ACS Applied Materials & Interfaces
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2023
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IF 9.5
Pengpeng Jia,Yu Zou,Jiang Jiang
Developing antibacterial hydrogels, with good mechanical strength and self-healing ability to resist bacterial invasion and accelerate skin regeneration, is critical for infected full-thickness skin wound treatment. Herein, we report a gelatin-assisted synthesis and direct incorporation strategy to construct a CuS hybrid hydrogel for infected wound healing applications. CuS nanodots (NDs) were synthesized directly inside a gelatin host matrix (Gel-CuS), and these tightly confined and evenly distributed CuS NDs displayed superb dispersibility and stability against oxidation. Gel-CuS was then used to crosslink with oxidized dextran (ODex) to form a Gel-CuS-8/ODex hydrogel (8 stands for the concentration of CuS, in mM) via a facile Schiff-base reaction, which exhibited improved mechanical properties, excellent adhesion and self-healing ability, suitable swelling and degradation behavior, and good biocompatibility. The Gel-CuS-8/ODex hydrogel can act as an efficient antibacterial agent due to its photothermal and photodynamic properties under a 1064 nm laser irradiation. Furthermore, in animal experiments, when being applied as wound dressing, the Gel-CuS-8/ODex hydrogel significantly promoted infected full-thickness cutaneous wound healing through improved epidermis and granulation tissue formation and accelerated generation of new blood vessels, hair follicles, and collagen deposition after proper near-infrared irradiation treatment. This work provides a promising strategy to synthesize functional inorganic nanomaterials tightly and evenly embedded inside modified natural hydrogel networks for wound healing applications.
研究领域:
生物医学工程
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材料科学
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皮肤病学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
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2021
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IF 8.947
Shiwei Niu,Xuejing Zhang,Gareth R. Williams,Jianrong Wu,Feng Gao,Zi Fu,Xia Chen,Sheng Lu,Li-Min Zhu
The combination of chemotherapy and photothermal therapy (PTT) into a single formulation has attracted increasing attention as a strategy for enhancing cancer treatment. Here, hollow mesoporous silica nanoparticles (HMSNs) were used as a base carrier material, loaded with the anti-cancer drug doxorubicin (DOX), and surface functionalized with chitosan (CS) and copper sulfide (CuS) nanodots to give [email protected] In this formulation, the CuS dots act as gatekeepers to seal the surface pores of the HMSNs, preventing a burst release of DOX into the systemic circulation. S-S bonds connect the CuS dots to the HMSNs; these are selectively cleaved under the reducing microenvironment of the tumor, permitting targeted drug release. This, coupled with the PTT properties of CuS, results in a potent chemo/PTT platform. The [email protected] nanoparticles have a uniform size (150 ± 13 nm), potent photothermal properties (η = 36.4 %), and tumor-targeted and near infrared (NIR) laser irradiation-triggered DOX release. In vitro and in vivo experimental results confirmed that the material has good biocompatibility, but is effectively taken up by cancer cells. Moreover, the CuS nanodots permit simultaneous thermal/photoacoustic dual-modality imaging. Treatment with [email protected] and NIR irradiation caused extensive apoptosis in cancer cells both in vitro and in vivo , and could dramatically extend the lifetimes of animals in a murine breast cancer model. The system developed in this work therefore merits further investigation as a potential nanotheranostic platform for cancer treatment. Statement of significance Conventional cancer chemotherapy is accompanied by unavoidable off-target toxicity. Combination therapies, which can ameliorate these issues, are attracting significant attention. Here, the anticancer drug doxorubicin (DOX) was encapsulated in the central cavity of chitosan (CS)-modified hollow mesoporous silica nanoparticles (HMSNs). The prepared system can target drug release to the tumor microenvironment. When exposed to near infrared laser (NIR) irradiation, CuS nanodots located at the surface pores of the HMSNs generate energy, accelerating drug release. In addition, a systematic in vitro and in vivo evaluation confirmed the [email protected] platform to give highly effective synergistic chemotherapeutic-photothermal therapy and have effective thermal/photoacoustic dual-imaging properties. This work may open up a new avenue for NIR-enhanced synergistic therapy with simultaneous thermal/photoacoustic dual imaging.
研究领域:
纳米技术
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癌症治疗
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材料科学
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生物医学工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Small
·
2023
·
IF 13.3
Xiaodan Wei,Honglin Huang,Junhan Guo,Ningxi Li,Qingzhi Li,Tian Zhao,Geng Yang,Lulu Cai,Hong Yang,Chunhui Wu,Yiyao Liu
Reprogramming the immunologically “cold” environment of solid tumors is currently becoming the mainstream strategy to elicit powerful and systemic anticancer immunity. Here, a facile and biomimetic nano-immunnoactivator ( CuS/Z@M 4T1 ) is detailed by engineering a Zn 2+ -bonded zeolitic imidazolate framework-8 (ZIF-8) with CuS nanodots (NDs) and cancer cell membrane for amplified near-infrared-II (NIR-II) photothermal immunotherapy via Zn 2+ metabolic modulation. Taking advantage of the NIR-II photothermal effect of CuS NDs and the acidic responsiveness of ZIF-8, CuS/Z@M 4T1 rapidly causes intracellular Zn 2+ pool overload and disturbs the metabolic flux of 4T1 cells, which effectively hamper the production of heat shock proteins and relieve the resistance of photothermal therapy (PTT). Thus, amplified immunogenic cell death is evoked and initiates the immune cascade both in vivo and in vitro as demonstrated by dendritic cells maturation and T-cell infiltration. Further combination with antiprogrammed death 1 (aPD-1) achieves escalated antitumor efficacy which eliminates the primary, distant tumor and avidly inhibits lung metastasis due to cooperation of enhanced photothermal stimulation and empowerment of cytotoxic T lymphocytes by aPD-1. Collectively, this work provides the first report of using the intrinsic modulation property of meta-organometallic ZIF-8 for enhanced cancer photoimmunotherapy together with aPD-1, thereby inspiring a novel combined paradigm of ion-rich nanomaterials for cancer treatment.
研究领域:
纳米技术
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癌症免疫治疗
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生物医学工程
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材料科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）