RSC Advances
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2017
·Vol. 7
·期 78
·49320-49328
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IF 3.108
Fengjie Ma,Xiaolin Pu,Bo Wang,Jia Li,Cheng Cao
In this study, polyampholyte inhibitor DAM was synthesized from three monomers, namely, diallyl dimethyl ammonium chloride (DMDAAC), methyl allyl alcohol (MP) and 2-acrylamido-2-methyl propane sulfonic acid (AMPS), by aqueous solution polymerization. The inhibition performance of DAM was evaluated from the perspectives of particle-size distribution, hot-rolling dispersion test, linear swelling test, and inherent viscosity. Inhibitory mechanisms were investigated by molecular weight pattern analysis, infrared radiation (IR) spectroscopy, zeta potential measurement, thermogravimetric analysis (TGA), and the scanning electron microscope (SEM) technique. The results demonstrated the good inhibitive effect exerted by DAM on the hydration and dispersion of shale, which achieved optimum values and showed a good synergetic effect with the addition of 3% KCL. Moreover, it is thermally stable at 288 °C.
研究领域:
高分子化学
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石油工程
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材料科学
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DOI
高影响因子
Geoenergy Science and Engineering
·
2024
·
IF 0
Yuhan Wu,Ming Duan,Qihai Wang,Bin Chen,Huaxin Chen,Xinliang Li,Shenwen Fang
Sand production in oil wells is a common challenge during the oil extraction process. Water-soluble polymers have attracted attention due to their low toxicity, cost-effectiveness, ease of direct injection, and excellent thermal stability. However, the dry polymer injection process commonly used in offshore oil fields is complex. Therefore, this paper employs acrylamide (AM), 2-acrylamide-2-methylpropane sulfonic acid (AMPS), a dihydroxy monomer (DOH), and a functional monomer (DAM) containing ketone groups and self-crosslinking properties as monomers. A polymer latex type sand control agent was prepared through dispersion polymerization for direct application on offshore platforms. This paper utilizes flocculation time and maximum sand free flow rate as inspection indicators and utilizes both the one-factor-at-a-time method and the surface response method to optimize the synthesis conditions of the sand control agent. The optimal synthesis conditions are obtained: total monomer concentration of 9.15 wt%, DOH concentration at 10 wt% of the total monomer concentration, ammonium sulfate (AS) concentration of 27.02 wt%, dispersant concentration of 2.13 wt%, initiator concentration at 0.25 wt% of the total monomer concentration, reaction time of 12 h, and reaction temperature of 40 °C. Under the conditions of concentration ≥2000 mg/L and curing time ≥4 h, the sand control agent is suitable for sand stabilization under formation conditions of temperatures between 50 and 80 °C, pH levels ranging from 3 to 9, salinity <30000 mg/L, and sand particle size of ≥100 μm. The research results of this paper can serve as a valuable reference for the control of oilfield sand production.
研究领域:
石油工程
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高分子化学
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DOI
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Zhenggang Wang,Jianwei Yuan,Renhao Li,Haipeng Zhu,Jingui Duan,Yanan Guo,Gongping Liu,Wanqin Jin
Compared with traditional separation methods, membrane-based technology shows advantages in energy efficiency for natural gas purification. To overcome the performance trade-off of conventional polymeric membranes, in this study, ZIF-301 MOF was employed as novel filler to fabricate 6FDA-DAM polyimide mixed-matrix membranes (MMMs) for CO 2 /CH 4 separation. A solvent exchange approach was proposed to remove the high-boiling-point solvent used for fabricating the MMMs. The microstructures and physico-chemical properties of the ZIF-301 fillers and ZIF-301/6FDA-DAM MMMs were characterized by SEM, EDX, XRD, IR, TGA, DSC and high-pressure sorption isotherms. The CO 2 /CH 4 transport properties through the MMMs were evaluated by permeation measurement at various feed pressures and analyzed by solution-diffusion model. The results showed that the incorporation of ZIF-301 into 6FDA-DAM enhanced both the CO 2 permeability and CO 2 /CH 4 selectivity, attributing to the preferential CO 2 sorption and aperture molecular sieving effect of the ZIF-301 filler. The MMM with optimal ZIF-301 loading of 20 wt% exhibited CO 2 permeability of 891 barrer and CO 2 /CH 4 of 29.3 that surpassed the 2008 Robeson upper-bound, suggesting that ZIF-301 based membrane could be a potential candidate for natural gas purification.
研究领域:
材料科学
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化学工程
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环境科学
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高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yi Wang,Liang Li,Fangli Zhang,Huajiang Wang,Zhaoliang Cui,Zhaohui Wang,Xiaozu Wang
Mixed matrix membranes (MMMs) can significantly improve gas separation performance, but the type and state of the filler in the membrane matrix are key indicators for the development of MMMs. Therefore, in this work, 6FDA-DAM/ODA (1:1), metal–organic frameworks (MOFs) with different particle sizes (UiO-66 and UiO-66-NH2) were synthesized, and then MOFs were doped into 6FDA-DAM/ODA to prepare MMMs. The effects of the dopant materials and their particle sizes on the gas separation performance of the membranes were investigated by testing the permeability of the MMMs to H2, CO2, CH4, and N2. When the dopant material was UIO-66, the permeability and selectivity of MMMs for each gas were significantly improved compared with that of the original membrane; when the dopant material was 300 nm UIO-66-NH2 with a loading of 10 wt %, the permeability performance and the CO2/CH4 selectivity increased from 44.1 to 57.2 compared with that of the original membrane. The permeation performance for CO2, N2, and H2 and the selectivity for CO2/N2, H2/N2, and H2/CH4 were also significantly improved. In terms of comprehensive separation performance, doping 300 nm UiO-66-NH2 was better than doping 70 and 400 nm UiO-66-NH2 and also showed excellent performance in 50:50 (vol/vol) CO2/CH4 binary mixed gas separation. This work provides an idea for the fabrication of MMMs for high-performance gas separation.
研究领域:
材料科学
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化学工程
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PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Xue Yang,Yuxuan Wang,Jingxian Hua,Rujing Hou,Jinfeng Chen,Qihan Gong,Chongqing Wang,Yichang Pan
Plate-like or sheet-like porous materials with nanometer thickness have been considered as the preferred fillers to improve mixed-matrix membranes (mmms)-based separation. Herein, hexagonal Co-fa (HG-Co-fa) nanoplates were simply synthesized without the addition of any modifier and used as fillers to construct 6FDA-DAM-based MMMs for efficient CO 2 /CH 4 separation. HG-Co-fa nanoplates exhibit high dispersion and interface compatibility in 6FDA-DAM matrix. The results demonstrated that the CO 2 /CH 4 separation performance of 6FDA-DAM was obviously improved after the incorporation of HG-Co-fa nanoplates. The resultant MMMs with nanoplate loading of 10 wt% showed CO 2 /CH 4 selectivity of 27 and CO 2 permeability of 1419 Barrer at 25 ℃ and 0.2 MPa, surpassing 2008 Robeson upper bound. Meanwhile, the high lattice integrity and structural stability of HG-Co-fa nanoplates contribute to the excellent thermal and mechanical stability of MMMs, contributing to their anti-plasticization property up to 14 bar and long-term stability up to 240 h, indicating their potential for natural gas separation.
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2023
·
IF 9.5
Xiuling Chen,Lei Wu,Cong Xie,Shan Xu,Yanfang Fan,Nanwen Li
Carbon molecular sieve (CMS), as the gas separation membrane materials, still faces challenges for regulation pore diameter precisely. In this work, we propose to reconstruct the 6FDA-DAM-Br-85% polyimide CMS membranes by introducing 6,6'-(1,4-phenylenebis(((4-hydroxyphenyl)amino)methylene))bis(dibenzo[c,e][1,2] oxaphosphinine6-oxide) small molecule compound (DOPO- p -DP) as crosslinking agent to regulate the pore distribution. The crosslinked precursors were obtained via the reaction between C–Br bond in 6FDA-DAM-Br-85% polyimide and N–H bond in DOPO- p -DP compound, the precursors and CMS membranes (550 °C- 2 h) were characterized with ATR-TFIR, XRD and XPS. The pore size distribution of crosslinked CMS membranes was range in 4.5–8.0 Å from the N 2 adsorption data. The crosslinked CMS membranes exhibited excellent gas separation performance, which was strongly dependent on the mass fraction of DOPO- p -DP, an increasing mass fraction of DOPO- p -DP leaded to improve in gas selectivity, while reduced its permeability. The 6FDA-DAM-Br-85%/DOPO- p -DP-20% CMS membrane showed the impressive permeability and superior gas selectivity, the permeabilities of O 2 , CO 2 , and H 2 are 798, 3018, and 13560 Barrer combined with the O 2 /N 2 , CO 2 /CH 4 , and H 2 /CH 4 selectivities of 7.8, 65.6, and 294.8 respectively, the separation performances surpassed the latest trade-off relationship. In addition, the 20% of the DOPO- p -DP crosslinked CMS membrane revealed the superior aging behaviour than that of the 6FDA-DAM-Br-85% CMS membrane over 480 h aging under vacuum conditions.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
Analytical Methods
·
2016
·Vol. 8
·期 13
·2771-2777
·
IF 1.915
Xue Li,Zhipeng Xie,Wei Wang,Yunlei Zhou,Huanshun Yin,Zhiqing Yang,Shiyun Ai
The DNA isothermal amplification cycle is an effective expansion strategy, which can overcome the inherent limitation of the target to signal ratio of 1 : 1. In this work, we fabricated an electrochemical biosensor for the rapid detection of Dam methyltransferase activity based on the exonuclease III (Exo III) assisted isothermal amplification cycle. First, double stranded DNA (ds-DNA) containing the symmetric sequence of 5′-GATC-3′ was immobilized on the magnetic bead surface. After the ds DNA was methylated by Dam MTase, it could be further cleaved by DpnI and formed a blunt end, which could lead to the digestion of a DNA strand by Exo III and release of a target single stranded DNA (ts-DNA). Then, the ts-DNA can further hybridize with DNA probes (DNA3) immobilized on the AuNPs/Au electrode surface and form a blunt end DNA–DNA duplex. Subsequently, the DNA3 in the DNA–DNA duplex can be digested by Exo III and release ts-DNA. The released ts-DNA can further hybridize with the unhybridized single stranded DNA (ss-DNA) and an isothermal amplification cycle is achieved. The method showed high sensitivity with a low detection limit of 0.031 unit per mL. Moreover, inhibition investigation indicates that Dam MTase activity can be inhibited by using 5-fluorouracil with an IC50 value of 131.22 μM.
研究领域:
生物化学
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分子生物学
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分析化学
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癌症研究
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
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2022
·
IF 12.545
Hao-Cheng Hu,Shao-Hua Wu,Lei-Xin Jin,Jian-Jun Sun
In this work, a novel “turn-on” mode Au nanocubes (AuNCs) enhanced surface-enhanced Raman scattering (SERS) biosensing platform coupled with heated Au electrode (HAuE) and strand displacement amplification (SDA) strategy was proposed for highly sensitive detection of DNA adenine methylation (Dam) Methyltransferase (MTase) activity. The Dam MTase and Dpn I enzyme activities were significantly increased by elevating the HAuE surface temperature, resulting in the rapid production of template DNA for later SDA. During the SDA process, the released single-stranded DNA (ssDNA) could be amplified exponentially, and its concentration was positively related to the Dam MTase activity. The plasmonic AuNCs in SERS tags could provide significant SERS enhancement due to their “lightning rod” effect resulting from the sharp feature of the edges and corners of AuNCs. Because of these factors, the proposed biosensors exhibited high sensitivity in detecting the Dam MTase activity. The limit of detection was estimated to be 8.65 × 10 −5 U mL −1 , which was lower than that in most of the sensors for detection of Dam MTase activity in the literature. This SERS biosensor could also be used to screen inhibitors of Dam MTase and had the potential for detecting Dam MTase activity in real biological samples.
研究领域:
生物化学
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纳米技术
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分子生物学
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分析化学
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DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Shan Xu,Xiaolong Ren,Ning Zhao,Lei Wu,Zhiguang Zhang,Yanfang Fan,Nanwen Li
The CO 2 -induced plasticization effects impose detrimental effects on polymeric membranes separation performance. To address this issue, a high-performance crosslinked brominated 6FDA-based polyimide (BMPI) is developed in this work, exhibiting highly suppressed plasticizing effects. The permeability and selectivity of polyimide precursor membranes are tuned by introducing bromine atoms into the polyimide structure, creating a best performing membrane with bromination degree of 60%. The membrane CO 2 permeability reaches 395 Barrer, and the selectivity of CO 2 /CH 4 increases from 22.0 for a non-brominated analogue to 26.0. The debromination induced crosslinked BMPI membranes are achieved upon thermal treatment within the temperature range of 150 °C–350 °C with varied crosslinking degree, resulting in large differences for the membrane separation performance. The completely crosslinked BMPI treated at 350 °C for 10 h demonstrates high CO 2 permeability of 483.6 Barrer and the CO 2 /CH 4 selectivity of 26.0. Most importantly, the crosslinking reaction greatly stabilizes the membrane performance against plasticization under high CO 2 feed pressure. Compared with the non-crosslinked membranes with a plasticizing pressure of 150 psia, the plasticization for the crosslinked membrane occurs at high CO 2 pressure of 600 psia. This study provides a facile approach for the preparation of high-performance gas separation polymeric membranes with enhanced plasticization resistance.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2022
·
IF 10.53
Shan Xu,Ning Zhao,Lei Wu,Shuanyan Kang,Zhiguang Zhang,Guolong Huo,Zhongde Dai,Nanwen Li
Tuning the relationship between the microporous structure of carbon molecular sieve (CMS) membranes and the corresponding gas permeability performance enables optimization for gas separation applications. The pre-crosslinked structure of the precursor plays a key role in improving the performance of the CMS membrane. Herein, the thermally crosslinkable brominated 6FDA-based polyimide (BMPI) by debromination is prepared and selected as the precursor to fabricate high performance CMS gas separation membranes . By heat-treating the BMPI membrane at 350 °C for 10 h, the debromination-induced crosslinking exhibited higher permeability over the uncrosslinked precursors, as it forms a pre-crosslinked structure that is more stable at 550 °C. A representative BMPI-350/10h-550 °C CMS membranes pyrolyzed at 550 °C had CO 2 and O 2 permeabilities of 11169 and 2182 Barrer with a CO 2 /CH 4 and O 2 /N 2 ideal selectivity of 26.5 and 5.4. These values are much higher than that of the un-crosslinkable precursor (6FDA-DAM) derived CMS membrane (P CO2 = 3465, α CO2/CH4 = 21.1). Even at the high carbonization temperature of 800 °C, the as-obtained CMS membrane still show a promising CO 2 permeability of 1119 Barrer and a CO 2 /CH 4 ideal gas selectivity of 41.2. Importantly, the excellent gas separation performance of CMS membranes obtained in this work exceeds the Robeson's upper-bound. This work outlines a new protocol to tailor CMS membrane microstructures to meet high permeability performance needs. These CMS membrane materials hold great potential in corrosive natural gas purification applications.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Xiaobing Wang,Qi Ding,Rimin You,Cong Yu,Yujia Li,Junjie Zhao,Xili Cui,Huabin Xing
The development of efficient membranes for ethylene/ethane (C2H4/C2H6) separation is highly important. Here, we report the development of a series of new mixed matrix membranes (ZnAtzPO4/6FDA-DAM MMMs) based on a microporous material with phosphate anion pillar ZnAtzPO4 (Atz = 3-amino-1, 2, 4-triazole) and 6FDA-DAM polymer matrix. Compared with the pure 6FDA-DAM membranes, the C2H4 permeability and the C2H4/C2H6 selectivity of 10 wt % ZnAtzPO4/6FDA-DAM MMMs were simultaneously increased by 46 and 6%, breaking the trade-off between permeability and selectivity. Interestingly, the separation performance of ZnAtzPO4/6FDA-DAM MMMs at 10 wt % for the equimolar C2H4/C2H6 gas mixture was 105.0 Barrer and 3.90, which surpassed the 2013 upper bound of C2H4/C2H6. For ZnAtzPO4/6FDA-DAM MMMs with 10 wt % filler loading, both the solubility selectivity and the diffusion selectivity continued to rise concurrently, enhancing the C2H4/C2H6 separation performance of ZnAtzPO4/6FDA-DAM MMMs. This work generates a useful concept for the design and fabrication of high-performance MMMs.
研究领域:
材料科学
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化学工程
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高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 193
·期 1
·49
·
IF 5.3
Wang Chuang,Peng Yue,Miao Yuanyuan,Sun Xinyuan,Cheng Wenting,Li Jinlong
DNA methyltransferases (MTases) play a critical role in epigenetic regulation and are closely associated with the occurrence and development of various diseases. To address the limitations of current detection methods, which often suffer from complicated operation and limited sensitivity we have developed a label-free fluorescent biosensing platform based on DNA-templated silver nanoclusters (DNA-AgNCs) for the detection of DNA adenine methyltransferase (Dam MTase) activity and the screening of its inhibitors. In this system, DNA-AgNCs signal probes are synthesized via a simple reduction reaction. Dumbbell-shaped DNA substrates are designed to be specifically methylated by Dam MTase in the presence of S-adenosylmethionine (SAM). The methylated substrates are subsequently recognized and cleaved by DpnI, yielding DNA fragments with 3′-OH termini. These termini are extended by terminal deoxynucleotidyl transferase (TdT) in the presence of dGTP, generating G-rich sequences, which hybridize with the DNA-AgNCs and significantly enhance the fluorescence intensity. This cascade reaction enables the sensitive detection of Dam MTase activity. Compared with the other approaches, the proposed method exhibits a wider linear range (0.5–10 U/mL) and a lower detection limit (0.165 U/mL). Furthermore, inhibition studies demonstrate that 5-fluorouracil and gentamicin effectively suppress Dam MTase activity. The method also shows excellent performance in complex biological samples. Overall, this fluorescence-based strategy offers high sensitivity and excellent specificity, demonstrating broad application prospects in epigenetic research and drug discovery. Graphical
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PubMed
高影响因子
危险品化学品经营许可证（带存储）