All-inorganic lead halide perovskite nanocrystals (NCs) as new emerging semiconducting luminescent materials have attracted tremendous attention for designing optoelectronic devices . We have synthesized high quality of the CsPbX 3 NCs with tunable entire visible spectral region by a modified lower temperature method, featured with facile, low-cost and easily operating in an open environment without vacuumization or glovebox system. Besides, we have investigated the incorporation of Ni and K ions into CsPbX 3 NCs by adjusting all kinds of composition concentration from halogen salts, based on above mentioned preparation method. The absolute photoluminescence quantum yields (PLQYs) of doped CsPbX 3 NCs with different dopant (Ni or K ions) concentration were discussed. It is found that a certain amount of doping is beneficial for suppressing the defects and improving the lattice structure of nanocrystals, whereas an excessive dopant may induce quenching centers of the emission. In addition, a glorious absolute PLQYs of doped CsPbX 3 NCs can be obtained by our method, especially for CsPbBr 3 and CsPbI 3 NCs, and nearly reach 80%.
Zhaoyan Yang,Shenfei Zong,Guohua Jiang,Kai Zhu,Ziting Qian,Kuo Yang,Zhuyuan Wang,Yiping Cui
All-inorganic perovskite nanocrystals (CsPbX3 NCs, X = Cl, Br, I) are promising fluorescence materials for biological detection due to their excellent optical properties. However, there is still a challenge to obtain stable CsPbX3 NCs with more biofunctions. Here, we proposed a distinct strategy by absorbing the functionalized metal nanoprobes onto the phospholipid encapsulated CsPbX3 NCs to achieve CsPbX3-metal hybrids as probes for the detection of tumor-derived exosomes. Here, the metal nanoprobes have two functions: first, it endows phospholipid encapsulated CsPbX3 NCs with recognition ability; second, it avoids the fluorescence quenching of CsPbX3 NCs during the biological modification process by using metal nanoparticles as a bridge to connect with CsPbX3 NCs and various biomolecules. The obtained CPXD–AD exhibited a bright fluorescence signal, narrow full width at half-maximum (FWHM), and high specificity. Under optimal conditions, the CPXD–AD-based fluorescence-linked immunosorbent assay (FLISA) was successfully established and used for both qualitative and quantitative detection of tumor-derived exosomes.
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