ELECTROCHIMICA ACTA
·
2022
·
IF 7.336
Xiaohui Niu,Simeng Yan,Jinliang Chen,Hongxia Li,Kunjie Wang
Chiral metal-organic frameworks (MOF) have received extensive attention from researchers due to their chiral properties and potential applications in chiral-related fields. However, the construction of chiral metal-organic framework remains challenging due to the unpredictability of the synthesis process and the difficulty in keeping chirality during the growth of chiral MOF. Herein, a chiral MOF (D-His-ZIF-8) is reported for the construction of electrochemical sensing interface, which was synthesized via in-situ substitution of 2-methylimidazole on ZIF-8 by D-histidine (D-His). The introduction of Ketjen Black (KB) to the D-His-ZIF-8 sensing interface can improve its conductivity. The electrochemical recognition results show that KB/D-His-ZIF-8 has enantiodiscrimination ability for amino acids in voltammetry experiments. The best recognition efficiency is observed with Trp enantiomers . The recognition mechanism shows that the chiral nanochannel of D-His-ZIF-8 is conducive to the binding of L-amino acid, which will lead to the recognition of chiral molecules of different configurations. This research points to the possibility of developing further chiral recognition protocols based on D-His-ZIF-8, particularly with the suggested improvement in the preparation procedure of chiral MOF.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2023
·Vol. 25
·期 28
·18998-19003
·
IF 3.3
Guangcun Gao,Jintong Zhu,Songrui Wei,Yang Cao,Wei Huang,Zhongxin Liu,Jieqiong Wang,Yijun Shen
Monolayers of transition metal dichalcogenides (TMDCs) are atomically thin direct-bandgap semiconductors with potential applications in nanoelectronics, opto-electronics, and electrochemical sensing. Recent theoretical and experimental results have suggested that they are ideal systems for exploiting the valley degrees of freedom of Bloch electrons. Here, we report detailed studies of the opto-valleytronic properties of a chiral histidine molecule embedded in monolayer MoS2 single crystals grown via chemical vapor deposition. By irradiating MoS2 with circularly polarized light and measuring the resulting spatially resolved circularly polarized emission, we find the existence of a significantly increased circular polarization for D-histidine doped MoS2. The increased valley contrast is attributed to the selective enhancement of both the excitation and emission rates having one particular handedness of the circular polarization. These results provide a promising pathway to enhance the valley contrast for monolayer TMDCs at room temperature.
研究领域:
材料科学
·
纳米技术
·
光电学
·
半导体物理
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2022
·Vol. 14
·期 41
·15414-15421
·
IF 8.307
Shuyu Xiao,Jiechun Liang,Junzi Li,Jiaji Cheng,Xi Zhu,Tingchao He
Chiral transition metal oxides (TMOs) are widely used in various optoelectronic devices. However, the currently poor understanding of how the optical activities of TMOs can be regulated considerably hinders their applications. We have synthesized a series of chiral TMO nanoparticles (NPs), i.e., MoOx (x = 2, 2.4 and 2.5) and Co3O4. Compared with TMO NPs with L-/D-cysteine molecules as the capping ligand, L-/D-histidine-capped TMO NPs possess larger anisotropic factors (gabs), which are as high as ∼0.01 and ∼0.02 for L-/D-histidine-capped MoO2.5 and Co3O4 NPs, respectively. A nondegenerate coupled oscillator (NDCO) theoretical calculation confirms that L-/D-histidine molecules can generate a smaller electric dipole moment and thus induce higher optical activity than L-/D-cysteine molecules. Impressively, the chiral NPs exhibit broadband second harmonic generation. This work indicates that chiral TMO NPs have potential for application in nonlinear optical devices.
研究领域:
材料科学
·
光学
·
纳米技术
·
化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2022
·
IF 6.911
Xiaohui Niu,Simeng Yan,Letong Wang,Jinliang Chen,Rui Zhao,Hongxia Li,Jian Liu,Kunjie Wang
So far, the fabrication of chiral metal-organic framework (CMOF) is difficult to predict and the chiral functionality mainly comes from the building blocks that is a part of the frameworks. The induction effect in the chiral nanochannels of the metal-organic framework (MOF) makes achiral polymers have chiral properties, which has not been well explored. Therefore, CMOFs with chiral nanochannels or chiral pores appear to have special functions. Herein, CMOFs (D-his-ZIF-8) with chiral micropores or chiral nanochannels are prepared through a simple 2-methyl imidazolate in-situ substitution by d -histidine. The unmodified polyaniline with chirality ( c -PANI) was synthesized in chiral nanochannels and pores of CMOF, which brought about chiral induction from the chiral nanochannels and pores of CMOF to c -PANI chains. The circular dichroism shows that the c -PANI chains released from the chiral nanochannel still maintains the chiral properties even leaves the chiral nanochannel. It can be seen from the electrochemical results that c -PANI has excellent conductivity, and the conductivity of CMOF is very poor. Electrochemical recognition showed that both CMOF and c -PANI have certain chiral recognition effects for L-Trp and D-Trp, from which the optimal recognition effect was obtained from c -PANI chains. This shows that the excellent conductivity of c -PANI not only expands the electrochemical signal, but also the helical structure of the c -PANI chains accelerates the distinction of chiral molecules. This study provides a novel perspective to induce chiral polymer chains with better conductivity in the nanochannels of CMOF.
研究领域:
材料科学
·
化学
·
纳米技术
·
电化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Qingqing Sun,Baocheng Bao,Wenqian Dong,Yanchao Lyu,Mengyuan Wang,Zheng Xi,Jie Han,Rong Guo
Understanding the structure-function relationships encoded on chiral catalysts is important for investigating the fundamental principles of catalytic enantioselectivity . Herein, the synthesis and self-assembly of naphthalene substituted bis - l / d -histidine amphiphiles ( bis - l / d - NapHis) in DMF/water solution mixture is reported. The resulting supramolecular assemblies featuring well-defined P/M nanoribbons (NRs). With combination of the ( P/M )-NR and metal ion catalytic centers (M n + = Co 2+ , Cu 2+ , Fe 3+ ), the ( P )-NR-M n + as chiral supramolecular catalysts show catalytic preference to 3,4-dihydroxy- S -phenylalanine ( S -DOPA) oxidation while the ( M )-NR-M n + show enantioselective bias to R -DOPA oxidation. In contrast, their monomeric counterparts bis - l / d - NapHis-M n + display an inverse and dramatically lower catalytic selectivity in the R/S -DOPA oxidation. Among them, the Co 2+ -coordinated supramolecular nanostructures show the highest catalytic efficiency and enantioselectivity (select factor up to 2.70), while the Fe 3+ -coordinated monomeric ones show nearly racemic products. Analysis of the kinetic results suggests that the synergistic effect between metal ions and the chiral supramolecular NRs can significantly regulate the enantioselective catalytic activity, while the metal ion-mediated monomeric bis - l / d - NapHis were less active. The studies on association constants and activation energies reveal the difference in catalytic efficiency and enantioselectivity resulting from the different energy barriers and binding affinities existed between the chiral molecular/supramolecular structures and R/S -DOPA enantiomers . This work clarifies the correlation between chiral molecular/supramolecular structures and enantioselective catalytic activity, shedding new light on the rational design of chiral catalysts with outstanding enantioselectivity.
研究领域:
催化
·
超分子化学
·
有机化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry A
·
2024
·Vol. 12
·期 16
·9421-9426
·
IF 10.7
Yaxin Wang,Yajie Zhou,Shanshan Zhao,Mingjiang Zhang,Anqi Li,Guangen Li,Qi Guo,Xueru Guo,Zhi Tong,Zeyi Li,Jing Lin,Taotao Zhuang
Chiral amino acids are crucial for humans, and their recognition can provide information for pharmaceutical quality and clinical diagnosis. Histidine (His) and tryptophan (Trp), for example, have a close association with nephropathy and are extensively utilized in the pharmaceutical field. However, efficiently distinguishing these two amino acids and their configurations is still in its infancy, requiring the development of a practical, cost-effective, and reliable detection method. Herein, we disclose a dual-optical-response recognition system, composed of 9-aminoacridine and cellulose nanocrystals, that can stepwise recognize His/Trp and their enantiomers based on photoluminescence and circular dichroism (CD) analysis. Amino acids cause variation in the fluorescence intensity of the DOR system, while their enantiomers give distinctive shifts in CD spectra. This study achieves a stepwise recognition of chiral amino acids, paving a new way for drug screening and clinical diagnosis.
研究领域:
生物化学
·
药物分析
·
临床诊断
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Yi-Ting Gu,Dong-Jin Qian
Multi(metallo)porphyrin arrays are important artificial biomimetics for mimicking the biological catalytic reactions in nature. Here, we report construction of multi(iron)porphyrin array ultrathin films on the quartz surface by coordination-driven layer-by-layer (LBL) assembling method with the Pd(II) ion as a connector and iron(III) tetrapyridylporphyrin (FeTPyP) as a linker. It is revealed that the (Pd-FeTPyP) n LBL multilayers can catalyze oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) in the presence of H 2 O 2 with peroxidase-like activity, resulting in the formation of the blue-colored oxidized TMB (oxTMB). Coupled with glucose oxidase, three sensitive probes based on the colorimetric, fluorometric and color-read methods have been developed by using modified quartz plates as the heterogenous catalyst, with a glucose detection limit of about 0.89, 1.5 and 0.65 μM, respectively. Mechanism studies confirm an enhanced affinity between (Pd-FeTPyP) n and H 2 O 2 /TMB molecules and an improved catalytic performance, which are attributed to the reason that the FeTPyP macrocycles are well-dispersed and arranged on the two-dimensional quartz surface. Furthermore, owing to chemically anchored on the transparent quartz surface, the (Pd-FeTPyP) n films exhibit good stability with naked-eye observation of color change under moderate conditions, thus providing a potential candidate for developing colorimetric, fluorometric and color-read glucose biosensors.
研究领域:
生物化学
·
材料科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Wenjing Wang,Guangrong Lu,Zhichao Deng,Huanyu Li,Wenfang He,Shouxing Yang,Yuanyuan Zhu,Chenxi Xu,Yujie Zhang,Lanqi Wang,Xiaoling Huang,Mingzhen Zhang,Changlong Xu
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), is characterized by the presence of chronic, nonspecific, and recurring inflammation in the intestine. Current therapies are insufficient in addressing the effective modulation of the intestinal oxidative stress-inflammation cycle, the repair of the intestinal mechanical barrier, and the regulation of gut microbiota and metabolites. There is a need for a comprehensive approach to orchestrate intestinal homeostasis more effectively. For this purpose, biocompatible antioxidant carbon dots nanozymes (GH-CDs) were synthesized based on glucose and D-histidine using a microwave-assisted method for the systematic management of intestinal inflammation. It was demonstrated that GH-CDs possessed excellent reactive oxygen/nitrogen species (ROS/RNS) scavenging capacities, thus modulating oxidative stress-induced damage and mitigating inflammation by inhibiting the TNF, MAPK, PI3K-Akt, NF-κB, and JAK-STAT signaling pathways. For in vivo experiments, GH-CDs have demonstrated both protective and therapeutic effects in mitigating colitis by reducing ROS levels, decreasing the infiltration of M1-type macrophages, suppressing the release of pro-inflammatory cytokines, and repairing intestinal mechanical and chemical barriers. Importantly, GH-CDs also influenced the gut microbiome to achieve a more beneficial state, which was accomplished by enhancing bacterial diversity and altering the microbial composition towards an anti-inflammatory type. Additionally, GH-CDs supported the biosynthesis of secondary bile acids and isoflavonoids. In conclusion, with excellent biocompatibility, GH-CDs will be a promising strategy for UC by comprehensively orchestrating intestinal homeostasis.
研究领域:
生物医学工程
·
消化病学
·
纳米医学
✓ 已验证
产品关联
DOI
高影响因子
Biomaterials Advances
·
2024
·
IF 5.5
Wuming Wu,Xiaolian Jiang,Qin Zeng,Huiyu Zou,Chunyan Deng
In this study, epigallocatechin-3-gallate nanospheres (EGCG NSs) are employed as an innovative alternative to traditional reducing agents for the in-situ growth of AuNPs on the EGCG NS surface to produce the Au nanoparticles decorated EGCG nanospheres (EGCG NS@AuNPs). This eco-friendly approach avoids toxic chemicals and simplifies the synthesis process, enhancing biocompatibility and functional properties of the resulting EGCG NS@AuNPs nanocomposite. The nanocomposite exhibits remarkable stability, photothermal properties, and peroxidase-like enzymatic activity. Taking advantage of the enhanced photothermal properties, the application of EGCG NS@AuNPs in the antibacterial field was investigated, and the antibacterial activity was greatly improved against both Gram-negative and Gram-positive bacteria comparing to bare AuNPs or EGCG Ns. Additionally, based on the excellent enzymatic activity, the sensing application of EGCG NS@AuNPs was explored by developing a colorimetric method for detecting ascorbic acid (AA). A remarkably low detection limit of 0.076 μM was achieved. This method has been successfully applied to measure the AA content in vitamin C tablets, demonstrating the practicality and accuracy of this approach. Therefore, the synthesis for EGCG NS@AuNPs is not only rapid, and cost-effective, but also eco-friendly and not harmful to biological systems, which is potential in biosensing, clinical diagnosis, and therapeutics. Future research could explore further applications of EGCG NS@AuNPs in biomedicine field, revealing even more of its remarkable potential.
研究领域:
纳米医学
·
生物材料
·
分析化学
·
生物医药
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHIRALITY
·
2024
·Vol. 36
·期 4
·e23665
·
IF 2.8
Luzheng Dong,Jun Wu,Xiashi Zhu
In this paper, the amino acid chiral ionic liquid (AACIL) was prepared with L-phenylalanine and imidazole. It was characterized by CD, FT-IR, 1 H NMR, and 13 C NMR spectrum. The chiral recognition sensor was constructed with AACIL and Cu(II), which exhibited different chiral visual responses (solubility or color difference) to the enantiomers of glutamine (Gln) and phenylalanine (Phe). The effects of solvent, pH, time, temperature, metal ions, and other amino acids on visual chiral recognition were optimized. The minimum concentrations of Gln and Phe for visual chiral recognition were 0.20 mg/ml and 0.28 mg/ml, respectively. The mechanism of chiral recognition was investigated by FT-IR, TEM, SEM, TG, XPS, and CD. The location of the host-guest inclusion or molecular placement has been conformationally searched based on Gaussian 09 software.
研究领域:
化学
·
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2024
·
IF 6
Yuanyi Wu,Yumei Xiao,Yang Ju,Yanque Sun,Jialin He,Tian Liu,Miao He,Kaiyong Wang,Yi Yang
The determination of gallic acid (GA), one of the most prevalent antioxidants in various plants, provides information for food nutrition evaluation. A novel colorimetric, fluorescent, and smartphone multi-mode GA sensing platform based on Fe 3 O 4 @Co/Ni/Al-layered double hydroxide (LDH) nanospheres was designed in this study. The core-shell magnetic Fe 3 O 4 @Co/Ni/Al-LDH nanospheres were synthesized through a simple co-precipitation approach. They showed dominate peroxidase-like activities capable of oxidizing 3,3′,5,5′-tetramethylbenzidine (TMB) into a blue colored oxidation oxTMB. Meanwhile, the generated oxTMB could quench the fluorescence of neutral red via the inner filter effect. GA acted as an inhibitor to prevent the oxidation of TMB to oxTMB and restoring the fluorescence of neutral red. Under optimized conditions, the linear ranges were 0.5–120 μmol/L with detection limits of 0.137–0.415 μmol/L. Besides, the sensor exhibited good selectivity toward GA over various interferents. Moreover, it was successfully utilized to analyze GA in tea beverages with ideal recoveries of 92.8–105%, demonstrating good reliability and stability in practical applications. This study provided Fe 3 O 4 @Co/Ni/Al-LDH nanospheres as candidate nanozymes for the construction of biosensors. The multi-mode self-checking function and the “turn on” fluorescent sensing strategy offered this sensor superior anti-interference ability, and opens up a new strategy for the determination of antioxidants in foods.
研究领域:
分析化学
·
纳米技术
·
食品科学
·
生物传感器
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
TALANTA
·
2025
·
IF 6.1
Yifei Ma,Lijie Zhang,Hong Yang,Shanshan Zhu,Jinhua Liu
Highly selective and sensitive determination of dopamine (DA) from multiple sources remains a persistent and significant challenge. Here, we develop an imidazole-triggered in situ fluorescence reaction system for highly selective and sensitive determination of DA from various sources (human, horse, dog, rabbit, and mouse). The system operates by catalyzing the oxidation of DA with 1,5-Dihydroxynaphthalene (1,5-DHA) through a Lewis base formed by imidazole, leading to the rapid generation of yellow azamonardine fluorescent compounds (AFC). Notably, the system demonstrates minimal background noise and a high signal-to-noise ratio of up to 300-fold with a determination limit of 33.33 pM, making it 10-100 times more sensitive than conventional enzyme-linked immunosorbent assay (ELISA) methods. Moreover, selectivity tests reveal that our system can effectively distinguish between several common interfering substances, even at concentrations as low as 10 nM. The developed system shows promising results in detecting DA from diverse sources (humans, horses, dogs, rabbits, and mice), including urine samples from clinical patients, exhibiting good agreement with traditional ELISA kits. Therefore, the established in situ fluorescence reaction system holds great potential for the determination of DA-related disorders due to its impressive analytical capabilities.
研究领域:
分析化学
·
神经生物学
·
医学检测
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）