APPLIED SURFACE SCIENCE
·
2024
·
IF 6.3
Songlin Chen,Zhihao Shen,Shuming Wen,Guang Han,Qicheng Feng
Flotation separation of Cu–Fe sulfide minerals typically necessitate the addition of substantial quantities of lime to depress pyrite flotation. Because lime can harm the environment, there is an urgent need to develop novel environmentally friendly depressants that are non-toxic and biodegradable. In this study, we investigated an environmentally friendly pyrite depressant containing amino and carboxyl groups, namely D-arginine (DA). The effect of DA on the surface hydrophobicity of Cu–Fe sulfide minerals and thus collector adsorption was investigated by analyzing zeta potentials, adsorption capacities, and contact angles. Additionally, changes in the surface properties of the minerals induced by DA were examined using X-ray photoelectron spectroscopy (XPS), time-of-flight secondary ion mass spectroscopy (ToF-SIMS), and atomic force microscopy (AFM). Flotation tests revealed that 2 × 10 –4 mol/L DA reduced the flotation recovery of pyrite to 9.96 % at low alkalinity while leaving chalcopyrite recovery unchanged. The results of mineral surface analysis indicated that DA exhibited significantly stronger adsorption on the pyrite surface than on the chalcopyrite surface. Furthermore, DA effectively reduced the adsorption of the collector on the surface of pyrite, thereby weakening pyrite floatability at low alkalinity. Therefore, DA is a promising alternative depressant for the flotation separation of chalcopyrite from pyrite.
研究领域:
矿物加工工程
·
环境科学
·
材料化学
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产品关联
DOI
高影响因子
ENERGY & FUELS
·
2025
·
IF 5.3
Yuanjian Chen,Zhengli Zhang,Ruirui Cui,Yi Wang,Ting Yang,Yong Deng,Shaolu Chen,Junli Li
The appearance of the cathode interlayer (CIL), a transition bridge between the cathode and the organic photoactive layer (OPL), provides a new pathway for the performance improvement of organic solar cells (OSCs). PFN-Br is widely employed in many optoelectronic devices, including nonfullerene OSCs, to transport electrons and improve charge injection at the interface. However, due to the relatively low conductivity of PFN-Br, the thickness of the CIL prepared with PFN-Br is usually less than 10 nm, which evidently contradicts the requirements for large-scale roll-to-roll manufacturing. Herein, a strategy using N-α-carbobenzyloxy-d-Arginine (NA) as the doping material is proposed to improve the performance of PFN-Br. The homogeneous distribution of NA in PFN-Br can modify the work function (WF) of PFN-Br and facilitate an interface dipole arrangement that is favorable for charge transfer, resulting in binary CILs with a tunable WF and increased conductivity. To verify this method, a series of devices were prepared with PBDB-T:IT-M or PM6:Y6 as the OPL and different proportions of NA in the CIL. The use of PFN-Br:NA (0.75:0.06, in weight%) in devices helps to improve the OPL morphology, making it exhibit a trend of fiber network structure, leading to a higher fill factor and short circuit current density. Consequently, the optimal power conversion efficiency (PCE) based on the PBDB-T:IT-M and PM6:Y6 is increased from 10.5% to 11.1% and from 15.4% to 16.0%, respectively. In addition, the NA-doped device exhibits better nitrogen stability after 360 h of dark storage compared to the control. The discovery of these modification approaches provides insight into the hybrid cathode interlayers required for efficient and reliable nonfullerene OSCs.
研究领域:
材料科学
·
物理化学
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产品关联
DOI
高影响因子
iScience
·
2022
·
IF 6.107
Xianzhe Yu,Binjie Zhang,Cailing Fan,Qianqian Yan,Shenglin Wang,Hui Hu,Qinxi Dong,Gengyu Du,Yanan Gao,Chaoyuan Zeng
D-amino acids are of biological significance yet are not clearly understood due to the lack of powerful analytical tools for their identification. Thus, the specific detection of a single enantiomer of a particular amino acid remains a great challenge due to their structural similarity. Here, we report a strategy to incorporate multiple reaction sites on a chiral 1,1′-bi-2,2′-naphthol-based fluorescent probe. It can respond specifically to D-arginine, while producing no response when in contact with all other amino acids. The probe can report arginine’s concentration, and enantiomeric configuration and colorimetric studies enable its qualitative determination.
研究领域:
分析化学
·
生物化学
·
分子生物学
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DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Yirou Wang,Yi Liu,Ji Chen,Zeyang Ge,Jing Wang,Dehua Li
Peri-implantitis, caused by bacterial biofilm on dental implants, leads to bone loss and tissue inflammation, ultimately causing oral health decline. Traditional methods to remove biofilm are ineffective in promoting reosseointegration on implant surfaces. This phenomenon can be attributed to two factors: incomplete removal of biofilm from hard-to-reach areas and alterations in the physicochemical properties of implant surfaces caused by decontamination procedures. To address this problem, we developed D-arginine-loaded chitooligosaccharide-capped pH-responsive mesoporous silica nanoparticles (Dar@MSN-COS) for improving the efficacy of decontamination of Water Jet (WJ). Dar@MSN-COS particles exhibit a targeted approach towards the extracellular polymeric substance (EPS) in order to disrupt the biofilm, and possess the capability to infiltrate confined areas between implant screws. Following this, the WJ treatment effectively removed residual biofilm and demonstrated improved cleaning efficacy. Furthermore, the decontamination of the Dar@MSN-COS combination with WJ promotes effective cell cytocompatibility on the titanium surface. The results of mechanistic experiments indicate that Dar@MSN-COS may act on biofilms by releasing a significant quantity of reactive oxygen species (ROS), suggesting it as a key contributing factor. In summary, our novel therapeutic protocol shows promise as an alternative solution for addressing the clinically complex aspects of peri-implantitis.
研究领域:
牙科学
·
材料科学
·
微生物学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Fengyuan Liu,Jiashan Xia,Chun Tao,Changmei Chen,Xiangshu Cheng,Rongchun Yi,Lulu Wang,Yue Wang,Tao Deng
Chirality is a ubiquitous phenomenon in nature. The advent of nanomaterials has led to a gradual evolution of chiral studies from the molecular scale to the nanoscale. The emergence of carbon dots (CDs) has inaugurated a novel domain in the scientific and technological realms of carbon nanomaterials. In recent years, CDs have attracted increasing attention due to their luminescent properties, excellent biocompatibility and remarkable bioactivity. However, little attention has been paid to the chirality of the CDs and, in particular, the differences between CDs synthesized from racemic compounds and other chiral CDs, as well as the differences in the biological effects of chiral CDs, remain to be explored. Here, chiral CDs were synthesized from L-/D-/DL-arginine, and the differences in various aspects of chiral CDs were evaluated. We found that L-CDs without extreme differences in structure had brighter fluorescence and a more significant ability of NO generation and lipid droplet inhibition than the other two chiral CDs. Combined with its better drug loading and release ability, we validated its superior efficacy in tumor treatment. Therefore, this study provides a basis for further research on chiral carbon dots and their differences.
研究领域:
纳米材料
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生物技术
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生物化学
·
药学
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产品关联
DOI
PubMed
高影响因子
METABOLISM-CLINICAL AND EXPERIMENTAL
·
2015
·
IF 3.894
Qian Huang,Yuan Chen,Nian Gong,Yong-Xiang Wang
Objective Methylglyoxal is known to be associated with the development of nephropathy , retinopathy , and other complications in diabetes. The present study tested the hypothesis that endogenously increased levels of methylglyoxal in diabetes are causally associated with the induction of neuropathic pain . Materials and methods Streptozotocin- and methylglyoxal-induced pain models were established in rats, and the anti-nociceptive effects of the methylglyoxal scavenging agents, selective transient receptor potential channel ankyrin 1 (TRPA1) antagonist, and Nav1.8 antagonist were tested. Results Systemic injection of streptozotocin in rats induced a prolonged increase in plasma methylglyoxal by approximately 60%, which was correlated with the progressive development of mechanical allodynia and thermal hyperalgesia . Local subcutaneous injection of methylglyoxal into the hindpaw produced dose-dependent and biphasic flinching nociceptive responses, which resembled formaldehyde (formalin)-induced nociception . The local methylglyoxal nociception was significantly blocked by co-injection into the hindpaw of the selective transient receptor potential channel ankyrin 1 (TRPA1) antagonist, A967079, and the Nav1.8 antagonist, A803467. Co-incubation with the methylglyoxal scavengers, aminoguanidine , d -arginine, and metformin , reduced the level of free methylglyoxal by more than 90%, and injection of their incubation solutions into the hindpaw produced negligible (3–17%) nociception. Like the clinically effective anti-diabetic neuropathic pain drug gabapentin , systemic injection of aminoguanidine, d -arginine, and metformin at doses that effectively inhibit paw-injected methylglyoxal-induced nociception significantly blocked streptozotocin-induced mechanical allodynia. Conclusion Endogenously increased methylglyoxal may mediate diabetic neuropathic pain via activation of both TRPA1 and Nav1.8 expressed on primary afferent sensory neurons , and injection of methylglyoxal into the hindpaw may serve as a simple and robust model for testing the anti-diabetic pain drugs.
研究领域:
药理学
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神经科学
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糖尿病研究
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疼痛管理
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2022
·Vol. 10
·期 18
·3491-3500
·
IF 7.571
Xiao He,Yannv Qu,Xiaohong Lin,Jiapan Sun,Zhiru Jiang,Chaodong Wang,Yuanfei Deng,Fei Yan,Yansun Sun
Self-assembled amino acid derivatives could form well-defined nanostructures which have great application value for drug delivery systems. In particular, D-amino acid derivatives possess tremendous advantages including anti-degradation and good lysosome escape compared with L-amino acid derivatives. In this work, 9-fluorenylmethyloxycarbonyl (Fmoc) neighboring D-arginine derivatives were replaced by dibenzocyclooctyne (DBCO) to extend the class of functional D-arginine derivatives, which were further reacted with various cross-linkers including azide to construct a library of self-assembled supramolecular nanovehicles and strengthen the stability of nanostructures for disease immunotherapy. Moreover, in vitro studies demonstrated that the combination of DBCO modified D-arginine derivative DR3 and cross-linker C1 not only reinforced the cellular uptake efficiency of ovalbumin (OVA) which was chosen as the model antigen, but also promoted the cytokine TNF-α release of RAW 264.7 cells after the introduction of adjuvant unmethylated cytosine-phosphate-guanine dinucleotides (CpG). Furthermore, the nanovaccine based on DR3C1 could enhance the antigen OVA and adjuvant cytosolic delivery of marrow derived dendritic cells (BMDCs), which improved the antigen-presentation cross efficiency and induced the maturation of BMDCs. Taken together, we believe that D-arginine derivatives functionalized by DBCO provide an effective strategy for disease immunotherapy and act as a great potential delivery tool.
研究领域:
纳米技术
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免疫学
·
药物递送系统
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生物材料
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药学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF CONTROLLED RELEASE
·
2015
·
IF 7.705
HongYan Zhu,ShengYu Zhang,Yong Ling,GuoLiang Meng,Yu Yang,Wei Zhang
Hypoxia is a characteristic of cancer and plays a key role in tumorigenesis, angiogenesis and resistance to cancer therapies. SiRNA treatment is effective against hypoxic tumors by gene silencing. However, siRNA delivery to the hypoxic regions of solid tumors still presents a challenge due to the distance from blood vessels and the increased presence of efflux transporters. Therefore, tumor therapies would be improved through the immediate development of an effective siRNA delivery system to hypoxic regions. To this end, we synthesized a system to deliver HIF-1α siRNA into hypoxic tumor cells. The system consists of a functional shell composed of 2-deoxyglucose (DG)-polyethylene glycol (PEG) connected with the compound of lipoic acid , lysine and 9-poly- d -arginine (LA–Lys–9R) by a hydrazone bond and a core of CdTe quantum dots (QDs). The molecular structure of DG–PEG–LA–Lys–9R was confirmed by liquid chromatography–mass spectrometry (LC–MS), nuclear magnetic resonance (NMR) spectroscopy, Fourier transform infrared spectroscopy (FTIR), and sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE). The multifunctional CdTe QDs measured approximately 200 nm and showed excellent biocompatibility , perfect siRNA binding capability and enhanced hypoxic tumor targeting. Importantly, the system described here is pH-responsive with a hydrazone bond; therefore, it avoids GLUT1 receptor-mediated endocytic recycling, resulting in irreversible delivery of the siRNA. We used Western blots to confirm the superior gene silencing efficiency induced by the DG–PEG–LA–Lys–9R with hydrazone modified CdTe QDs. Here, we demonstrate high efficacy of the siRNA tumor delivery system using in vitro and in vivo experiments. In addition, these studies demonstrate that pH-responsive hybrid quantum dots show improved antitumor efficacy with decreased organ toxicity , indicating a promising siRNA delivery system for hypoxic cancer therapy.
研究领域:
癌症治疗
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纳米技术
·
分子生物学
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药学
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产品关联
DOI
PubMed
高影响因子
CHIRALITY
·
2024
·Vol. 36
·期 4
·e23665
·
IF 2.8
Luzheng Dong,Jun Wu,Xiashi Zhu
In this paper, the amino acid chiral ionic liquid (AACIL) was prepared with L-phenylalanine and imidazole. It was characterized by CD, FT-IR, 1 H NMR, and 13 C NMR spectrum. The chiral recognition sensor was constructed with AACIL and Cu(II), which exhibited different chiral visual responses (solubility or color difference) to the enantiomers of glutamine (Gln) and phenylalanine (Phe). The effects of solvent, pH, time, temperature, metal ions, and other amino acids on visual chiral recognition were optimized. The minimum concentrations of Gln and Phe for visual chiral recognition were 0.20 mg/ml and 0.28 mg/ml, respectively. The mechanism of chiral recognition was investigated by FT-IR, TEM, SEM, TG, XPS, and CD. The location of the host-guest inclusion or molecular placement has been conformationally searched based on Gaussian 09 software.
研究领域:
化学
·
分析化学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2026
·
IF 8.3
Mingzhe Hu,Xin Zhang,Chang Zhang,Feng Qiu,Jiujie Ruan,Xiaoli Wang,Yu Zhang,Jie Zou,Qinghui Jin,Jiawen Jian
Metal halide perovskite nanocrystals (MHPNCs) have emerged as promising fluorescent sensing materials owing to their excellent optical properties. However, surface defects significantly influence their sensing performance, highlighting the importance of defect passivation for improving sensing capability. In this study, a fluorescent NH 3 sensor film was fabricated via electrospinning, in which arginine(ARG)-modified MAPbBr 3 (MA refers to methylammonium) quantum dots were encapsulated within poly(methyl methacrylate) (PMMA) nanofibers to investigate the effect of arginine passivation on NH 3 sensing performance. Under dynamic gas sensing conditions at 25°C and an ambient relative humidity, the sensor exhibited a concentration-dependent NH 3 response in the range of 1.25–200 ppm. The ARG-modified sensor exhibited an approximately 115% higher sensitivity than the sensor without ARG. The sensor showed a more pronounced response toward NH 3 than interfering gases at 200 ppm. Moreover, the maximum response variation was 3.33% during five consecutive NH 3 sensing cycles, and the fluorescence intensity of the sensor membrane remained above 80% of its initial value after 180 days of storage.
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产品关联
DOI
高影响因子
ANALYTICAL CHEMISTRY
·
2026
·
IF 7.3
Simin Zhang,Xiangfeng Chen,Yaping Shi,Xiangyu Zhu,Zongwei Cai
As bioactive compounds, chiral amino acids (AAs) have been demonstrated to play pivotal roles in different physiological processes, thereby influencing human health. The assessment of the relative enantiomeric ratio through analytical methods is essential for indicating the abnormal status of disease progression, which drives the development of effective methods for resolving and identifying enantiomers. This work presents a robust strategy for the ultrahigh-resolution analysis of chiral AAs using MALDI-TIMS-MS. By employing a chiral derivatization process using S-NIFE and stabilizing the soft chain of the derivatization reagent with bimetal ion addition, the separation of 19 pairs of proteinogenic AAs was successfully achieved. This method not only demonstrates outstanding separation capability but also proves its efficiency in determining enantiomeric ratios, extending its applicability to real sample analysis.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2025
·
IF 5.4
Qiaoru Zhang,Yu Wang,Tianyu Song,Mashooq Khan,Yanjun Gong,Yongxian Guo,Qiongzheng Hu
Hydrogen peroxide (H 2 O 2 ) plays a vital role in various physiological activities. Its efficient detection in exhaled breath condensate (EBC), a highly promising noninvasive diagnostic matrix, is of great significance for the early diagnosis of diseases. However, complex biological components present in EBC impede efficient H 2 O 2 detection. Herein, we synthesize an H 2 O 2 probe, TPEB , which demonstrates excellent sensing performance in phosphate-buffered saline (PBS) and EBC. TPEB exhibits turn-on fluorescence signal generated through H 2 O 2 -triggered hydrolysis, releasing TPEN , a compound with characteristic aggregation-induced emission properties. Density functional theory (DFT) and time-dependent DFT calculations reveal a molecular transformation from the donor–acceptor (D–A) structure of TPEB to the D–D′ structure of TPEN . Leveraging this transformation, the probe achieves a limit of detection (LOD) of approximately 0.1 μM in a DMSO/PBS buffer solution for H 2 O 2 , with excellent selectivity and stability. To enhance its portability and applicability, a probe film is fabricated by depositing TPEB nanoparticles onto a filter paper. This film exhibits stronger emission than TPEB in the DMSO/PBS buffer solution and achieves a lower LOD of 0.01 μM. The probe film enables effective H 2 O 2 detection in complex matrices, such as cell culture medium and EBC, demonstrating potential for practical point-of-care testing applications.
研究领域:
生物化学
·
医学诊断
·
材料科学
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产品关联
DOI
高影响因子
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