CHEMISTRY-A EUROPEAN JOURNAL
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2025
·
IF 3.7
Mengtian Lu,Tianye Zhang,Yue Yang,Xin Lin,Jin Huang,Yuan Sun,Tiedong Sun
Graphical The study innovatively combines etched/stripped monolayer Ti 3 C 2 MXene with Cu (2- x ) Se nanoparticles in a one-pot method. The synthesized Ti 3 C 2 /Cu (2- x ) Se nanocomposite has catalase (CAT) and peroxidase (POD) -like activities combined with the excellent photothermal properties of MXene, which enhances the catalytic performance of Cu (2- x ) Se under near infrared (NIR) irradiation, and realizes the synergic photothermal catalytic treatment. Traditional tumor treatments (surgery, radiotherapy, chemotherapy, etc.) have certain limitations and can have serious negative effects, such as difficulty in cutting out tumors, damage to normal tissues, and complications. Ordinary nanozymes have low catalytic activity and require higher doses for treatment, which can increase in vivo toxicity and side effects. To address these limitations, we developed a Ti 3 C 2 MXene-based nanocomposite (Ti 3 C 2 /Cu (2- x ) Se) integrating Cu (2- x ) Se nanozymes with dual enzyme-mimicking activities (catalase and peroxidase) and MXene's photothermal properties. The Cu (2- x ) Se component catalyzes the decomposition of tumor-overexpressed H 2 O 2 into O 2 and cytotoxic ·OH, alleviating hypoxia while inducing oxidative stress. Simultaneously, MXene's high surface area and photothermal capability enhance nanozyme stability, biocompatibility, and catalytic efficiency under near-infrared irradiation. Notably, the photothermal effect amplifies enzymatic activity, enabling synergistic nanocatalytic-photothermal therapy. This synergy not only degrades glutathione to suppress tumor antioxidant defenses but also achieves targeted tumor ablation with reduced dosage requirements. Our work highlights a rational design of MXene-based nanozymes for enhanced multimodal tumor therapy, offering a paradigm for nanocomposite-driven disease treatment.
研究领域:
生物医学工程
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纳米医学
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肿瘤学
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DOI
PubMed
高影响因子
MONATSHEFTE FUR CHEMIE
·
2019
·Vol. 150
·期 11
·1903-1910
·
IF 1.501
Li Zhongqiu,Yang Kunhao,Lv Yueguang,Wang Qingnan,Li Chang,Wu Li,He Yujian
Abstract A novel method, based on modified silver nanoparticles, for high-throughput visual detection of heavy metal ions in polyvinyl chloride (PVC) products was developed including a key pretreatment process in which tetrahydrofuran was used to dissolve PVC powder samples quickly. Heavy metal ions were successfully transferred from THF to the aqueous phase by the liquid–liquid extraction method during the pretreatment procedures. Then, enriched Cu 2+ , Mn 2+ , and Cr 3+ were detected by three kinds of silver nanoparticles (4-MBA-AgNPs, 4-MBA-MA-AgNPs, and 4-NBT/4-MBA-AgNPs) using naked eyes and microplate reader, respectively. The visual detection limits of Cu 2+ , Mn 2+ , and Cr 3+ were 1.0 × 10 −6 M, 1.0 × 10 −7 M, and 1.0 × 10 −6 M, while the detection limits of Cu 2+ , Mn 2+ , and Cr 3+ were 2.5 × 10 −8 M, 5.0 × 10 −8 M, and 5.0 × 10 −8 M using microplate reader, respectively. Apparently, the proposed method could provide a potent means in the practical detection of heavy metal ions in PVC products with advantages of low-cost, rapid, high-throughput, and on-site detection. Graphic abstract
研究领域:
分析化学
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环境科学
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材料科学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Shiyu Xie,Jing Hu,Ke Li,Yaxin Zhao,Na Ma,Yaomin Wang,Yujuan Jin,Gaiping Guo,Rakesh Kumar,Jian Li,Jin Huang,Huafeng Tian
The adverse effects of heavy metal pollutants in wastewater have threatened human health in recent decades. Therefore, the development of absorbents for such pollutants is essential to overcome these problems. Electrospun nanofibers are often used for wastewater treatment owing to their high porosity and high specific surface area. Zein from plants and collagen from animals are vulnerable to moisture, which limits its broad application in practice. However fully biodegradable polyvinyl alcohol (PVA), which is soluble in water, can be mixed with protein individually to overcome the limitation. In this work, the two proteins described above and PVA were combined to prepare protein nanofibers by electrospinning technology, which could achieve adsorption of Cu 2+ . As the protein content increased, the adsorption properties of the obtained nanofibers for Cu 2+ showed a rising and then decreasing trend, with the highest point at 50 % of protein content, especially the collagen nanofibers, which reached 24.62 mg/g. Both protein nanofibers reached adsorption equilibrium after 15 h, but overall, collagen nanofibers showed a superior adsorption performance for Cu 2+ than that by zein nanofibers. In the process of Cu 2+ adsorption by protein nanofibers, both physical and chemical effect existed, and the physical effect played the leading role.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY A-CHEMISTRY
·
2019
·
IF 3.261
Yutao Yang,Xueli Yang,Keyan Zhou,Ming Jin,Wei Li
A new near-infrared (NIR) fluorescent probe based on 2-Methylchromone was exploited for relay recognition of Cu 2+ and biothiols. The mechanism involved in complex between metal ion and probe, and subsequent displacement reaction, which make the probe can detect GSH by NIR fluorescence turn on emission. Probe showed a fluorescence band at 718 nm in PBS-EtOH (3:2, v/v, 10 mM PBS, pH 7.4) solution. Upon the addition of Cu 2+ , a large fluorescence quenching was observed due to the coordination between probe 1 and Cu 2+ . The 1 -Cu 2+ could be used to detect biothiols utilizing high affinity of biothiols with Cu 2+ . This “on-off-on” fluorescent probe was also successfully applied to image GSH in MCF-7 cells and zebrafish.
研究领域:
分析化学
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生物化学
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生物医学工程
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细胞生物学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
·
2021
·Vol. 32
·期 12
·1-14
·
IF 3.896
Wang Shijia,Liu Xiaoli,Lei Miao,Sun Junjie,Qu Xue,Liu Changsheng
The contamination of chronic wound with bacteria especially methicillin-resistant Staphylococcus aureus (MRSA) is considered as the major factor interferencing normal wound healing. There still remain great challenges in developing safe and effective wound dressings with wide-spectrum antibacterial functions. Alginate hydrogel is a common dressing for wound treatment. Copper is one of the trace elements in human body with inherent antibacterial activity. Traditional methods for preparing a structure-controlled copper-alginate antibacterial matrix are difficult however, due to the fast and uncontrolled gelation between alginate and metal ions. In this work, we report an electrodeposition method for rapid fabrication of copper cross-linked alginate antibacterial films (Cu 2+ -Alg) with controlled structure and copper content, which is relied on an electrical signal controlled release of copper ions from the reaction of insoluble salt Cu 2 (OH) 2 CO 3 and the generated protons via water electrolysis on anode. The results prove that the physical structure and chemical composition of the electrodeposited Cu 2+ -Alg films can be continuously modulated by the imposed charges during electrodeposition. In vitro tests demonstrate the film has Cu 2+ content-dependent bactericidal activities. Film’s cytocompatibility is well controlled by the imposed charges for Cu 2+ -Alg fabrication. The MRSA infected wound model in vivo also indicates that Cu 2+ -Alg film can effectively eliminate bacterial infection and suppress host inflammatory responses. We believe this study demonstrates a convenient and controllable strategy to fabricate alginate antibacterial dressings with potential applications for infected wound treatment. More broadly, our work reveals electrodeposition is a general and simple platform to design alginate films with versatile functions.
研究领域:
材料科学
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生物医学工程
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伤口愈合
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抗菌技术
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DOI
PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 23
·e202401018
·
IF 1.9
Hai Shuai,Hanfeng Cui,Jie Zhang,Huiting Hu,Qian Long,Xiaocui Yin,Fusheng Liao,Hao Fan,Zhiqiang Liu,Bo Wu
Graphical In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples. In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples.
研究领域:
分析化学
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环境科学
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材料科学
·
传感器
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 18
·7559-7570
·
IF 4.5
Qin Minghao,Zong Siyu,Zhang Peng,Li Jiyang
The environmentally friendly luminescent sensing materials are desired for detection of heavy metal ions. Herein, two kinds of fluorescent nanomaterials, carbon dots (CDs-1) and N-doped carbon dots (CDs-2) were designed and synthesized as effectively sensors for simultaneous detection of Fe 3+ and Cu 2+ ions. A simple one-step hydrothermal synthesis was adopted by using cost-effective precursor humic acid (HA) as a carbon source and ammonium hydroxide as a nitrogen source. Photoluminescence (PL) spectra and TEM images reveal the distinct structure and property of these two CDs, in which CDs-1 display blue fluorescence with the average diameter of about 1.73 nm, while CDs-2 possess larger size (av. 2.41 nm) because of the larger conjugated structures and exhibit green fluorescence. The successful doping of N on the surface of CDs-2 was confirmed by characterizations of X-ray photoelectron spectroscopy (XPS) and Fourier transform infrared spectroscopy (FT-IR), which endows CDs-2 improved detection performance than that of CDs-1. CDs-2 could selectively and sensitively detect iron(III) and copper(II) ions, and the limit of detection (LOD) can reach 73 nM and 61 nM with a liner range from 0 to 20 μM and 0 to 50 μM, respectively. The fluorescence static quenching effect and the formation of the ground-state complex may explain the quenching mechanism of CDs-2 in this process. This work demonstrates the more possibilities of applying the low-cost waste and developing high-efficiency CDs-based luminescent sensors.
研究领域:
材料科学
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环境科学
·
分析化学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2017
·
IF 5.401
Ce-Ce Hu,Qiang Gao,Zhi-Xiu Zhu,Li-Li Chang,Wen-Jun Zhou,Kai-Sheng Xia,Bo Han,Cheng-Gang Zhou
Multi-ion-responsive probes are particularly attractive due to their high detection efficiencies and potential cost reductions, while there still remains the formidable challenge of discriminating different metal ions in pure aqueous media. Herein, a novel imidazolium chloride ionic liquid-grafted rhodamine B salicylaldehyde hydrazone (IMI-SARhBH) was rationally designed and developed as a promising multi-ion-responsive probe for the colorimetric detections and individual identifications of Cu 2+ and Al 3+ in 100% aqueous solutions. Benefitting from the remarkably hydrophilic nature of the grafted ionic liquid , the IMI-SARhBH was highly water-soluble, and showed excellent sensing performances for detections of Cu 2+ and Al 3+ under pure aqueous conditions in terms of high sensitivity, satisfactory selectivity, and strong anti-disturbance ability. More importantly, dissociation of the grafted ionic liquid in water made the probe positively charged, which caused electrostatic repulsion between itself and metal ions and thus offered the chance to differentially recognize Cu 2+ and Al 3+ . The Cu 2+ was repelled relatively weakly by IMI-SARhBH and thus identified quickly (<1 min), while the sensing detection of Al 3+ required a longer time (5 h) due to the relatively stronger electrostatic repulsion. Accordingly, a new and convenient method for individual identifications of Cu 2+ and Al 3+ from Cu 2+ –Al 3+ -coexisted solution was also successfully established.
研究领域:
分析化学
·
材料科学
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环境科学
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Mingliang Mei,Lixuan Mu,Sen Liang,Yuan Wang,Guangwei She,Wensheng Shi
The aptasensor , developed from the aptamer, has aroused wide concern in recent years owing to its high sensitivity and specificity. However, the quenching unit involved in the most of the aptasensors is indispensable to the fabrication of an aptasensor, which would undoubtedly increase the complexity of the device. In this study, a facile strategy was developed for construction of the quencher-free aptasensors, in which the quenching units can be omitted, and only an aptamer strand and a fluorophore are necessary. Distinguishable from the configuration of the traditional ones, the aptasensors developed in this work rationally employed the intrinsic quenching abilities of the analytes to directly regulate the fluorescence of the fluorophore. Furthermore, the aptamer strand as a discriminatory unit efficiently captured the corresponding analytes to around the fluorophores. As a result, the fluorescence of the aptasensor can be significantly sensitive to the analytes. The generality of the current design is evidenced by the successful fabrication of seven quencher-free aptasensors for Cu 2+ , Ag + , Hg 2+ , ATP and dopamine through 6-FAM labeling aptamers of Cu 2+ , Ag + , Hg 2+ , ATP, dopamine, 5-TAMRA and ROX labeling aptamers of Cu 2+ . Present strategy endows an aptasensor with a simple structure, high selectivity and fine sensitivity. The configuration of the quencher-free aptasensors fabricated in this work can be readily utilized for more aptasensors.
研究领域:
分析化学
·
生物传感器
·
分子生物学
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Xiu-Fang Huang,Bing-Xue Ren,Chi-Fang Peng,Xin-Lin Wei,Zheng-Jun Xie
In this study, the fluorescence enhancement effect of guanine base on DNA-Cu/AgNCs was reported and fluorescent methods for the determination of Hg 2+ or Cu 2+ ion were established. The effect of adjacent and inserted guanine base (G) sequences in DNA template on the fluorescence intensity of DNA-Cu/AgNCs was investigated. It was found that G 5 sequence extended from the 5′ end of a typical C-riched DNA strand, 5′-CCCTTAATCCCC-3′ (DNA1), demonstrated fluorescence enhancement effect in the preparation of the DNA-Cu/AgNCs. Moreover, this G5-DNA-Cu/AgNCs can be used to determine Hg 2+ and Cu 2+ ions due to fluorescence quenching by the two metal ions while the DNA1-Cu/AgNCs only can determine Hg 2+ ions. Specific assays for Hg 2+ ions and Cu 2+ ions were established through masking Cu 2+ ions by EDTA and Hg 2+ ions by NaBH 4 , respectively. In Hg 2+ determination, a linear range from 5.0 nM to 40 nM was obtained with a detection limit of 1.0 nM. In Cu 2+ determination, a wide linear range from 0.01 µM to 5.0 µM was obtained with a detection limit of 5.0 nM. The recoveries of 89.6–106.8% for Cu 2+ ions and 90.6–106.2% for Hg 2+ ions were obtained in the measurements of Hg 2+ and Cu 2+ ions spiked lake samples, respectively. The results indicate the potential application of the DNA-Cu/AgNCs as a metal ions probes in real samples.
研究领域:
分析化学
·
环境科学
·
纳米技术
·
生物化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2020
·
IF 3.594
Ying Zhou,Waqar Uddin,Gang Hu
In this paper, a kinetic method for identification of metal ions (Fe 3+ , Cu 2+ and Ag + ) was reported by using their perturbation effects on a Briggs-Rauscher (BR) oscillating system involving a tetraazamacrocyclic complex [NiL](ClO 4 ) 2 as a catalyst. The ligand (L) in the catalyst is 5,7,7,12,14, 14-hexamethyl-1,4,8,11-tetraazacyclotetradeca-4,11-diene. When an equal amount of analytes (metal ions) were separately added to the active BR-system under the same concentration, quite different perturbation results were obtained in their concentration ranges from 1.0 × 10 −4 to 2.0 × 10 −3 mol/L. Furthermore, based on the FCA and NF models, the perturbation mechanisms of three metal ions on BR system were explained in details. It is shown that the different perturbation manners are attributed to kinetic-controlled mechanisms. Such mechanisms suggested that both Fe 3+ and Cu 2+ may face a competitive reaction with IO 3 − to form iodate precipitate when they react with I − (an intermediate in BR system) vs redox reaction, whereas Ag + directly binds to I − to generate AgI without a competitive reaction which yields iodate precipitate. Also, the method could be used for quantitative determination of Ag + .
研究领域:
分析化学
·
物理化学
·
无机化学
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产品关联
DOI
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2023
·
IF 10.8
Tiantian Liu,Zehang Zhou,Mengxing Zhang,Puxin Lang,Jing Li,Zhenmi Liu,Zhirong Zhang,Lin Li,Ling Zhang
The cuproptosis cell death pathway brings fresh opportunities for tumor therapy. However, efficient and targeted cuproptosis induction in tumors is still a challenge. Unfortunately, the well-known cuproptosis initiator, disulfiram and copper complex (DSF/Cu 2+ ), also increases PD-L1 level in tumors, which may diminish the final therapeutic outcome. In this study, DSF/Cu 2+ -loading MXene nanosheets are coated with PD-1 overexpressing T cell membrane to generate CuX-P system. CuX-P could recognize and stick to PD-L1 on tumor cells like a patch, which promotes the endocytosis of both CuX-P and PD-L1 by tumor cells. Following internalization and release of DSF/Cu 2+ in the cytoplasm, PD-L1 expression is upregulated. However, due to the presence of CuX-P in the tumor microenvironment , the then supplemented PD-L1 on tumor surface again binds CuX-P for internalization. This feedback loop keeps blocking and consuming the PD-L1 on tumor surface and promotes the enrichment of CuX-P in tumors to induce cuproptosis. After CuX-P treatment with laser irradiation, strong anti-tumor immune responses are stimulated in a mouse model with triple-negative breast cancer. Thus, this study develops a tumor-targeted biomimetic system that offers simultaneous cuproptosis killing, photothermal therapy (PTT) and immunotherapy in mice.
研究领域:
肿瘤学
·
免疫治疗
·
纳米技术
·
癌症生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）