Analytical Methods
·
2025
·
IF 2.6
Guang Wu,Shipeng He,Liwen Wang,Zhao Deng,Dating Tian,Na Zhou
Ascorbic acid (AA) is essential to human health, and accurate detection of AA content in food and drugs is necessary for disease monitoring. In this study, a hydrogen-bonded organic framework (HOF-TCBPA) was constructed with tris [(4-carboxyl)biphenyl] amine (H3TCBPA) as the only raw material, and Cu2+ was added for modification to develop a simple off-on fluorescence sensor (HOF-TCBPA/Cu2+) for detecting AA. Cu2+ can quench the fluorescence emission of HOF-TCBPA. However, in the presence of AA, the fluorescence emission of HOF-TCBPA is restored, resulting in an off-on response mechanism. The results indicated that the linear range for detecting AA concentration utilizing HOF-TCBPA/Cu2+ was 0.1-1.0 mmol/L, with a detection limit of 0.076 mmol/L. This work introduces a new platform for developing off-on fluorescence sensors using HOF/metal ions.
研究领域:
分析化学
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材料科学
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生物传感
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 8
·1-8
·
IF 5.833
Hu Cong Yi,Jiang Zhong Wei,Huang Cheng Zhi,Li Yuan Fang
Based on the laccase-mimicking activity of Cu 2+ -modified University of Oslo (UiO) metal–organic framework (UiO-67-Cu 2+ ), we developed a colorimetric sensor array for distinguishing a series of phenols with different number and position of substituted hydroxyl group (-OH) and different substituent group on the benzene ring, including phenol, catechol, quinol, resorcinol, pyrogallol, phloroglucinol, o -chlorophenol, o -aminophenol, and o -nitrophenol. The highest occupied molecular orbital (HOMO) and lowest unoccupied molecular orbital (LUMO) energy levels of phenolic compounds were obtained by theoretical calculation. The results show that the lower the LUMO energy level, the easier the chromogenic reaction occurs. The UiO-67-Cu 2+ -catalyzed phenol chromogenic reaction showed a good linearity in the range from 0.1 to 200 μM with limit of detection approximately 61 nM. Through the detection of phenol in tap water and river water, the recovery rate and RSD ( n = 3) were calculated as 94.1~103% and 1.0~3.3, respectively, showing good recovery, reliable results, and outstanding stability. Therefore, the proposed colorimetric sensor array will have a great potential for the detection of phenols in the environment. Graphical abstract
Schematic presentation of a simple and sensitive colorimetric strategy based on the laccase-mimicking activity of Cu 2+ -modified UiO-type metal–organic framework (MOFs, Uio-67-Cu 2+ ) to distinguish phenols with analogous structures.
研究领域:
分析化学
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环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2021
·Vol. 188
·期 1
·1-10
·
IF 5.833
Zhu Junlun,Luo Guan,Xi Xiaoxue,Wang Yijia,Selvaraj Jonathan Nimal,Wen Wei,Zhang Xiuhua,Wang Shengfu
A Cu 2+ -modified carboxylated hollow carbon nanospheres (Cu 2+ -HCNSs-COOH) was designed with enhanced peroxidase-like activity for the detection of hydrogen peroxide (H 2 O 2 ) and degradation of methylene blue (MB). Hollow polymer nanospheres were fabricated from aniline, pyrrole, Triton-100, and ammonium persulfate via confined interfacial copolymerization reaction, which can be pyrolyzed to create HCNSs with the hollow gap diameter of about 20 nm under high temperature. Combining the synergistic effect of coordination and electrostatic interaction, Cu 2+ -HCNSs-COOH was constructed by anchoring Cu 2+ on the surface of HCNSs-COOH. Furthermore, Cu 2+ -HCNSs-COOH has higher affinity for 3,3′,5,5′-tetramethylbenzidine and H 2 O 2 of 0.20 mM and 0.88 mM, respectively. Based on the rapid response of Cu 2+ -HCNSs-COOH to H 2 O 2 , we constructed a colorimetric sensing platform by detecting the absorbance of the 3,3′,5,5′-tetramethylbenzidine-H 2 O 2 system at 652 nm for quantifying H 2 O 2 , which holds good linear relationship between 1 and 150 μM and has a detection limit of 0.61 μM. We also investigated the degradation of MB in the presence of Cu 2+ -HCNSs-COOH and H 2 O 2 , which can degrade 80.7% pollutants within 30 min. This research developed an unusual nanozyme for bioassays and water pollution treatment, which broadened the way for the rapid development of clinical diagnostics and water pollution treatment. Graphical abstract
研究领域:
纳米材料科学
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生物分析化学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2023
·
IF 8.4
You Lei,Yuting Gao,Yi Xiao,Pengcheng Huang,Fang-Ying Wu
Developing a fluorescence sensor capable of precisely identifying highly toxic nerve agents has become a focus of research, given that they are easily available and can be used by terrorists to threaten the security of the world. In this work, we designed a ratiometric fluorescence sensing platform with Cu 2+ -modified UiO-66-NH 2 (Cu 2+ @UiO-66-NH 2 ) and o-phenenediamine (OPD) as signal indicators and successfully used for the liquid and gas detection of the nerve agent simulant diethyl chlorophosphate (DCP). UiO-66-NH 2 obtained oxidase activity by simple Cu 2+ modification, which catalyzed the oxidation of OPD to give a yellow fluorescent product 2, 3-diaminophenazine (DAP). In this detection system, the fluorescence of UiO-66-NH 2 was greatly enhanced by blocking the ligand metal charge transfer (LMCT) process inside the framework by DCP. At the same time, the amino group of DAP was phosphorylated by DCP, and the attenuation of DAP fluorescence was observed by the static quenching effect. In addition, the Cu 2+ @UiO-66-NH 2 /OPD loaded agarose hydrogel device can be used to detect DCP vapor with naked eyes and showed satisfactory detection result (LOD: 6.65 ppb).
研究领域:
化学传感器
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环境科学
·
材料科学
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产品关联
DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2018
·
IF 5.667
Yi Lin,Palanisamy Kannan,Yanbo Zeng,Bin Qiu,Longhua Guo,Zhenyu Lin
In this work, we have synthesized Cu 2+ -modified carbon nitride nanosheets (Cu 2+ -C 3 N 4 ) as peroxidase mimic catalytic substance, which is more active than the horseradish peroxidase enzyme in extreme environments. Gold nanobipyramid (Au NBP) is a good chromogenic substrate for multicolor display because the longitudinal plasmon bands of AuNRs can be easily tuned by adjusting their aspect ratios and used as an excellent indicator for colorimetric detection of immunoassays . The generation of TMB 2+ from sandwich complex (peroxidase-like catalysis) efficiently etches Au NPBs to produce multicolor variations from brown to olive, green, blue, purple, purple, red, pink, and colorless in presence of varied concentrations of neuron specific enolase (NSE). The experimental results show that the colorimetric detection ranging from 312.5 to 20,000 pM with a detection limit of 92.8 pM, which is higher than other multicolor based sensors. The Cu 2+ -C 3 N 4 nanosheets and Au NBPs based colorimetric visual (naked eye) semi-quantitative method as a potential platform towards the detection of important biomolecules in clinical and therapeutic applications. The proposed method is simple, low-cost and enzyme-free to detect NSE for the first time.
研究领域:
纳米技术
·
生物传感器
·
分析化学
·
医学诊断
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）