PLGA–PEG–PLGA are known as injectable sustained-release depots for biologics, but they face challenges due to the occurrence of severe burst release. This study aimed to develop a strategy to avoid the initial burst release by pre-encapsulating proteins in polysaccharide microparticles through an aqueous–aqueous emulsion mechanism, thereby enhancing therapeutic retention and linear release kinetics.Methods: Five model proteins (G-CSF, GM-CSF, IGF-1, FVIII, BSA) were encapsulated in dextran microparticles, using an organic solvent-free aqueous–aqueous emulsion method. These particles were dispersed in a 23% (w/w) PLGA–PEG–PLGA solution and injected into a 37 °C release buffer to form a gel depot. The in vitro release profiles were quantified using ELISA and MicroBCA assays over 9–42 days. The bioactivity of the proteins was validated using cell proliferation assays (NFS-60, TF-1, MCF-7) and chromogenic kits. The in vivo pharmacokinetics of the FVIII-loaded formulations were evaluated in Sprague–Dawley rats (n = 5/group) over 28 days.Results: Protein-loaded dextran particles retained their structural integrity within the hydrogel and exhibited minimal burst release (≤5% within 30 min vs. >25% for free proteins). Sustained near-linear release profiles were observed for all the proteins, with complete release by day 9 (G-CSF, GM-CSF, BSA) or day 42 (FVIII). Rats administered with the thermal gel with FVIII–dextran particles showed a significantly lower peak plasma concentration (Cmax: 88.25 ± 30.21 vs. 132.63 ± 66.67 ng/mL) and prolonged therapeutic coverage (>18 days vs. 15 days) compared to those administered with the thermal gel with the FVIII solution. The bioactivity of the released proteins remained at ≥90% of the native forms.Conclusions: Pre-encapsulation in dextran microparticles effectively mitigates burst release from thermosensitive hydrogels, while preserving protein functionality.
研究领域:
药剂学
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生物医学工程
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药物递送系统
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蛋白质工程
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产品关联
DOI
PubMed
高影响因子
CARBON
·
2025
·
IF 11.6
Wenhao Dou,Bingzhu Wang,Daxin Li,Xiaoliang Sun,Haobo Jiang,Yan Wang,Xingqi Liao,Ling Li,Yingying Wang,Zhihua Yang,Dechang Jia,Yu Zhou
To achieve low-temperature densification of short carbon fiber reinforced mechanical alloyed SiBCN composites (C sf /MA-SiBCN) and fill the research gap of high-temperature mechanical properties of C sf /MA-SiBCN composites, C sf /SiBCN composites containing both polymer derived SiBCN (PDCs-SiBCN) and MA-SiBCN were prepared by the densification of C sf /MA-SiBCN composites at 1100 °C via the repeated polymer infiltration and pyrolysis (PIP) process. Unlike traditional hot-pressed C sf /MA-SiBCN composites, the as-prepared C sf /SiBCN composites exhibit 2D layered structure and short carbon fibers are evenly distributed in the matrix. On this basis, mechanical properties and microstructural evolution were fully studied from room temperature (RT) to 1600 °C. The strength of 7 th PIP-ed composites at RT increases by 55.9% compared with that of C sf /MA-SiBCN composites because of higher density (2.00±0.01 g/cm 3 ) and lower porosity (4.14%±0.28%). At 1400 °C, the strength of C sf /SiBCN composites shows slightly higher value compared with the strength at RT. At 1600 °C, some SiC crystals and pores are observed in the interfacial region, and thus C sf /SiBCN composites show nonbrittle fracture behavior at 1600 °C with a strength retention ratio of 41.8%.
研究领域:
材料科学
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机械工程
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产品关联
DOI
高影响因子
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
·
2023
·Vol. 107
·期 1
·404-416
·
IF 3.9
Wenhao Dou,Daxin Li,Bingzhu Wang,Delong Cai,Zhihua Yang,Dechang Jia,Ralf Riedel,Shaohua Qin,Yu Zhou
The layering process using phenolic resin coupled with pressureless sintering technique was explored to prepare short carbon fiber-reinforced SiBCN composites (C sf /SiBCN). The effect of phenolic resin content on the microstructure and mechanical properties of C sf /SiBCN was mainly studied. Results suggest that the addition of phenolic resin can appropriately improve density and flexural strength and reduce total pore volume of the composites because phenolic resin can partly consolidate SiBCN powders to promote shaping via low-temperature pressureless sintering. As the phenolic resin content increases, the fracture behavior changes from delamination fracture to monolithic fracture, thereby reducing fracture displacement. The reason for this performance is that the interlayer bonding is enhanced to hinder crack propagation along the layers.
研究领域:
材料科学
·
力学
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产品关联
DOI
高影响因子
Autophagy
·
2024
·
IF 14.6
Kateřina Veverová,Jan Laczó,Alžběta Katonová,Hana Horáková,Veronika Matušková,Francesco Angelucci,Martina Laczó,Zuzana Nedelská,Jakub Hort,He-Ling Wang,Jianying Zhang,Liu Shi,Evandro Fei Fang,Martin Vyhnálek
Defective mitophagy is consistently found in postmortem brain and iPSC-derived neurons from Alzheimer disease (AD) patients. However, there is a lack of extensive examination of mitophagy status in serum or cerebrospinal fluid (CSF), and the clinical potential of mitophagy biomarkers has not been tested. We quantified biomarkers of mitophagy/autophagy and lysosomal degradation (PINK1, BNIP3L and TFEB) in CSF and serum from 246 individuals, covering mild cognitive impairment due to AD (MCI-AD, n = 100), dementia due to AD (AD-dementia, n = 100), and cognitively unimpaired individuals (CU, n = 46), recruited from the Czech Brain Aging Study. Cognitive function and brain atrophy were also assessed. Our data show that serum and CSF PINK1 and serum BNIP3L were higher, and serum TFEB was lower in individuals with AD than in corresponding CU individuals. Additionally, the magnitude of mitophagy impairment correlated with the severity of clinical indicators in AD patients. Specifically, levels of PINK1 positively correlated with phosphorylated (p)-MAPT/tau (181), total (t)-MAPT/tau, NEFL (neurofilament light chain), and NRGN (neurogranin) levels in CSF and negatively with memory, executive function, and language domain. Serum TFEB levels negatively correlated with NEFL and positively with executive function and language. This study reveals mitophagy impairment reflected in biofluid biomarkers of individuals with AD and associated with more advanced AD pathology.Abbreviation: Aβ: amyloid beta; AD: Alzheimer disease; AVs: autophagic vacuoles; BNIP3L: BCL2 interacting protein 3 like; CU: cognitively unimpaired; CSF: cerebrospinal fluid; LAMP1: lysosomal-associated membrane protein 1; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; MCI: mild cognitive impairment; NRGN: neurogranin; NEFL: neurofilament light chain; p-MAPT/tau: phosphorylated microtubule associated protein tau; PINK1: PTEN induced kinase 1; t-MAPT/tau: total microtubule associated protein tau; TFEB: transcription factor EB; TMT: Trail Making Test.
研究领域:
神经病学
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神经退行性疾病
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生物标志物研究
·
临床神经科学
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DOI
高影响因子
ELECTROCHIMICA ACTA
·
2025
·
IF 5.6
Hao Deng,Wanjie Xu,Xinle Li,Pengfei Liu,Ding Tang,Sen Huang
The extremely high theoretical capacity of lithium metal anode positions it as an ideal candidate for next-generation high-energy-density energy storage systems. However, its practical application is hindered by uncontrollable lithium dendrite growth and the instability of the solid electrolyte interphase (SEI) layer. This study proposes an electrolyte modification strategy based on the synergetic effect of Cs + and F – , employing low-concentration CsF additives to simultaneously achieve uniform lithium deposition and optimized the composition of SEI. The results reveal that Cs + preferentially adsorbs at the tip regions of the lithium metal surface via an electrostatic shielding mechanism, forcing Li + to nucleate uniformly on flat regions, thereby effectively suppressing dendrite formation. Meanwhile, F – promotes the formation of LiF within the SEI layer, significantly enhancing interfacial stability. Electrochemical tests revealed that the addition of 0.05 M CsF enhanced the average Coulombic efficiency of Li||Cu cells from 58.9% to 70.9% after 100 cycles at 0.5 mA/cm 2 , while significantly extending the cycling lifespan of Li||Li symmetric cells from 100 h to over 250 h under 1 mA/cm 2 current density. In NCM622||Li cells, the capacity retention after 100 cycles at 1C improves from 38.6% to 80.6%. X-ray photoelectron spectroscopy and scanning electron microscopy characterization confirm that the LiF-enriched SEI layer induced by CsF effectively reduces interfacial impedance and inhibits dead lithium accumulation. This work provides innovative insights into developing high-performance lithium metal batteries through cation-anion synergetic regulation of electrolyte interfaces.
研究领域:
材料科学
·
能源存储技术
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产品关联
DOI
高影响因子
Journal of Advanced Ceramics
·
2021
·Vol. 10
·期 6
·1371-1380
·
IF 6.707
Lu Jun,Ni Dewei,Liao Chunjing,Zhou Haijun,Jiang Youlin,Chen Bowen,Zou Xuegang,Cai Feiyan,Ding Yusheng,Dong Shaoming
Fiber damage and uniform interphase preparation are the main challenges in conventional short fiber reinforced ceramic matrix composites. In this work, we develop a novel processing route in fabrication of short carbon fiber reinforced ZrB 2 -SiC composites (C sf /ZrB 2 -SiC) overcoming the above two issues. At first, C sf preforms with oriented designation and uniform PyC/SiC interphase are fabricated via direct ink writing (DIW) of short carbon fiber paste followed by chemical vapor infiltration. After that, ZrB 2 and SiC are introduced into the preforms by slurry impregnation and reactive melt infiltration, respectively. Microstructure evolution and optimization of the composites during fabrication are investigated in detail. The as-fabricated C sf /ZrB 2 -SiC composites have a bulk density of 2.47 g/cm 3 , with uniform weak interphase and without serious fiber damage. Consequently, non-brittle fracture occurs in the C sf /ZrB 2 -SiC composites with widespread toughening mechanisms such as crack deflection and bridging, interphase debonding, and fiber pull-out. This work provides a new opportunity to the material design and selection of short fiber reinforced composites.
研究领域:
材料科学
·
复合材料工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）