Frontiers in Bioengineering and Biotechnology
·
2023
·
IF 5.7
Du Jinsong,Chen Guanping,Yuan Xinyi,Yuan Jiang,Li Li
Although the potential of metal-organic framework (MOF) nanoparticles as drug delivery systems (DDS) for cancer treatment has been established by numerous studies, their clinical applications are still limited due to relatively poor biocompatibility. We fabricated a multifunctional Cu-MOFs@Keratin DDS for loaded drug and chemodynamic therapy (CDT) against tumor cells. The Cu-MOFs core was prepared using a hydrothermal method, and then loaded with the anticancer drug DOX and wrapped in human hair keratin. The Cu-MOFs@Keratin was well characterized by transmission electron microscopy (TEM), fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), and X-ray photoelectron spectroscopy (XPS). Characterization and pharmacokinetic studies of Cu-MOFs@Keratin were performed in vitro and in vivo. The keratin shell reduced the cytotoxicity and potential leakage of Cu-MOFs to normal cells, and allowed the drug-loaded nanoparticles to accumulate in the tumor tissues through enhanced permeability and retention effect (EPR). The particles entered the tumor cells via endocytosis and disintegrated under the stimulation of intracellular environment, thereby releasing DOX in a controlled manner. In addition, the Cu-MOFs produced hydroxyl radicals (·OH) by consuming presence of high intracellular levels of glutathione (GSH) and H2O2, which decreased the viability of the tumor cells.
研究领域:
生物医学工程
·
纳米医学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOELECTROCHEMISTRY
·
2022
·
IF 5.76
Axin Liang,Shanshan Tang,Miao Liu,Yue Yi,Bingteng Xie,Huipeng Hou,Aiqin Luo
Human IgG is one of the most important immunoglobulins in the human body. The present study described the fabrication of four kinds of layer-by-layer structures of copper metal-organic frameworks (Cu-MOFs) on the working electrode by electrodeposition, which were then applied as an electrochemical sensor for the sensitive determination of IgG in serum. First, MOFs synthesized using different deposition potentials are expected to have varied morphology and properties. Herein, four copper MOFs (Cu-MOFs) were electrosynthesized by a simple and direct reduction approach. The as-synthesized Cu-MOFs exhibit varied morphology and electrocatalytic behavior. Then, IgG was employed as a template in the electropolymerization of pyrrole-imprinted films on the surface of glassy carbon electrodes. Finally, the template protein was removed to form a molecularly imprinted film with the capability to qualitatively and quantitatively signaling of IgG. Under optimized conditions, the sensor for IgG exhibits a wide detection range of 0.01–10 ng mL −1 with a limit of detection (LOD) of 3 pg mL −1 (S/N = 3). Besides, other parameters including the selectivity, reproducibility (RSD 3.6%), and recovery rate (95.2–102.0%) are all satisfactory. The practicability of the sensor was verified by detecting IgG in human serum samples, which indicated that the sensor was suitable for potential clinical applications.
研究领域:
分析化学
·
生物传感器
·
材料科学
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2018
·
IF 4.244
Xuemei Wang,Xiaomin Ma,Pengfei Huang,Juan Wang,Tongtong Du,Xinzhen Du,Xiaoquan Lu
Hybrid magnetic nanocomposites based on Cu-MOFs, graphene oxide (GO), and Fe 3 O 4 nanoparticles (NPs) were prepared via chemical bonding approach, which GO were used as platforms to load nanostructured Cu-MOFs and Fe 3 O 4 NPs. The composite features both magnetic separation characteristics and high MOFs porosity, making it an excellent adsorbent for magnetic solid-phase extraction (MSPE). The as-synthesized nanocomposites are characterized by XRD, TGA , SEM, TEM, nitrogen adsorption-desorption analysis and FT-IR spectroscopy. The composites are used in MSPE of six aromatic insecticides from various real samples prior to their quantification by HPLC . Amount of adsorbent, extraction times, extraction temperature, desorption times and oscillation rate are optimized. Under the optimal conditions, the method has a relative standard deviations (RSDs) of 1.9–2.7%, and good linearity (correlation coefficients higher than 0.9931). The low LOD and LOQ for six insecticides are found to be 0.30–1.58 μg L -1 and 1.0–5.2 μg L -1 , respectively. The RSDs of within batch extraction are 1.6–9.5% and 3.9–12% for batch to batch extraction. The experimental results suggest that the nanocomposites have potential application for removal of hazardous pollutants from effluents.
研究领域:
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Foods
·
2025
·Vol. 14
·期 8
·1311
·
IF 5.1
Yanyan Huang,Jiatong Han,Yi Ping,Xin Chen,Yiming Zhao,Ge Chen,Jun Lv,Donghui Xu,Yanguo Zhang,Jing Chen,Guangyang Liu
In this study, two types of Cu-MOFs (Cu-TCPP and CuO-TCPP) with a two-dimensional layered porous structure were prepared via in situ polymerization using Cu2+, CuO, and TCPP as raw materials. Both Cu-MOFs exhibited peroxidase-like activity, capable of catalyzing the oxidation of TMB by H2O2to form oxTMB, resulting in an absorption peak at 652 nm and a color change from colorless to blue. Subsequently, the addition of AA can reduce oxTMB back to TMB, causing the color of the system to lighten or become colorless. Based on this principle, a simple and rapid colorimetric method for AA detection was established and successfully applied to the detection of TAC in fruits and vegetables. The results showed that Cu-TCPP and CuO-TCPP had a large linear range of ascorbic acid detection of 0.01–100 mM (Cu-TCPP) and 0.05–100 mM (CuO-TCPP). This study not only provides a novel method for preparing nanozymes with peroxidase-like activity, but also offers a simple approach for analyzing the TAC of food.
研究领域:
食品科学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Xueer Lin,Jiahui Zou,Guancheng Zhu,Linfeng Pang,Yuqi Chen,Yanyan Huang
To effectively overcome the shortcomings of traditional chromatographic and enzymatic methods for detecting organophosphorus pesticides, Cu-MOFs with inherent peroxidase (POD)-like activity were constructed for direct colorimetric detection of omethoate (OMT). Benefiting from the mesoporous and benzene ring structure, Cu-MOFs demonstrated excellent OMT enrichment capability. OMT exhibited a pronounced inhibitory effect on the POD-like activity of Cu-MOFs whereas other pesticides showed negligible interference, demonstrating the specific identification of OMT by Cu-MOFs. Experimental data and theoretical calculations indicated that OMT effectively bond to Cu-MOFs through Cu 2+ coordination and ligand binding. Owning to its enrichment, identification and catalytic abilities, OMT detection was achieved and the limit of detection (LOD) was 16 μg L −1 . Furthermore, a smartphone-assisted portable detection was established with a LOD of 79 μg L −1 . Validation experiments of cabbage samples confirmed its’ reliability for practical applications. Our system integrated the enrichment, identification, and detection of OMT within a single system, improving both sensitivity and operational convenience.
研究领域:
分析化学
·
纳米技术
·
环境科学
·
生物传感器
·
农药检测
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2023
·
IF 13.6
Shi-Xian Guan,Tao Xu,Jian-Yong Zhang,You-Guo Luo,Xingwu Zhai,Na Zhang,Yong-Zheng Fang,Qin-Fei Ke
Herein, we developed a multimodal antibacterial nanoplatform via synergism effect including knife-effect, photothermal, photocatalytic induced reactive oxygen species (ROS), and Cu 2+ inherent attribute. Typically, 0.8-TC/Cu-NS possesses higher photothermal property with the higher photothermal conversion efficiency of 24% and the moderate temperature up to 97 °C. Meanwhile, 0.8-TC/Cu-NS exhibits the more active ROS, 1 O 2 and ·O 2 - . Hence, 0.8-TC/Cu-NS possesses best antibacterial properties against S. aureus and E. coli in vitro with efficiency of 99.94%/99.97% under near-infrared (NIR) light, respectively. In the therapeutic practical use for wound healing of Kunming mice, this system exhibits outstanding curing capacity and good biocompatibility. Based on the electron configuration measurement and density functional theory (DFT) simulation, it is confirmed that the electrons on CB of Cu-TCPP flow fleetingly to MXene trough the interface, with redistribution of charge and band upward bending over Cu-TCPP. As a result, the self-assembled 2D/2D interfacial Schottky junction have made great favor to accelerate photogenerated charges mobility, hamper charge recombination, and increases the photothermal/photocatalytic activity. This work gives us a hint to mostly design the multimodal synergistic nanoplatform under NIR light in biological applications without drug resistance.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
化学
·
生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2019
·
IF 6.97
Lei Wang,Wenjing Zhi,Jing Wan,Juan Han,Chunmei Li,Yun Wang
Enhancing the stability and reusability of enzymes by encapsulating them within a powerful class of porous materials termed metal–organic frameworks (MOFs) has been demonstrated by recent studies. However, in all of these reports, the stability of MOFs under acidic conditions was a major issue for enzymes with catalytic activity at low pH. The objective of this study is to encapsulate the β-glucosidase (β-G) into the Cu-MOF due to its acidic stability, using a coprecipitation approach. Indeed, the as-prepared β-G@Cu(PABA) biocomposite with high encapsulation efficiency exhibited enhanced resistance to acidic and thermal conditions as well as organic solvents. Importantly, the β-G@Cu(PABA) biocomposite showed superior reusability, retaining 90% of activity even after 10 cycles. Using the hydrolysis of carboxymethylcellulose (CMC) as a mode, the mixture of β-G@Cu(PABA) biocomposite and coimmobilized cellulase afforded 98% glucose yield, which was twofold enhancement when compared with coimmobilized cellulose alone. The β-G@Cu(PABA) biocomposite and coimmobilized cellulase could been easily recovered and recycled to still retain 70% productivity in the eight cycles for hydrolyzing CMC. This discovery for the first time highlights the potential of Cu-MOF in preserving the enzymes under acidic conditions. The developed β-G@Cu(PABA) biocomposite by coprecipitation approach affords a valuable platform for enzyme-based industrial applications.
研究领域:
生物化学
·
材料科学
·
生物技术
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2020
·Vol. 9
·期 1
·238-248
·
IF 7.059
Qigao Shang,Nannan Liu,Dan You,Qingrong Cheng,Guiying Liao,Zhiquan Pan
Two coordination polymers, {[Cu3(tib)4(NO3)4(H2O)]·2NO3·2.96H2O}n (1) and {[Ni(tib)2]·2NO3}n (2), were synthesized by a solvothermal reaction using a flexible tripodal ligand, 1,3,5-tris(imidazol-1-ylmethyl)benzene (TIB), and metal salts; the polymers were characterized by X-ray diffraction, Fourier transform infrared spectroscopy, thermogravimetric analysis, X-ray photoelectron spectroscopy and UV-vis diffuse reflectance spectra. The two complexes exhibited excellent active performance for photodegradation of tetracycline (TC) and photocatalytic hydrogen evolution under visible light. Control experiments revealed clearly that the pH value plays an important role in TC degradation, especially in alkaline solution; 93.21% of tetracycline was degraded by complex 1 within 60 min. In addition, using a Pt cocatalyst, the visible-light-driven photocatalytic H2 evolution rate of complex 2 reached 681.66 μmol h−1 g−1. Moreover, the photocatalysts can remain stable and retain high photocatalytic activity after several cycles of reuse. These MOF-based photocatalysts will provide new efforts for environmental purification and hydrogen evolution.
研究领域:
环境科学
·
材料科学
·
化学
·
催化
·
可持续能源
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2020
·
IF 3.807
Jianbo Liu,Yonghui Shang,Jinqiong Xu,Yi Chen,Yarong Jia,Jianbin Zheng
Carcinoembryonic antigen (CEA) is a typical biomarker for lung cancer. It is very urgent to develop a sensitive and rapid method to assay CEA content in human serum. In this work, Cu-MOFs nanomaterials were synthesized by a hydrothermal method . Toluidine blue (TB) loaded mesoporous Cu-MOFs with polydopamine (PDA) coating were employed as a signal probe. The proposed sandwich immunosensor was fabricated by Cu-MOFs-TB/PDA, chitosan and MWCNTs on the glassy carbon electrode with a large surface area to immobilize primary antibodies (Ab 1 ) and provide excellent conductivity. The sensitivity improvement of this new strategy was based on the destruction of the probe and the immune complex by HCl, which resulted in the closer distance between TB and the sensing electrode. Under optimal conditions, CEA was quantitatively detected with a wide linear range from 20 fg mL −1 to 200 ng mL −1 , a low detection limit of 3.0 fg mL −1 (S/N = 3). In addition, the method showed good stability, selectivity, and reproducibility, which possessed wide potential applications for the detection of other tumour biomarkers.
研究领域:
分析化学
·
生物标志物检测
·
纳米技术
·
电化学
·
癌症诊断
✓ 已验证
产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Ruiqi Zou,Junxiao Shi,Qi Lu,Chunyan Sun,Haiqing Ye,Xu Yan,Fangjie Tian,Hongxia Li
Given the potential dangers of organophosphorus pesticides to food safety and human health, the development of a reliable and precise detection platform for pesticides is essential. In this study, we present a novel ‘armor-plating’ laccase-mimetic catalyst (DNA-Cu@MOFs)-based colorimetric platform, which enables stable and selective pesticide detection. The DNA-Cu@MOFs enhance catalytic stability and overcome pH limitations, enabling effective catalysis under neutral and alkaline physiological conditions, making them well-suited for practical applications in biosensor development. By combining the catalytic properties of DNA-Cu@MOFs with a high-affinity biorecognition element (acetylcholinesterase), the platform achieves a linear detection range of 3.0–90 ng mL −1 for chlorpyrifos, with a detection limit of 0.75 ng mL −1 . Notably, this platform demonstrates significant stability in chlorpyrifos detection even in the presence of environmental interferents. This robust colorimetric platform offers new possibilities for pesticide detection and provides a solid foundation for the development of comprehensive and accurate pesticide monitoring systems.
研究领域:
生物传感
·
环境科学
·
食品科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2023
·
IF 3.8
Yanan Chen,Yuanbo Zhao,Weijun He,Yanan Liu,Hongna Xing,Xiuhong Zhu,Yanqun Guo,Juan Feng,Chunyan Liao,Yan Zong,Xinghua Li,Xinliang Zheng
Significant volume changes and slow ionic transport during charge/discharge processes restrict the improvement of electrochemical performance for Cu x S (x = 1–2). Herein, a new strategy by introducing Cu-BTC (copper(II)-benzene-1,3,5-tricarboxylate) as a processor to derive three-dimensional Cu 1.81 S@C using green sulfurization and calcination methods is proposed. Benefiting from the high electrical conductivity , multistage pore size structure and stable structure brought by the conductive carbon skeleton after calcination , Cu 1.81 S@C-650 o C exhibits a high specific capacitance of 291.1 F g -1 at a current density of 1 A g -1 and a superior rate capability of 83.6 % at a current density of 10 A g -1 . In addition, the assembled asymmetric supercapacitor (Cu 1.81 S@C-650 o C//AC ASC) also shows impressive performances, such as an energy density up to 16 Wh kg -1 at a power density of 352 W kg -1 and an excellent cycling stability of 93.1 % over 5000 cycles at a current density of 2 A g -1 . This work demonstrates that the Cu-BTC-derived Cu 1.81 S@C is an attractive material with potential applications in energy storage devices.
研究领域:
材料科学
·
能量存储
·
超级电容器
·
金属有机框架（MOFs）
·
纳米材料
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Saisai Chen,Chaohai Wang,Ming Zhang,Wuxiang Zhang,Junwen Qi,Xiuyun Sun,Lianjun Wang,Jiansheng Li
Fast and efficient tracking of micropollutants in aquatic environment by developing novel electrode materials is of great significance. Herein, a polyvinylpyrrolidone (PVP) assisted strategy is applied for synthesis of nitrogen doped Cu MOFs (N-Cu-MOF) for micropollutants electrochemical detection. The designed N-Cu-MOFs possess uniform octahedral shape with large surface area (1184 m 2 g −1 ) and an average size of roughly 450 nm, exhibiting the excellent electroanalytical capability for the detection of multipollutants. In the case of dopamine (DA) and sulfonamides (SA) as typical microcontaminants, the designed N-Cu-MOFs exhibited wide linear ranges of 0.50 nM–1.78 mM and low detection limit (LOD, 0.15 nM, S / N = 3) for the determination of DA, as well as a linear range of 0.01–58.3 μM and LOD (0.003 μM, S / N = 3) for monitoring SA. The improved performance is attributed to the heteroatom introduction and good dispersion stability of N-Cu-MOF with PVP-decorated. The good electroanalytical ability of N-Cu-MOF for detection of DA and SA can provide a guide to efficient and rapid monitor other micropollutants and construct novel electrochemical sensors.
研究领域:
环境科学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）