Nanomaterials
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2025
·Vol. 15
·期 6
·432
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IF 4.3
Xin Zhong,Xiaojun Liu,Meihuan Ji,Fubin Jiang
As the most promising techniques for refractory antibiotic degradation in wastewater management, sulfate radical-based advanced oxidation processes (SR-AOPs) have attracted considerable attention. However, systematic studies on potassium peroxymonosulfate (PMS) activation by MOF-derived metal oxides coated with LDH materials are still lacking. In this work, a series of catalysts consisting of CoCu-MOFs coated with CuAl/LDH were synthesized for PMS activation in the removal of sulfamethoxazole (SMX). As expected, CoCu-MOFs coated with CuAl/LDH catalyst showed high SMX removal and stability in PMS activation. In the CoCu/LDH/PMS reaction, the SMX removal was nearly 100% after 60 min, and the mineralization reached 53.7%. The catalyst showed excellent catalytic stability and low metal leaching concentrations (Co: 0.013 mg/L, Cu: 0.313 mg/L), as detected by ICP. Sulfate radicals and hydroxyl radicals were identified as the dominant reactive species in the CoCu/LDH/PMS system. Moreover, the presence of 1 O 2 in the process revealed the coupling of non-radical and radical processes. The XPS results showed that the layered structure of CoCu/LDH promoted the recycling of metal ions (high and low valence), which facilitated heterogeneous PMS activation. The effects of different reaction conditions and reuse cycles were also determined. The SMX oxidation pathways were proposed based on the intermediates identified by LC/MS. The high activity and stability of CoCu/LDH provide a new mechanistic understanding of PMS activation catalysts and their potential utilization in practical wastewater treatment.
研究领域:
环境科学
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材料科学
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DOI
PubMed
高影响因子
SENSORS
·
2020
·Vol. 20
·期 15
·4146
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IF 3.275
Chuxuan Zhang,Xinqiang Liang,Yuanyuan Lu,Hua Li,Xiangyang Xu
Glyphosate, which has been widely reported to be a toxic pollutant, is often present at trace amounts in the environment. In this study, a novel copper-aluminum metal hydroxide doped graphene nanoprobe (labeled as CuAl–LDH/Gr NC) was first developed to construct a non-enzymatic electrochemical sensor for detection trace glyphosate. The characterization results showed that the synthesized CuAl–LDH had a high-crystallinity flowered structure, abundant metallic bands and an intercalated functional group. After mixed with Gr, the nanocomposites provided a larger surface area and better conductivity. The as-prepared CuAl–LDH/Gr NC dramatically improved the enrichment capability for glyphosate to realize the stripping voltammetry detection. The logarithmic linear detection range of the sensor was found to be 2.96 × 10−9–1.18 × 10−6mol L−1with the detection limit of 1 × 10−9mol L−1with excellent repeatability, good stability and anti-interference ability. Further, the sensor achieved satisfactory recovery rates in spiked surface water, ranging from 97.64% to 108.08%, demonstrating great accuracy and practicality.Keywords:electrochemical detection;glyphosate;layer double hydroxides;sensor
研究领域:
环境科学
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分析化学
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纳米技术
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水质监测
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Sa Wang,Shuqing Yang,Zhuolin Cui,Xueyan Liu,Yu Yang,Tao Wang,Wenjuan Ma,Yubin Zhou,Ruizheng Liang,Dan Yan,Huizhi Chen
Precise activation of therapeutic molecules in tumor tissues is the key step to ensure targeted antitumor performance and reduce adverse effects towards normal tissues and organs. Although the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC), i.e., bioorthogonal chemistry, has been used for the rapid synthesis of anticancer drugs in cells, it remains a great challenge to realize precise in vivo drug synthesis in tumor sites for precise cancer treatment. In this work, we first report the in-situ activation of CuAl-layered double hydroxide (CuAl-LDH) nanosheets to realize Cu(I)-catalyzed bioorthogonal chemistry in vivo in tumor microenvironment (TME) for precise chemotherapy and chemodynamic therapy (CDT). The Cu(II) ions in the biocompatible CuAl-LDH nanosheets can be in-situ reduced to Cu(I) ions partially by the overexpressed glutathione in TME. The generated Cu(I) can serve as a catalyst to catalyze the CuAAC reaction between alkyne and azide in TME, thus realizing in vivo drug synthesis for precise chemotherapy. Meanwhile, the generated Cu(I) can catalyze the Fenton-like reaction to generate toxic hydroxyl radicals (⋅OH) from H 2 O 2 in TME for CDT. Therefore, CuAl-LDHs can be used for the targeted synergistic chemotherapy and CDT to achieve highly precise and efficient elimination of cancer cells in vitro and inhibition of tumors in vivo .
研究领域:
纳米技术
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癌症治疗
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生物化学
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材料科学
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DOI
高影响因子
Inorganics
·
2023
·Vol. 11
·期 4
·155
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IF 2.9
Tie Shi,Yanmei Feng,Yi Zhong,Hao Ding,Kai Chen,Daimei Chen
High photoelectrochemical water oxidation efficiency can be achieved through an efficient photogenerated holes transfer pathway. Constructing a photoanode semiconductor heterojunction with close interface contact is an effective tactic to improve the efficiency of photogenerated carrier separation. Here, we reported a novel photoanode p-n junction of Ti:Fe2O3/Cu2O (n-Ti:Fe2O3and p-Cu2O), Cu2O being obtained by in situ reduction in CuAl-LDH (layered double hydroxides). The Ti:Fe2O3/Cu2O photoanode exhibits a high photocurrent density reaching 1.35 mA/cm2at 1.23 V vs. RHE is about 1.67 and 50 times higher than the Ti:Fe2O3and α-Fe2O3photoanode, respectively. The enhanced PEC activity for the n-Ti:Fe2O3/p-Cu2O photoelectrode is due to the remarkable surface charge separation efficiency (ηsurface85%) and bulk charge separation efficiency (ηbulk72%) formed by the p-n junction and the tight interface contact formed by in situ reduction. Moreover, as a cocatalyst, CuAl-LDH can protect the Ti:Fe2O3/Cu2O photoanode and improve its stability to a certain extent. This study provides insight into the manufacturing potential of in situ reduction layered double hydroxides semiconductor for designing highly active photoanodes in the field of photoelectrochemical water oxidation.
研究领域:
材料科学
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电化学
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纳米技术
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DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
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IF 12.5
Shaohua Liu,Xiaoling Zhang,Yunge Wang,Hongjun Xia,Wenping Zhu,Yanxia Li,Weijie Yang,Zengchen Liu,Boshi Tian,Piaoping Yang
2D centrosymmetric CuAl-LDH as flexocatalysts for sono-flexocatalytic tumor therapy. • Non-uniform lattice distortion induces a strain gradient and flexoelectricity. • Ultrasound-driven generation of superoxide anions, singlet oxygen, and H 2 O 2 . • POD-like activity and GSH depletion synergistically amplify tumor oxidative stress. Sonocatalytic therapy has emerged as a promising antitumor modality owing to its deep tissue penetration and high spatiotemporal accuracy. However, the rapid electron–hole recombination in sonocatalysts severely restricts the reactive oxygen species (ROS) production and therapeutic efficacy. Although piezoelectric materials enable efficient charge separation, their prerequisite of a non-centrosymmetric crystal structure severely constrains the availability of suitable candidates. Herein, we demonstrate that two-dimensional (2D) CuAl-LDH nanosheets, synthesized via a facile coprecipitation route, serve as flexoelectric nanoagents for ultrasound-driven tumor treatment. Under ultrasound stimulation, the nanosheets efficiently generate superoxide anions (·O 2 − ) and singlet oxygen ( 1 O 2 ) through the flexocatalytic effect, alongside simultaneous in situ H 2 O 2 production. Density functional theory calculations reveal that compressive stress creates non-uniform strain gradients that break local inversion symmetry in 2D CuAl-LDH, inducing an in-plane flexoelectric polarization and built-in electric field that synergistically promote charge separation and directional carrier migration. Moreover, the CuAl-LDH nanosheets exhibit intrinsic peroxidase-like activity and glutathione-depleting ability; the ultrasound-generated H 2 O 2 is continuously catalyzed to produce hydroxyl radicals, thereby establishing a cascade ROS-amplification loop that synergistically amplifies intracellular oxidative stress. Furthermore, the nanosheets exhibit favorable biodegradability and biosafety. This work uncovers the intrinsic flexoelectric effect in CuAl-LDH nanosheets and provides insights for the design of 2D LDH-based flexocatalytic nanoplatforms for tumor therapy. 2D centrosymmetric CuAl-LDH nanosheets are developed as flexocatalysts for sono-flexocatalytic tumor therapy. Under ultrasound stimulation, non-uniform lattice distortion induces a strain gradient, leading to flexoelectric polarization that drives the generation of superoxide anions, singlet oxygen, and H 2 O 2 . Additionally, the nanosheets exhibit POD-like activity and deplete GSH, synergistically amplifying intratumoral oxidative stress to enhance antitumor efficacy. Download: Download high-res image (290KB) Download: Download full-size image
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高影响因子
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